ATP-grasp domain/D-ala D-ala ligase C-terminus/SET domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATP-grasp domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WZE7_LEIDO

TriTrypDb:

LdBPK_251860.1 , LdCL_250024300 , LDHU3_25.2300

Length:

865

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WZE7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WZE7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	5
GO:0003824	catalytic activity	1	5
GO:0005488	binding	1	5
GO:0005524	ATP binding	5	5
GO:0008716	D-alanine-D-alanine ligase activity	5	5
GO:0016740	transferase activity	2	5
GO:0016874	ligase activity	2	5
GO:0016879	ligase activity, forming carbon-nitrogen bonds	3	5
GO:0016881	acid-amino acid ligase activity	4	5
GO:0017076	purine nucleotide binding	4	5
GO:0030554	adenyl nucleotide binding	5	5
GO:0032553	ribonucleotide binding	3	5
GO:0032555	purine ribonucleotide binding	4	5
GO:0032559	adenyl ribonucleotide binding	5	5
GO:0035639	purine ribonucleoside triphosphate binding	4	5
GO:0036094	small molecule binding	2	5
GO:0043167	ion binding	2	5
GO:0043168	anion binding	3	5
GO:0043169	cation binding	3	5
GO:0046872	metal ion binding	4	5
GO:0097159	organic cyclic compound binding	2	5
GO:0097367	carbohydrate derivative binding	2	5
GO:1901265	nucleoside phosphate binding	3	5
GO:1901363	heterocyclic compound binding	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	317	321	PF00656	0.494
CLV_C14_Caspase3-7	401	405	PF00656	0.453
CLV_NRD_NRD_1	145	147	PF00675	0.733
CLV_NRD_NRD_1	222	224	PF00675	0.727
CLV_NRD_NRD_1	251	253	PF00675	0.727
CLV_NRD_NRD_1	303	305	PF00675	0.590
CLV_NRD_NRD_1	360	362	PF00675	0.599
CLV_NRD_NRD_1	641	643	PF00675	0.506
CLV_PCSK_KEX2_1	145	147	PF00082	0.724
CLV_PCSK_KEX2_1	151	153	PF00082	0.657
CLV_PCSK_KEX2_1	222	224	PF00082	0.725
CLV_PCSK_KEX2_1	251	253	PF00082	0.766
CLV_PCSK_KEX2_1	257	259	PF00082	0.725
CLV_PCSK_KEX2_1	303	305	PF00082	0.590
CLV_PCSK_KEX2_1	383	385	PF00082	0.454
CLV_PCSK_KEX2_1	732	734	PF00082	0.329
CLV_PCSK_KEX2_1	785	787	PF00082	0.580
CLV_PCSK_KEX2_1	810	812	PF00082	0.603
CLV_PCSK_PC1ET2_1	151	153	PF00082	0.844
CLV_PCSK_PC1ET2_1	257	259	PF00082	0.681
CLV_PCSK_PC1ET2_1	303	305	PF00082	0.590
CLV_PCSK_PC1ET2_1	383	385	PF00082	0.454
CLV_PCSK_PC1ET2_1	732	734	PF00082	0.329
CLV_PCSK_PC1ET2_1	785	787	PF00082	0.580
CLV_PCSK_PC1ET2_1	810	812	PF00082	0.603
CLV_PCSK_PC7_1	806	812	PF00082	0.590
