Helicase-like protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

helicase-like protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WZF4_LEIDO

TriTrypDb:

LdBPK_252130.1 , LdCL_250027100 , LDHU3_25.2600

Length:

1044

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0000785	chromatin	2	1
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WZF4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WZF4

Function

Biological processes
Term	Name	Level	Count
GO:0006325	chromatin organization	4	1
GO:0006338	chromatin remodeling	5	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	13
GO:0003824	catalytic activity	1	13
GO:0004386	helicase activity	2	9
GO:0005488	binding	1	13
GO:0005524	ATP binding	5	13
GO:0008094	ATP-dependent activity, acting on DNA	2	13
GO:0016491	oxidoreductase activity	2	12
GO:0017076	purine nucleotide binding	4	13
GO:0030554	adenyl nucleotide binding	5	13
GO:0032553	ribonucleotide binding	3	13
GO:0032555	purine ribonucleotide binding	4	13
GO:0032559	adenyl ribonucleotide binding	5	13
GO:0035639	purine ribonucleoside triphosphate binding	4	13
GO:0036094	small molecule binding	2	13
GO:0043167	ion binding	2	13
GO:0043168	anion binding	3	13
GO:0043169	cation binding	3	10
GO:0046872	metal ion binding	4	10
GO:0051213	dioxygenase activity	3	12
GO:0097159	organic cyclic compound binding	2	13
GO:0097367	carbohydrate derivative binding	2	13
GO:0140097	catalytic activity, acting on DNA	3	13
GO:0140640	catalytic activity, acting on a nucleic acid	2	13
GO:0140657	ATP-dependent activity	1	13
GO:0140658	ATP-dependent chromatin remodeler activity	3	13
GO:1901265	nucleoside phosphate binding	3	13
GO:1901363	heterocyclic compound binding	2	13
GO:0003676	nucleic acid binding	3	1
GO:0003677	DNA binding	4	1
GO:0003682	chromatin binding	2	1
GO:0005515	protein binding	2	1
GO:0016462	pyrophosphatase activity	5	1
GO:0016787	hydrolase activity	2	1
GO:0016817	hydrolase activity, acting on acid anhydrides	3	1
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	1
GO:0016887	ATP hydrolysis activity	7	1
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	1
GO:0042393	histone binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1005	1009	PF00656	0.566
CLV_C14_Caspase3-7	1021	1025	PF00656	0.704
CLV_C14_Caspase3-7	1040	1044	PF00656	0.449
CLV_C14_Caspase3-7	140	144	PF00656	0.572
CLV_C14_Caspase3-7	648	652	PF00656	0.446
CLV_NRD_NRD_1	382	384	PF00675	0.290
CLV_NRD_NRD_1	413	415	PF00675	0.233
CLV_NRD_NRD_1	440	442	PF00675	0.221
CLV_NRD_NRD_1	502	504	PF00675	0.246
CLV_NRD_NRD_1	743	745	PF00675	0.372
CLV_NRD_NRD_1	92	94	PF00675	0.512
CLV_NRD_NRD_1	979	981	PF00675	0.477
CLV_PCSK_KEX2_1	122	124	PF00082	0.708
CLV_PCSK_KEX2_1	148	150	PF00082	0.630
