Pex2 / Pex12 amino terminal region/Zinc finger, C3HC4 type (RING finger)/Ring finger domain/zinc-RING finger domain/Anaphase-promoting complex subunit 11 RING-H2 finger containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Pex2 / Pex12 amino terminal region/Ring finger domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WZG1_LEIDO

TriTrypDb:

LdBPK_252400.1 , LdCL_250029800 , LDHU3_25.2880

Length:

295

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005777	peroxisome	6	9
GO:0042579	microbody	5	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043231	intracellular membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	11
GO:0005737	cytoplasm	2	1
GO:0005778	peroxisomal membrane	6	1
GO:0016020	membrane	2	3
GO:0031090	organelle membrane	3	1
GO:0031903	microbody membrane	5	1
GO:0098588	bounding membrane of organelle	4	1

Expansion

Sequence features

A0A3S7WZG1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WZG1

Function

Biological processes
Term	Name	Level	Count
GO:0006605	protein targeting	5	1
GO:0006625	protein targeting to peroxisome	5	1
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0006996	organelle organization	4	1
GO:0007031	peroxisome organization	5	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0015919	peroxisomal membrane transport	5	1
GO:0016043	cellular component organization	3	1
GO:0016558	protein import into peroxisome matrix	5	1
GO:0033036	macromolecule localization	2	1
GO:0033365	protein localization to organelle	5	1
GO:0043574	peroxisomal transport	4	1
GO:0044743	protein transmembrane import into intracellular organelle	4	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0055085	transmembrane transport	2	1
GO:0065002	intracellular protein transmembrane transport	4	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0071806	protein transmembrane transport	3	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0072594	establishment of protein localization to organelle	4	1
GO:0072662	protein localization to peroxisome	6	1
GO:0072663	establishment of protein localization to peroxisome	5	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	135	141	PF00089	0.418
CLV_NRD_NRD_1	109	111	PF00675	0.330
CLV_NRD_NRD_1	226	228	PF00675	0.256
CLV_PCSK_KEX2_1	198	200	PF00082	0.412
CLV_PCSK_PC1ET2_1	198	200	PF00082	0.437
CLV_PCSK_SKI1_1	110	114	PF00082	0.329
CLV_PCSK_SKI1_1	127	131	PF00082	0.201
CLV_PCSK_SKI1_1	195	199	PF00082	0.418
CLV_PCSK_SKI1_1	219	223	PF00082	0.274
CLV_PCSK_SKI1_1	26	30	PF00082	0.317
CLV_PCSK_SKI1_1	90	94	PF00082	0.250
CLV_Separin_Metazoa	279	283	PF03568	0.681
DEG_APCC_DBOX_1	89	97	PF00400	0.486
DEG_Nend_UBRbox_3	1	3	PF02207	0.545
DOC_CYCLIN_RxL_1	107	117	PF00134	0.531
DOC_CYCLIN_RxL_1	144	157	PF00134	0.343
DOC_MAPK_gen_1	145	154	PF00069	0.374
DOC_MAPK_gen_1	216	224	PF00069	0.544
DOC_PP1_RVXF_1	146	152	PF00149	0.376
DOC_USP7_MATH_1	114	118	PF00917	0.539
DOC_USP7_MATH_1	197	201	PF00917	0.649
