60S ribosomal protein L7, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

60S ribosomal protein L7, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WZH9_LEIDO

TriTrypDb:

LdBPK_260160.1 , LdCL_260007100 , LDHU3_26.0240

Length:

252

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 32

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

Cellular components
Term	Name	Level	Count
GO:0015934	large ribosomal subunit	4	17
GO:0022625	cytosolic large ribosomal subunit	5	17
GO:0032991	protein-containing complex	1	17
GO:0044391	ribosomal subunit	3	17
GO:1990904	ribonucleoprotein complex	2	17
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0005840	ribosome	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1

Expansion

Sequence features

A0A3S7WZH9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WZH9

Function

Biological processes
Term	Name	Level	Count
GO:0000463	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	10	17
GO:0000470	maturation of LSU-rRNA	9	17
GO:0006139	nucleobase-containing compound metabolic process	3	17
GO:0006364	rRNA processing	8	17
GO:0006396	RNA processing	6	17
GO:0006725	cellular aromatic compound metabolic process	3	17
GO:0006807	nitrogen compound metabolic process	2	17
GO:0008152	metabolic process	1	17
GO:0009987	cellular process	1	17
GO:0016070	RNA metabolic process	5	17
GO:0016072	rRNA metabolic process	7	17
GO:0034470	ncRNA processing	7	17
GO:0034641	cellular nitrogen compound metabolic process	3	17
GO:0034660	ncRNA metabolic process	6	17
GO:0043170	macromolecule metabolic process	3	17
GO:0044237	cellular metabolic process	2	17
GO:0044238	primary metabolic process	2	17
GO:0046483	heterocycle metabolic process	3	17
GO:0071704	organic substance metabolic process	2	17
GO:0090304	nucleic acid metabolic process	4	17
GO:1901360	organic cyclic compound metabolic process	3	17

Molecular functions
Term	Name	Level	Count
GO:0003735	structural constituent of ribosome	2	17
GO:0005198	structural molecule activity	1	17
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	109	111	PF00675	0.317
CLV_NRD_NRD_1	228	230	PF00675	0.427
CLV_NRD_NRD_1	42	44	PF00675	0.466
CLV_NRD_NRD_1	58	60	PF00675	0.388
CLV_NRD_NRD_1	76	78	PF00675	0.297
CLV_PCSK_FUR_1	225	229	PF00082	0.443
CLV_PCSK_KEX2_1	160	162	PF00082	0.367
CLV_PCSK_KEX2_1	227	229	PF00082	0.441
CLV_PCSK_KEX2_1	24	26	PF00082	0.305
CLV_PCSK_KEX2_1	76	78	PF00082	0.297
CLV_PCSK_PC1ET2_1	160	162	PF00082	0.372
CLV_PCSK_PC1ET2_1	227	229	PF00082	0.445
CLV_PCSK_PC1ET2_1	24	26	PF00082	0.305
CLV_PCSK_SKI1_1	110	114	PF00082	0.305
CLV_PCSK_SKI1_1	119	123	PF00082	0.305
CLV_PCSK_SKI1_1	206	210	PF00082	0.366
CLV_PCSK_SKI1_1	25	29	PF00082	0.305
CLV_PCSK_SKI1_1	44	48	PF00082	0.305
CLV_PCSK_SKI1_1	71	75	PF00082	0.401
DEG_APCC_DBOX_1	109	117	PF00400	0.317
DOC_ANK_TNKS_1	228	235	PF00023	0.446
DOC_MAPK_gen_1	108	118	PF00069	0.305
DOC_MAPK_gen_1	160	166	PF00069	0.368
DOC_PP2B_LxvP_1	217	220	PF13499	0.383
DOC_USP7_UBL2_3	104	108	PF12436	0.317
DOC_USP7_UBL2_3	47	51	PF12436	0.348
LIG_14-3-3_CanoR_1	170	179	PF00244	0.471
LIG_14-3-3_CanoR_1	206	215	PF00244	0.493
LIG_14-3-3_CanoR_1	77	87	PF00244	0.357
LIG_Actin_WH2_2	122	140	PF00022	0.305
LIG_FHA_1	1	7	PF00498	0.694
LIG_FHA_1	122	128	PF00498	0.305
LIG_FHA_1	51	57	PF00498	0.436
LIG_LIR_Gen_1	124	133	PF02991	0.296
LIG_LIR_Nem_3	141	146	PF02991	0.382
LIG_LYPXL_yS_3	148	151	PF13949	0.345
LIG_PCNA_yPIPBox_3	104	116	PF02747	0.308
LIG_PCNA_yPIPBox_3	128	137	PF02747	0.317
LIG_Pex14_2	122	126	PF04695	0.305
LIG_PTB_Apo_2	120	127	PF02174	0.305
LIG_PTB_Apo_2	193	200	PF02174	0.343
LIG_PTB_Phospho_1	193	199	PF10480	0.336
LIG_Rb_LxCxE_1	187	200	PF01857	0.409
LIG_SH2_CRK	146	150	PF00017	0.338
LIG_SH2_NCK_1	183	187	PF00017	0.538
LIG_SH2_SRC	86	89	PF00017	0.330
LIG_SH2_STAP1	61	65	PF00017	0.305
LIG_SH2_STAT5	143	146	PF00017	0.327
LIG_SH2_STAT5	163	166	PF00017	0.514
LIG_SH2_STAT5	199	202	PF00017	0.396
LIG_SH2_STAT5	55	58	PF00017	0.429
LIG_SH2_STAT5	86	89	PF00017	0.317
LIG_SH3_3	11	17	PF00018	0.558
LIG_TRFH_1	215	219	PF08558	0.384
MOD_CK1_1	150	156	PF00069	0.348
MOD_GlcNHglycan	20	23	PF01048	0.291
MOD_LATS_1	204	210	PF00433	0.367
MOD_N-GLC_1	8	13	PF02516	0.624
MOD_NEK2_1	36	41	PF00069	0.326
MOD_NEK2_1	50	55	PF00069	0.330
MOD_PKA_1	59	65	PF00069	0.439
MOD_PKA_2	239	245	PF00069	0.383
MOD_PKB_1	57	65	PF00069	0.439
MOD_Plk_4	121	127	PF00069	0.305
MOD_Plk_4	2	8	PF00069	0.659
MOD_Plk_4	239	245	PF00069	0.377
MOD_Plk_4	36	42	PF00069	0.136
MOD_SUMO_rev_2	64	73	PF00179	0.307
TRG_ENDOCYTIC_2	148	151	PF00928	0.345
TRG_ENDOCYTIC_2	163	166	PF00928	0.514
TRG_ER_diArg_1	116	119	PF00400	0.305
TRG_ER_diArg_1	56	59	PF00400	0.451
TRG_ER_diArg_1	75	77	PF00400	0.297
TRG_NLS_MonoExtN_4	225	231	PF00514	0.430
TRG_Pf-PMV_PEXEL_1	110	114	PF00026	0.317

