Calponin-homology (CH) domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WZE8_LEIDO

TriTrypDb:

LdBPK_252420.1 , LdCL_250030000 , LDHU3_25.2900

Length:

577

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WZE8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WZE8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	207	211	PF00656	0.387
CLV_C14_Caspase3-7	368	372	PF00656	0.536
CLV_C14_Caspase3-7	66	70	PF00656	0.446
CLV_NRD_NRD_1	148	150	PF00675	0.470
CLV_NRD_NRD_1	45	47	PF00675	0.579
CLV_NRD_NRD_1	505	507	PF00675	0.453
CLV_NRD_NRD_1	98	100	PF00675	0.477
CLV_PCSK_KEX2_1	148	150	PF00082	0.470
CLV_PCSK_KEX2_1	45	47	PF00082	0.639
CLV_PCSK_KEX2_1	505	507	PF00082	0.499
CLV_PCSK_SKI1_1	115	119	PF00082	0.443
CLV_PCSK_SKI1_1	148	152	PF00082	0.416
CLV_PCSK_SKI1_1	29	33	PF00082	0.537
CLV_PCSK_SKI1_1	309	313	PF00082	0.435
CLV_PCSK_SKI1_1	468	472	PF00082	0.447
CLV_PCSK_SKI1_1	571	575	PF00082	0.457
DEG_APCC_DBOX_1	147	155	PF00400	0.509
DEG_APCC_DBOX_1	467	475	PF00400	0.375
DOC_CKS1_1	22	27	PF01111	0.516
DOC_MAPK_MEF2A_6	230	238	PF00069	0.453
DOC_MAPK_MEF2A_6	425	432	PF00069	0.459
DOC_PP1_RVXF_1	113	119	PF00149	0.494
DOC_PP1_SILK_1	260	265	PF00149	0.355
DOC_PP2B_LxvP_1	23	26	PF13499	0.593
DOC_PP4_FxxP_1	526	529	PF00568	0.736
DOC_USP7_MATH_1	12	16	PF00917	0.539
DOC_USP7_MATH_1	127	131	PF00917	0.522
DOC_USP7_MATH_1	158	162	PF00917	0.390
DOC_USP7_MATH_1	384	388	PF00917	0.438
DOC_USP7_MATH_1	44	48	PF00917	0.495
DOC_USP7_MATH_1	535	539	PF00917	0.710
DOC_USP7_UBL2_3	155	159	PF12436	0.508
DOC_USP7_UBL2_3	571	575	PF12436	0.484
DOC_USP7_UBL2_3	59	63	PF12436	0.432
DOC_WW_Pin1_4	21	26	PF00397	0.530
DOC_WW_Pin1_4	270	275	PF00397	0.376
DOC_WW_Pin1_4	291	296	PF00397	0.364
DOC_WW_Pin1_4	317	322	PF00397	0.455
DOC_WW_Pin1_4	423	428	PF00397	0.494
DOC_WW_Pin1_4	525	530	PF00397	0.683
LIG_14-3-3_CanoR_1	29	37	PF00244	0.644
LIG_14-3-3_CanoR_1	45	53	PF00244	0.405
LIG_Actin_WH2_2	140	157	PF00022	0.462
LIG_Actin_WH2_2	453	470	PF00022	0.380
LIG_BIR_II_1	1	5	PF00653	0.620
LIG_BRCT_BRCA1_1	194	198	PF00533	0.456
LIG_BRCT_BRCA1_1	448	452	PF00533	0.514
LIG_DLG_GKlike_1	67	75	PF00625	0.430
LIG_EH_1	76	80	PF12763	0.455
LIG_eIF4E_1	466	472	PF01652	0.385
LIG_FHA_1	120	126	PF00498	0.466
LIG_FHA_1	183	189	PF00498	0.468
LIG_FHA_1	197	203	PF00498	0.405
LIG_FHA_1	266	272	PF00498	0.315
