LeishMANIAdb
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Mitochondrial carrier domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Mitochondrial carrier domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3S7WZN2_LEIDO
TriTrypDb:
LdBPK_260530.1 , LdCL_260011000 , LDHU3_26.0700
Length:
702

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0016020 membrane 2 2
GO:0110165 cellular anatomical entity 1 2

Expansion

Sequence features

A0A3S7WZN2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WZN2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 109 113 PF00656 0.751
CLV_C14_Caspase3-7 12 16 PF00656 0.724
CLV_C14_Caspase3-7 183 187 PF00656 0.472
CLV_C14_Caspase3-7 323 327 PF00656 0.765
CLV_C14_Caspase3-7 420 424 PF00656 0.704
CLV_C14_Caspase3-7 536 540 PF00656 0.663
CLV_MEL_PAP_1 413 419 PF00089 0.515
CLV_NRD_NRD_1 147 149 PF00675 0.394
CLV_NRD_NRD_1 237 239 PF00675 0.684
CLV_NRD_NRD_1 611 613 PF00675 0.348
CLV_NRD_NRD_1 691 693 PF00675 0.503
CLV_PCSK_KEX2_1 147 149 PF00082 0.394
CLV_PCSK_KEX2_1 175 177 PF00082 0.621
CLV_PCSK_KEX2_1 237 239 PF00082 0.684
CLV_PCSK_KEX2_1 611 613 PF00082 0.348
CLV_PCSK_PC1ET2_1 175 177 PF00082 0.621
CLV_PCSK_SKI1_1 168 172 PF00082 0.505
CLV_PCSK_SKI1_1 612 616 PF00082 0.382
CLV_PCSK_SKI1_1 684 688 PF00082 0.373
CLV_Separin_Metazoa 314 318 PF03568 0.691
DEG_APCC_DBOX_1 139 147 PF00400 0.590
DEG_APCC_DBOX_1 220 228 PF00400 0.488
DEG_APCC_DBOX_1 610 618 PF00400 0.530
DEG_SPOP_SBC_1 351 355 PF00917 0.767
DEG_SPOP_SBC_1 602 606 PF00917 0.500
DOC_CKS1_1 332 337 PF01111 0.786
DOC_CYCLIN_yCln2_LP_2 146 152 PF00134 0.492
DOC_MAPK_gen_1 237 243 PF00069 0.485
DOC_MAPK_gen_1 611 619 PF00069 0.524
DOC_MAPK_MEF2A_6 280 289 PF00069 0.292
DOC_PP2B_LxvP_1 211 214 PF13499 0.504
DOC_PP2B_LxvP_1 289 292 PF13499 0.335
DOC_PP2B_LxvP_1 587 590 PF13499 0.618
DOC_PP4_FxxP_1 397 400 PF00568 0.732
DOC_PP4_FxxP_1 634 637 PF00568 0.573
DOC_USP7_MATH_1 162 166 PF00917 0.313
DOC_USP7_MATH_1 185 189 PF00917 0.521
DOC_USP7_MATH_1 202 206 PF00917 0.480
DOC_USP7_MATH_1 338 342 PF00917 0.814
DOC_USP7_MATH_1 351 355 PF00917 0.642
DOC_USP7_MATH_1 378 382 PF00917 0.792
DOC_USP7_MATH_1 460 464 PF00917 0.719
DOC_USP7_MATH_1 479 483 PF00917 0.615
DOC_USP7_MATH_1 48 52 PF00917 0.688
DOC_USP7_MATH_1 511 515 PF00917 0.757
DOC_USP7_MATH_1 526 530 PF00917 0.739
DOC_USP7_MATH_1 646 650 PF00917 0.588
DOC_USP7_MATH_1 90 94 PF00917 0.702
DOC_USP7_UBL2_3 689 693 PF12436 0.619
DOC_WW_Pin1_4 114 119 PF00397 0.666
DOC_WW_Pin1_4 331 336 PF00397 0.723
DOC_WW_Pin1_4 344 349 PF00397 0.703
DOC_WW_Pin1_4 408 413 PF00397 0.704
