Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WZJ8_LEIDO

TriTrypDb:

LdBPK_252350.1 , LdCL_250029300 , LDHU3_25.2830

Length:

532

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A0A3S7WZJ8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WZJ8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	402	406	PF00656	0.443
CLV_NRD_NRD_1	151	153	PF00675	0.702
CLV_NRD_NRD_1	399	401	PF00675	0.753
CLV_NRD_NRD_1	437	439	PF00675	0.667
CLV_NRD_NRD_1	469	471	PF00675	0.679
CLV_NRD_NRD_1	516	518	PF00675	0.444
CLV_NRD_NRD_1	526	528	PF00675	0.426
CLV_PCSK_KEX2_1	153	155	PF00082	0.641
CLV_PCSK_KEX2_1	399	401	PF00082	0.753
CLV_PCSK_KEX2_1	436	438	PF00082	0.635
CLV_PCSK_KEX2_1	469	471	PF00082	0.650
CLV_PCSK_KEX2_1	516	518	PF00082	0.497
CLV_PCSK_KEX2_1	526	528	PF00082	0.422
CLV_PCSK_PC1ET2_1	153	155	PF00082	0.641
CLV_PCSK_SKI1_1	153	157	PF00082	0.635
CLV_PCSK_SKI1_1	249	253	PF00082	0.685
CLV_Separin_Metazoa	372	376	PF03568	0.552
DEG_COP1_1	250	260	PF00400	0.465
DOC_ANK_TNKS_1	322	329	PF00023	0.541
DOC_CYCLIN_yCln2_LP_2	206	209	PF00134	0.561
DOC_CYCLIN_yCln2_LP_2	330	336	PF00134	0.491
DOC_MAPK_DCC_7	203	212	PF00069	0.561
DOC_MAPK_gen_1	152	159	PF00069	0.406
DOC_MAPK_gen_1	436	443	PF00069	0.488
DOC_MAPK_MEF2A_6	203	212	PF00069	0.505
DOC_PP1_RVXF_1	364	370	PF00149	0.549
DOC_PP2B_LxvP_1	206	209	PF13499	0.561
DOC_USP7_MATH_1	127	131	PF00917	0.471
DOC_USP7_MATH_1	256	260	PF00917	0.520
DOC_USP7_MATH_1	376	380	PF00917	0.551
DOC_USP7_MATH_1	398	402	PF00917	0.586
DOC_USP7_MATH_1	447	451	PF00917	0.565
DOC_USP7_MATH_1	462	466	PF00917	0.423
DOC_USP7_MATH_1	71	75	PF00917	0.496
DOC_WW_Pin1_4	14	19	PF00397	0.486
DOC_WW_Pin1_4	26	31	PF00397	0.444
DOC_WW_Pin1_4	309	314	PF00397	0.526
DOC_WW_Pin1_4	334	339	PF00397	0.540
LIG_14-3-3_CanoR_1	147	151	PF00244	0.459
LIG_14-3-3_CanoR_1	19	28	PF00244	0.499
LIG_14-3-3_CanoR_1	249	255	PF00244	0.439
LIG_14-3-3_CanoR_1	332	337	PF00244	0.559
LIG_14-3-3_CanoR_1	366	370	PF00244	0.558
LIG_14-3-3_CanoR_1	375	384	PF00244	0.603
LIG_14-3-3_CanoR_1	436	442	PF00244	0.493
LIG_14-3-3_CanoR_1	469	474	PF00244	0.496
LIG_Actin_WH2_2	360	377	PF00022	0.549
LIG_Actin_WH2_2	500	518	PF00022	0.385
LIG_APCC_ABBA_1	322	327	PF00400	0.441
LIG_FHA_1	114	120	PF00498	0.477
LIG_FHA_1	130	136	PF00498	0.267