CLV_PCSK_KEX2_1	382	384	PF00082	0.378
CLV_PCSK_KEX2_1	410	412	PF00082	0.243
CLV_PCSK_KEX2_1	415	417	PF00082	0.215
CLV_PCSK_KEX2_1	502	504	PF00082	0.246
CLV_PCSK_KEX2_1	585	587	PF00082	0.564
CLV_PCSK_KEX2_1	909	911	PF00082	0.557
CLV_PCSK_KEX2_1	92	94	PF00082	0.512
CLV_PCSK_KEX2_1	979	981	PF00082	0.439
CLV_PCSK_PC1ET2_1	122	124	PF00082	0.708
CLV_PCSK_PC1ET2_1	148	150	PF00082	0.543
CLV_PCSK_PC1ET2_1	410	412	PF00082	0.243
CLV_PCSK_PC1ET2_1	415	417	PF00082	0.215
CLV_PCSK_PC1ET2_1	585	587	PF00082	0.445
CLV_PCSK_PC1ET2_1	909	911	PF00082	0.571
CLV_PCSK_PC7_1	411	417	PF00082	0.248
CLV_PCSK_SKI1_1	148	152	PF00082	0.571
CLV_PCSK_SKI1_1	275	279	PF00082	0.560
CLV_PCSK_SKI1_1	374	378	PF00082	0.238
CLV_PCSK_SKI1_1	410	414	PF00082	0.238
CLV_PCSK_SKI1_1	441	445	PF00082	0.253
CLV_PCSK_SKI1_1	783	787	PF00082	0.496
CLV_PCSK_SKI1_1	833	837	PF00082	0.536
DEG_Nend_UBRbox_3	1	3	PF02207	0.631
DEG_SPOP_SBC_1	196	200	PF00917	0.689
DEG_SPOP_SBC_1	210	214	PF00917	0.516
DOC_CKS1_1	400	405	PF01111	0.430
DOC_CYCLIN_RxL_1	145	152	PF00134	0.661
DOC_MAPK_FxFP_2	469	472	PF00069	0.420
DOC_MAPK_gen_1	122	131	PF00069	0.522
DOC_MAPK_gen_1	392	400	PF00069	0.430
DOC_MAPK_gen_1	410	421	PF00069	0.388
DOC_MAPK_gen_1	502	512	PF00069	0.430
DOC_MAPK_MEF2A_6	368	375	PF00069	0.420
DOC_MAPK_MEF2A_6	414	423	PF00069	0.523
DOC_MAPK_MEF2A_6	503	512	PF00069	0.443
DOC_MAPK_NFAT4_5	505	513	PF00069	0.423
DOC_PP1_RVXF_1	238	245	PF00149	0.341
DOC_PP1_RVXF_1	620	627	PF00149	0.446
DOC_PP2B_LxvP_1	510	513	PF13499	0.420
DOC_PP4_FxxP_1	469	472	PF00568	0.420
DOC_USP7_MATH_1	1022	1026	PF00917	0.741
DOC_USP7_MATH_1	135	139	PF00917	0.645
DOC_USP7_MATH_1	196	200	PF00917	0.628
DOC_USP7_MATH_1	217	221	PF00917	0.538
DOC_USP7_MATH_1	297	301	PF00917	0.333
DOC_USP7_MATH_1	331	335	PF00917	0.525
DOC_USP7_MATH_1	387	391	PF00917	0.525
DOC_USP7_MATH_1	435	439	PF00917	0.525
DOC_USP7_MATH_1	46	50	PF00917	0.656
DOC_USP7_MATH_1	669	673	PF00917	0.485
DOC_USP7_MATH_1	816	820	PF00917	0.547
DOC_USP7_MATH_1	978	982	PF00917	0.485
DOC_USP7_UBL2_3	792	796	PF12436	0.528
DOC_USP7_UBL2_3	9	13	PF12436	0.519
DOC_WW_Pin1_4	131	136	PF00397	0.595
DOC_WW_Pin1_4	191	196	PF00397	0.634
DOC_WW_Pin1_4	198	203	PF00397	0.633
DOC_WW_Pin1_4	25	30	PF00397	0.507
DOC_WW_Pin1_4	399	404	PF00397	0.430
DOC_WW_Pin1_4	451	456	PF00397	0.446
DOC_WW_Pin1_4	56	61	PF00397	0.635
DOC_WW_Pin1_4	64	69	PF00397	0.641
DOC_WW_Pin1_4	771	776	PF00397	0.551
DOC_WW_Pin1_4	79	84	PF00397	0.476
DOC_WW_Pin1_4	803	808	PF00397	0.603
DOC_WW_Pin1_4	858	863	PF00397	0.641
LIG_14-3-3_CanoR_1	104	112	PF00244	0.522
LIG_14-3-3_CanoR_1	416	422	PF00244	0.531
LIG_14-3-3_CanoR_1	441	449	PF00244	0.433
LIG_14-3-3_CanoR_1	643	648	PF00244	0.507
LIG_14-3-3_CanoR_1	910	915	PF00244	0.388
LIG_14-3-3_CanoR_1	979	985	PF00244	0.447
