Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WZS1_LEIDO

TriTrypDb:

LdBPK_261050.1 , LdCL_260016100 , LDHU3_26.1330

Length:

562

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WZS1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WZS1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	256	260	PF00656	0.693
CLV_MEL_PAP_1	250	256	PF00089	0.628
CLV_NRD_NRD_1	26	28	PF00675	0.662
CLV_NRD_NRD_1	309	311	PF00675	0.573
CLV_NRD_NRD_1	44	46	PF00675	0.714
CLV_NRD_NRD_1	507	509	PF00675	0.636
CLV_NRD_NRD_1	522	524	PF00675	0.654
CLV_NRD_NRD_1	539	541	PF00675	0.468
CLV_NRD_NRD_1	544	546	PF00675	0.632
CLV_PCSK_KEX2_1	26	28	PF00082	0.662
CLV_PCSK_KEX2_1	309	311	PF00082	0.579
CLV_PCSK_KEX2_1	43	45	PF00082	0.730
CLV_PCSK_KEX2_1	507	509	PF00082	0.636
CLV_PCSK_KEX2_1	539	541	PF00082	0.526
CLV_PCSK_KEX2_1	544	546	PF00082	0.632
CLV_PCSK_PC1ET2_1	43	45	PF00082	0.692
CLV_PCSK_PC7_1	40	46	PF00082	0.665
CLV_PCSK_PC7_1	540	546	PF00082	0.581
CLV_PCSK_SKI1_1	120	124	PF00082	0.653
CLV_PCSK_SKI1_1	202	206	PF00082	0.707
CLV_PCSK_SKI1_1	496	500	PF00082	0.700
DEG_APCC_DBOX_1	154	162	PF00400	0.788
DOC_CYCLIN_RxL_1	117	127	PF00134	0.677
DOC_MAPK_MEF2A_6	353	361	PF00069	0.555
DOC_PP4_FxxP_1	162	165	PF00568	0.620
DOC_USP7_MATH_1	109	113	PF00917	0.757
DOC_USP7_MATH_1	137	141	PF00917	0.757
DOC_USP7_MATH_1	165	169	PF00917	0.725
DOC_USP7_MATH_1	216	220	PF00917	0.691
DOC_USP7_MATH_1	257	261	PF00917	0.623
DOC_USP7_MATH_1	299	303	PF00917	0.630
DOC_USP7_MATH_1	373	377	PF00917	0.647
DOC_USP7_MATH_1	420	424	PF00917	0.728
DOC_USP7_MATH_1	473	477	PF00917	0.716
DOC_USP7_MATH_1	65	69	PF00917	0.772
DOC_WW_Pin1_4	163	168	PF00397	0.635
DOC_WW_Pin1_4	183	188	PF00397	0.600
DOC_WW_Pin1_4	217	222	PF00397	0.695
DOC_WW_Pin1_4	29	34	PF00397	0.686
DOC_WW_Pin1_4	60	65	PF00397	0.671
DOC_WW_Pin1_4	86	91	PF00397	0.748
LIG_14-3-3_CanoR_1	147	157	PF00244	0.686
LIG_14-3-3_CanoR_1	239	247	PF00244	0.535
LIG_14-3-3_CanoR_1	26	30	PF00244	0.653
LIG_14-3-3_CanoR_1	309	317	PF00244	0.535
LIG_14-3-3_CanoR_1	38	46	PF00244	0.685
LIG_14-3-3_CanoR_1	388	395	PF00244	0.567
LIG_14-3-3_CanoR_1	421	430	PF00244	0.697
LIG_14-3-3_CanoR_1	477	485	PF00244	0.767
LIG_14-3-3_CanoR_1	496	502	PF00244	0.705
LIG_14-3-3_CanoR_1	544	552	PF00244	0.703
LIG_BIR_III_2	425	429	PF00653	0.717
LIG_BRCT_BRCA1_1	139	143	PF00533	0.760
LIG_BRCT_BRCA1_1	185	189	PF00533	0.742
LIG_BRCT_BRCA1_1	227	231	PF00533	0.701
LIG_BRCT_BRCA1_1	250	254	PF00533	0.739
LIG_BRCT_BRCA1_1	259	263	PF00533	0.520
LIG_BRCT_BRCA1_1	303	307	PF00533	0.640
LIG_BRCT_BRCA1_1	311	315	PF00533	0.426
LIG_BRCT_BRCA1_1	348	352	PF00533	0.397
