LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Hypothetical_protein_conserved

Quick info Annotations Function or PPIs Localization Phosphorylation Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Hypothetical_protein_conserved
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3S7WZJ4_LEIDO
TriTrypDb:
LdBPK_252520.1 , LdCL_250031100 , LDHU3_25.3030
Length:
961

Annotations

Annotations by Jardim et al.

Nucleic acid binding, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) yes yes: 4
Forrest at al. (procyclic) yes yes: 4
Silverman et al. no yes: 0
Pissara et al. yes yes: 15
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 12
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 9
GO:0110165 cellular anatomical entity 1 9
GO:0005634 nucleus 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1

Phosphorylation

Amastigote: 801

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A0A3S7WZJ4
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WZJ4

Function

Biological processes
Term Name Level Count
GO:0006325 chromatin organization 4 1
GO:0006338 chromatin remodeling 5 1
GO:0006355 regulation of DNA-templated transcription 6 1
GO:0006357 regulation of transcription by RNA polymerase II 7 1
GO:0009889 regulation of biosynthetic process 4 1
GO:0009893 positive regulation of metabolic process 4 1
GO:0009987 cellular process 1 1
GO:0010468 regulation of gene expression 5 1
GO:0010556 regulation of macromolecule biosynthetic process 5 1
GO:0010604 positive regulation of macromolecule metabolic process 5 1
GO:0016043 cellular component organization 3 1
GO:0019219 regulation of nucleobase-containing compound metabolic process 5 1
GO:0019222 regulation of metabolic process 3 1
GO:0031056 regulation of histone modification 7 1
GO:0031058 obsolete positive regulation of histone modification 8 1
GO:0031323 regulation of cellular metabolic process 4 1
GO:0031326 regulation of cellular biosynthetic process 5 1
GO:0031399 regulation of protein modification process 6 1
GO:0031401 positive regulation of protein modification process 7 1
GO:0035065 regulation of histone acetylation 8 1
GO:0035066 positive regulation of histone acetylation 9 1
GO:0048518 positive regulation of biological process 3 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0051171 regulation of nitrogen compound metabolic process 4 1
GO:0051173 positive regulation of nitrogen compound metabolic process 5 1
GO:0051246 regulation of protein metabolic process 5 1
GO:0051247 positive regulation of protein metabolic process 6 1
GO:0051252 regulation of RNA metabolic process 5 1
GO:0060255 regulation of macromolecule metabolic process 4 1
GO:0065007 biological regulation 1 1
GO:0071840 cellular component organization or biogenesis 2 1
