Hypothetical_protein_conserved

Quick info Annotations Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WZN6_LEIDO

TriTrypDb:

LdBPK_260430.1 , LdCL_260009800 , LDHU3_26.0560

Length:

332

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0005743	mitochondrial inner membrane	5	1
GO:0019866	organelle inner membrane	4	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A0A3S7WZN6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WZN6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	163	167	PF00656	0.584
CLV_NRD_NRD_1	16	18	PF00675	0.475
CLV_NRD_NRD_1	27	29	PF00675	0.424
CLV_PCSK_KEX2_1	16	18	PF00082	0.475
CLV_PCSK_KEX2_1	27	29	PF00082	0.424
CLV_PCSK_SKI1_1	224	228	PF00082	0.246
DEG_Nend_UBRbox_3	1	3	PF02207	0.597
DOC_CYCLIN_RxL_1	218	230	PF00134	0.534
DOC_MAPK_gen_1	16	26	PF00069	0.668
DOC_PP1_RVXF_1	222	229	PF00149	0.390
DOC_USP7_MATH_1	144	148	PF00917	0.655
DOC_USP7_MATH_1	155	159	PF00917	0.610
DOC_USP7_MATH_1	239	243	PF00917	0.223
DOC_USP7_MATH_1	64	68	PF00917	0.667
DOC_USP7_MATH_1	77	81	PF00917	0.666
DOC_WW_Pin1_4	100	105	PF00397	0.665
DOC_WW_Pin1_4	201	206	PF00397	0.706
DOC_WW_Pin1_4	44	49	PF00397	0.675
DOC_WW_Pin1_4	78	83	PF00397	0.634
LIG_14-3-3_CanoR_1	27	32	PF00244	0.656
LIG_14-3-3_CanoR_1	95	104	PF00244	0.634
LIG_BRCT_BRCA1_1	96	100	PF00533	0.659
LIG_CtBP_PxDLS_1	48	52	PF00389	0.576
LIG_deltaCOP1_diTrp_1	302	311	PF00928	0.388
LIG_FHA_1	19	25	PF00498	0.696
LIG_FHA_2	122	128	PF00498	0.593
LIG_FHA_2	158	164	PF00498	0.651
LIG_FHA_2	56	62	PF00498	0.687
LIG_LIR_Gen_1	230	239	PF02991	0.241
LIG_LIR_Gen_1	309	317	PF02991	0.291
LIG_LIR_Nem_3	230	235	PF02991	0.241
LIG_LIR_Nem_3	301	307	PF02991	0.320
LIG_LIR_Nem_3	309	314	PF02991	0.265
LIG_PCNA_PIPBox_1	182	191	PF02747	0.590
LIG_Pex14_1	228	232	PF04695	0.241
LIG_SH2_CRK	223	227	PF00017	0.420
LIG_SH2_CRK	250	254	PF00017	0.396
LIG_SH2_NCK_1	272	276	PF00017	0.295
LIG_SH2_SRC	142	145	PF00017	0.502
LIG_SH2_STAP1	272	276	PF00017	0.295
LIG_SH2_STAT5	142	145	PF00017	0.533
LIG_SH2_STAT5	246	249	PF00017	0.406
LIG_SH2_STAT5	293	296	PF00017	0.368
LIG_SH3_3	2	8	PF00018	0.644
LIG_SH3_3	207	213	PF00018	0.664
LIG_SH3_3	294	300	PF00018	0.384
LIG_SH3_3	42	48	PF00018	0.656
LIG_SUMO_SIM_par_1	293	298	PF11976	0.337
LIG_SUMO_SIM_par_1	46	53	PF11976	0.716
LIG_TRAF2_1	124	127	PF00917	0.629
LIG_TYR_ITIM	221	226	PF00017	0.563
MOD_CDC14_SPxK_1	209	212	PF00782	0.569
MOD_CDK_SPxK_1	206	212	PF00069	0.574
MOD_CK1_1	158	164	PF00069	0.663
MOD_CK1_1	172	178	PF00069	0.682
MOD_CK1_1	47	53	PF00069	0.662
MOD_CK1_1	80	86	PF00069	0.659
MOD_CK2_1	111	117	PF00069	0.553
MOD_CK2_1	121	127	PF00069	0.537
MOD_CK2_1	157	163	PF00069	0.726
MOD_GlcNHglycan	113	116	PF01048	0.390
MOD_GlcNHglycan	146	149	PF01048	0.434
MOD_GlcNHglycan	159	163	PF01048	0.451
MOD_GlcNHglycan	171	174	PF01048	0.519
MOD_GlcNHglycan	191	194	PF01048	0.454
MOD_GlcNHglycan	237	240	PF01048	0.398
MOD_GlcNHglycan	311	314	PF01048	0.569
MOD_GlcNHglycan	66	69	PF01048	0.478
MOD_GSK3_1	165	172	PF00069	0.734
MOD_GSK3_1	235	242	PF00069	0.391
MOD_GSK3_1	320	327	PF00069	0.444
MOD_GSK3_1	43	50	PF00069	0.643
MOD_LATS_1	25	31	PF00433	0.648
MOD_N-GLC_1	324	329	PF02516	0.632
MOD_NEK2_1	189	194	PF00069	0.529
MOD_NEK2_1	227	232	PF00069	0.260
MOD_NEK2_1	235	240	PF00069	0.251
MOD_NEK2_1	49	54	PF00069	0.707
MOD_NEK2_1	94	99	PF00069	0.668
MOD_NEK2_2	249	254	PF00069	0.371
MOD_PIKK_1	175	181	PF00454	0.573
MOD_PIKK_1	95	101	PF00454	0.620
MOD_PK_1	27	33	PF00069	0.693
MOD_PKA_1	27	33	PF00069	0.705
MOD_PKA_2	27	33	PF00069	0.705
MOD_PKA_2	94	100	PF00069	0.609
MOD_Plk_1	324	330	PF00069	0.416
MOD_Plk_4	285	291	PF00069	0.452
MOD_ProDKin_1	100	106	PF00069	0.663
MOD_ProDKin_1	201	207	PF00069	0.706
MOD_ProDKin_1	44	50	PF00069	0.678
MOD_ProDKin_1	78	84	PF00069	0.633
TRG_ENDOCYTIC_2	223	226	PF00928	0.495
TRG_ENDOCYTIC_2	250	253	PF00928	0.392
TRG_ER_diArg_1	15	17	PF00400	0.677
TRG_ER_diArg_1	19	22	PF00400	0.647
TRG_ER_diArg_1	26	28	PF00400	0.622
TRG_Pf-PMV_PEXEL_1	254	258	PF00026	0.600
TRG_Pf-PMV_PEXEL_1	305	309	PF00026	0.506

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P498	Leptomonas seymouri	49%	100%
A0A0S4KLN6	Bodo saltans	28%	100%
A0A1X0NSG9	Trypanosomatidae	34%	100%
A0A3R7MX83	Trypanosoma rangeli	31%	100%
A4HEQ0	Leishmania braziliensis	63%	100%
A4I1Y0	Leishmania infantum	100%	100%
C9ZS39	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AY26	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4Q9E7	Leishmania major	88%	100%
V5B9G1	Trypanosoma cruzi	37%	100%