Leucine_rich_repeat/Leucine_Rich_Repeat/Leucine_R ich_repeat_putative/Pfam:PF13504/Pfam:PF00560/Pfam:PF13516

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WZL6_LEIDO

TriTrypDb:

LdBPK_260490.1 , LdCL_260010400 , LDHU3_26.0630

Length:

429

Annotations

LeishMANIAdb annotations

Leucine-rich repeat proteins with a hydrophobic terminal helix. Unlike its distant animal relatives, this cytoplasmic sensor protein might be anchored to the membrane.

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	12
GO:0042995	cell projection	2	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0110165	cellular anatomical entity	1	12
GO:0120025	plasma membrane bounded cell projection	3	12

Expansion

Sequence features

A0A3S7WZL6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WZL6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	33	37	PF00656	0.321
CLV_NRD_NRD_1	198	200	PF00675	0.496
CLV_PCSK_KEX2_1	198	200	PF00082	0.517
CLV_PCSK_KEX2_1	384	386	PF00082	0.567
CLV_PCSK_PC1ET2_1	384	386	PF00082	0.504
CLV_PCSK_PC7_1	380	386	PF00082	0.503
CLV_PCSK_SKI1_1	18	22	PF00082	0.414
CLV_PCSK_SKI1_1	198	202	PF00082	0.394
CLV_PCSK_SKI1_1	281	285	PF00082	0.518
CLV_PCSK_SKI1_1	393	397	PF00082	0.588
DEG_APCC_DBOX_1	280	288	PF00400	0.452
DEG_Nend_UBRbox_3	1	3	PF02207	0.617
DOC_ANK_TNKS_1	120	127	PF00023	0.516
DOC_CKS1_1	25	30	PF01111	0.385
DOC_CYCLIN_RxL_1	15	24	PF00134	0.421
DOC_MAPK_gen_1	192	202	PF00069	0.400
DOC_MIT_MIM_1	226	235	PF04212	0.366
DOC_PP1_SILK_1	159	164	PF00149	0.438
DOC_PP4_FxxP_1	25	28	PF00568	0.400
DOC_WW_Pin1_4	24	29	PF00397	0.532
DOC_WW_Pin1_4	51	56	PF00397	0.459
LIG_14-3-3_CanoR_1	101	107	PF00244	0.438
LIG_14-3-3_CanoR_1	136	140	PF00244	0.413
LIG_14-3-3_CanoR_1	163	172	PF00244	0.531
LIG_14-3-3_CanoR_1	198	203	PF00244	0.513
LIG_14-3-3_CanoR_1	231	236	PF00244	0.290
LIG_14-3-3_CanoR_1	301	306	PF00244	0.394
LIG_Actin_RPEL_3	16	35	PF02755	0.456
LIG_Actin_WH2_2	298	315	PF00022	0.490
LIG_DLG_GKlike_1	104	112	PF00625	0.513
LIG_FHA_1	180	186	PF00498	0.420
LIG_FHA_1	271	277	PF00498	0.495
LIG_FHA_1	29	35	PF00498	0.416
LIG_FHA_1	333	339	PF00498	0.519
LIG_FHA_1	40	46	PF00498	0.252
LIG_FHA_2	191	197	PF00498	0.493
LIG_FHA_2	222	228	PF00498	0.321
LIG_GBD_Chelix_1	302	310	PF00786	0.404
LIG_LIR_Apic_2	22	28	PF02991	0.400
LIG_LIR_Nem_3	57	63	PF02991	0.458
LIG_NRBOX	385	391	PF00104	0.494
LIG_PCNA_yPIPBox_3	364	372	PF02747	0.454
LIG_PCNA_yPIPBox_3	380	390	PF02747	0.291
LIG_SH2_NCK_1	63	67	PF00017	0.394
LIG_SH2_STAT5	139	142	PF00017	0.321
LIG_SH2_STAT5	178	181	PF00017	0.468
LIG_SH3_3	396	402	PF00018	0.559
LIG_SUMO_SIM_anti_2	252	258	PF11976	0.374
LIG_SUMO_SIM_anti_2	31	36	PF11976	0.335
LIG_SUMO_SIM_anti_2	339	344	PF11976	0.362
LIG_SUMO_SIM_par_1	182	189	PF11976	0.384
LIG_SUMO_SIM_par_1	255	260	PF11976	0.398
LIG_SUMO_SIM_par_1	30	36	PF11976	0.302
LIG_SUMO_SIM_par_1	338	344	PF11976	0.350
LIG_SUMO_SIM_par_1	367	373	PF11976	0.437
LIG_TRAF2_1	224	227	PF00917	0.413
LIG_TYR_ITIM	61	66	PF00017	0.386
MOD_CK1_1	107	113	PF00069	0.423
MOD_CK1_1	304	310	PF00069	0.461
MOD_CK1_1	54	60	PF00069	0.471
MOD_CK2_1	143	149	PF00069	0.316
MOD_CK2_1	150	156	PF00069	0.321
MOD_CK2_1	190	196	PF00069	0.490
MOD_CK2_1	221	227	PF00069	0.286
MOD_CK2_1	257	263	PF00069	0.452
MOD_CK2_1	279	285	PF00069	0.419
MOD_CK2_1	308	314	PF00069	0.339
MOD_CK2_1	46	52	PF00069	0.426
MOD_GlcNHglycan	152	155	PF01048	0.390
MOD_GlcNHglycan	166	169	PF01048	0.458
MOD_GlcNHglycan	259	262	PF01048	0.346
MOD_GlcNHglycan	296	299	PF01048	0.442
MOD_GlcNHglycan	420	423	PF01048	0.682
MOD_GlcNHglycan	94	97	PF01048	0.478
MOD_GSK3_1	102	109	PF00069	0.374
MOD_GSK3_1	135	142	PF00069	0.325
MOD_GSK3_1	24	31	PF00069	0.582
MOD_GSK3_1	270	277	PF00069	0.460
MOD_GSK3_1	288	295	PF00069	0.281
MOD_GSK3_1	301	308	PF00069	0.387
MOD_GSK3_1	332	339	PF00069	0.398
MOD_GSK3_1	46	53	PF00069	0.444
MOD_N-GLC_1	221	226	PF02516	0.326
MOD_N-GLC_1	250	255	PF02516	0.390
MOD_N-GLC_1	315	320	PF02516	0.305
MOD_N-GLC_1	332	337	PF02516	0.376
MOD_N-GLC_1	376	381	PF02516	0.506
MOD_N-GLC_1	78	83	PF02516	0.396
MOD_NEK2_1	102	107	PF00069	0.371
MOD_NEK2_1	143	148	PF00069	0.316
MOD_NEK2_1	162	167	PF00069	0.399
MOD_NEK2_1	257	262	PF00069	0.372
MOD_NEK2_1	287	292	PF00069	0.339
MOD_NEK2_1	294	299	PF00069	0.351
MOD_NEK2_1	305	310	PF00069	0.337
MOD_NEK2_1	80	85	PF00069	0.493
MOD_PIKK_1	270	276	PF00454	0.472
MOD_PIKK_1	353	359	PF00454	0.344
MOD_PKA_1	198	204	PF00069	0.510
MOD_PKA_2	135	141	PF00069	0.413
MOD_PKA_2	162	168	PF00069	0.464
MOD_PKA_2	198	204	PF00069	0.510
MOD_Plk_1	143	149	PF00069	0.303
MOD_Plk_1	221	227	PF00069	0.284
MOD_Plk_1	250	256	PF00069	0.390
MOD_Plk_1	270	276	PF00069	0.488
MOD_Plk_4	135	141	PF00069	0.356
MOD_Plk_4	301	307	PF00069	0.378
MOD_ProDKin_1	24	30	PF00069	0.526
MOD_ProDKin_1	51	57	PF00069	0.456
TRG_DiLeu_BaLyEn_6	98	103	PF01217	0.481
TRG_ENDOCYTIC_2	63	66	PF00928	0.395
TRG_ER_diArg_1	197	199	PF00400	0.490
TRG_Pf-PMV_PEXEL_1	18	22	PF00026	0.378
TRG_Pf-PMV_PEXEL_1	241	245	PF00026	0.300