GO:0080090 regulation of primary metabolic process 4 1
GO:1901983 regulation of protein acetylation 7 1
GO:1901985 positive regulation of protein acetylation 8 1
GO:1903506 regulation of nucleic acid-templated transcription 7 1
GO:2000756 regulation of peptidyl-lysine acetylation 8 1
GO:2000758 positive regulation of peptidyl-lysine acetylation 9 1
GO:2001141 regulation of RNA biosynthetic process 6 1
Molecular functions
Term Name Level Count
GO:0003682 chromatin binding 2 1
GO:0003712 transcription coregulator activity 2 1
GO:0003713 transcription coactivator activity 3 1
GO:0005488 binding 1 1
GO:0140110 transcription regulator activity 1 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 296 298 PF00675 0.442
CLV_NRD_NRD_1 340 342 PF00675 0.447
CLV_NRD_NRD_1 484 486 PF00675 0.497
CLV_NRD_NRD_1 546 548 PF00675 0.567
CLV_NRD_NRD_1 554 556 PF00675 0.520
CLV_NRD_NRD_1 582 584 PF00675 0.542
CLV_NRD_NRD_1 632 634 PF00675 0.544
CLV_NRD_NRD_1 655 657 PF00675 0.496
CLV_NRD_NRD_1 747 749 PF00675 0.531
CLV_NRD_NRD_1 759 761 PF00675 0.420
CLV_NRD_NRD_1 843 845 PF00675 0.521
CLV_PCSK_KEX2_1 296 298 PF00082 0.426
CLV_PCSK_KEX2_1 340 342 PF00082 0.446
CLV_PCSK_KEX2_1 405 407 PF00082 0.526
CLV_PCSK_KEX2_1 413 415 PF00082 0.535
CLV_PCSK_KEX2_1 459 461 PF00082 0.515
CLV_PCSK_KEX2_1 484 486 PF00082 0.544
CLV_PCSK_KEX2_1 554 556 PF00082 0.521
CLV_PCSK_KEX2_1 632 634 PF00082 0.562
CLV_PCSK_KEX2_1 747 749 PF00082 0.628
CLV_PCSK_KEX2_1 843 845 PF00082 0.425
CLV_PCSK_KEX2_1 96 98 PF00082 0.425
CLV_PCSK_PC1ET2_1 405 407 PF00082 0.531
CLV_PCSK_PC1ET2_1 413 415 PF00082 0.526
CLV_PCSK_PC1ET2_1 459 461 PF00082 0.515
CLV_PCSK_PC1ET2_1 96 98 PF00082 0.450
CLV_PCSK_PC7_1 92 98 PF00082 0.435
CLV_PCSK_SKI1_1 176 180 PF00082 0.513
CLV_PCSK_SKI1_1 246 250 PF00082 0.504
CLV_PCSK_SKI1_1 265 269 PF00082 0.413
CLV_PCSK_SKI1_1 435 439 PF00082 0.573
CLV_PCSK_SKI1_1 563 567 PF00082 0.559
CLV_PCSK_SKI1_1 67 71 PF00082 0.570
CLV_PCSK_SKI1_1 709 713 PF00082 0.568
CLV_PCSK_SKI1_1 761 765 PF00082 0.403
CLV_PCSK_SKI1_1 843 847 PF00082 0.429
CLV_PCSK_SKI1_1 849 853 PF00082 0.447
CLV_PCSK_SKI1_1 889 893 PF00082 0.566
DEG_APCC_DBOX_1 245 253 PF00400 0.508
DEG_APCC_DBOX_1 264 272 PF00400 0.474
DEG_APCC_KENBOX_2 679 683 PF00400 0.576
DOC_CYCLIN_RxL_1 262 269 PF00134 0.528
DOC_CYCLIN_RxL_1 517 528 PF00134 0.584
DOC_MAPK_gen_1 278 286 PF00069 0.459
DOC_MAPK_gen_1 405 412 PF00069 0.649
DOC_MAPK_gen_1 458 467 PF00069 0.629
DOC_MAPK_gen_1 632 640 PF00069 0.579
DOC_MAPK_gen_1 643 650 PF00069 0.502
DOC_MAPK_gen_1 747 756 PF00069 0.470
DOC_MAPK_gen_1 757 766 PF00069 0.407
DOC_MAPK_gen_1 79 87 PF00069 0.403
DOC_MAPK_gen_1 886 894 PF00069 0.448
DOC_MAPK_HePTP_8 754 766 PF00069 0.386
DOC_MAPK_MEF2A_6 156 163 PF00069 0.472
DOC_MAPK_MEF2A_6 210 218 PF00069 0.487
