MORN repeat/Vacuolar sorting protein 9 (VPS9) domain containing protein, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Vacuolar sorting protein 9 (VPS9) domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WZE1_LEIDO

TriTrypDb:

LdBPK_252440.1 , LdCL_250030200 , LDHU3_25.2920

Length:

837

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WZE1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WZE1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	28	32	PF00656	0.544
CLV_C14_Caspase3-7	313	317	PF00656	0.561
CLV_NRD_NRD_1	181	183	PF00675	0.462
CLV_NRD_NRD_1	320	322	PF00675	0.635
CLV_NRD_NRD_1	365	367	PF00675	0.411
CLV_NRD_NRD_1	409	411	PF00675	0.519
CLV_NRD_NRD_1	662	664	PF00675	0.613
CLV_PCSK_FUR_1	179	183	PF00082	0.452
CLV_PCSK_KEX2_1	181	183	PF00082	0.462
CLV_PCSK_KEX2_1	320	322	PF00082	0.635
CLV_PCSK_KEX2_1	365	367	PF00082	0.411
CLV_PCSK_KEX2_1	409	411	PF00082	0.499
CLV_PCSK_KEX2_1	662	664	PF00082	0.588
CLV_PCSK_SKI1_1	320	324	PF00082	0.604
CLV_PCSK_SKI1_1	355	359	PF00082	0.430
CLV_PCSK_SKI1_1	432	436	PF00082	0.487
CLV_PCSK_SKI1_1	663	667	PF00082	0.607
CLV_PCSK_SKI1_1	767	771	PF00082	0.719
DEG_APCC_DBOX_1	431	439	PF00400	0.476
DEG_Nend_UBRbox_1	1	4	PF02207	0.753
DEG_SCF_FBW7_1	76	82	PF00400	0.501
DEG_SPOP_SBC_1	569	573	PF00917	0.398
DOC_CKS1_1	76	81	PF01111	0.500
DOC_CYCLIN_RxL_1	764	774	PF00134	0.716
DOC_CYCLIN_RxL_1	819	828	PF00134	0.713
DOC_MAPK_FxFP_2	192	195	PF00069	0.521
DOC_MAPK_gen_1	355	363	PF00069	0.540
DOC_MAPK_gen_1	492	499	PF00069	0.534
DOC_MAPK_gen_1	662	670	PF00069	0.597
DOC_MAPK_MEF2A_6	107	116	PF00069	0.528
DOC_MAPK_MEF2A_6	640	649	PF00069	0.634
DOC_MAPK_MEF2A_6	662	670	PF00069	0.614
DOC_PP1_RVXF_1	703	710	PF00149	0.672
DOC_PP2B_LxvP_1	284	287	PF13499	0.657
DOC_PP2B_LxvP_1	701	704	PF13499	0.661
DOC_PP2B_LxvP_1	738	741	PF13499	0.645
DOC_PP4_FxxP_1	192	195	PF00568	0.599
DOC_USP7_MATH_1	13	17	PF00917	0.683
DOC_USP7_MATH_1	171	175	PF00917	0.449
DOC_USP7_MATH_1	507	511	PF00917	0.652
DOC_USP7_MATH_1	568	572	PF00917	0.407
DOC_USP7_MATH_1	811	815	PF00917	0.680
DOC_WW_Pin1_4	1	6	PF00397	0.668
DOC_WW_Pin1_4	275	280	PF00397	0.559
DOC_WW_Pin1_4	287	292	PF00397	0.702
DOC_WW_Pin1_4	75	80	PF00397	0.503
DOC_WW_Pin1_4	812	817	PF00397	0.740
LIG_14-3-3_CanoR_1	125	135	PF00244	0.575