DOC_WW_Pin1_4 423 428 PF00397 0.746
DOC_WW_Pin1_4 484 489 PF00397 0.799
DOC_WW_Pin1_4 500 505 PF00397 0.690
DOC_WW_Pin1_4 509 514 PF00397 0.697
DOC_WW_Pin1_4 537 542 PF00397 0.669
DOC_WW_Pin1_4 648 653 PF00397 0.596
LIG_14-3-3_CanoR_1 116 126 PF00244 0.650
LIG_14-3-3_CanoR_1 140 144 PF00244 0.595
LIG_14-3-3_CanoR_1 168 174 PF00244 0.503
LIG_14-3-3_CanoR_1 221 225 PF00244 0.404
LIG_14-3-3_CanoR_1 306 315 PF00244 0.667
LIG_14-3-3_CanoR_1 416 425 PF00244 0.747
LIG_14-3-3_CanoR_1 440 448 PF00244 0.736
LIG_14-3-3_CanoR_1 533 538 PF00244 0.668
LIG_14-3-3_CanoR_1 568 574 PF00244 0.498
LIG_14-3-3_CanoR_1 611 617 PF00244 0.583
LIG_APCC_ABBA_1 26 31 PF00400 0.705
LIG_APCC_ABBA_1 70 75 PF00400 0.706
LIG_BIR_II_1 1 5 PF00653 0.690
LIG_BIR_III_2 326 330 PF00653 0.676
LIG_BIR_III_2 345 349 PF00653 0.659
LIG_BRCT_BRCA1_1 122 126 PF00533 0.638
LIG_BRCT_BRCA1_1 90 94 PF00533 0.740
LIG_CtBP_PxDLS_1 590 594 PF00389 0.611
LIG_deltaCOP1_diTrp_1 273 278 PF00928 0.481
LIG_FHA_1 311 317 PF00498 0.684
LIG_FHA_1 420 426 PF00498 0.759
LIG_FHA_1 442 448 PF00498 0.760
LIG_FHA_1 596 602 PF00498 0.527
LIG_FHA_2 260 266 PF00498 0.491
LIG_FHA_2 384 390 PF00498 0.680
LIG_LIR_Apic_2 632 637 PF02991 0.534
LIG_LIR_Gen_1 123 131 PF02991 0.625
LIG_LIR_Gen_1 208 217 PF02991 0.520
LIG_LIR_Gen_1 51 62 PF02991 0.767
LIG_LIR_Gen_1 670 680 PF02991 0.590
LIG_LIR_Gen_1 98 108 PF02991 0.667
LIG_LIR_Nem_3 123 129 PF02991 0.625
LIG_LIR_Nem_3 208 213 PF02991 0.440
LIG_LIR_Nem_3 51 57 PF02991 0.766
LIG_LIR_Nem_3 670 675 PF02991 0.614
LIG_LIR_Nem_3 98 104 PF02991 0.745
LIG_PCNA_yPIPBox_3 268 280 PF02747 0.495
LIG_Pex14_2 173 177 PF04695 0.500
LIG_Pex14_2 290 294 PF04695 0.335
LIG_SH2_CRK 101 105 PF00017 0.744
LIG_SH2_CRK 54 58 PF00017 0.766
LIG_SH2_CRK 682 686 PF00017 0.518
LIG_SH2_GRB2like 131 134 PF00017 0.611
LIG_SH2_GRB2like 210 213 PF00017 0.469
LIG_SH2_GRB2like 84 87 PF00017 0.681
LIG_SH2_NCK_1 101 105 PF00017 0.707
LIG_SH2_NCK_1 54 58 PF00017 0.682
LIG_SH2_PTP2 642 645 PF00017 0.530
LIG_SH2_SRC 210 213 PF00017 0.469
LIG_SH2_SRC 38 41 PF00017 0.782
LIG_SH2_STAP1 101 105 PF00017 0.707
LIG_SH2_STAP1 131 135 PF00017 0.611
LIG_SH2_STAP1 682 686 PF00017 0.573
LIG_SH2_STAT5 135 138 PF00017 0.695
LIG_SH2_STAT5 152 155 PF00017 0.219
LIG_SH2_STAT5 210 213 PF00017 0.515
LIG_SH2_STAT5 433 436 PF00017 0.735
LIG_SH2_STAT5 61 64 PF00017 0.767
LIG_SH2_STAT5 642 645 PF00017 0.530
LIG_SH2_STAT5 77 80 PF00017 0.628
LIG_SH3_1 280 286 PF00018 0.292
LIG_SH3_3 280 286 PF00018 0.292
LIG_SH3_3 329 335 PF00018 0.794
LIG_SH3_3 395 401 PF00018 0.728
LIG_SH3_3 409 415 PF00018 0.696