DOC_MAPK_MEF2A_6 278 286 PF00069 0.459
DOC_MAPK_MEF2A_6 747 756 PF00069 0.470
DOC_MAPK_MEF2A_6 757 766 PF00069 0.407
DOC_PP2B_LxvP_1 282 285 PF13499 0.475
DOC_PP4_FxxP_1 33 36 PF00568 0.446
DOC_PP4_MxPP_1 34 37 PF00568 0.388
DOC_USP7_MATH_1 23 27 PF00917 0.568
DOC_USP7_MATH_1 329 333 PF00917 0.419
DOC_USP7_MATH_2 625 631 PF00917 0.652
DOC_USP7_UBL2_3 434 438 PF12436 0.648
DOC_USP7_UBL2_3 482 486 PF12436 0.488
DOC_USP7_UBL2_3 712 716 PF12436 0.482
DOC_WW_Pin1_4 13 18 PF00397 0.580
DOC_WW_Pin1_4 24 29 PF00397 0.493
DOC_WW_Pin1_4 800 805 PF00397 0.480
DOC_WW_Pin1_4 91 96 PF00397 0.433
LIG_14-3-3_CanoR_1 168 175 PF00244 0.423
LIG_14-3-3_CanoR_1 265 274 PF00244 0.438
LIG_14-3-3_CanoR_1 341 347 PF00244 0.587
LIG_14-3-3_CanoR_1 485 494 PF00244 0.430
LIG_14-3-3_CanoR_1 547 551 PF00244 0.535
LIG_14-3-3_CanoR_1 820 826 PF00244 0.448
LIG_14-3-3_CanoR_1 934 942 PF00244 0.422
LIG_Actin_WH2_2 27 42 PF00022 0.398
LIG_Actin_WH2_2 392 407 PF00022 0.601
LIG_Actin_WH2_2 689 707 PF00022 0.448
LIG_APCC_ABBA_1 764 769 PF00400 0.555
LIG_BIR_II_1 1 5 PF00653 0.585
LIG_BRCT_BRCA1_1 234 238 PF00533 0.401
LIG_Clathr_ClatBox_1 615 619 PF01394 0.541
LIG_Clathr_ClatBox_1 647 651 PF01394 0.556
LIG_deltaCOP1_diTrp_1 327 333 PF00928 0.460
LIG_eIF4E_1 812 818 PF01652 0.426
LIG_EVH1_2 908 912 PF00568 0.401
LIG_FHA_1 198 204 PF00498 0.604
LIG_FHA_1 211 217 PF00498 0.379
LIG_FHA_1 261 267 PF00498 0.490
LIG_FHA_1 312 318 PF00498 0.410
LIG_FHA_1 499 505 PF00498 0.575
LIG_FHA_1 626 632 PF00498 0.540
LIG_FHA_1 751 757 PF00498 0.451
LIG_FHA_1 797 803 PF00498 0.509
LIG_FHA_1 923 929 PF00498 0.472
LIG_FHA_2 169 175 PF00498 0.509
LIG_FHA_2 322 328 PF00498 0.488
LIG_FHA_2 434 440 PF00498 0.679
LIG_FHA_2 576 582 PF00498 0.578
LIG_FHA_2 605 611 PF00498 0.508
LIG_FHA_2 831 837 PF00498 0.428
LIG_FHA_2 848 854 PF00498 0.510
LIG_FHA_2 927 933 PF00498 0.412
LIG_LIR_Apic_2 32 36 PF02991 0.388
LIG_LIR_Gen_1 235 245 PF02991 0.401
LIG_LIR_Gen_1 330 339 PF02991 0.407
LIG_LIR_Gen_1 768 777 PF02991 0.538
LIG_LIR_LC3C_4 374 378 PF02991 0.690
LIG_LIR_Nem_3 224 230 PF02991 0.482
LIG_LIR_Nem_3 235 241 PF02991 0.334
LIG_LIR_Nem_3 330 336 PF02991 0.418
LIG_LIR_Nem_3 768 774 PF02991 0.452
LIG_LIR_Nem_3 876 882 PF02991 0.571
LIG_NRBOX 841 847 PF00104 0.414
LIG_PCNA_yPIPBox_3 50 59 PF02747 0.571
LIG_PDZ_Class_2 956 961 PF00595 0.503
LIG_Pex14_2 635 639 PF04695 0.519
LIG_SH2_CRK 948 952 PF00017 0.430
LIG_SH2_GRB2like 227 230 PF00017 0.489
LIG_SH2_NCK_1 230 234 PF00017 0.532
LIG_SH2_SRC 130 133 PF00017 0.403
LIG_SH2_SRC 230 233 PF00017 0.496
LIG_SH2_STAP1 109 113 PF00017 0.385
LIG_SH2_STAP1 476 480 PF00017 0.516
LIG_SH2_STAP1 767 771 PF00017 0.470
LIG_SH2_STAP1 931 935 PF00017 0.432
LIG_SH2_STAP1 948 952 PF00017 0.189
LIG_SH2_STAT3 101 104 PF00017 0.493
LIG_SH2_STAT3 186 189 PF00017 0.503