LIG_14-3-3_CanoR_1	204	211	PF00244	0.602
LIG_14-3-3_CanoR_1	320	325	PF00244	0.603
LIG_14-3-3_CanoR_1	409	418	PF00244	0.527
LIG_14-3-3_CanoR_1	508	516	PF00244	0.574
LIG_14-3-3_CanoR_1	822	827	PF00244	0.651
LIG_APCC_ABBA_1	517	522	PF00400	0.454
LIG_Clathr_ClatBox_1	823	827	PF01394	0.665
LIG_CSL_BTD_1	701	704	PF09270	0.556
LIG_deltaCOP1_diTrp_1	301	308	PF00928	0.592
LIG_EH1_1	595	603	PF00400	0.413
LIG_eIF4E_1	449	455	PF01652	0.478
LIG_eIF4E_1	596	602	PF01652	0.328
LIG_FHA_1	188	194	PF00498	0.430
LIG_FHA_1	338	344	PF00498	0.555
LIG_FHA_1	372	378	PF00498	0.630
LIG_FHA_1	519	525	PF00498	0.413
LIG_FHA_1	536	542	PF00498	0.270
LIG_FHA_1	597	603	PF00498	0.363
LIG_FHA_1	622	628	PF00498	0.338
LIG_FHA_1	685	691	PF00498	0.648
LIG_FHA_1	78	84	PF00498	0.469
LIG_FHA_1	829	835	PF00498	0.690
LIG_FHA_2	496	502	PF00498	0.469
LIG_FHA_2	613	619	PF00498	0.344
LIG_FHA_2	727	733	PF00498	0.699
LIG_GBD_Chelix_1	17	25	PF00786	0.554
LIG_LIR_Apic_2	190	195	PF02991	0.581
LIG_LIR_Apic_2	734	740	PF02991	0.645
LIG_LIR_Gen_1	305	315	PF02991	0.531
LIG_LIR_Gen_1	696	706	PF02991	0.610
LIG_LIR_Nem_3	106	111	PF02991	0.396
LIG_LIR_Nem_3	163	168	PF02991	0.341
LIG_LIR_Nem_3	188	194	PF02991	0.304
LIG_LIR_Nem_3	305	311	PF02991	0.518
LIG_LIR_Nem_3	514	520	PF02991	0.487
LIG_LIR_Nem_3	696	701	PF02991	0.665
LIG_LIR_Nem_3	71	76	PF02991	0.446
LIG_LYPXL_yS_3	468	471	PF13949	0.516
LIG_MYND_1	287	291	PF01753	0.677
LIG_NRBOX	536	542	PF00104	0.449
LIG_NRBOX	829	835	PF00104	0.663
LIG_PCNA_yPIPBox_3	626	640	PF02747	0.437
LIG_Pex14_1	302	306	PF04695	0.476
LIG_Pex14_1	69	73	PF04695	0.530
LIG_Pex14_2	364	368	PF04695	0.386
LIG_Pex14_2	65	69	PF04695	0.541
LIG_PTB_Apo_2	722	729	PF02174	0.732
LIG_SH2_CRK	475	479	PF00017	0.503
LIG_SH2_CRK	73	77	PF00017	0.438
LIG_SH2_NCK_1	324	328	PF00017	0.570
LIG_SH2_NCK_1	475	479	PF00017	0.557
LIG_SH2_PTP2	698	701	PF00017	0.684
LIG_SH2_STAP1	475	479	PF00017	0.557
LIG_SH2_STAP1	520	524	PF00017	0.321
LIG_SH2_STAP1	756	760	PF00017	0.662
LIG_SH2_STAT5	108	111	PF00017	0.426
LIG_SH2_STAT5	153	156	PF00017	0.328
LIG_SH2_STAT5	168	171	PF00017	0.328
LIG_SH2_STAT5	176	179	PF00017	0.376
LIG_SH2_STAT5	342	345	PF00017	0.565
LIG_SH2_STAT5	369	372	PF00017	0.441
LIG_SH2_STAT5	520	523	PF00017	0.437
LIG_SH2_STAT5	585	588	PF00017	0.356
LIG_SH2_STAT5	698	701	PF00017	0.553