LIG_FHA_1	167	173	PF00498	0.465
LIG_FHA_1	175	181	PF00498	0.454
LIG_FHA_1	232	238	PF00498	0.459
LIG_FHA_1	27	33	PF00498	0.479
LIG_FHA_1	275	281	PF00498	0.470
LIG_FHA_1	316	322	PF00498	0.509
LIG_FHA_1	341	347	PF00498	0.609
LIG_FHA_1	430	436	PF00498	0.556
LIG_FHA_2	269	275	PF00498	0.502
LIG_GBD_Chelix_1	507	515	PF00786	0.299
LIG_LIR_Apic_2	34	38	PF02991	0.515
LIG_LIR_Apic_2	472	478	PF02991	0.478
LIG_LIR_Gen_1	499	510	PF02991	0.417
LIG_LIR_Nem_3	222	228	PF02991	0.498
LIG_LIR_Nem_3	26	31	PF02991	0.416
LIG_LIR_Nem_3	418	424	PF02991	0.533
LIG_LIR_Nem_3	499	505	PF02991	0.417
LIG_LYPXL_S_1	125	129	PF13949	0.654
LIG_LYPXL_yS_3	126	129	PF13949	0.455
LIG_NRBOX	48	54	PF00104	0.415
LIG_NRBOX	510	516	PF00104	0.415
LIG_PCNA_yPIPBox_3	133	147	PF02747	0.417
LIG_SH2_CRK	225	229	PF00017	0.497
LIG_SH2_CRK	502	506	PF00017	0.513
LIG_SH2_STAP1	166	170	PF00017	0.437
LIG_SH2_STAP1	352	356	PF00017	0.526
LIG_SH2_STAT5	166	169	PF00017	0.420
LIG_SH2_STAT5	299	302	PF00017	0.510
LIG_SH2_STAT5	502	505	PF00017	0.436
LIG_SH2_STAT5	54	57	PF00017	0.430
LIG_SH3_3	239	245	PF00018	0.438
LIG_SH3_3	367	373	PF00018	0.607
LIG_SH3_3	450	456	PF00018	0.521
LIG_Sin3_3	168	175	PF02671	0.441
LIG_SUMO_SIM_par_1	312	318	PF11976	0.600
LIG_TRAF2_1	362	365	PF00917	0.598
LIG_TYR_ITIM	124	129	PF00017	0.454
LIG_WRC_WIRS_1	421	426	PF05994	0.490
LIG_WRC_WIRS_1	82	87	PF05994	0.414
MOD_CDK_SPK_2	14	19	PF00069	0.467
MOD_CK1_1	23	29	PF00069	0.516
MOD_CK1_1	250	256	PF00069	0.476
MOD_CK1_1	337	343	PF00069	0.569
MOD_CK1_1	422	428	PF00069	0.558
MOD_CK2_1	268	274	PF00069	0.535
MOD_CK2_1	491	497	PF00069	0.420
MOD_GlcNHglycan	105	108	PF01048	0.600
MOD_GlcNHglycan	116	119	PF01048	0.551
MOD_GlcNHglycan	129	132	PF01048	0.602
MOD_GlcNHglycan	184	187	PF01048	0.684
MOD_GlcNHglycan	22	25	PF01048	0.694
MOD_GlcNHglycan	258	261	PF01048	0.628
MOD_GlcNHglycan	385	388	PF01048	0.685
MOD_GlcNHglycan	443	446	PF01048	0.763
MOD_GlcNHglycan	497	501	PF01048	0.513
MOD_GlcNHglycan	56	60	PF01048	0.647
MOD_GSK3_1	160	167	PF00069	0.443
MOD_GSK3_1	19	26	PF00069	0.483
MOD_GSK3_1	328	335	PF00069	0.557
MOD_GSK3_1	399	406	PF00069	0.532
MOD_GSK3_1	437	444	PF00069	0.435
MOD_GSK3_1	464	471	PF00069	0.539
MOD_N-GLC_1	340	345	PF02516	0.808
MOD_N-GLC_1	42	47	PF02516	0.618
MOD_NEK2_1	148	153	PF00069	0.483