LIG_SH2_STAT5 130 133 PF00017 0.438
LIG_SH2_STAT5 611 614 PF00017 0.486
LIG_SH2_STAT5 646 649 PF00017 0.497
LIG_SH2_STAT5 703 706 PF00017 0.431
LIG_SH2_STAT5 724 727 PF00017 0.406
LIG_SH2_STAT5 767 770 PF00017 0.482
LIG_SH3_3 619 625 PF00018 0.609
LIG_SH3_3 862 868 PF00018 0.757
LIG_SUMO_SIM_anti_2 316 321 PF11976 0.475
LIG_SUMO_SIM_anti_2 824 829 PF11976 0.394
LIG_SUMO_SIM_anti_2 936 944 PF11976 0.475
LIG_SUMO_SIM_par_1 135 143 PF11976 0.543
LIG_SUMO_SIM_par_1 18 27 PF11976 0.560
LIG_SUMO_SIM_par_1 614 620 PF11976 0.543
LIG_TRAF2_1 255 258 PF00917 0.538
LIG_TRAF2_1 429 432 PF00917 0.654
LIG_TRAF2_1 592 595 PF00917 0.606
LIG_TRAF2_1 607 610 PF00917 0.540
LIG_TRAF2_1 895 898 PF00917 0.487
LIG_UBA3_1 354 362 PF00899 0.664
LIG_UBA3_1 647 654 PF00899 0.562
LIG_UBA3_1 845 849 PF00899 0.491
LIG_WRC_WIRS_1 771 776 PF05994 0.586
MOD_CDK_SPK_2 91 96 PF00069 0.433
MOD_CDK_SPxK_1 91 97 PF00069 0.432
MOD_CK1_1 289 295 PF00069 0.400
MOD_CK1_1 444 450 PF00069 0.542
MOD_CK1_1 72 78 PF00069 0.524
MOD_CK1_1 770 776 PF00069 0.559
MOD_CK1_1 900 906 PF00069 0.525
MOD_CK1_1 927 933 PF00069 0.411
MOD_CK2_1 151 157 PF00069 0.480
MOD_CK2_1 225 231 PF00069 0.490
MOD_CK2_1 252 258 PF00069 0.603
MOD_CK2_1 321 327 PF00069 0.530
MOD_CK2_1 35 41 PF00069 0.501
MOD_CK2_1 588 594 PF00069 0.585
MOD_CK2_1 604 610 PF00069 0.515
MOD_CK2_1 692 698 PF00069 0.572
MOD_CK2_1 830 836 PF00069 0.417
MOD_CK2_1 847 853 PF00069 0.445
MOD_CK2_1 892 898 PF00069 0.496
MOD_GlcNHglycan 142 145 PF01048 0.603
MOD_GlcNHglycan 268 271 PF01048 0.402
MOD_GlcNHglycan 348 351 PF01048 0.589
MOD_GlcNHglycan 391 394 PF01048 0.680
MOD_GlcNHglycan 443 446 PF01048 0.550
MOD_GlcNHglycan 590 593 PF01048 0.668
MOD_GlcNHglycan 71 74 PF01048 0.563
MOD_GlcNHglycan 894 897 PF01048 0.506
MOD_GlcNHglycan 936 939 PF01048 0.428
MOD_GlcNHglycan 943 946 PF01048 0.380
MOD_GSK3_1 112 119 PF00069 0.472
MOD_GSK3_1 164 171 PF00069 0.496
MOD_GSK3_1 273 280 PF00069 0.466
MOD_GSK3_1 342 349 PF00069 0.539
MOD_GSK3_1 440 447 PF00069 0.654
MOD_GSK3_1 68 75 PF00069 0.540
MOD_GSK3_1 724 731 PF00069 0.511
MOD_GSK3_1 786 793 PF00069 0.473
MOD_GSK3_1 796 803 PF00069 0.510
MOD_GSK3_1 920 927 PF00069 0.473
MOD_N-GLC_1 334 339 PF02516 0.527
MOD_N-GLC_1 46 51 PF02516 0.629
MOD_N-GLC_1 461 466 PF02516 0.635
MOD_N-GLC_1 470 475 PF02516 0.636
MOD_N-GLC_1 790 795 PF02516 0.587
MOD_NEK2_1 125 130 PF00069 0.373
MOD_NEK2_1 252 257 PF00069 0.654
MOD_NEK2_1 260 265 PF00069 0.545
MOD_NEK2_1 286 291 PF00069 0.437
MOD_NEK2_1 346 351 PF00069 0.569
MOD_NEK2_1 527 532 PF00069 0.626
MOD_NEK2_1 546 551 PF00069 0.384
MOD_NEK2_1 69 74 PF00069 0.517
MOD_NEK2_1 711 716 PF00069 0.575
MOD_NEK2_1 941 946 PF00069 0.382
MOD_NEK2_2 329 334 PF00069 0.415
MOD_NEK2_2 433 438 PF00069 0.507
MOD_PIKK_1 252 258 PF00454 0.636
MOD_PIKK_1 289 295 PF00454 0.416