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBU7	Leptomonas seymouri	92%	100%
A0A0S4IU62	Bodo saltans	83%	100%
A0A0S4JDH9	Bodo saltans	25%	72%
A0A1D8PDL6	Candida albicans (strain SC5314 / ATCC MYA-2876)	42%	100%
A0A1X0NSK2	Trypanosomatidae	87%	100%
A0A3Q8INU3	Leishmania donovani	100%	100%
A0A3R7M5J8	Trypanosoma rangeli	77%	100%
A0A422NVF3	Trypanosoma rangeli	86%	100%
A0BD73	Paramecium tetraurelia	42%	100%
A0CEY2	Paramecium tetraurelia	42%	100%
A1RU38	Pyrobaculum islandicum (strain DSM 4184 / JCM 9189 / GEO3)	29%	100%
A2BME0	Hyperthermus butylicus (strain DSM 5456 / JCM 9403 / PLM1-5)	27%	100%
A3MU87	Pyrobaculum calidifontis (strain DSM 21063 / JCM 11548 / VA1)	31%	100%
A4HEM2	Leishmania braziliensis	96%	100%
A4HEM3	Leishmania braziliensis	93%	100%
A4I1V4	Leishmania infantum	99%	100%
A4WHQ9	Pyrobaculum arsenaticum (strain DSM 13514 / JCM 11321 / PZ6)	30%	100%
B1Y8Q5	Pyrobaculum neutrophilum (strain DSM 2338 / JCM 9278 / NBRC 100436 / V24Sta)	27%	100%
C9ZS66	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	88%	100%
C9ZS67	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	84%	98%
E9AHB0	Leishmania infantum	100%	100%
E9AXZ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
E9AXZ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
O01802	Caenorhabditis elegans	48%	100%
O60143	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	43%	100%
P05426	Rattus norvegicus	49%	97%
P05737	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	42%	100%
P0DJ13	Tetrahymena thermophila	42%	100%
P11874	Dictyostelium discoideum	46%	100%
P14148	Mus musculus	49%	93%
P17937	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	36%	100%
P18124	Homo sapiens	49%	100%
P25457	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	42%	100%
P32100	Drosophila melanogaster	48%	100%
P40693	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	78%
P60039	Arabidopsis thaliana	44%	100%
P60040	Arabidopsis thaliana	45%	100%
Q12213	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	42%	100%
Q4Q9H4	Leishmania major	98%	100%
Q4R506	Macaca fascicularis	49%	100%
Q58DT1	Bos taurus	49%	100%
Q5R9R4	Pongo abelii	49%	100%
Q5RAH8	Pongo abelii	29%	100%
Q5ZJ56	Gallus gallus	50%	100%
Q6BTA4	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	42%	100%
Q6C603	Yarrowia lipolytica (strain CLIB 122 / E 150)	49%	100%
Q6DKI1	Homo sapiens	29%	99%
Q6FSN6	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	42%	100%
Q755A7	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	43%	100%
Q7SBD5	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	41%	100%
Q8SS93	Encephalitozoon cuniculi (strain GB-M1)	31%	100%
Q8ZXN8	Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2)	31%	100%
Q9D8M4	Mus musculus	29%	100%
Q9LHP1	Arabidopsis thaliana	45%	100%
Q9SAI5	Arabidopsis thaliana	33%	100%
V5DR72	Trypanosoma cruzi	85%	100%