Leucine rich repeat/Leucine Rich repeats (2 copies), putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Leucine Rich repeats (2 copies), putative

Species:

Leishmania donovani

UniProt:

A0A3S7WZE2_LEIDO

TriTrypDb:

LdBPK_252410.1 , LdCL_250029900 , LDHU3_25.2890

Length:

663

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	12
GO:0042995	cell projection	2	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0110165	cellular anatomical entity	1	12
GO:0120025	plasma membrane bounded cell projection	3	12
GO:0005737	cytoplasm	2	1
GO:0016020	membrane	2	1

Expansion

Sequence features

A0A3S7WZE2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WZE2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0005509	calcium ion binding	5	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	12	16	PF00656	0.592
CLV_C14_Caspase3-7	171	175	PF00656	0.581
CLV_C14_Caspase3-7	27	31	PF00656	0.398
CLV_C14_Caspase3-7	275	279	PF00656	0.469
CLV_C14_Caspase3-7	336	340	PF00656	0.613
CLV_NRD_NRD_1	213	215	PF00675	0.487
CLV_NRD_NRD_1	259	261	PF00675	0.465
CLV_NRD_NRD_1	306	308	PF00675	0.753
CLV_NRD_NRD_1	357	359	PF00675	0.799
CLV_NRD_NRD_1	369	371	PF00675	0.686
CLV_NRD_NRD_1	440	442	PF00675	0.512
CLV_NRD_NRD_1	479	481	PF00675	0.385
CLV_NRD_NRD_1	538	540	PF00675	0.449
CLV_NRD_NRD_1	592	594	PF00675	0.505
CLV_PCSK_KEX2_1	213	215	PF00082	0.452
CLV_PCSK_KEX2_1	259	261	PF00082	0.475
CLV_PCSK_KEX2_1	273	275	PF00082	0.553
CLV_PCSK_KEX2_1	306	308	PF00082	0.762
CLV_PCSK_KEX2_1	357	359	PF00082	0.761
CLV_PCSK_KEX2_1	369	371	PF00082	0.636
CLV_PCSK_KEX2_1	440	442	PF00082	0.512
CLV_PCSK_KEX2_1	486	488	PF00082	0.434
CLV_PCSK_KEX2_1	537	539	PF00082	0.436
CLV_PCSK_KEX2_1	592	594	PF00082	0.505
CLV_PCSK_PC1ET2_1	273	275	PF00082	0.515
CLV_PCSK_PC1ET2_1	486	488	PF00082	0.434
CLV_PCSK_SKI1_1	213	217	PF00082	0.341
CLV_PCSK_SKI1_1	226	230	PF00082	0.362
CLV_PCSK_SKI1_1	259	263	PF00082	0.475
CLV_PCSK_SKI1_1	380	384	PF00082	0.404
CLV_PCSK_SKI1_1	476	480	PF00082	0.466
CLV_PCSK_SKI1_1	570	574	PF00082	0.340
CLV_Separin_Metazoa	477	481	PF03568	0.354
DEG_APCC_DBOX_1	537	545	PF00400	0.455
DOC_CDC14_PxL_1	110	118	PF14671	0.526
DOC_CDC14_PxL_1	85	93	PF14671	0.452
DOC_CYCLIN_RxL_1	210	218	PF00134	0.437
DOC_CYCLIN_RxL_1	566	574	PF00134	0.349