LIG_Actin_WH2_2	261	277	PF00022	0.562
LIG_BIR_III_2	936	940	PF00653	0.324
LIG_BIR_III_4	955	959	PF00653	0.382
LIG_BRCT_BRCA1_1	48	52	PF00533	0.553
LIG_BRCT_BRCA1_1	670	674	PF00533	0.420
LIG_BRCT_BRCA1_1	940	944	PF00533	0.353
LIG_Clathr_ClatBox_1	405	409	PF01394	0.448
LIG_deltaCOP1_diTrp_1	462	469	PF00928	0.445
LIG_DLG_GKlike_1	643	650	PF00625	0.486
LIG_eIF4E_1	877	883	PF01652	0.344
LIG_FHA_1	1002	1008	PF00498	0.697
LIG_FHA_1	328	334	PF00498	0.456
LIG_FHA_1	361	367	PF00498	0.439
LIG_FHA_1	400	406	PF00498	0.457
LIG_FHA_1	418	424	PF00498	0.457
LIG_FHA_1	519	525	PF00498	0.446
LIG_FHA_1	628	634	PF00498	0.420
LIG_FHA_1	692	698	PF00498	0.438
LIG_FHA_1	718	724	PF00498	0.347
LIG_FHA_1	772	778	PF00498	0.675
LIG_FHA_1	847	853	PF00498	0.597
LIG_FHA_2	1019	1025	PF00498	0.529
LIG_FHA_2	502	508	PF00498	0.525
LIG_FHA_2	629	635	PF00498	0.530
LIG_FHA_2	688	694	PF00498	0.420
LIG_FHA_2	731	737	PF00498	0.382
LIG_FHA_2	776	782	PF00498	0.531
LIG_FHA_2	824	830	PF00498	0.442
LIG_LIR_Apic_2	468	472	PF02991	0.485
LIG_LIR_Gen_1	251	260	PF02991	0.490
LIG_LIR_Gen_1	4	11	PF02991	0.537
LIG_LIR_Gen_1	462	472	PF02991	0.443
LIG_LIR_Gen_1	49	60	PF02991	0.519
LIG_LIR_Gen_1	646	651	PF02991	0.518
LIG_LIR_Gen_1	671	682	PF02991	0.420
LIG_LIR_Gen_1	784	791	PF02991	0.399
LIG_LIR_Gen_1	941	952	PF02991	0.359
LIG_LIR_Nem_3	251	256	PF02991	0.421
LIG_LIR_Nem_3	4	10	PF02991	0.593
LIG_LIR_Nem_3	468	474	PF02991	0.478
LIG_LIR_Nem_3	49	55	PF02991	0.728
LIG_LIR_Nem_3	646	650	PF02991	0.518
LIG_LIR_Nem_3	671	677	PF02991	0.420
LIG_LIR_Nem_3	784	789	PF02991	0.546
LIG_LIR_Nem_3	941	947	PF02991	0.337
LIG_LYPXL_S_1	470	474	PF13949	0.243
LIG_LYPXL_yS_3	471	474	PF13949	0.485
LIG_NRBOX	163	169	PF00104	0.478
LIG_NRBOX	531	537	PF00104	0.448
LIG_PCNA_yPIPBox_3	522	536	PF02747	0.531
LIG_Pex14_2	256	260	PF04695	0.494
LIG_Pex14_2	469	473	PF04695	0.502
LIG_Pex14_2	698	702	PF04695	0.485
LIG_REV1ctd_RIR_1	257	267	PF16727	0.391
LIG_REV1ctd_RIR_1	410	420	PF16727	0.416
LIG_SH2_NCK_1	666	670	PF00017	0.448
LIG_SH2_PTP2	498	501	PF00017	0.485
LIG_SH2_STAT3	91	94	PF00017	0.553
LIG_SH2_STAT5	237	240	PF00017	0.481
LIG_SH2_STAT5	498	501	PF00017	0.485
LIG_SH2_STAT5	6	9	PF00017	0.628
LIG_SH2_STAT5	608	611	PF00017	0.525
LIG_SH2_STAT5	747	750	PF00017	0.385
LIG_SH2_STAT5	951	954	PF00017	0.342
LIG_SH2_STAT5	984	987	PF00017	0.301
LIG_SH3_3	190	196	PF00018	0.681
LIG_SH3_3	34	40	PF00018	0.676
LIG_SH3_3	397	403	PF00018	0.443
LIG_SH3_3	513	519	PF00018	0.443
LIG_SH3_3	801	807	PF00018	0.545
LIG_SH3_3	875	881	PF00018	0.403
LIG_SH3_3	898	904	PF00018	0.509
LIG_SUMO_SIM_anti_2	161	168	PF11976	0.596
LIG_SUMO_SIM_anti_2	630	637	PF11976	0.431
LIG_SUMO_SIM_par_1	281	289	PF11976	0.424
LIG_SUMO_SIM_par_1	419	425	PF11976	0.433
LIG_SUMO_SIM_par_1	531	537	PF11976	0.571