LIG_FHA_1	298	304	PF00498	0.292
LIG_FHA_1	32	38	PF00498	0.516
LIG_FHA_1	343	349	PF00498	0.447
LIG_FHA_1	557	563	PF00498	0.343
LIG_FHA_2	134	140	PF00498	0.591
LIG_FHA_2	205	211	PF00498	0.382
LIG_FHA_2	288	294	PF00498	0.467
LIG_FHA_2	31	37	PF00498	0.468
LIG_FHA_2	334	340	PF00498	0.417
LIG_LIR_Apic_2	298	302	PF02991	0.411
LIG_LIR_Apic_2	378	384	PF02991	0.513
LIG_LIR_Gen_1	250	259	PF02991	0.360
LIG_LIR_Gen_1	268	274	PF02991	0.331
LIG_LIR_Gen_1	363	372	PF02991	0.438
LIG_LIR_Gen_1	498	504	PF02991	0.331
LIG_LIR_Gen_1	5	14	PF02991	0.623
LIG_LIR_Nem_3	250	254	PF02991	0.333
LIG_LIR_Nem_3	268	272	PF02991	0.376
LIG_LIR_Nem_3	363	369	PF02991	0.419
LIG_LIR_Nem_3	498	502	PF02991	0.325
LIG_LIR_Nem_3	5	10	PF02991	0.614
LIG_MLH1_MIPbox_1	448	452	PF16413	0.514
LIG_Pex14_1	564	568	PF04695	0.297
LIG_Pex14_2	447	451	PF04695	0.500
LIG_SH2_CRK	299	303	PF00017	0.323
LIG_SH2_CRK	318	322	PF00017	0.332
LIG_SH2_CRK	381	385	PF00017	0.525
LIG_SH2_NCK_1	318	322	PF00017	0.464
LIG_SH2_SRC	381	384	PF00017	0.489
LIG_SH2_SRC	393	396	PF00017	0.339
LIG_SH2_STAP1	251	255	PF00017	0.434
LIG_SH2_STAP1	572	576	PF00017	0.420
LIG_SH2_STAT3	85	88	PF00017	0.506
LIG_SH2_STAT5	156	159	PF00017	0.517
LIG_SH2_STAT5	265	268	PF00017	0.346
LIG_SH2_STAT5	299	302	PF00017	0.314
LIG_SH2_STAT5	318	321	PF00017	0.428
LIG_SH2_STAT5	466	469	PF00017	0.356
LIG_SH3_3	159	165	PF00018	0.461
LIG_SH3_3	19	25	PF00018	0.511
LIG_SH3_3	268	274	PF00018	0.387
LIG_SUMO_SIM_anti_2	17	24	PF11976	0.593
LIG_SUMO_SIM_anti_2	252	258	PF11976	0.276
LIG_SUMO_SIM_par_1	12	18	PF11976	0.553
LIG_SUMO_SIM_par_1	252	258	PF11976	0.346
LIG_SUMO_SIM_par_1	287	294	PF11976	0.410
LIG_SUMO_SIM_par_1	492	498	PF11976	0.449
LIG_UBA3_1	304	309	PF00899	0.350
LIG_WRC_WIRS_1	266	271	PF05994	0.325
LIG_WRC_WIRS_1	68	73	PF05994	0.445
MOD_CDK_SPK_2	270	275	PF00069	0.407
MOD_CK1_1	15	21	PF00069	0.583
MOD_CK1_1	48	54	PF00069	0.508
MOD_CK1_1	528	534	PF00069	0.737
MOD_CK1_1	538	544	PF00069	0.596
MOD_CK1_1	546	552	PF00069	0.406
MOD_CK1_1	70	76	PF00069	0.417
MOD_CK1_1	93	99	PF00069	0.457
MOD_CK2_1	287	293	PF00069	0.364
MOD_CK2_1	30	36	PF00069	0.479
MOD_CK2_1	333	339	PF00069	0.468
MOD_GlcNHglycan	105	108	PF01048	0.401
MOD_GlcNHglycan	26	29	PF01048	0.608
MOD_GlcNHglycan	386	389	PF01048	0.421
MOD_GlcNHglycan	414	417	PF01048	0.550
MOD_GlcNHglycan	42	45	PF01048	0.454
