2Fe-2S iron-sulfur cluster binding domain family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

2Fe-2S iron-sulfur cluster binding domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WZQ5_LEIDO

TriTrypDb:

LdBPK_261030.1 , LdCL_260015900 , LDHU3_26.1310

Length:

175

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WZQ5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WZQ5

Function

Biological processes
Term	Name	Level	Count
GO:0006091	generation of precursor metabolites and energy	3	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0022900	electron transport chain	4	11
GO:0044237	cellular metabolic process	2	11
GO:0140647	P450-containing electron transport chain	5	11

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0051536	iron-sulfur cluster binding	3	11
GO:0051537	2 iron, 2 sulfur cluster binding	4	11
GO:0051540	metal cluster binding	2	11
GO:0003824	catalytic activity	1	1
GO:0009055	electron transfer activity	3	1
GO:0016491	oxidoreductase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	64	68	PF00656	0.609
CLV_NRD_NRD_1	21	23	PF00675	0.621
CLV_NRD_NRD_1	46	48	PF00675	0.609
CLV_PCSK_KEX2_1	147	149	PF00082	0.557
CLV_PCSK_KEX2_1	21	23	PF00082	0.621
CLV_PCSK_KEX2_1	46	48	PF00082	0.562
CLV_PCSK_PC1ET2_1	147	149	PF00082	0.557
CLV_PCSK_SKI1_1	21	25	PF00082	0.654
DEG_Nend_Nbox_1	1	3	PF02207	0.564
DOC_MAPK_gen_1	157	167	PF00069	0.522
DOC_MAPK_gen_1	55	63	PF00069	0.501
DOC_MAPK_HePTP_8	144	158	PF00069	0.542
DOC_MAPK_MEF2A_6	55	63	PF00069	0.501
DOC_PP4_FxxP_1	117	120	PF00568	0.255
DOC_PP4_FxxP_1	63	66	PF00568	0.607
DOC_WW_Pin1_4	7	12	PF00397	0.630
LIG_14-3-3_CanoR_1	7	11	PF00244	0.670
LIG_APCC_ABBA_1	114	119	PF00400	0.280
LIG_BRCT_BRCA1_1	44	48	PF00533	0.580
LIG_eIF4E_1	76	82	PF01652	0.255
LIG_FHA_1	102	108	PF00498	0.237
LIG_FHA_1	135	141	PF00498	0.255
LIG_FHA_1	18	24	PF00498	0.702
LIG_FHA_1	25	31	PF00498	0.549
LIG_FHA_1	34	40	PF00498	0.368
LIG_FHA_2	119	125	PF00498	0.252
LIG_FHA_2	62	68	PF00498	0.513
LIG_FHA_2	78	84	PF00498	0.172
LIG_Integrin_isoDGR_2	16	18	PF01839	0.521
LIG_LIR_Apic_2	115	120	PF02991	0.256
LIG_LIR_Apic_2	60	66	PF02991	0.615
LIG_SH2_CRK	2	6	PF00017	0.600
LIG_SH2_SRC	166	169	PF00017	0.507
LIG_SH2_STAT3	76	79	PF00017	0.237
LIG_SH2_STAT5	108	111	PF00017	0.237
LIG_SH2_STAT5	166	169	PF00017	0.507
LIG_SH3_3	153	159	PF00018	0.556
LIG_SUMO_SIM_par_1	56	62	PF11976	0.500
LIG_TRAF2_1	121	124	PF00917	0.233
MOD_CK1_1	9	15	PF00069	0.644
MOD_CK2_1	118	124	PF00069	0.252
MOD_GlcNHglycan	33	36	PF01048	0.468
MOD_GSK3_1	17	24	PF00069	0.580
MOD_GSK3_1	38	45	PF00069	0.576
MOD_GSK3_1	6	13	PF00069	0.670
MOD_GSK3_1	96	103	PF00069	0.285
MOD_NEK2_1	1	6	PF00069	0.582
MOD_NEK2_1	42	47	PF00069	0.684
MOD_NEK2_2	101	106	PF00069	0.237
MOD_NEK2_2	142	147	PF00069	0.600
MOD_NEK2_2	33	38	PF00069	0.357
MOD_OFUCOSY	100	105	PF10250	0.238
MOD_PKA_1	21	27	PF00069	0.496
MOD_PKA_2	159	165	PF00069	0.518
MOD_PKA_2	17	23	PF00069	0.575
MOD_PKA_2	6	12	PF00069	0.682
MOD_Plk_1	61	67	PF00069	0.574
MOD_Plk_2-3	77	83	PF00069	0.255
MOD_Plk_4	25	31	PF00069	0.670
MOD_Plk_4	38	44	PF00069	0.693
MOD_Plk_4	77	83	PF00069	0.254
MOD_ProDKin_1	7	13	PF00069	0.631
MOD_SUMO_rev_2	67	73	PF00179	0.315
TRG_DiLeu_BaEn_1	77	82	PF01217	0.255
TRG_ENDOCYTIC_2	2	5	PF00928	0.600
TRG_ER_diArg_1	21	23	PF00400	0.617
TRG_ER_diArg_1	46	48	PF00400	0.678

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6W3	Leptomonas seymouri	30%	100%
A0A0N1HYR7	Leptomonas seymouri	29%	100%
A0A0N1HZ74	Leptomonas seymouri	72%	100%
A0A0N1I5P4	Leptomonas seymouri	35%	100%
A0A0S4JS28	Bodo saltans	63%	100%
A0A1X0NSB1	Trypanosomatidae	59%	97%
A0A3R7MK78	Trypanosoma rangeli	38%	100%
A0A3R7NM96	Trypanosoma rangeli	65%	91%
A4HEW1	Leishmania braziliensis	85%	100%
A4HJN3	Leishmania braziliensis	35%	100%
A4I234	Leishmania infantum	99%	100%
C9ZRX1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	98%
E9AY84	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
P37193	Drosophila melanogaster	39%	100%
P46656	Mus musculus	34%	93%
Q05B51	Bos taurus	43%	94%
Q08C57	Danio rerio	40%	90%
Q12184	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	47%	100%
Q4Q989	Leishmania major	95%	100%
Q5FWQ0	Xenopus laevis	40%	91%
Q6P4F2	Homo sapiens	42%	94%
Q8S904	Arabidopsis thaliana	45%	89%
Q8SZA8	Drosophila melanogaster	34%	100%
Q9CPW2	Mus musculus	42%	100%
Q9M0V0	Arabidopsis thaliana	42%	89%