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUH0	Leptomonas seymouri	77%	91%
A0A0N1I317	Leptomonas seymouri	28%	100%
A0A0N1PD72	Leptomonas seymouri	25%	96%
A0A0S4JGH2	Bodo saltans	27%	100%
A0A0S4JL85	Bodo saltans	25%	100%
A0A0S4JPV3	Bodo saltans	38%	89%
A0A0S4JXN4	Bodo saltans	26%	99%
A0A0S4KL56	Bodo saltans	29%	89%
A0A1X0NTY3	Trypanosomatidae	54%	96%
A0A1X0P2M5	Trypanosomatidae	30%	100%
A0A1X0P364	Trypanosomatidae	25%	100%
A0A3Q8IDE6	Leishmania donovani	26%	100%
A0A3R7L7Y9	Trypanosoma rangeli	53%	96%
A0A3R7P015	Trypanosoma rangeli	25%	91%
A0A3S5H5G2	Leishmania donovani	28%	100%
A0A3S7WXH1	Leishmania donovani	26%	100%
A0JPI9	Rattus norvegicus	30%	90%
A4H461	Leishmania braziliensis	28%	100%
A4HCM9	Leishmania braziliensis	25%	100%
A4HEQ6	Leishmania braziliensis	79%	100%
A4HFQ6	Leishmania braziliensis	24%	100%
A4HHW0	Leishmania braziliensis	30%	100%
A4HSD0	Leishmania infantum	29%	100%
A4I053	Leishmania infantum	26%	100%
A4I1Y5	Leishmania infantum	100%	100%
A4I2T1	Leishmania infantum	26%	100%
C9ZPX6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	99%
C9ZS33	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	96%
E9ADA9	Leishmania major	28%	100%
E9AKB9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9AN05	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9AW16	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9AY32	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
E9AZ34	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
O13066	Xenopus laevis	24%	74%
P10775	Sus scrofa	28%	94%
P13489	Homo sapiens	25%	93%
P46060	Homo sapiens	25%	73%
P46061	Mus musculus	25%	73%
Q0VAA2	Homo sapiens	26%	88%
Q4Q9E1	Leishmania major	95%	100%
Q4QBG0	Leishmania major	23%	100%
Q4QJI8	Leishmania major	28%	100%
Q4V8D9	Rattus norvegicus	25%	100%
Q6ZQY2	Homo sapiens	31%	100%
Q8HZP9	Pan troglodytes	25%	93%
Q8IZ02	Homo sapiens	25%	92%
Q91VI7	Mus musculus	27%	94%
Q9DAM1	Mus musculus	25%	100%
Q9LE82	Arabidopsis thaliana	27%	80%
Q9M651	Arabidopsis thaliana	25%	79%
Q9VIW3	Drosophila melanogaster	24%	72%
V5BJF0	Trypanosoma cruzi	25%	87%
V5BN05	Trypanosoma cruzi	25%	72%
V5BPZ7	Trypanosoma cruzi	55%	96%