CLV_PCSK_SKI1_1	136	140	PF00082	0.704
CLV_PCSK_SKI1_1	145	149	PF00082	0.710
CLV_PCSK_SKI1_1	252	256	PF00082	0.597
CLV_PCSK_SKI1_1	273	277	PF00082	0.624
CLV_PCSK_SKI1_1	362	366	PF00082	0.454
CLV_PCSK_SKI1_1	443	447	PF00082	0.329
CLV_PCSK_SKI1_1	514	518	PF00082	0.410
CLV_PCSK_SKI1_1	53	57	PF00082	0.600
CLV_PCSK_SKI1_1	564	568	PF00082	0.329
CLV_PCSK_SKI1_1	668	672	PF00082	0.488
CLV_PCSK_SKI1_1	725	729	PF00082	0.329
CLV_PCSK_SKI1_1	782	786	PF00082	0.598
CLV_PCSK_SKI1_1	806	810	PF00082	0.584
DEG_Nend_Nbox_1	1	3	PF02207	0.523
DEG_SCF_FBW7_1	238	244	PF00400	0.586
DEG_SPOP_SBC_1	311	315	PF00917	0.443
DEG_SPOP_SBC_1	815	819	PF00917	0.619
DEG_SPOP_SBC_1	830	834	PF00917	0.580
DEG_SPOP_SBC_1	847	851	PF00917	0.538
DOC_CKS1_1	238	243	PF01111	0.640
DOC_CKS1_1	330	335	PF01111	0.466
DOC_CYCLIN_RxL_1	662	673	PF00134	0.488
DOC_CYCLIN_RxL_1	782	790	PF00134	0.580
DOC_CYCLIN_yCln2_LP_2	445	451	PF00134	0.530
DOC_MAPK_gen_1	300	309	PF00069	0.554
DOC_MAPK_gen_1	380	389	PF00069	0.442
DOC_MAPK_gen_1	440	447	PF00069	0.530
DOC_MAPK_MEF2A_6	302	311	PF00069	0.511
DOC_MAPK_MEF2A_6	412	419	PF00069	0.459
DOC_MAPK_NFAT4_5	412	420	PF00069	0.461
DOC_PP1_RVXF_1	441	448	PF00149	0.530
DOC_PP1_RVXF_1	515	522	PF00149	0.530
DOC_PP1_RVXF_1	576	582	PF00149	0.530
DOC_PP1_RVXF_1	723	730	PF00149	0.530
DOC_PP1_RVXF_1	764	771	PF00149	0.499
DOC_PP4_FxxP_1	770	773	PF00568	0.560
DOC_USP7_MATH_1	108	112	PF00917	0.565
DOC_USP7_MATH_1	163	167	PF00917	0.692
DOC_USP7_MATH_1	173	177	PF00917	0.590
DOC_USP7_MATH_1	192	196	PF00917	0.533
DOC_USP7_MATH_1	241	245	PF00917	0.715
DOC_USP7_MATH_1	322	326	PF00917	0.468
DOC_USP7_MATH_1	347	351	PF00917	0.459
DOC_USP7_MATH_1	74	78	PF00917	0.612
DOC_USP7_MATH_1	816	820	PF00917	0.670
DOC_USP7_MATH_1	830	834	PF00917	0.537
DOC_USP7_MATH_1	839	843	PF00917	0.603
DOC_USP7_MATH_1	847	851	PF00917	0.538
DOC_USP7_MATH_1	95	99	PF00917	0.688
DOC_USP7_UBL2_3	136	140	PF12436	0.669
DOC_USP7_UBL2_3	339	343	PF12436	0.502
DOC_USP7_UBL2_3	412	416	PF12436	0.452
DOC_USP7_UBL2_3	683	687	PF12436	0.600
DOC_WW_Pin1_4	159	164	PF00397	0.670
DOC_WW_Pin1_4	20	25	PF00397	0.568
DOC_WW_Pin1_4	205	210	PF00397	0.788
DOC_WW_Pin1_4	234	239	PF00397	0.737
DOC_WW_Pin1_4	287	292	PF00397	0.566
DOC_WW_Pin1_4	329	334	PF00397	0.474
DOC_WW_Pin1_4	506	511	PF00397	0.600
LIG_14-3-3_CanoR_1	223	233	PF00244	0.689
LIG_14-3-3_CanoR_1	258	264	PF00244	0.773
LIG_14-3-3_CanoR_1	285	291	PF00244	0.652
