Microsomal_signal_peptidase_12_kDa_subunit_(SPC12 )_putative/Pfam:PF06645

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Microsomal signal peptidase 12 kDa subunit (SPC12), putative

Species:

Leishmania donovani

UniProt:

A0A3S7WZI3_LEIDO

TriTrypDb:

LdBPK_252430.1 , LdCL_250030100 , LDHU3_25.2910

Length:

145

Annotations

LeishMANIAdb annotations

These kinetoplastid proteins share some structural homology to the signal peptidase complex subunit 1 of other Eukaryotes.. Localization: ER (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005787	signal peptidase complex	3	8
GO:0016020	membrane	2	8
GO:0032991	protein-containing complex	1	8
GO:0098796	membrane protein complex	2	8
GO:0110165	cellular anatomical entity	1	8
GO:0140534	endoplasmic reticulum protein-containing complex	2	8
GO:1902494	catalytic complex	2	8
GO:1905368	peptidase complex	3	8
GO:0005783	endoplasmic reticulum	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A0A3S7WZI3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WZI3

Function

Biological processes
Term	Name	Level	Count
GO:0006465	signal peptide processing	5	8
GO:0006508	proteolysis	4	8
GO:0006518	peptide metabolic process	4	8
GO:0006807	nitrogen compound metabolic process	2	8
GO:0008152	metabolic process	1	8
GO:0016485	protein processing	5	8
GO:0019538	protein metabolic process	3	8
GO:0043170	macromolecule metabolic process	3	8
GO:0043603	amide metabolic process	3	8
GO:0044238	primary metabolic process	2	8
GO:0051604	protein maturation	4	8
GO:0071704	organic substance metabolic process	2	8
GO:1901564	organonitrogen compound metabolic process	3	8

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	16	18	PF00675	0.545
CLV_PCSK_SKI1_1	141	145	PF00082	0.432
DEG_Nend_UBRbox_2	1	3	PF02207	0.737
DOC_CYCLIN_yCln2_LP_2	29	35	PF00134	0.711
DOC_PP2B_LxvP_1	83	86	PF13499	0.501
DOC_WW_Pin1_4	129	134	PF00397	0.798
DOC_WW_Pin1_4	28	33	PF00397	0.673
DOC_WW_Pin1_4	3	8	PF00397	0.717
LIG_14-3-3_CterR_2	141	145	PF00244	0.632
LIG_BIR_III_2	130	134	PF00653	0.701
LIG_CtBP_PxDLS_1	32	36	PF00389	0.671
LIG_LIR_Gen_1	43	53	PF02991	0.535
LIG_LIR_Nem_3	102	108	PF02991	0.675
LIG_LIR_Nem_3	43	48	PF02991	0.535
LIG_Pex14_2	84	88	PF04695	0.430
LIG_SH2_SRC	89	92	PF00017	0.686
LIG_SH2_STAT3	107	110	PF00017	0.692
LIG_SH2_STAT5	40	43	PF00017	0.556
LIG_SH3_3	130	136	PF00018	0.793
LIG_SH3_3	52	58	PF00018	0.376
LIG_SH3_3	8	14	PF00018	0.688
LIG_SH3_CIN85_PxpxPR_1	136	141	PF14604	0.631
MOD_CK1_1	122	128	PF00069	0.764
MOD_CK1_1	31	37	PF00069	0.673
MOD_GlcNHglycan	120	124	PF01048	0.483
MOD_GSK3_1	125	132	PF00069	0.706
MOD_GSK3_1	49	56	PF00069	0.430
MOD_NEK2_1	49	54	PF00069	0.378
MOD_Plk_4	66	72	PF00069	0.480
MOD_Plk_4	74	80	PF00069	0.338
MOD_ProDKin_1	129	135	PF00069	0.798
MOD_ProDKin_1	28	34	PF00069	0.673
MOD_ProDKin_1	3	9	PF00069	0.717

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5M9	Leptomonas seymouri	59%	100%
A4HED5	Leishmania braziliensis	79%	100%
A4I1T2	Leishmania infantum	99%	100%
C9ZKD8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AXW6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q95ZB5	Leishmania major	90%	100%