Uncharacterized conserved protein (DUF2305)/Alpha/beta hydrolase family, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Uncharacterised conserved protein (DUF2305), putative

Species:

Leishmania donovani

UniProt:

A0A3S7WZH7_LEIDO

TriTrypDb:

LdBPK_260210.1 , LdCL_260007600 , LDHU3_26.0310

Length:

314

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005811	lipid droplet	5	12
GO:0016020	membrane	2	8
GO:0043226	organelle	2	12
GO:0043228	non-membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043232	intracellular non-membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

A0A3S7WZH7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WZH7

Function

Biological processes
Term	Name	Level	Count
GO:0019915	lipid storage	3	12
GO:0051179	localization	1	12
GO:0051235	maintenance of location	2	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0016298	lipase activity	4	12
GO:0016787	hydrolase activity	2	12
GO:0016788	hydrolase activity, acting on ester bonds	3	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	38	42	PF00656	0.582
CLV_NRD_NRD_1	121	123	PF00675	0.299
CLV_NRD_NRD_1	170	172	PF00675	0.238
CLV_NRD_NRD_1	43	45	PF00675	0.371
CLV_NRD_NRD_1	49	51	PF00675	0.242
CLV_PCSK_KEX2_1	170	172	PF00082	0.267
CLV_PCSK_KEX2_1	43	45	PF00082	0.360
CLV_PCSK_SKI1_1	170	174	PF00082	0.225
CLV_PCSK_SKI1_1	199	203	PF00082	0.457
CLV_PCSK_SKI1_1	239	243	PF00082	0.443
CLV_PCSK_SKI1_1	255	259	PF00082	0.371
CLV_PCSK_SKI1_1	50	54	PF00082	0.208
DEG_APCC_DBOX_1	254	262	PF00400	0.254
DOC_CYCLIN_RxL_1	196	206	PF00134	0.263
DOC_MAPK_gen_1	50	56	PF00069	0.391
DOC_PP1_RVXF_1	49	56	PF00149	0.452
DOC_PP4_FxxP_1	65	68	PF00568	0.433
DOC_USP7_MATH_1	131	135	PF00917	0.470
DOC_USP7_MATH_1	158	162	PF00917	0.545
DOC_USP7_MATH_1	86	90	PF00917	0.430
DOC_WW_Pin1_4	163	168	PF00397	0.414
LIG_14-3-3_CanoR_1	146	154	PF00244	0.436
LIG_14-3-3_CanoR_1	44	54	PF00244	0.532
LIG_14-3-3_CanoR_1	97	102	PF00244	0.512
LIG_Actin_WH2_2	234	252	PF00022	0.242
LIG_BIR_II_1	1	5	PF00653	0.559
LIG_deltaCOP1_diTrp_1	264	271	PF00928	0.223
LIG_eIF4E_1	196	202	PF01652	0.293
LIG_FHA_1	226	232	PF00498	0.299
LIG_FHA_2	202	208	PF00498	0.328
LIG_GBD_Chelix_1	214	222	PF00786	0.368
LIG_Integrin_isoDGR_2	168	170	PF01839	0.306
LIG_LIR_Gen_1	230	240	PF02991	0.273
LIG_LIR_Gen_1	75	86	PF02991	0.426
LIG_LIR_Nem_3	236	241	PF02991	0.214
LIG_LIR_Nem_3	264	269	PF02991	0.251
LIG_LIR_Nem_3	75	81	PF02991	0.426
LIG_NRBOX	186	192	PF00104	0.357
LIG_NRBOX	197	203	PF00104	0.334
LIG_PTB_Apo_2	226	233	PF02174	0.275
LIG_PTB_Phospho_1	226	232	PF10480	0.312
LIG_SH2_CRK	147	151	PF00017	0.454
LIG_SH2_STAT5	174	177	PF00017	0.424
LIG_SH2_STAT5	260	263	PF00017	0.253
LIG_SH2_STAT5	32	35	PF00017	0.510
LIG_SH3_3	51	57	PF00018	0.422
LIG_SUMO_SIM_anti_2	79	84	PF11976	0.415
LIG_SUMO_SIM_par_1	199	207	PF11976	0.282
LIG_TRAF2_1	34	37	PF00917	0.629
LIG_TRFH_1	154	158	PF08558	0.475
LIG_UBA3_1	190	197	PF00899	0.308
MOD_CDK_SPxxK_3	163	170	PF00069	0.442
MOD_CK1_1	206	212	PF00069	0.260
MOD_CK1_1	3	9	PF00069	0.608
MOD_CK2_1	201	207	PF00069	0.299
MOD_CK2_1	267	273	PF00069	0.356
MOD_CK2_1	31	37	PF00069	0.578
MOD_CK2_1	86	92	PF00069	0.499
MOD_Cter_Amidation	168	171	PF01082	0.267
MOD_Cter_Amidation	41	44	PF01082	0.464
MOD_GSK3_1	107	114	PF00069	0.501
MOD_GSK3_1	202	209	PF00069	0.261
MOD_GSK3_1	31	38	PF00069	0.639
MOD_N-GLC_1	299	304	PF02516	0.546
MOD_NEK2_1	111	116	PF00069	0.450
MOD_NEK2_1	173	178	PF00069	0.480
MOD_NEK2_1	201	206	PF00069	0.277
MOD_NEK2_1	214	219	PF00069	0.280
MOD_NEK2_1	227	232	PF00069	0.312
MOD_NEK2_1	23	28	PF00069	0.553
MOD_NEK2_1	72	77	PF00069	0.482
MOD_PKA_2	145	151	PF00069	0.499
MOD_Plk_4	107	113	PF00069	0.469
MOD_Plk_4	227	233	PF00069	0.340
MOD_Plk_4	3	9	PF00069	0.571
MOD_ProDKin_1	163	169	PF00069	0.414
TRG_DiLeu_BaEn_1	237	242	PF01217	0.312
TRG_DiLeu_BaLyEn_6	196	201	PF01217	0.304
TRG_DiLeu_BaLyEn_6	252	257	PF01217	0.281
TRG_ENDOCYTIC_2	147	150	PF00928	0.512
TRG_ENDOCYTIC_2	232	235	PF00928	0.334
TRG_ENDOCYTIC_2	66	69	PF00928	0.408
TRG_ER_diArg_1	170	172	PF00400	0.438
TRG_ER_diArg_1	43	45	PF00400	0.562
TRG_NES_CRM1_1	192	207	PF08389	0.231
TRG_Pf-PMV_PEXEL_1	239	243	PF00026	0.531

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJP9	Leptomonas seymouri	67%	100%
A0A0S4IN66	Bodo saltans	37%	100%
A0A1X0NSK1	Trypanosomatidae	44%	100%
A0A422NVG9	Trypanosoma rangeli	43%	100%
A4HEN1	Leishmania braziliensis	80%	100%
A4I1V9	Leishmania infantum	99%	100%
C9ZS60	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	98%
E9AY04	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q9G9	Leishmania major	94%	100%
Q54LL8	Dictyostelium discoideum	25%	100%
Q5F477	Gallus gallus	26%	97%
Q5HZX7	Rattus norvegicus	24%	97%
Q5R7E8	Pongo abelii	28%	97%
Q8BVA5	Mus musculus	25%	96%
Q9H6V9	Homo sapiens	26%	97%
Q9W0H3	Drosophila melanogaster	24%	100%
V5BUL9	Trypanosoma cruzi	45%	100%