Helicase-like protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

helicase-like protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WZF4_LEIDO

TriTrypDb:

LdBPK_252130.1 , LdCL_250027100 , LDHU3_25.2600

Length:

1044

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

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Cellular components
Term	Name	Level	Count
GO:0000785	chromatin	2	1
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

A0A3S7WZF4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WZF4

Function

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Biological processes
Term	Name	Level	Count
GO:0006325	chromatin organization	4	1
GO:0006338	chromatin remodeling	5	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0071840	cellular component organization or biogenesis	2	1

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	13
GO:0003676	nucleic acid binding	3	1
GO:0003677	DNA binding	4	1
GO:0003682	chromatin binding	2	1
GO:0003824	catalytic activity	1	13
GO:0004386	helicase activity	2	9
GO:0005488	binding	1	13
GO:0005515	protein binding	2	1
GO:0005524	ATP binding	5	13
GO:0008094	ATP-dependent activity, acting on DNA	2	13

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1005	1009	PF00656	0.566
CLV_C14_Caspase3-7	1021	1025	PF00656	0.704
CLV_C14_Caspase3-7	1040	1044	PF00656	0.449
CLV_C14_Caspase3-7	140	144	PF00656	0.572
CLV_C14_Caspase3-7	648	652	PF00656	0.446
CLV_NRD_NRD_1	382	384	PF00675	0.290
CLV_NRD_NRD_1	413	415	PF00675	0.233
CLV_NRD_NRD_1	440	442	PF00675	0.221
CLV_NRD_NRD_1	502	504	PF00675	0.246
CLV_NRD_NRD_1	743	745	PF00675	0.372

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE28	Leptomonas seymouri	65%	100%
A0A0S4JP66	Bodo saltans	41%	94%
A0A1X0NY53	Trypanosomatidae	55%	100%
A0A422P4R6	Trypanosoma rangeli	58%	100%
A4HEA7	Leishmania braziliensis	84%	100%
A4HRE5	Leishmania infantum	28%	100%
A4I1Q3	Leishmania infantum	100%	100%
C9ZKA7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9AXT7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q9N4	Leishmania major	93%	100%

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