LIG_SH2_STAT5	737	740	PF00017	0.735
LIG_SH3_2	817	822	PF14604	0.726
LIG_SH3_3	113	119	PF00018	0.447
LIG_SH3_3	258	264	PF00018	0.363
LIG_SH3_3	40	46	PF00018	0.574
LIG_SH3_3	814	820	PF00018	0.657
LIG_SH3_3	97	103	PF00018	0.584
LIG_SUMO_SIM_anti_2	687	692	PF11976	0.709
LIG_SUMO_SIM_anti_2	731	737	PF11976	0.645
LIG_SUMO_SIM_par_1	686	692	PF11976	0.708
LIG_SUMO_SIM_par_1	821	828	PF11976	0.652
LIG_TRAF2_1	615	618	PF00917	0.413
LIG_TRAF2_1	729	732	PF00917	0.687
MOD_CDK_SPK_2	1	6	PF00069	0.728
MOD_CDK_SPxxK_3	287	294	PF00069	0.714
MOD_CK1_1	126	132	PF00069	0.419
MOD_CK1_1	16	22	PF00069	0.626
MOD_CK1_1	212	218	PF00069	0.638
MOD_CK1_1	275	281	PF00069	0.511
MOD_CK1_1	310	316	PF00069	0.527
MOD_CK1_1	337	343	PF00069	0.532
MOD_CK1_1	675	681	PF00069	0.643
MOD_CK1_1	825	831	PF00069	0.615
MOD_CK2_1	612	618	PF00069	0.363
MOD_CK2_1	726	732	PF00069	0.668
MOD_CK2_1	777	783	PF00069	0.686
MOD_CMANNOS	84	87	PF00535	0.379
MOD_Cter_Amidation	407	410	PF01082	0.599
MOD_GlcNHglycan	120	123	PF01048	0.642
MOD_GlcNHglycan	128	131	PF01048	0.572
MOD_GlcNHglycan	148	151	PF01048	0.281
MOD_GlcNHglycan	171	174	PF01048	0.385
MOD_GlcNHglycan	214	217	PF01048	0.689
MOD_GlcNHglycan	264	267	PF01048	0.421
MOD_GlcNHglycan	269	272	PF01048	0.507
MOD_GlcNHglycan	274	277	PF01048	0.518
MOD_GlcNHglycan	411	414	PF01048	0.622
MOD_GlcNHglycan	53	56	PF01048	0.482
MOD_GlcNHglycan	572	575	PF01048	0.319
MOD_GlcNHglycan	674	677	PF01048	0.645
MOD_GlcNHglycan	757	760	PF01048	0.658
MOD_GSK3_1	12	19	PF00069	0.658
MOD_GSK3_1	131	138	PF00069	0.525
MOD_GSK3_1	200	207	PF00069	0.605
MOD_GSK3_1	422	429	PF00069	0.402
MOD_GSK3_1	529	536	PF00069	0.336
MOD_GSK3_1	551	558	PF00069	0.442
MOD_GSK3_1	568	575	PF00069	0.398
MOD_GSK3_1	596	603	PF00069	0.418
MOD_GSK3_1	675	682	PF00069	0.670
MOD_GSK3_1	75	82	PF00069	0.486
MOD_GSK3_1	818	825	PF00069	0.683
MOD_N-GLC_1	337	342	PF02516	0.592
MOD_N-GLC_1	714	719	PF02516	0.736
MOD_NEK2_1	145	150	PF00069	0.553
MOD_NEK2_1	17	22	PF00069	0.631
MOD_NEK2_1	185	190	PF00069	0.476
MOD_NEK2_1	371	376	PF00069	0.441
MOD_NEK2_1	426	431	PF00069	0.402
MOD_NEK2_1	486	491	PF00069	0.532
MOD_NEK2_1	587	592	PF00069	0.453
MOD_NEK2_1	611	616	PF00069	0.345
MOD_NEK2_1	620	625	PF00069	0.305
MOD_NEK2_1	755	760	PF00069	0.580
MOD_NEK2_1	94	99	PF00069	0.518
MOD_NEK2_2	391	396	PF00069	0.653