MOD_PIKK_1 775 781 PF00454 0.586
MOD_PIKK_1 796 802 PF00454 0.523
MOD_PKA_1 486 492 PF00069 0.564
MOD_PKA_2 546 552 PF00069 0.559
MOD_PKA_2 933 939 PF00069 0.438
MOD_PKB_1 166 174 PF00069 0.455
MOD_PKB_1 496 504 PF00069 0.574
MOD_Plk_1 164 170 PF00069 0.559
MOD_Plk_1 329 335 PF00069 0.405
MOD_Plk_1 461 467 PF00069 0.582
MOD_Plk_1 476 482 PF00069 0.458
MOD_Plk_1 897 903 PF00069 0.492
MOD_Plk_2-3 604 610 PF00069 0.481
MOD_Plk_4 189 195 PF00069 0.517
MOD_Plk_4 210 216 PF00069 0.402
MOD_Plk_4 234 240 PF00069 0.410
MOD_Plk_4 29 35 PF00069 0.579
MOD_Plk_4 313 319 PF00069 0.434
MOD_Plk_4 334 340 PF00069 0.474
MOD_Plk_4 350 356 PF00069 0.511
MOD_Plk_4 546 552 PF00069 0.522
MOD_Plk_4 642 648 PF00069 0.523
MOD_Plk_4 692 698 PF00069 0.451
MOD_Plk_4 699 705 PF00069 0.425
MOD_Plk_4 750 756 PF00069 0.450
MOD_Plk_4 767 773 PF00069 0.454
MOD_ProDKin_1 13 19 PF00069 0.587
MOD_ProDKin_1 24 30 PF00069 0.484
MOD_ProDKin_1 800 806 PF00069 0.470
MOD_ProDKin_1 91 97 PF00069 0.432
MOD_SUMO_for_1 169 172 PF00179 0.520
MOD_SUMO_for_1 399 402 PF00179 0.561
MOD_SUMO_for_1 592 595 PF00179 0.527
MOD_SUMO_for_1 687 690 PF00179 0.489
MOD_SUMO_for_1 915 918 PF00179 0.442
MOD_SUMO_rev_2 222 228 PF00179 0.481
MOD_SUMO_rev_2 401 407 PF00179 0.533
MOD_SUMO_rev_2 427 436 PF00179 0.621
MOD_SUMO_rev_2 598 608 PF00179 0.502
MOD_SUMO_rev_2 636 645 PF00179 0.565
MOD_SUMO_rev_2 651 655 PF00179 0.452
MOD_SUMO_rev_2 872 879 PF00179 0.607
TRG_AP2beta_CARGO_1 330 340 PF09066 0.480
TRG_AP2beta_CARGO_1 876 886 PF09066 0.544
TRG_DiLeu_BaEn_4 499 505 PF01217 0.563
TRG_DiLeu_BaLyEn_6 841 846 PF01217 0.407
TRG_ENDOCYTIC_2 812 815 PF00928 0.389
TRG_ENDOCYTIC_2 948 951 PF00928 0.388
TRG_ER_diArg_1 159 162 PF00400 0.455
TRG_ER_diArg_1 166 169 PF00400 0.452
TRG_ER_diArg_1 281 284 PF00400 0.479
TRG_ER_diArg_1 295 297 PF00400 0.424
TRG_ER_diArg_1 339 341 PF00400 0.464
TRG_ER_diArg_1 483 485 PF00400 0.610
TRG_ER_diArg_1 631 633 PF00400 0.565
TRG_ER_diArg_1 667 670 PF00400 0.532
TRG_ER_diArg_1 719 722 PF00400 0.438
TRG_ER_diArg_1 842 844 PF00400 0.523
TRG_NES_CRM1_1 629 642 PF08389 0.580
TRG_NLS_MonoExtC_3 484 490 PF00514 0.440
TRG_NLS_MonoExtN_4 482 489 PF00514 0.446
TRG_Pf-PMV_PEXEL_1 112 116 PF00026 0.475
TRG_Pf-PMV_PEXEL_1 356 361 PF00026 0.579

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5M6 Leptomonas seymouri 76% 100%
A0A0S4J6N5 Bodo saltans 51% 99%
A0A1X0NYF6 Trypanosomatidae 62% 100%
A0A3R7KAV4 Trypanosoma rangeli 64% 100%
A4HEE3 Leishmania braziliensis 78% 100%
C9ZKE8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 61% 100%
E9AHA1 Leishmania infantum 100% 100%
E9AXX5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
Q4Q9J7 Leishmania major 96% 100%
V5AK68 Trypanosoma cruzi 61% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS