Hypothetical_protein_conserved

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WZK4_LEIDO

TriTrypDb:

LdBPK_260170.1 , LdCL_260007200 , LDHU3_26.0260

Length:

161

Annotations

LeishMANIAdb annotations

A conserved eukaryotic protein family also seen in higher plants. Its function is, however very unclear.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

A0A3S7WZK4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WZK4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	123	127	PF00082	0.509
CLV_PCSK_SKI1_1	148	152	PF00082	0.415
CLV_PCSK_SKI1_1	2	6	PF00082	0.504
DEG_Nend_UBRbox_1	1	4	PF02207	0.619
DOC_CDC14_PxL_1	80	88	PF14671	0.319
DOC_CKS1_1	74	79	PF01111	0.291
DOC_MAPK_MEF2A_6	13	20	PF00069	0.562
DOC_PP4_FxxP_1	41	44	PF00568	0.291
DOC_PP4_FxxP_1	74	77	PF00568	0.367
DOC_WW_Pin1_4	73	78	PF00397	0.291
LIG_14-3-3_CanoR_1	59	67	PF00244	0.629
LIG_Actin_WH2_2	130	146	PF00022	0.319
LIG_Actin_WH2_2	43	61	PF00022	0.313
LIG_FHA_1	113	119	PF00498	0.453
LIG_FHA_1	45	51	PF00498	0.336
LIG_FHA_1	61	67	PF00498	0.504
LIG_FHA_2	22	28	PF00498	0.380
LIG_FHA_2	59	65	PF00498	0.613
LIG_LIR_Gen_1	24	32	PF02991	0.369
LIG_LIR_Nem_3	129	135	PF02991	0.365
LIG_LIR_Nem_3	24	28	PF02991	0.393
LIG_Pex14_2	41	45	PF04695	0.319
LIG_SH2_CRK	127	131	PF00017	0.373
LIG_SH2_NCK_1	127	131	PF00017	0.367
LIG_SH2_STAP1	114	118	PF00017	0.401
LIG_SH2_STAT5	114	117	PF00017	0.354
LIG_SH2_STAT5	57	60	PF00017	0.460
LIG_SH3_3	13	19	PF00018	0.474
LIG_SH3_3	132	138	PF00018	0.385
LIG_SUMO_SIM_anti_2	47	54	PF11976	0.296
LIG_SUMO_SIM_par_1	27	33	PF11976	0.389
LIG_TRFH_1	80	84	PF08558	0.343
LIG_TYR_ITIM	125	130	PF00017	0.385
LIG_WRC_WIRS_1	114	119	PF05994	0.468
MOD_CK1_1	21	27	PF00069	0.486
MOD_CK1_1	48	54	PF00069	0.330
MOD_CK2_1	21	27	PF00069	0.387
MOD_CK2_1	58	64	PF00069	0.525
MOD_GSK3_1	113	120	PF00069	0.421
MOD_GSK3_1	44	51	PF00069	0.291
MOD_NEK2_1	106	111	PF00069	0.381
MOD_NEK2_1	117	122	PF00069	0.373
MOD_NEK2_1	126	131	PF00069	0.335
MOD_NEK2_1	45	50	PF00069	0.335
MOD_NEK2_1	58	63	PF00069	0.512
MOD_NEK2_1	67	72	PF00069	0.399
MOD_PIKK_1	18	24	PF00454	0.252
MOD_PIKK_1	6	12	PF00454	0.589
MOD_PKA_2	58	64	PF00069	0.561
MOD_Plk_4	113	119	PF00069	0.426
MOD_Plk_4	45	51	PF00069	0.318
MOD_ProDKin_1	73	79	PF00069	0.291
TRG_ENDOCYTIC_2	114	117	PF00928	0.385
TRG_ENDOCYTIC_2	127	130	PF00928	0.227

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCS7	Leptomonas seymouri	57%	93%
A0A1X0NSJ4	Trypanosomatidae	32%	100%
A0A3R7KTL0	Trypanosoma rangeli	33%	100%
A4HEM4	Leishmania braziliensis	73%	100%
A4I1V5	Leishmania infantum	100%	100%
E9AY00	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4Q9H3	Leishmania major	93%	100%