LIG_14-3-3_CanoR_1	341	347	PF00244	0.478
LIG_14-3-3_CanoR_1	361	371	PF00244	0.454
LIG_14-3-3_CanoR_1	659	665	PF00244	0.472
LIG_14-3-3_CanoR_1	712	719	PF00244	0.530
LIG_BRCT_BRCA1_1	404	408	PF00533	0.470
LIG_BRCT_BRCA1_1	766	770	PF00533	0.500
LIG_BRCT_BRCA1_1	77	81	PF00533	0.536
LIG_deltaCOP1_diTrp_1	619	627	PF00928	0.455
LIG_FHA_1	259	265	PF00498	0.736
LIG_FHA_1	292	298	PF00498	0.679
LIG_FHA_1	321	327	PF00498	0.543
LIG_FHA_1	36	42	PF00498	0.572
LIG_FHA_1	52	58	PF00498	0.608
LIG_FHA_2	399	405	PF00498	0.476
LIG_FHA_2	745	751	PF00498	0.514
LIG_Integrin_RGD_1	701	703	PF01839	0.544
LIG_LIR_Apic_2	327	333	PF02991	0.480
LIG_LIR_Apic_2	767	773	PF02991	0.530
LIG_LIR_Gen_1	345	354	PF02991	0.464
LIG_LIR_Gen_1	366	375	PF02991	0.434
LIG_LIR_Gen_1	455	462	PF02991	0.530
LIG_LIR_Gen_1	528	534	PF02991	0.563
LIG_LIR_Gen_1	553	563	PF02991	0.495
LIG_LIR_Gen_1	589	597	PF02991	0.498
LIG_LIR_Gen_1	610	616	PF02991	0.436
LIG_LIR_Gen_1	742	753	PF02991	0.616
LIG_LIR_Nem_3	345	349	PF02991	0.460
LIG_LIR_Nem_3	355	360	PF02991	0.364
LIG_LIR_Nem_3	366	372	PF02991	0.359
LIG_LIR_Nem_3	455	460	PF02991	0.530
LIG_LIR_Nem_3	528	533	PF02991	0.563
LIG_LIR_Nem_3	543	549	PF02991	0.485
LIG_LIR_Nem_3	553	559	PF02991	0.470
LIG_LIR_Nem_3	589	595	PF02991	0.498
LIG_LIR_Nem_3	610	614	PF02991	0.438
LIG_LIR_Nem_3	742	748	PF02991	0.530
LIG_NRP_CendR_1	864	865	PF00754	0.564
LIG_Pex14_2	533	537	PF04695	0.530
LIG_SH2_CRK	357	361	PF00017	0.466
LIG_SH2_CRK	457	461	PF00017	0.530
LIG_SH2_CRK	546	550	PF00017	0.530
LIG_SH2_CRK	556	560	PF00017	0.464
LIG_SH2_CRK	745	749	PF00017	0.501
LIG_SH2_NCK_1	457	461	PF00017	0.530
LIG_SH2_NCK_1	556	560	PF00017	0.490
LIG_SH2_STAP1	369	373	PF00017	0.419
LIG_SH2_STAP1	69	73	PF00017	0.598
LIG_SH2_STAT5	532	535	PF00017	0.530
LIG_SH2_STAT5	556	559	PF00017	0.604
LIG_SH2_STAT5	569	572	PF00017	0.506
LIG_SH2_STAT5	591	594	PF00017	0.530
LIG_SH2_STAT5	646	649	PF00017	0.482
LIG_SH3_3	227	233	PF00018	0.789
LIG_SH3_3	235	241	PF00018	0.753
LIG_SH3_3	285	291	PF00018	0.582
LIG_SH3_3	421	427	PF00018	0.382
LIG_SH3_3	504	510	PF00018	0.530
LIG_SH3_3	512	518	PF00018	0.477
LIG_SH3_3	765	771	PF00018	0.499
LIG_TRAF2_1	392	395	PF00917	0.456
LIG_TYR_ITAM	543	559	PF00017	0.530
LIG_TYR_ITIM	574	579	PF00017	0.530
LIG_TYR_ITIM	743	748	PF00017	0.600
MOD_CK1_1	165	171	PF00069	0.679
MOD_CK1_1	178	184	PF00069	0.549
MOD_CK1_1	196	202	PF00069	0.574
MOD_CK1_1	213	219	PF00069	0.620