MOD_GlcNHglycan	530	533	PF01048	0.741
MOD_GlcNHglycan	537	540	PF01048	0.656
MOD_GSK3_1	160	167	PF00069	0.495
MOD_GSK3_1	182	189	PF00069	0.381
MOD_GSK3_1	192	199	PF00069	0.385
MOD_GSK3_1	287	294	PF00069	0.390
MOD_GSK3_1	342	349	PF00069	0.557
MOD_GSK3_1	361	368	PF00069	0.241
MOD_GSK3_1	40	47	PF00069	0.483
MOD_GSK3_1	400	407	PF00069	0.600
MOD_GSK3_1	513	520	PF00069	0.685
MOD_GSK3_1	537	544	PF00069	0.679
MOD_GSK3_1	67	74	PF00069	0.538
MOD_GSK3_1	90	97	PF00069	0.486
MOD_N-GLC_1	103	108	PF02516	0.398
MOD_N-GLC_1	192	197	PF02516	0.543
MOD_NEK2_1	160	165	PF00069	0.464
MOD_NEK2_1	184	189	PF00069	0.466
MOD_NEK2_1	198	203	PF00069	0.469
MOD_NEK2_1	255	260	PF00069	0.330
MOD_NEK2_1	342	347	PF00069	0.589
MOD_NEK2_1	358	363	PF00069	0.363
MOD_NEK2_1	400	405	PF00069	0.658
MOD_NEK2_1	447	452	PF00069	0.450
MOD_NEK2_1	495	500	PF00069	0.357
MOD_NEK2_1	71	76	PF00069	0.480
MOD_PIKK_1	202	208	PF00454	0.512
MOD_PIKK_1	48	54	PF00454	0.541
MOD_PIKK_1	71	77	PF00454	0.433
MOD_PK_1	230	236	PF00069	0.488
MOD_PK_1	45	51	PF00069	0.599
MOD_PKA_1	45	51	PF00069	0.544
MOD_PKA_2	346	352	PF00069	0.577
MOD_PKA_2	44	50	PF00069	0.483
MOD_Plk_1	447	453	PF00069	0.456
MOD_Plk_1	5	11	PF00069	0.555
MOD_Plk_4	204	210	PF00069	0.372
MOD_Plk_4	287	293	PF00069	0.364
MOD_Plk_4	361	367	PF00069	0.474
MOD_Plk_4	447	453	PF00069	0.416
MOD_Plk_4	90	96	PF00069	0.493
MOD_ProDKin_1	21	27	PF00069	0.529
MOD_ProDKin_1	270	276	PF00069	0.378
MOD_ProDKin_1	291	297	PF00069	0.365
MOD_ProDKin_1	317	323	PF00069	0.452
MOD_ProDKin_1	423	429	PF00069	0.486
MOD_ProDKin_1	525	531	PF00069	0.685
MOD_SUMO_for_1	221	224	PF00179	0.493
MOD_SUMO_rev_2	210	219	PF00179	0.558
MOD_SUMO_rev_2	368	375	PF00179	0.508
MOD_SUMO_rev_2	56	61	PF00179	0.509
TRG_ENDOCYTIC_2	251	254	PF00928	0.384
TRG_ENDOCYTIC_2	81	84	PF00928	0.425
TRG_ER_diArg_1	147	149	PF00400	0.468
TRG_ER_diArg_1	504	506	PF00400	0.531
TRG_ER_diLys_1	574	577	PF00400	0.398

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P620	Leptomonas seymouri	73%	100%
A0A0S4J1E1	Bodo saltans	34%	97%
A0A1X0NY27	Trypanosomatidae	39%	100%
A0A3R7RTJ3	Trypanosoma rangeli	38%	100%
A4HED4	Leishmania braziliensis	87%	100%
A4I1T1	Leishmania infantum	100%	100%
E9AXW5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q95ZB6	Leishmania major	95%	100%
V5B817	Trypanosoma cruzi	41%	100%