LIG_deltaCOP1_diTrp_1	243	247	PF00928	0.634
LIG_deltaCOP1_diTrp_1	280	289	PF00928	0.593
LIG_eIF4E_1	553	559	PF01652	0.592
LIG_FHA_1	133	139	PF00498	0.686
LIG_FHA_1	388	394	PF00498	0.647
LIG_FHA_1	395	401	PF00498	0.630
LIG_FHA_1	497	503	PF00498	0.675
LIG_FHA_2	203	209	PF00498	0.726
LIG_FHA_2	285	291	PF00498	0.593
LIG_FHA_2	400	406	PF00498	0.615
LIG_FHA_2	409	415	PF00498	0.486
LIG_GBD_Chelix_1	529	537	PF00786	0.539
LIG_LIR_Apic_2	160	165	PF02991	0.624
LIG_LIR_Gen_1	242	252	PF02991	0.568
LIG_LIR_Gen_1	451	461	PF02991	0.645
LIG_LIR_Nem_3	17	22	PF02991	0.674
LIG_LIR_Nem_3	186	192	PF02991	0.592
LIG_LIR_Nem_3	228	234	PF02991	0.749
LIG_LIR_Nem_3	242	247	PF02991	0.494
LIG_LIR_Nem_3	349	355	PF02991	0.382
LIG_LIR_Nem_3	451	457	PF02991	0.631
LIG_MYND_1	2	6	PF01753	0.575
LIG_Pex14_1	7	11	PF04695	0.614
LIG_SH2_CRK	133	137	PF00017	0.654
LIG_SH2_CRK	19	23	PF00017	0.721
LIG_SH2_NCK_1	133	137	PF00017	0.654
LIG_SH2_NCK_1	401	405	PF00017	0.614
LIG_SH2_STAP1	347	351	PF00017	0.389
LIG_SH2_STAT3	234	237	PF00017	0.756
LIG_SH2_STAT3	347	350	PF00017	0.614
LIG_SH2_STAT5	125	128	PF00017	0.654
LIG_SH2_STAT5	319	322	PF00017	0.603
LIG_SH2_STAT5	401	404	PF00017	0.489
LIG_SH2_STAT5	532	535	PF00017	0.617
LIG_SH3_2	3	8	PF14604	0.644
LIG_SH3_3	103	109	PF00018	0.640
LIG_SH3_3	189	195	PF00018	0.626
LIG_SH3_3	209	215	PF00018	0.700
LIG_SH3_3	549	555	PF00018	0.713
LIG_SH3_3	59	65	PF00018	0.798
LIG_SH3_3	87	93	PF00018	0.766
LIG_TRAF2_1	114	117	PF00917	0.780
LIG_TRAF2_1	288	291	PF00917	0.507
LIG_WW_3	107	111	PF00397	0.702
MOD_CDC14_SPxK_1	63	66	PF00782	0.700
MOD_CDK_SPxK_1	60	66	PF00069	0.711
MOD_CDK_SPxxK_3	217	224	PF00069	0.626
MOD_CDK_SPxxK_3	29	36	PF00069	0.630
MOD_CK1_1	112	118	PF00069	0.785
MOD_CK1_1	170	176	PF00069	0.804
MOD_CK1_1	203	209	PF00069	0.743
MOD_CK1_1	217	223	PF00069	0.625
MOD_CK1_1	255	261	PF00069	0.668
MOD_CK1_1	32	38	PF00069	0.703
MOD_CK1_1	476	482	PF00069	0.681
MOD_CK1_1	82	88	PF00069	0.777
MOD_CK1_1	89	95	PF00069	0.685
MOD_CK2_1	111	117	PF00069	0.752
MOD_CK2_1	163	169	PF00069	0.726
MOD_CK2_1	202	208	PF00069	0.707
MOD_CK2_1	229	235	PF00069	0.691
MOD_CK2_1	284	290	PF00069	0.588
MOD_CK2_1	399	405	PF00069	0.573
MOD_CK2_1	519	525	PF00069	0.541
MOD_Cter_Amidation	542	545	PF01082	0.495
MOD_GlcNHglycan	139	142	PF01048	0.760
MOD_GlcNHglycan	16	19	PF01048	0.672
MOD_GlcNHglycan	169	172	PF01048	0.798
MOD_GlcNHglycan	176	179	PF01048	0.708
MOD_GlcNHglycan	216	219	PF01048	0.597
MOD_GlcNHglycan	22	25	PF01048	0.558
MOD_GlcNHglycan	250	253	PF01048	0.740
MOD_GlcNHglycan	255	258	PF01048	0.581
MOD_GlcNHglycan	296	299	PF01048	0.652
MOD_GlcNHglycan	301	304	PF01048	0.686