MOD_CK1_1	237	243	PF00069	0.633
MOD_CK1_1	244	250	PF00069	0.625
MOD_CK1_1	260	266	PF00069	0.751
MOD_CK1_1	286	292	PF00069	0.618
MOD_CK1_1	356	362	PF00069	0.437
MOD_CK1_1	75	81	PF00069	0.561
MOD_CK1_1	759	765	PF00069	0.497
MOD_CK1_1	818	824	PF00069	0.672
MOD_CK1_1	829	835	PF00069	0.549
MOD_CK1_1	841	847	PF00069	0.560
MOD_CK1_1	848	854	PF00069	0.523
MOD_CK1_1	857	863	PF00069	0.557
MOD_CK1_1	98	104	PF00069	0.682
MOD_CK2_1	430	436	PF00069	0.510
MOD_CK2_1	857	863	PF00069	0.647
MOD_GlcNHglycan	102	105	PF01048	0.670
MOD_GlcNHglycan	120	123	PF01048	0.565
MOD_GlcNHglycan	125	128	PF01048	0.601
MOD_GlcNHglycan	165	168	PF01048	0.816
MOD_GlcNHglycan	170	173	PF01048	0.729
MOD_GlcNHglycan	175	178	PF01048	0.645
MOD_GlcNHglycan	180	183	PF01048	0.583
MOD_GlcNHglycan	184	187	PF01048	0.554
MOD_GlcNHglycan	189	192	PF01048	0.613
MOD_GlcNHglycan	196	199	PF01048	0.632
MOD_GlcNHglycan	212	215	PF01048	0.540
MOD_GlcNHglycan	234	237	PF01048	0.666
MOD_GlcNHglycan	243	246	PF01048	0.663
MOD_GlcNHglycan	264	267	PF01048	0.669
MOD_GlcNHglycan	285	288	PF01048	0.631
MOD_GlcNHglycan	291	294	PF01048	0.582
MOD_GlcNHglycan	320	323	PF01048	0.481
MOD_GlcNHglycan	421	424	PF01048	0.397
MOD_GlcNHglycan	454	457	PF01048	0.333
MOD_GlcNHglycan	47	50	PF01048	0.556
MOD_GlcNHglycan	571	574	PF01048	0.229
MOD_GlcNHglycan	74	77	PF01048	0.623
MOD_GlcNHglycan	818	821	PF01048	0.681
MOD_GlcNHglycan	822	825	PF01048	0.665
MOD_GlcNHglycan	828	831	PF01048	0.583
MOD_GlcNHglycan	834	837	PF01048	0.519
MOD_GlcNHglycan	841	844	PF01048	0.546
MOD_GlcNHglycan	850	853	PF01048	0.601
MOD_GlcNHglycan	856	859	PF01048	0.568
MOD_GlcNHglycan	98	101	PF01048	0.688
MOD_GSK3_1	158	165	PF00069	0.700
MOD_GSK3_1	167	174	PF00069	0.604
MOD_GSK3_1	178	185	PF00069	0.616
MOD_GSK3_1	192	199	PF00069	0.692
MOD_GSK3_1	237	244	PF00069	0.681
MOD_GSK3_1	258	265	PF00069	0.731
MOD_GSK3_1	279	286	PF00069	0.671
MOD_GSK3_1	287	294	PF00069	0.561
MOD_GSK3_1	312	319	PF00069	0.467
MOD_GSK3_1	398	405	PF00069	0.446
MOD_GSK3_1	430	437	PF00069	0.575
MOD_GSK3_1	452	459	PF00069	0.535
MOD_GSK3_1	463	470	PF00069	0.458
MOD_GSK3_1	47	54	PF00069	0.525
MOD_GSK3_1	654	661	PF00069	0.489
MOD_GSK3_1	68	75	PF00069	0.656
MOD_GSK3_1	810	817	PF00069	0.627
MOD_GSK3_1	826	833	PF00069	0.525
MOD_GSK3_1	837	844	PF00069	0.583
MOD_GSK3_1	846	853	PF00069	0.534
MOD_GSK3_1	854	861	PF00069	0.560
MOD_GSK3_1	95	102	PF00069	0.675
MOD_N-GLC_2	374	376	PF02516	0.418