DOC_MAPK_gen_1	38	47	PF00069	0.424
DOC_MAPK_gen_1	546	554	PF00069	0.544
DOC_MAPK_MEF2A_6	566	575	PF00069	0.487
DOC_MAPK_MEF2A_6	582	590	PF00069	0.374
DOC_MAPK_MEF2A_6	90	98	PF00069	0.512
DOC_PP2B_LxvP_1	98	101	PF13499	0.622
DOC_PP4_FxxP_1	583	586	PF00568	0.372
DOC_USP7_MATH_1	157	161	PF00917	0.564
DOC_USP7_MATH_1	168	172	PF00917	0.460
DOC_USP7_MATH_1	368	372	PF00917	0.592
DOC_USP7_MATH_1	522	526	PF00917	0.448
DOC_USP7_MATH_1	558	562	PF00917	0.497
DOC_USP7_MATH_1	616	620	PF00917	0.542
DOC_USP7_MATH_1	622	626	PF00917	0.531
DOC_USP7_MATH_1	632	636	PF00917	0.532
DOC_USP7_UBL2_3	395	399	PF12436	0.408
DOC_WW_Pin1_4	324	329	PF00397	0.742
DOC_WW_Pin1_4	343	348	PF00397	0.509
DOC_WW_Pin1_4	552	557	PF00397	0.729
LIG_14-3-3_CanoR_1	238	244	PF00244	0.441
LIG_14-3-3_CanoR_1	25	30	PF00244	0.532
LIG_14-3-3_CanoR_1	321	325	PF00244	0.714
LIG_14-3-3_CanoR_1	361	366	PF00244	0.777
LIG_14-3-3_CanoR_1	369	374	PF00244	0.695
LIG_14-3-3_CanoR_1	472	476	PF00244	0.489
LIG_14-3-3_CanoR_1	537	542	PF00244	0.442
LIG_14-3-3_CanoR_1	90	95	PF00244	0.491
LIG_Actin_WH2_2	411	427	PF00022	0.384
LIG_Actin_WH2_2	637	655	PF00022	0.370
LIG_BRCT_BRCA1_1	642	646	PF00533	0.394
LIG_CtBP_PxDLS_1	56	60	PF00389	0.440
LIG_DLG_GKlike_1	25	32	PF00625	0.397
LIG_FHA_1	372	378	PF00498	0.509
LIG_FHA_1	389	395	PF00498	0.252
LIG_FHA_1	431	437	PF00498	0.365
LIG_FHA_1	527	533	PF00498	0.477
LIG_FHA_2	175	181	PF00498	0.559
LIG_FHA_2	194	200	PF00498	0.424
LIG_FHA_2	25	31	PF00498	0.485
LIG_FHA_2	334	340	PF00498	0.653
LIG_FHA_2	472	478	PF00498	0.340
LIG_FHA_2	504	510	PF00498	0.396
LIG_FHA_2	61	67	PF00498	0.388
LIG_FHA_2	637	643	PF00498	0.416
LIG_LIR_Apic_2	151	157	PF02991	0.641
LIG_LIR_Gen_1	164	175	PF02991	0.477
LIG_LIR_Gen_1	180	189	PF02991	0.458
LIG_LIR_Gen_1	371	379	PF02991	0.506
LIG_LIR_Gen_1	567	575	PF02991	0.382
LIG_LIR_Gen_1	585	591	PF02991	0.455
LIG_LIR_Gen_1	606	614	PF02991	0.363
LIG_LIR_Nem_3	164	170	PF02991	0.491
LIG_LIR_Nem_3	178	184	PF02991	0.433
LIG_LIR_Nem_3	218	224	PF02991	0.429
LIG_LIR_Nem_3	255	261	PF02991	0.494
LIG_LIR_Nem_3	371	376	PF02991	0.631
LIG_LIR_Nem_3	461	467	PF02991	0.375
LIG_LIR_Nem_3	509	515	PF02991	0.343
LIG_LIR_Nem_3	567	571	PF02991	0.392
LIG_LIR_Nem_3	585	590	PF02991	0.433
LIG_LIR_Nem_3	606	610	PF02991	0.334