LIG_SH3_3 424 430 PF00018 0.799
LIG_SH3_3 516 522 PF00018 0.709
LIG_SH3_3 571 577 PF00018 0.490
LIG_SUMO_SIM_anti_2 572 578 PF11976 0.550
LIG_SUMO_SIM_par_1 15 25 PF11976 0.774
LIG_SUMO_SIM_par_1 481 487 PF11976 0.751
LIG_SUMO_SIM_par_1 533 540 PF11976 0.702
LIG_SUMO_SIM_par_1 572 578 PF11976 0.527
LIG_TRAF2_1 30 33 PF00917 0.705
LIG_TYR_ITIM 52 57 PF00017 0.766
LIG_TYR_ITIM 680 685 PF00017 0.505
LIG_UBA3_1 293 300 PF00899 0.389
LIG_WRC_WIRS_1 631 636 PF05994 0.589
MOD_CDC14_SPxK_1 336 339 PF00782 0.684
MOD_CDC14_SPxK_1 540 543 PF00782 0.527
MOD_CDK_SPK_2 486 491 PF00069 0.746
MOD_CDK_SPxK_1 333 339 PF00069 0.688
MOD_CDK_SPxK_1 537 543 PF00069 0.554
MOD_CDK_SPxxK_3 484 491 PF00069 0.745
MOD_CDK_SPxxK_3 513 520 PF00069 0.743
MOD_CK1_1 117 123 PF00069 0.654
MOD_CK1_1 138 144 PF00069 0.572
MOD_CK1_1 180 186 PF00069 0.506
MOD_CK1_1 195 201 PF00069 0.412
MOD_CK1_1 205 211 PF00069 0.511
MOD_CK1_1 223 229 PF00069 0.344
MOD_CK1_1 24 30 PF00069 0.792
MOD_CK1_1 360 366 PF00069 0.752
MOD_CK1_1 372 378 PF00069 0.663
MOD_CK1_1 381 387 PF00069 0.723
MOD_CK1_1 42 48 PF00069 0.646
MOD_CK1_1 426 432 PF00069 0.759
MOD_CK1_1 441 447 PF00069 0.660
MOD_CK1_1 482 488 PF00069 0.745
MOD_CK1_1 55 61 PF00069 0.641
MOD_CK1_1 65 71 PF00069 0.765
MOD_CK1_1 82 88 PF00069 0.598
MOD_CK2_1 223 229 PF00069 0.389
MOD_CK2_1 259 265 PF00069 0.483
MOD_CK2_1 27 33 PF00069 0.705
MOD_CMANNOS 275 278 PF00535 0.681
MOD_GlcNHglycan 112 115 PF01048 0.492
MOD_GlcNHglycan 159 162 PF01048 0.337
MOD_GlcNHglycan 179 182 PF01048 0.529
MOD_GlcNHglycan 194 197 PF01048 0.604
MOD_GlcNHglycan 207 210 PF01048 0.598
MOD_GlcNHglycan 254 257 PF01048 0.715
MOD_GlcNHglycan 268 271 PF01048 0.659
MOD_GlcNHglycan 308 311 PF01048 0.514
MOD_GlcNHglycan 354 357 PF01048 0.542
MOD_GlcNHglycan 359 362 PF01048 0.614
MOD_GlcNHglycan 376 379 PF01048 0.480
MOD_GlcNHglycan 383 386 PF01048 0.564
MOD_GlcNHglycan 577 580 PF01048 0.400
MOD_GlcNHglycan 67 70 PF01048 0.551
MOD_GSK3_1 100 107 PF00069 0.634
MOD_GSK3_1 110 117 PF00069 0.666
MOD_GSK3_1 121 128 PF00069 0.634
MOD_GSK3_1 135 142 PF00069 0.593
MOD_GSK3_1 180 187 PF00069 0.515
MOD_GSK3_1 201 208 PF00069 0.493
MOD_GSK3_1 274 281 PF00069 0.524
MOD_GSK3_1 306 313 PF00069 0.648
MOD_GSK3_1 327 334 PF00069 0.708
MOD_GSK3_1 368 375 PF00069 0.790
MOD_GSK3_1 38 45 PF00069 0.699
MOD_GSK3_1 383 390 PF00069 0.674
MOD_GSK3_1 419 426 PF00069 0.724
MOD_GSK3_1 434 441 PF00069 0.811
MOD_GSK3_1 478 485 PF00069 0.772
MOD_GSK3_1 48 55 PF00069 0.684
MOD_GSK3_1 509 516 PF00069 0.793
MOD_GSK3_1 533 540 PF00069 0.680
MOD_GSK3_1 591 598 PF00069 0.609
MOD_GSK3_1 60 67 PF00069 0.688