MOD_NEK2_1	123	128	PF00069	0.601
MOD_NEK2_1	264	269	PF00069	0.615
MOD_NEK2_1	363	368	PF00069	0.456
MOD_NEK2_1	418	423	PF00069	0.620
MOD_NEK2_1	68	73	PF00069	0.619
MOD_NEK2_1	756	761	PF00069	0.506
MOD_NEK2_1	88	93	PF00069	0.499
MOD_NEK2_2	347	352	PF00069	0.460
MOD_NEK2_2	35	40	PF00069	0.628
MOD_PKA_1	224	230	PF00069	0.721
MOD_PKA_1	257	263	PF00069	0.742
MOD_PKA_1	535	541	PF00069	0.530
MOD_PKA_1	809	815	PF00069	0.616
MOD_PKA_2	123	129	PF00069	0.627
MOD_PKA_2	193	199	PF00069	0.628
MOD_PKA_2	216	222	PF00069	0.659
MOD_PKA_2	247	253	PF00069	0.776
MOD_PKA_2	257	263	PF00069	0.640
MOD_PKA_2	658	664	PF00069	0.467
MOD_PKA_2	711	717	PF00069	0.530
MOD_PKA_2	810	816	PF00069	0.626
MOD_PKA_2	86	92	PF00069	0.678
MOD_PKB_1	495	503	PF00069	0.530
MOD_Plk_1	347	353	PF00069	0.458
MOD_Plk_1	434	440	PF00069	0.469
MOD_Plk_1	739	745	PF00069	0.530
MOD_Plk_1	749	755	PF00069	0.449
MOD_Plk_2-3	739	745	PF00069	0.530
MOD_Plk_4	497	503	PF00069	0.530
MOD_Plk_4	681	687	PF00069	0.584
MOD_ProDKin_1	159	165	PF00069	0.669
MOD_ProDKin_1	20	26	PF00069	0.565
MOD_ProDKin_1	205	211	PF00069	0.790
MOD_ProDKin_1	234	240	PF00069	0.740
MOD_ProDKin_1	287	293	PF00069	0.564
MOD_ProDKin_1	329	335	PF00069	0.473
MOD_ProDKin_1	506	512	PF00069	0.600
MOD_SUMO_rev_2	377	385	PF00179	0.459
MOD_SUMO_rev_2	409	418	PF00179	0.463
MOD_SUMO_rev_2	528	538	PF00179	0.530
TRG_DiLeu_BaLyEn_6	783	788	PF01217	0.583
TRG_ENDOCYTIC_2	357	360	PF00928	0.462
TRG_ENDOCYTIC_2	369	372	PF00928	0.294
TRG_ENDOCYTIC_2	457	460	PF00928	0.530
TRG_ENDOCYTIC_2	546	549	PF00928	0.580
TRG_ENDOCYTIC_2	556	559	PF00928	0.565
TRG_ENDOCYTIC_2	576	579	PF00928	0.400
TRG_ENDOCYTIC_2	745	748	PF00928	0.488
TRG_ER_diArg_1	145	147	PF00400	0.766
TRG_ER_diArg_1	251	253	PF00400	0.585
TRG_ER_diArg_1	304	307	PF00400	0.527
TRG_ER_diArg_1	494	497	PF00400	0.514
TRG_NLS_Bipartite_1	791	813	PF00514	0.566
TRG_NLS_MonoCore_2	222	227	PF00514	0.724
TRG_NLS_MonoCore_2	301	306	PF00514	0.587
TRG_NLS_MonoExtC_3	301	306	PF00514	0.587
TRG_NLS_MonoExtN_4	136	143	PF00514	0.666
TRG_NLS_MonoExtN_4	222	228	PF00514	0.718
TRG_NLS_MonoExtN_4	300	307	PF00514	0.580
TRG_NLS_MonoExtN_4	806	813	PF00514	0.594
TRG_Pf-PMV_PEXEL_1	634	638	PF00026	0.450
TRG_Pf-PMV_PEXEL_1	786	790	PF00026	0.560

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HEJ2	Leishmania braziliensis	85%	100%
E9AXR0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q9R1	Leishmania major	93%	100%