LIG_NRBOX	239	245	PF00104	0.515
LIG_PTB_Apo_2	514	521	PF02174	0.404
LIG_PTB_Phospho_1	514	520	PF10480	0.400
LIG_SH2_CRK	415	419	PF00017	0.384
LIG_SH2_GRB2like	184	187	PF00017	0.426
LIG_SH2_NCK_1	520	524	PF00017	0.296
LIG_SH2_PTP2	587	590	PF00017	0.501
LIG_SH2_STAP1	217	221	PF00017	0.371
LIG_SH2_STAP1	246	250	PF00017	0.530
LIG_SH2_STAP1	254	258	PF00017	0.427
LIG_SH2_STAP1	390	394	PF00017	0.406
LIG_SH2_STAT5	390	393	PF00017	0.479
LIG_SH2_STAT5	415	418	PF00017	0.354
LIG_SH2_STAT5	535	538	PF00017	0.507
LIG_SH2_STAT5	587	590	PF00017	0.474
LIG_SH3_3	346	352	PF00018	0.722
LIG_SH3_3	93	99	PF00018	0.407
LIG_SUMO_SIM_par_1	490	496	PF11976	0.401
LIG_TRAF2_1	127	130	PF00917	0.560
LIG_TRAF2_1	177	180	PF00917	0.491
LIG_UBA3_1	385	393	PF00899	0.479
LIG_WRC_WIRS_1	1	6	PF05994	0.547
LIG_WRC_WIRS_1	637	642	PF05994	0.417
MOD_CDK_SPxxK_3	324	331	PF00069	0.580
MOD_CK1_1	371	377	PF00069	0.541
MOD_CK1_1	60	66	PF00069	0.510
MOD_CK2_1	174	180	PF00069	0.463
MOD_CK2_1	193	199	PF00069	0.315
MOD_CK2_1	282	288	PF00069	0.576
MOD_CK2_1	302	308	PF00069	0.563
MOD_CK2_1	45	51	PF00069	0.454
MOD_CK2_1	471	477	PF00069	0.337
MOD_CK2_1	503	509	PF00069	0.414
MOD_CK2_1	60	66	PF00069	0.425
MOD_CK2_1	614	620	PF00069	0.516
MOD_CK2_1	622	628	PF00069	0.495
MOD_CK2_1	636	642	PF00069	0.336
MOD_GlcNHglycan	148	151	PF01048	0.649
MOD_GlcNHglycan	159	162	PF01048	0.545
MOD_GlcNHglycan	21	24	PF01048	0.490
MOD_GlcNHglycan	226	229	PF01048	0.442
MOD_GlcNHglycan	247	250	PF01048	0.533
MOD_GlcNHglycan	292	295	PF01048	0.607
MOD_GlcNHglycan	317	320	PF01048	0.703
MOD_GlcNHglycan	489	492	PF01048	0.474
MOD_GlcNHglycan	524	527	PF01048	0.490
MOD_GSK3_1	320	327	PF00069	0.700
MOD_GSK3_1	329	336	PF00069	0.605
MOD_GSK3_1	356	363	PF00069	0.701
MOD_GSK3_1	371	378	PF00069	0.480
MOD_GSK3_1	522	529	PF00069	0.550
MOD_GSK3_1	554	561	PF00069	0.664
MOD_GSK3_1	632	639	PF00069	0.389
MOD_GSK3_1	90	97	PF00069	0.519
MOD_N-GLC_1	119	124	PF02516	0.426
MOD_N-GLC_1	45	50	PF02516	0.405
MOD_NEK2_1	119	124	PF00069	0.402
MOD_NEK2_1	19	24	PF00069	0.458
MOD_NEK2_1	329	334	PF00069	0.697
MOD_NEK2_1	338	343	PF00069	0.683
MOD_NEK2_1	45	50	PF00069	0.434
MOD_NEK2_1	503	508	PF00069	0.504
MOD_NEK2_1	57	62	PF00069	0.389
MOD_NEK2_1	640	645	PF00069	0.483
MOD_NEK2_1	652	657	PF00069	0.565