LIG_SUMO_SIM_par_1	630	637	PF11976	0.485
LIG_SUMO_SIM_par_1	693	699	PF11976	0.446
LIG_TRAF2_1	540	543	PF00917	0.448
LIG_TRAF2_1	733	736	PF00917	0.341
LIG_TYR_ITIM	496	501	PF00017	0.485
LIG_UBA3_1	405	410	PF00899	0.448
LIG_UBA3_1	612	617	PF00899	0.525
LIG_UBA3_1	785	792	PF00899	0.568
LIG_UBA3_1	882	890	PF00899	0.338
LIG_WRC_WIRS_1	466	471	PF05994	0.483
LIG_WW_3	512	516	PF00397	0.430
LIG_WW_3	900	904	PF00397	0.461
MOD_CDC14_SPxK_1	861	864	PF00782	0.599
MOD_CDK_SPxK_1	858	864	PF00069	0.631
MOD_CK1_1	110	116	PF00069	0.566
MOD_CK1_1	15	21	PF00069	0.749
MOD_CK1_1	198	204	PF00069	0.669
MOD_CK1_1	227	233	PF00069	0.555
MOD_CK1_1	284	290	PF00069	0.538
MOD_CK1_1	357	363	PF00069	0.463
MOD_CK1_1	465	471	PF00069	0.474
MOD_CK1_1	534	540	PF00069	0.525
MOD_CK1_1	579	585	PF00069	0.593
MOD_CK1_1	627	633	PF00069	0.428
MOD_CK1_1	79	85	PF00069	0.656
MOD_CK1_1	802	808	PF00069	0.710
MOD_CK1_1	819	825	PF00069	0.619
MOD_CK1_1	995	1001	PF00069	0.500
MOD_CK2_1	50	56	PF00069	0.604
MOD_CK2_1	730	736	PF00069	0.355
MOD_CK2_1	996	1002	PF00069	0.524
MOD_GlcNHglycan	139	142	PF01048	0.698
MOD_GlcNHglycan	14	17	PF01048	0.742
MOD_GlcNHglycan	213	216	PF01048	0.616
MOD_GlcNHglycan	227	230	PF01048	0.414
MOD_GlcNHglycan	248	251	PF01048	0.595
MOD_GlcNHglycan	30	33	PF01048	0.564
MOD_GlcNHglycan	317	320	PF01048	0.262
MOD_GlcNHglycan	333	336	PF01048	0.183
MOD_GlcNHglycan	389	392	PF01048	0.284
MOD_GlcNHglycan	437	440	PF01048	0.304
MOD_GlcNHglycan	581	584	PF01048	0.447
MOD_GlcNHglycan	601	605	PF01048	0.331
MOD_GlcNHglycan	821	824	PF01048	0.685
MOD_GlcNHglycan	955	959	PF01048	0.622
MOD_GlcNHglycan	998	1001	PF01048	0.610
MOD_GSK3_1	1018	1025	PF00069	0.664
MOD_GSK3_1	107	114	PF00069	0.690
MOD_GSK3_1	117	124	PF00069	0.571
MOD_GSK3_1	131	138	PF00069	0.520
MOD_GSK3_1	191	198	PF00069	0.640
MOD_GSK3_1	223	230	PF00069	0.630
MOD_GSK3_1	327	334	PF00069	0.488
MOD_GSK3_1	354	361	PF00069	0.421
MOD_GSK3_1	41	48	PF00069	0.602
MOD_GSK3_1	431	438	PF00069	0.462
MOD_GSK3_1	624	631	PF00069	0.480
MOD_GSK3_1	687	694	PF00069	0.443
MOD_GSK3_1	771	778	PF00069	0.657
MOD_GSK3_1	796	803	PF00069	0.681
MOD_GSK3_1	819	826	PF00069	0.664
MOD_GSK3_1	99	106	PF00069	0.710
MOD_GSK3_1	992	999	PF00069	0.462
MOD_LATS_1	115	121	PF00433	0.567
MOD_LATS_1	641	647	PF00433	0.425
MOD_LATS_1	794	800	PF00433	0.516
MOD_N-GLC_1	627	632	PF02516	0.220
MOD_N-GLC_1	819	824	PF02516	0.478
MOD_NEK2_1	105	110	PF00069	0.609
MOD_NEK2_1	167	172	PF00069	0.614
MOD_NEK2_1	197	202	PF00069	0.766
MOD_NEK2_1	308	313	PF00069	0.397
MOD_NEK2_1	327	332	PF00069	0.407
MOD_NEK2_1	336	341	PF00069	0.446
MOD_NEK2_1	501	506	PF00069	0.420
MOD_NEK2_1	541	546	PF00069	0.495
MOD_NEK2_1	624	629	PF00069	0.452
MOD_NEK2_1	650	655	PF00069	0.464
MOD_NEK2_1	676	681	PF00069	0.453