MOD_GlcNHglycan	311	314	PF01048	0.317
MOD_GlcNHglycan	479	482	PF01048	0.740
MOD_GlcNHglycan	541	544	PF01048	0.626
MOD_GlcNHglycan	67	70	PF01048	0.809
MOD_GSK3_1	108	115	PF00069	0.698
MOD_GSK3_1	163	170	PF00069	0.722
MOD_GSK3_1	216	223	PF00069	0.716
MOD_GSK3_1	225	232	PF00069	0.542
MOD_GSK3_1	248	255	PF00069	0.686
MOD_GSK3_1	25	32	PF00069	0.661
MOD_GSK3_1	301	308	PF00069	0.635
MOD_GSK3_1	369	376	PF00069	0.644
MOD_GSK3_1	387	394	PF00069	0.680
MOD_GSK3_1	399	406	PF00069	0.527
MOD_GSK3_1	473	480	PF00069	0.714
MOD_GSK3_1	539	546	PF00069	0.632
MOD_GSK3_1	79	86	PF00069	0.677
MOD_LATS_1	494	500	PF00433	0.705
MOD_LATS_1	77	83	PF00433	0.716
MOD_NEK2_1	132	137	PF00069	0.758
MOD_NEK2_1	174	179	PF00069	0.742
MOD_NEK2_1	25	30	PF00069	0.662
MOD_NEK2_1	369	374	PF00069	0.728
MOD_NEK2_1	403	408	PF00069	0.473
MOD_NEK2_1	450	455	PF00069	0.520
MOD_NEK2_1	84	89	PF00069	0.684
MOD_NEK2_2	157	162	PF00069	0.692
MOD_PIKK_1	148	154	PF00454	0.630
MOD_PIKK_1	319	325	PF00454	0.534
MOD_PIKK_1	346	352	PF00454	0.413
MOD_PIKK_1	79	85	PF00454	0.800
MOD_PKA_1	309	315	PF00069	0.542
MOD_PKA_1	539	545	PF00069	0.602
MOD_PKA_2	109	115	PF00069	0.726
MOD_PKA_2	146	152	PF00069	0.757
MOD_PKA_2	25	31	PF00069	0.716
MOD_PKA_2	252	258	PF00069	0.736
MOD_PKA_2	309	315	PF00069	0.542
MOD_PKA_2	387	393	PF00069	0.597
MOD_PKA_2	420	426	PF00069	0.747
MOD_PKA_2	476	482	PF00069	0.627
MOD_PKA_2	519	525	PF00069	0.688
MOD_PKA_2	539	545	PF00069	0.602
MOD_PKB_1	36	44	PF00069	0.622
MOD_Plk_1	465	471	PF00069	0.776
MOD_Plk_4	157	163	PF00069	0.646
MOD_Plk_4	450	456	PF00069	0.520
MOD_Plk_4	497	503	PF00069	0.682
MOD_Plk_4	554	560	PF00069	0.744
MOD_ProDKin_1	163	169	PF00069	0.636
MOD_ProDKin_1	183	189	PF00069	0.602
MOD_ProDKin_1	217	223	PF00069	0.693
MOD_ProDKin_1	29	35	PF00069	0.686
MOD_ProDKin_1	60	66	PF00069	0.670
MOD_ProDKin_1	86	92	PF00069	0.747
TRG_DiLeu_BaEn_2	184	190	PF01217	0.588
TRG_DiLeu_BaEn_2	443	449	PF01217	0.558
TRG_DiLeu_BaLyEn_6	245	250	PF01217	0.737
TRG_ENDOCYTIC_2	133	136	PF00928	0.653
TRG_ENDOCYTIC_2	19	22	PF00928	0.722
TRG_ER_diArg_1	25	27	PF00400	0.666
TRG_ER_diArg_1	36	39	PF00400	0.671
TRG_ER_diArg_1	44	46	PF00400	0.643
TRG_ER_diArg_1	539	541	PF00400	0.526
TRG_NLS_Bipartite_1	26	47	PF00514	0.634
TRG_NLS_MonoExtC_3	42	48	PF00514	0.645
TRG_NLS_MonoExtN_4	40	47	PF00514	0.658
TRG_Pf-PMV_PEXEL_1	130	134	PF00026	0.661

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P648	Leptomonas seymouri	33%	100%
A4HEW3	Leishmania braziliensis	66%	100%
A4I236	Leishmania infantum	99%	100%
E9AY86	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4Q987	Leishmania major	89%	100%