DOC_WW_Pin1_4	289	294	PF00397	0.650
LIG_14-3-3_CanoR_1	150	155	PF00244	0.296
LIG_14-3-3_CanoR_1	199	206	PF00244	0.656
LIG_14-3-3_CanoR_1	26	33	PF00244	0.559
LIG_14-3-3_CanoR_1	261	271	PF00244	0.511
LIG_14-3-3_CanoR_1	63	68	PF00244	0.463
LIG_Actin_WH2_2	139	157	PF00022	0.508
LIG_BIR_III_2	214	218	PF00653	0.538
LIG_Clathr_ClatBox_1	133	137	PF01394	0.313
LIG_EH1_1	169	177	PF00400	0.310
LIG_eIF4E_1	170	176	PF01652	0.388
LIG_FHA_1	116	122	PF00498	0.570
LIG_FHA_1	264	270	PF00498	0.582
LIG_FHA_2	191	197	PF00498	0.651
LIG_FHA_2	283	289	PF00498	0.723
LIG_LIR_Gen_1	54	64	PF02991	0.488
LIG_LIR_Gen_1	70	78	PF02991	0.360
LIG_LIR_LC3C_4	180	183	PF02991	0.418
LIG_LIR_Nem_3	137	142	PF02991	0.298
LIG_LIR_Nem_3	169	173	PF02991	0.256
LIG_LIR_Nem_3	54	59	PF02991	0.488
LIG_LIR_Nem_3	70	74	PF02991	0.360
LIG_NRBOX	92	98	PF00104	0.341
LIG_SH2_STAP1	44	48	PF00017	0.456
LIG_SH2_STAT5	170	173	PF00017	0.285
LIG_SH2_STAT5	273	276	PF00017	0.570
LIG_SH2_STAT5	56	59	PF00017	0.449
LIG_SH3_1	79	85	PF00018	0.531
LIG_SH3_2	85	90	PF14604	0.531
LIG_SH3_3	79	85	PF00018	0.531
LIG_SUMO_SIM_par_1	174	180	PF11976	0.298
LIG_UBA3_1	221	228	PF00899	0.455
LIG_UBA3_1	9	15	PF00899	0.532
LIG_WW_3	279	283	PF00397	0.697
MOD_CK1_1	54	60	PF00069	0.511
MOD_CK2_1	190	196	PF00069	0.612
MOD_CK2_1	204	210	PF00069	0.612
MOD_GSK3_1	150	157	PF00069	0.311
MOD_GSK3_1	186	193	PF00069	0.581
MOD_GSK3_1	59	66	PF00069	0.519
MOD_NEK2_1	222	227	PF00069	0.480
MOD_NEK2_1	32	37	PF00069	0.585
MOD_NEK2_1	59	64	PF00069	0.486
MOD_PIKK_1	19	25	PF00454	0.543
MOD_PIKK_1	263	269	PF00454	0.582
MOD_PKA_1	198	204	PF00069	0.660
MOD_PKA_2	186	192	PF00069	0.604
MOD_PKA_2	198	204	PF00069	0.663
MOD_PKB_1	148	156	PF00069	0.358
MOD_Plk_4	166	172	PF00069	0.334
MOD_Plk_4	265	271	PF00069	0.564
MOD_Plk_4	51	57	PF00069	0.490
MOD_ProDKin_1	289	295	PF00069	0.653
MOD_SUMO_rev_2	191	200	PF00179	0.617
TRG_DiLeu_BaEn_1	70	75	PF01217	0.456
TRG_ENDOCYTIC_2	170	173	PF00928	0.318
TRG_ENDOCYTIC_2	273	276	PF00928	0.570
TRG_ENDOCYTIC_2	56	59	PF00928	0.464
TRG_ER_diArg_1	147	150	PF00400	0.336
TRG_NES_CRM1_1	123	137	PF08389	0.548
TRG_Pf-PMV_PEXEL_1	11	16	PF00026	0.318
TRG_Pf-PMV_PEXEL_1	110	115	PF00026	0.412
TRG_Pf-PMV_PEXEL_1	158	162	PF00026	0.630
TRG_Pf-PMV_PEXEL_1	242	246	PF00026	0.260
TRG_Pf-PMV_PEXEL_1	26	30	PF00026	0.254

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5N1	Leptomonas seymouri	76%	96%
A0A0S4J0W7	Bodo saltans	40%	100%
A0A1X0NY02	Trypanosomatidae	52%	96%
A0A3R7LE72	Trypanosoma rangeli	47%	100%
A4I1S9	Leishmania infantum	99%	100%
B1AUE5	Mus musculus	25%	91%
C0HKD7	Caenorhabditis elegans	25%	94%
C9ZKD7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	99%
E9AXW3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q00940	Pichia angusta	25%	100%
Q05568	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	88%
Q54S31	Dictyostelium discoideum	26%	79%
Q95ZB8	Leishmania major	95%	100%
V5D8I1	Trypanosoma cruzi	53%	98%