MOD_NEK2_1	233	238	PF00069	0.542
MOD_NEK2_1	273	278	PF00069	0.475
MOD_NEK2_1	304	309	PF00069	0.596
MOD_NEK2_1	31	36	PF00069	0.547
MOD_NEK2_1	315	320	PF00069	0.527
MOD_NEK2_1	346	351	PF00069	0.602
MOD_NEK2_1	41	46	PF00069	0.295
MOD_NEK2_1	441	446	PF00069	0.440
MOD_NEK2_1	481	486	PF00069	0.526
MOD_NEK2_1	496	501	PF00069	0.426
MOD_NEK2_2	447	452	PF00069	0.536
MOD_PIKK_1	304	310	PF00454	0.551
MOD_PIKK_1	315	321	PF00454	0.516
MOD_PIKK_1	346	352	PF00454	0.598
MOD_PIKK_1	405	411	PF00454	0.507
MOD_PIKK_1	95	101	PF00454	0.449
MOD_PK_1	247	253	PF00069	0.467
MOD_PK_1	469	475	PF00069	0.412
MOD_PK_1	526	532	PF00069	0.641
MOD_PKA_1	399	405	PF00069	0.581
MOD_PKA_1	437	443	PF00069	0.489
MOD_PKA_1	469	475	PF00069	0.509
MOD_PKA_1	526	532	PF00069	0.641
MOD_PKA_2	146	152	PF00069	0.457
MOD_PKA_2	365	371	PF00069	0.549
MOD_PKA_2	398	404	PF00069	0.584
MOD_PKA_2	437	443	PF00069	0.449
MOD_PKA_2	468	474	PF00069	0.473
MOD_PKA_2	526	532	PF00069	0.796
MOD_Plk_1	315	321	PF00069	0.528
MOD_Plk_1	340	346	PF00069	0.543
MOD_Plk_1	352	358	PF00069	0.509
MOD_Plk_1	42	48	PF00069	0.355
MOD_Plk_1	496	502	PF00069	0.405
MOD_Plk_2-3	268	274	PF00069	0.457
MOD_Plk_4	208	214	PF00069	0.544
MOD_Plk_4	233	239	PF00069	0.530
MOD_Plk_4	268	274	PF00069	0.555
MOD_Plk_4	31	37	PF00069	0.546
MOD_Plk_4	352	358	PF00069	0.580
MOD_Plk_4	365	371	PF00069	0.453
MOD_Plk_4	447	453	PF00069	0.539
MOD_Plk_4	471	477	PF00069	0.447
MOD_Plk_4	491	497	PF00069	0.530
MOD_ProDKin_1	14	20	PF00069	0.491
MOD_ProDKin_1	26	32	PF00069	0.446
MOD_ProDKin_1	309	315	PF00069	0.526
MOD_ProDKin_1	334	340	PF00069	0.540
MOD_SUMO_for_1	36	39	PF00179	0.455
TRG_DiLeu_BaLyEn_6	27	32	PF01217	0.488
TRG_DiLeu_BaLyEn_6	310	315	PF01217	0.526
TRG_ENDOCYTIC_2	126	129	PF00928	0.440
TRG_ENDOCYTIC_2	225	228	PF00928	0.497
TRG_ENDOCYTIC_2	266	269	PF00928	0.509
TRG_ENDOCYTIC_2	502	505	PF00928	0.478
TRG_ER_diArg_1	246	249	PF00400	0.448
TRG_ER_diArg_1	435	438	PF00400	0.432
TRG_ER_diArg_1	515	517	PF00400	0.634
TRG_Pf-PMV_PEXEL_1	361	365	PF00026	0.800

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD48	Leptomonas seymouri	36%	100%
A4HEC9	Leishmania braziliensis	73%	100%
A4I1S4	Leishmania infantum	99%	100%
E9AXV9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q9L2	Leishmania major	91%	100%