MOD_OFUCOSY	206	213	PF10250	0.573
MOD_OFUCOSY	370	375	PF10250	0.573
MOD_PIKK_1	473	479	PF00454	0.565
MOD_PIKK_1	509	515	PF00454	0.707
MOD_PIKK_1	535	541	PF00454	0.455
MOD_PIKK_1	555	561	PF00454	0.358
MOD_PIKK_1	585	591	PF00454	0.449
MOD_PIKK_1	613	619	PF00454	0.413
MOD_PIKK_1	726	732	PF00454	0.724
MOD_PIKK_1	787	793	PF00454	0.653
MOD_PKA_1	320	326	PF00069	0.408
MOD_PKA_1	409	415	PF00069	0.553
MOD_PKA_2	267	273	PF00069	0.501
MOD_PKA_2	302	308	PF00069	0.607
MOD_PKA_2	320	326	PF00069	0.324
MOD_PKA_2	409	415	PF00069	0.558
MOD_PKA_2	507	513	PF00069	0.645
MOD_PKA_2	555	561	PF00069	0.403
MOD_PKA_2	569	575	PF00069	0.447
MOD_PKA_2	777	783	PF00069	0.735
MOD_Plk_1	481	487	PF00069	0.520
MOD_Plk_1	731	737	PF00069	0.697
MOD_Plk_2-3	495	501	PF00069	0.493
MOD_Plk_2-3	684	690	PF00069	0.667
MOD_Plk_4	187	193	PF00069	0.410
MOD_Plk_4	307	313	PF00069	0.492
MOD_Plk_4	628	634	PF00069	0.330
MOD_Plk_4	731	737	PF00069	0.720
MOD_ProDKin_1	1	7	PF00069	0.666
MOD_ProDKin_1	275	281	PF00069	0.570
MOD_ProDKin_1	287	293	PF00069	0.700
MOD_ProDKin_1	75	81	PF00069	0.498
MOD_ProDKin_1	812	818	PF00069	0.739
MOD_SUMO_rev_2	212	221	PF00179	0.706
MOD_SUMO_rev_2	310	319	PF00179	0.478
MOD_SUMO_rev_2	328	337	PF00179	0.260
TRG_DiLeu_BaEn_1	731	736	PF01217	0.678
TRG_DiLeu_BaEn_4	731	737	PF01217	0.673
TRG_DiLeu_BaLyEn_6	764	769	PF01217	0.713
TRG_DiLeu_BaLyEn_6	819	824	PF01217	0.674
TRG_ENDOCYTIC_2	108	111	PF00928	0.420
TRG_ENDOCYTIC_2	468	471	PF00928	0.462
TRG_ENDOCYTIC_2	475	478	PF00928	0.450
TRG_ENDOCYTIC_2	698	701	PF00928	0.657
TRG_ENDOCYTIC_2	73	76	PF00928	0.432
TRG_ER_diArg_1	139	142	PF00400	0.525
TRG_ER_diArg_1	180	182	PF00400	0.533
TRG_ER_diArg_1	320	322	PF00400	0.634
TRG_ER_diArg_1	364	366	PF00400	0.404
TRG_ER_diArg_1	409	411	PF00400	0.468
TRG_Pf-PMV_PEXEL_1	219	223	PF00026	0.639
TRG_Pf-PMV_PEXEL_1	822	827	PF00026	0.686

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKV2	Leptomonas seymouri	62%	99%
A0A0S4IXM9	Bodo saltans	35%	78%
A0A1X0NY26	Trypanosomatidae	39%	92%
A0A422P4H0	Trypanosoma rangeli	38%	90%
A4HED6	Leishmania braziliensis	87%	100%
A4I1T3	Leishmania infantum	99%	100%
C9ZKD9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	91%
E9AXW7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q9K3	Leishmania major	95%	100%
V5BH11	Trypanosoma cruzi	40%	95%