Nuclear lim interactor-interacting factor-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nuclear lim interactor-interacting factor-like protein

Species:

Leishmania donovani

UniProt:

A0A3S7WZH2_LEIDO

TriTrypDb:

LdBPK_260140.1 , LdCL_260006900 , LDHU3_26.0210

Length:

290

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WZH2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WZH2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	17
GO:0016787	hydrolase activity	2	17
GO:0016788	hydrolase activity, acting on ester bonds	3	17
GO:0016791	phosphatase activity	5	17
GO:0042578	phosphoric ester hydrolase activity	4	17
GO:0004721	phosphoprotein phosphatase activity	3	2
GO:0140096	catalytic activity, acting on a protein	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	168	170	PF00675	0.399
CLV_NRD_NRD_1	225	227	PF00675	0.375
CLV_NRD_NRD_1	69	71	PF00675	0.557
CLV_NRD_NRD_1	81	83	PF00675	0.349
CLV_PCSK_KEX2_1	168	170	PF00082	0.399
CLV_PCSK_KEX2_1	225	227	PF00082	0.365
CLV_PCSK_KEX2_1	69	71	PF00082	0.604
CLV_PCSK_PC7_1	164	170	PF00082	0.399
CLV_PCSK_SKI1_1	138	142	PF00082	0.466
CLV_PCSK_SKI1_1	257	261	PF00082	0.290
CLV_PCSK_SKI1_1	99	103	PF00082	0.451
DEG_SPOP_SBC_1	57	61	PF00917	0.646
DOC_CDC14_PxL_1	260	268	PF14671	0.320
DOC_CYCLIN_yCln2_LP_2	101	104	PF00134	0.448
DOC_MAPK_DCC_7	99	107	PF00069	0.505
DOC_MAPK_gen_1	168	175	PF00069	0.250
DOC_MAPK_gen_1	219	229	PF00069	0.248
DOC_MAPK_gen_1	255	263	PF00069	0.268
DOC_MAPK_MEF2A_6	112	119	PF00069	0.243
DOC_MAPK_MEF2A_6	255	263	PF00069	0.250
DOC_MAPK_MEF2A_6	99	107	PF00069	0.420
DOC_MAPK_NFAT4_5	112	120	PF00069	0.272
DOC_PP2B_LxvP_1	101	104	PF13499	0.366
DOC_PP2B_LxvP_1	261	264	PF13499	0.221
DOC_SPAK_OSR1_1	169	173	PF12202	0.364
DOC_USP7_MATH_1	106	110	PF00917	0.489
DOC_WW_Pin1_4	230	235	PF00397	0.271
DOC_WW_Pin1_4	38	43	PF00397	0.710
DOC_WW_Pin1_4	81	86	PF00397	0.426
LIG_14-3-3_CanoR_1	25	33	PF00244	0.634
LIG_14-3-3_CanoR_1	70	80	PF00244	0.486
LIG_Actin_WH2_2	210	227	PF00022	0.364
LIG_APCC_ABBA_1	199	204	PF00400	0.271
LIG_BIR_II_1	1	5	PF00653	0.675
LIG_BRCT_BRCA1_1	166	170	PF00533	0.364
LIG_eIF4E_1	136	142	PF01652	0.221
LIG_EVH1_1	102	106	PF00568	0.352
LIG_EVH1_2	103	107	PF00568	0.383
LIG_FHA_1	112	118	PF00498	0.249
LIG_FHA_1	146	152	PF00498	0.258
LIG_FHA_1	59	65	PF00498	0.635
LIG_FHA_1	73	79	PF00498	0.485
LIG_FHA_2	205	211	PF00498	0.364
LIG_FHA_2	6	12	PF00498	0.558
LIG_FHA_2	74	80	PF00498	0.538
LIG_LIR_Gen_1	133	143	PF02991	0.440
LIG_LIR_Gen_1	160	170	PF02991	0.281
LIG_LIR_Gen_1	258	266	PF02991	0.341
LIG_LIR_Gen_1	273	284	PF02991	0.312
LIG_LIR_Nem_3	133	139	PF02991	0.425
LIG_LIR_Nem_3	152	158	PF02991	0.192
LIG_LIR_Nem_3	160	165	PF02991	0.260
LIG_LIR_Nem_3	167	173	PF02991	0.258
LIG_LIR_Nem_3	258	263	PF02991	0.345
LIG_LIR_Nem_3	273	279	PF02991	0.329
LIG_MAD2	226	234	PF02301	0.250
LIG_MYND_1	100	104	PF01753	0.420
LIG_PCNA_TLS_4	156	163	PF02747	0.250
LIG_PDZ_Class_3	285	290	PF00595	0.386
LIG_REV1ctd_RIR_1	13	21	PF16727	0.593
LIG_SH2_CRK	136	140	PF00017	0.283
LIG_SH2_STAP1	136	140	PF00017	0.331
LIG_SH2_STAP1	149	153	PF00017	0.331
LIG_SH2_STAT3	237	240	PF00017	0.271
LIG_SH2_STAT5	149	152	PF00017	0.302
LIG_SH2_STAT5	158	161	PF00017	0.286
LIG_SH2_STAT5	182	185	PF00017	0.271
LIG_SH2_STAT5	213	216	PF00017	0.271
LIG_SH3_3	97	103	PF00018	0.427
LIG_SH3_4	6	13	PF00018	0.601
LIG_SUMO_SIM_anti_2	137	145	PF11976	0.221
LIG_SUMO_SIM_anti_2	73	82	PF11976	0.555
LIG_SUMO_SIM_par_1	113	118	PF11976	0.270
LIG_SUMO_SIM_par_1	137	145	PF11976	0.326
LIG_SUMO_SIM_par_1	226	231	PF11976	0.309
LIG_SxIP_EBH_1	62	71	PF03271	0.443
LIG_TRAF2_1	8	11	PF00917	0.603
LIG_TRFH_1	260	264	PF08558	0.364
LIG_TYR_ITIM	134	139	PF00017	0.364
LIG_WRPW_2	155	158	PF00400	0.271
LIG_WW_2	103	106	PF00397	0.369
MOD_CK1_1	274	280	PF00069	0.288
MOD_CK1_1	34	40	PF00069	0.643
MOD_CK2_1	204	210	PF00069	0.235
MOD_CK2_1	5	11	PF00069	0.543
MOD_GlcNHglycan	2	5	PF01048	0.754
MOD_GlcNHglycan	27	30	PF01048	0.732
MOD_GSK3_1	119	126	PF00069	0.271
MOD_GSK3_1	141	148	PF00069	0.298
MOD_GSK3_1	34	41	PF00069	0.553
MOD_GSK3_1	56	63	PF00069	0.592
MOD_N-GLC_1	38	43	PF02516	0.572
MOD_N-GLC_1	70	75	PF02516	0.554
MOD_N-GLC_1	86	91	PF02516	0.353
MOD_NEK2_1	123	128	PF00069	0.317
MOD_NEK2_1	175	180	PF00069	0.290
MOD_NEK2_1	23	28	PF00069	0.519
MOD_NEK2_1	271	276	PF00069	0.384
MOD_NEK2_2	149	154	PF00069	0.311
MOD_PIKK_1	31	37	PF00454	0.698
MOD_PIKK_1	45	51	PF00454	0.376
MOD_PIKK_1	6	12	PF00454	0.533
MOD_PKA_2	24	30	PF00069	0.653
MOD_PKA_2	31	37	PF00069	0.625
MOD_Plk_1	119	125	PF00069	0.271
MOD_Plk_1	209	215	PF00069	0.282
MOD_Plk_2-3	204	210	PF00069	0.364
MOD_Plk_4	111	117	PF00069	0.322
MOD_Plk_4	119	125	PF00069	0.285
MOD_Plk_4	246	252	PF00069	0.299
MOD_Plk_4	271	277	PF00069	0.336
MOD_ProDKin_1	230	236	PF00069	0.271
MOD_ProDKin_1	38	44	PF00069	0.699
MOD_ProDKin_1	81	87	PF00069	0.417
MOD_SUMO_rev_2	144	148	PF00179	0.221
MOD_SUMO_rev_2	95	101	PF00179	0.341
TRG_AP2beta_CARGO_1	160	169	PF09066	0.250
TRG_DiLeu_BaEn_1	258	263	PF01217	0.261
TRG_DiLeu_BaLyEn_6	261	266	PF01217	0.343
TRG_DiLeu_LyEn_5	97	102	PF01217	0.321
TRG_ENDOCYTIC_2	136	139	PF00928	0.314
TRG_ENDOCYTIC_2	276	279	PF00928	0.339
TRG_ER_diArg_1	168	170	PF00400	0.404
TRG_ER_diArg_1	224	226	PF00400	0.366
TRG_NES_CRM1_1	44	58	PF08389	0.482