MOD_NEK2_1	954	959	PF00069	0.458
MOD_NEK2_1	993	998	PF00069	0.487
MOD_NEK2_2	669	674	PF00069	0.485
MOD_NEK2_2	978	983	PF00069	0.464
MOD_OFUCOSY	982	987	PF10250	0.443
MOD_PIKK_1	135	141	PF00454	0.530
MOD_PIKK_1	167	173	PF00454	0.574
MOD_PIKK_1	576	582	PF00454	0.632
MOD_PIKK_1	58	64	PF00454	0.587
MOD_PIKK_1	821	827	PF00454	0.576
MOD_PKA_1	441	447	PF00069	0.443
MOD_PKA_2	103	109	PF00069	0.498
MOD_PKA_2	230	236	PF00069	0.400
MOD_PKA_2	381	387	PF00069	0.459
MOD_PKA_2	501	507	PF00069	0.420
MOD_PKA_2	810	816	PF00069	0.605
MOD_PKA_2	94	100	PF00069	0.504
MOD_PKA_2	964	970	PF00069	0.505
MOD_PKA_2	978	984	PF00069	0.333
MOD_Plk_1	1035	1041	PF00069	0.668
MOD_Plk_1	659	665	PF00069	0.414
MOD_Plk_2-3	1006	1012	PF00069	0.593
MOD_Plk_4	417	423	PF00069	0.507
MOD_Plk_4	465	471	PF00069	0.507
MOD_Plk_4	531	537	PF00069	0.486
MOD_Plk_4	608	614	PF00069	0.472
MOD_Plk_4	659	665	PF00069	0.428
MOD_Plk_4	691	697	PF00069	0.430
MOD_Plk_4	805	811	PF00069	0.606
MOD_ProDKin_1	131	137	PF00069	0.591
MOD_ProDKin_1	191	197	PF00069	0.638
MOD_ProDKin_1	198	204	PF00069	0.633
MOD_ProDKin_1	25	31	PF00069	0.506
MOD_ProDKin_1	399	405	PF00069	0.430
MOD_ProDKin_1	451	457	PF00069	0.446
MOD_ProDKin_1	56	62	PF00069	0.638
MOD_ProDKin_1	64	70	PF00069	0.642
MOD_ProDKin_1	771	777	PF00069	0.534
MOD_ProDKin_1	79	85	PF00069	0.476
MOD_ProDKin_1	803	809	PF00069	0.604
MOD_ProDKin_1	858	864	PF00069	0.631
TRG_DiLeu_BaEn_1	163	168	PF01217	0.480
TRG_DiLeu_BaEn_1	462	467	PF01217	0.430
TRG_DiLeu_BaEn_2	303	309	PF01217	0.385
TRG_DiLeu_BaLyEn_6	146	151	PF01217	0.579
TRG_DiLeu_BaLyEn_6	565	570	PF01217	0.371
TRG_DiLeu_BaLyEn_6	878	883	PF01217	0.431
TRG_DiLeu_BaLyEn_6	957	962	PF01217	0.509
TRG_ENDOCYTIC_2	471	474	PF00928	0.443
TRG_ENDOCYTIC_2	498	501	PF00928	0.485
TRG_ENDOCYTIC_2	647	650	PF00928	0.525
TRG_ENDOCYTIC_2	951	954	PF00928	0.337
TRG_ENDOCYTIC_2	968	971	PF00928	0.393
TRG_ER_diArg_1	382	385	PF00400	0.448
TRG_ER_diArg_1	413	416	PF00400	0.434
TRG_ER_diArg_1	480	483	PF00400	0.425
TRG_ER_diArg_1	501	503	PF00400	0.446
TRG_ER_diArg_1	91	93	PF00400	0.514
TRG_ER_diArg_1	978	980	PF00400	0.484
TRG_NLS_MonoExtN_4	411	418	PF00514	0.448
TRG_Pf-PMV_PEXEL_1	240	245	PF00026	0.502
TRG_Pf-PMV_PEXEL_1	568	572	PF00026	0.389
TRG_Pf-PMV_PEXEL_1	950	955	PF00026	0.461

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE28	Leptomonas seymouri	65%	100%
A0A0S4JP66	Bodo saltans	41%	94%
A0A1X0NY53	Trypanosomatidae	55%	100%
A0A422P4R6	Trypanosoma rangeli	58%	100%
A4HEA7	Leishmania braziliensis	84%	100%
A4HRE5	Leishmania infantum	28%	100%
A4I1Q3	Leishmania infantum	100%	100%
C9ZKA7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9AXT7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q9N4	Leishmania major	93%	100%
V5DIY2	Trypanosoma cruzi	55%	100%