MOD_NEK2_1	68	73	PF00069	0.312
MOD_NEK2_1	94	99	PF00069	0.480
MOD_NEK2_2	162	167	PF00069	0.389
MOD_PIKK_1	175	181	PF00454	0.500
MOD_PIKK_1	356	362	PF00454	0.754
MOD_PIKK_1	558	564	PF00454	0.585
MOD_PIKK_1	632	638	PF00454	0.473
MOD_PKA_1	369	375	PF00069	0.675
MOD_PKA_1	537	543	PF00069	0.476
MOD_PKA_2	24	30	PF00069	0.529
MOD_PKA_2	264	270	PF00069	0.570
MOD_PKA_2	320	326	PF00069	0.703
MOD_PKA_2	356	362	PF00069	0.777
MOD_PKA_2	368	374	PF00069	0.675
MOD_PKA_2	406	412	PF00069	0.382
MOD_PKA_2	471	477	PF00069	0.355
MOD_PKA_2	503	509	PF00069	0.553
MOD_PKA_2	537	543	PF00069	0.491
MOD_PKA_2	89	95	PF00069	0.430
MOD_Plk_1	17	23	PF00069	0.504
MOD_Plk_1	338	344	PF00069	0.632
MOD_Plk_1	57	63	PF00069	0.417
MOD_Plk_2-3	282	288	PF00069	0.590
MOD_Plk_4	162	168	PF00069	0.540
MOD_Plk_4	239	245	PF00069	0.435
MOD_Plk_4	606	612	PF00069	0.418
MOD_Plk_4	622	628	PF00069	0.597
MOD_ProDKin_1	324	330	PF00069	0.742
MOD_ProDKin_1	343	349	PF00069	0.507
MOD_ProDKin_1	552	558	PF00069	0.728
MOD_SUMO_for_1	4	7	PF00179	0.440
MOD_SUMO_rev_2	359	368	PF00179	0.746
TRG_DiLeu_BaEn_2	461	467	PF01217	0.345
TRG_DiLeu_BaEn_2	641	647	PF01217	0.329
TRG_DiLeu_BaLyEn_6	211	216	PF01217	0.479
TRG_DiLeu_BaLyEn_6	31	36	PF01217	0.317
TRG_DiLeu_BaLyEn_6	567	572	PF01217	0.448
TRG_ENDOCYTIC_2	415	418	PF00928	0.397
TRG_ENDOCYTIC_2	587	590	PF00928	0.501
TRG_ER_diArg_1	213	215	PF00400	0.499
TRG_ER_diArg_1	258	260	PF00400	0.461
TRG_ER_diArg_1	40	43	PF00400	0.498
TRG_ER_diArg_1	439	441	PF00400	0.505
TRG_ER_diArg_1	536	539	PF00400	0.418
TRG_ER_diArg_1	591	593	PF00400	0.495
TRG_Pf-PMV_PEXEL_1	213	218	PF00026	0.358
TRG_Pf-PMV_PEXEL_1	259	263	PF00026	0.459
TRG_Pf-PMV_PEXEL_1	284	288	PF00026	0.534
TRG_Pf-PMV_PEXEL_1	380	384	PF00026	0.449
TRG_Pf-PMV_PEXEL_1	53	58	PF00026	0.512
TRG_Pf-PMV_PEXEL_1	570	574	PF00026	0.336

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6P4	Leptomonas seymouri	63%	99%
A0A0S4IQL8	Bodo saltans	26%	100%
A0A0S4J4H6	Bodo saltans	38%	97%
A0A1X0NY28	Trypanosomatidae	41%	97%
A0A3R7KSG2	Trypanosoma rangeli	40%	97%
A4I1T0	Leishmania infantum	100%	100%
E9AIR7	Leishmania braziliensis	79%	100%
E9AXW4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q95ZB7	Leishmania major	95%	100%
V5ASI1	Trypanosoma cruzi	40%	90%