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7Z9	Leptomonas seymouri	28%	100%
A0A0N1HTD7	Leptomonas seymouri	72%	100%
A0A0N1PG96	Leptomonas seymouri	53%	82%
A0A0S4IJH3	Bodo saltans	43%	100%
A0A0S4ILH7	Bodo saltans	26%	81%
A0A0S4IMS1	Bodo saltans	52%	86%
A0A0S4JIG1	Bodo saltans	43%	79%
A0A0S4JKZ9	Bodo saltans	27%	66%
A0A0S4JMG9	Bodo saltans	30%	72%
A0A1X0NYI7	Trypanosomatidae	52%	72%
A0A3Q8IDG4	Leishmania donovani	52%	79%
A0A3R7NSE5	Trypanosoma rangeli	30%	100%
A0A422P4K3	Trypanosoma rangeli	46%	71%
A4HEA5	Leishmania braziliensis	51%	79%
A4HEM1	Leishmania braziliensis	88%	100%
A4I1Q1	Leishmania infantum	52%	79%
A4I1V3	Leishmania infantum	99%	100%
C9ZKA3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	69%
E9AEA2	Leishmania major	27%	100%
E9AXT5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	79%
E9AXZ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
M9PFN0	Drosophila melanogaster	39%	82%
O14595	Homo sapiens	38%	100%
P58465	Mus musculus	36%	100%
P58466	Mus musculus	44%	100%
Q07949	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	40%	73%
Q20432	Caenorhabditis elegans	39%	100%
Q4Q9H6	Leishmania major	98%	100%
Q4Q9N6	Leishmania major	51%	80%
Q61C05	Caenorhabditis briggsae	39%	100%
Q9GZU7	Homo sapiens	44%	100%
Q9PTJ6	Gallus gallus	40%	100%
V5BSW0	Trypanosoma cruzi	31%	100%