MOD_GSK3_1 71 78 PF00069 0.686
MOD_GSK3_1 88 95 PF00069 0.674
MOD_GSK3_1 9 16 PF00069 0.702
MOD_LATS_1 304 310 PF00433 0.635
MOD_LATS_1 438 444 PF00433 0.767
MOD_N-GLC_1 13 18 PF02516 0.489
MOD_N-GLC_1 310 315 PF02516 0.552
MOD_N-GLC_1 357 362 PF02516 0.495
MOD_NEK2_1 122 127 PF00069 0.635
MOD_NEK2_1 13 18 PF00069 0.728
MOD_NEK2_1 139 144 PF00069 0.591
MOD_NEK2_1 169 174 PF00069 0.471
MOD_NEK2_1 177 182 PF00069 0.427
MOD_NEK2_1 352 357 PF00069 0.730
MOD_NEK2_1 52 57 PF00069 0.682
MOD_NEK2_1 667 672 PF00069 0.547
MOD_NEK2_2 135 140 PF00069 0.563
MOD_PIKK_1 39 45 PF00454 0.782
MOD_PIKK_1 442 448 PF00454 0.721
MOD_PK_1 533 539 PF00069 0.689
MOD_PKA_2 139 145 PF00069 0.591
MOD_PKA_2 220 226 PF00069 0.406
MOD_PKA_2 252 258 PF00069 0.447
MOD_PKA_2 338 344 PF00069 0.740
MOD_PKA_2 372 378 PF00069 0.761
MOD_PKA_2 381 387 PF00069 0.728
MOD_PKA_2 441 447 PF00069 0.805
MOD_PKA_2 65 71 PF00069 0.794
MOD_PKB_1 440 448 PF00069 0.730
MOD_Plk_1 13 19 PF00069 0.689
MOD_Plk_1 185 191 PF00069 0.437
MOD_Plk_1 21 27 PF00069 0.696
MOD_Plk_1 52 58 PF00069 0.700
MOD_Plk_1 99 105 PF00069 0.708
MOD_Plk_4 100 106 PF00069 0.696
MOD_Plk_4 125 131 PF00069 0.697
MOD_Plk_4 223 229 PF00069 0.427
MOD_Plk_4 24 30 PF00069 0.752
MOD_Plk_4 338 344 PF00069 0.742
MOD_Plk_4 479 485 PF00069 0.741
MOD_Plk_4 569 575 PF00069 0.493
MOD_Plk_4 603 609 PF00069 0.580
MOD_Plk_4 612 618 PF00069 0.509
MOD_Plk_4 79 85 PF00069 0.681
MOD_ProDKin_1 114 120 PF00069 0.661
MOD_ProDKin_1 331 337 PF00069 0.717
MOD_ProDKin_1 344 350 PF00069 0.704
MOD_ProDKin_1 408 414 PF00069 0.704
MOD_ProDKin_1 423 429 PF00069 0.746
MOD_ProDKin_1 484 490 PF00069 0.800
MOD_ProDKin_1 500 506 PF00069 0.691
MOD_ProDKin_1 509 515 PF00069 0.696
MOD_ProDKin_1 537 543 PF00069 0.668
MOD_ProDKin_1 648 654 PF00069 0.591
TRG_DiLeu_BaLyEn_6 681 686 PF01217 0.568
TRG_ENDOCYTIC_2 101 104 PF00928 0.679
TRG_ENDOCYTIC_2 105 108 PF00928 0.659
TRG_ENDOCYTIC_2 152 155 PF00928 0.335
TRG_ENDOCYTIC_2 210 213 PF00928 0.431
TRG_ENDOCYTIC_2 54 57 PF00928 0.766
TRG_ENDOCYTIC_2 642 645 PF00928 0.499
TRG_ENDOCYTIC_2 682 685 PF00928 0.512
TRG_ER_diArg_1 146 148 PF00400 0.632
TRG_ER_diArg_1 236 238 PF00400 0.475
TRG_ER_diArg_1 316 319 PF00400 0.781
TRG_Pf-PMV_PEXEL_1 452 456 PF00026 0.558
TRG_Pf-PMV_PEXEL_1 684 688 PF00026 0.373

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P4A2 Leptomonas seymouri 49% 99%
A4HER1 Leishmania braziliensis 74% 100%
A4I1Y8 Leishmania infantum 100% 100%
E9AY35 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
Q4Q9D8 Leishmania major 94% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS