LeishMANIAdb
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Hypothetical_protein_conserved

Quick info Annotations Function or PPIs Localization Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Hypothetical_protein_conserved
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3S7WZD1_LEIDO
TriTrypDb:
LdBPK_252100.1 , LdCL_250026800 , LDHU3_25.2570
Length:
305

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) yes yes: 4
Forrest at al. (procyclic) yes yes: 4
Silverman et al. no yes: 2
Pissara et al. yes yes: 10
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 4
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Could not find GO cellular_component term for this entry.

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A0A3S7WZD1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WZD1

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 3
GO:0003824 catalytic activity 1 3
GO:0004127 cytidylate kinase activity 6 3
GO:0005488 binding 1 3
GO:0005524 ATP binding 5 3
GO:0016301 kinase activity 4 3
GO:0016740 transferase activity 2 3
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 3
GO:0016776 phosphotransferase activity, phosphate group as acceptor 4 3
GO:0017076 purine nucleotide binding 4 3
GO:0019205 nucleobase-containing compound kinase activity 5 3
GO:0030554 adenyl nucleotide binding 5 3
GO:0032553 ribonucleotide binding 3 3
GO:0032555 purine ribonucleotide binding 4 3
GO:0032559 adenyl ribonucleotide binding 5 3
GO:0035639 purine ribonucleoside triphosphate binding 4 3
GO:0036094 small molecule binding 2 3
GO:0043167 ion binding 2 3
GO:0043168 anion binding 3 3
GO:0050145 nucleoside monophosphate kinase activity 5 3
GO:0097159 organic cyclic compound binding 2 3
GO:0097367 carbohydrate derivative binding 2 3
GO:1901265 nucleoside phosphate binding 3 3
GO:1901363 heterocyclic compound binding 2 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 183 187 PF00656 0.504
CLV_NRD_NRD_1 268 270 PF00675 0.356
CLV_NRD_NRD_1 60 62 PF00675 0.536
CLV_PCSK_KEX2_1 169 171 PF00082 0.504
CLV_PCSK_KEX2_1 268 270 PF00082 0.356
CLV_PCSK_KEX2_1 43 45 PF00082 0.523
CLV_PCSK_PC1ET2_1 169 171 PF00082 0.496
CLV_PCSK_PC1ET2_1 43 45 PF00082 0.570
CLV_PCSK_SKI1_1 121 125 PF00082 0.417
CLV_PCSK_SKI1_1 126 130 PF00082 0.342
CLV_PCSK_SKI1_1 152 156 PF00082 0.476
CLV_PCSK_SKI1_1 169 173 PF00082 0.280
DEG_Nend_UBRbox_3 1 3 PF02207 0.632
DEG_SCF_FBW7_1 198 205 PF00400 0.413
DOC_AGCK_PIF_1 136 141 PF00069 0.350
DOC_CKS1_1 199 204 PF01111 0.433
DOC_MAPK_DCC_7 254 264 PF00069 0.483
DOC_MAPK_MEF2A_6 51 60 PF00069 0.406
DOC_MAPK_RevD_3 255 269 PF00069 0.359
DOC_PP1_RVXF_1 124 131 PF00149 0.372
DOC_PP1_RVXF_1 167 174 PF00149 0.383
DOC_PP2B_LxvP_1 257 260 PF13499 0.497
DOC_USP7_MATH_1 94 98 PF00917 0.523
DOC_USP7_UBL2_3 293 297 PF12436 0.406
DOC_WW_Pin1_4 198 203 PF00397 0.447
DOC_WW_Pin1_4 248 253 PF00397 0.350
DOC_WW_Pin1_4 69 74 PF00397 0.560
LIG_14-3-3_CanoR_1 137 142 PF00244 0.363
LIG_14-3-3_CanoR_1 170 174 PF00244 0.472
LIG_14-3-3_CanoR_1 242 247 PF00244 0.390
LIG_BIR_III_2 122 126 PF00653 0.460
LIG_FHA_1 158 164 PF00498 0.399
LIG_FHA_1 186 192 PF00498 0.494
LIG_FHA_1 199 205 PF00498 0.368
LIG_FHA_1 3 9 PF00498 0.403
LIG_FHA_1 86 92 PF00498 0.386
LIG_FHA_2 181 187 PF00498 0.474
LIG_FHA_2 213 219 PF00498 0.389
LIG_LIR_Gen_1 138 147 PF02991 0.319
LIG_LIR_Gen_1 178 185 PF02991 0.376
LIG_LIR_Gen_1 233 239 PF02991 0.443
LIG_LIR_Nem_3 138 142 PF02991 0.307
LIG_LIR_Nem_3 233 238 PF02991 0.445
LIG_SH2_CRK 139 143 PF00017 0.342
LIG_SH2_CRK 235 239 PF00017 0.354
LIG_SH2_STAT5 139 142 PF00017 0.340
LIG_SH2_STAT5 248 251 PF00017 0.405
LIG_SUMO_SIM_anti_2 261 266 PF11976 0.411
LIG_TRAF2_1 287 290 PF00917 0.468
LIG_TRAF2_1 83 86 PF00917 0.459
LIG_UBA3_1 104 113 PF00899 0.434
MOD_CDC14_SPxK_1 251 254 PF00782 0.363
MOD_CDK_SPxK_1 248 254 PF00069 0.343
MOD_CDK_SPxxK_3 69 76 PF00069 0.541
MOD_CK2_1 162 168 PF00069 0.501
MOD_CK2_1 212 218 PF00069 0.392
MOD_CK2_1 284 290 PF00069 0.561
MOD_CK2_1 31 37 PF00069 0.413
MOD_CK2_1 80 86 PF00069 0.443
MOD_GlcNHglycan 108 111 PF01048 0.394
MOD_GlcNHglycan 230 233 PF01048 0.528
MOD_GlcNHglycan 283 287 PF01048 0.435
MOD_GlcNHglycan 65 68 PF01048 0.483
MOD_GlcNHglycan 82 85 PF01048 0.264
MOD_GSK3_1 108 115 PF00069 0.383
MOD_GSK3_1 194 201 PF00069 0.404
MOD_GSK3_1 203 210 PF00069 0.404
MOD_NEK2_1 1 6 PF00069 0.462
MOD_NEK2_1 108 113 PF00069 0.376
MOD_NEK2_1 180 185 PF00069 0.449
MOD_NEK2_1 203 208 PF00069 0.573
MOD_NEK2_1 282 287 PF00069 0.452
MOD_PIKK_1 212 218 PF00454 0.380
MOD_PIKK_1 240 246 PF00454 0.492
MOD_PKA_1 169 175 PF00069 0.499
MOD_PKA_2 169 175 PF00069 0.520
MOD_Plk_1 155 161 PF00069 0.418
MOD_Plk_2-3 157 163 PF00069 0.528
MOD_Plk_2-3 284 290 PF00069 0.527
MOD_Plk_4 137 143 PF00069 0.376
MOD_Plk_4 169 175 PF00069 0.456
MOD_Plk_4 180 186 PF00069 0.370
MOD_Plk_4 194 200 PF00069 0.343
MOD_ProDKin_1 198 204 PF00069 0.440
MOD_ProDKin_1 248 254 PF00069 0.343
MOD_ProDKin_1 69 75 PF00069 0.560
MOD_SUMO_for_1 174 177 PF00179 0.415
TRG_DiLeu_BaLyEn_6 199 204 PF01217 0.518
TRG_ENDOCYTIC_2 139 142 PF00928 0.365
TRG_ENDOCYTIC_2 235 238 PF00928 0.354
TRG_NES_CRM1_1 247 263 PF08389 0.447

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I1G0 Leptomonas seymouri 79% 100%
A0A0S4IKR6 Bodo saltans 55% 100%
A0A1X0NZI5 Trypanosomatidae 59% 100%
A0A422P4M6 Trypanosoma rangeli 58% 100%
A4HEA4 Leishmania braziliensis 87% 100%
A4I1Q0 Leishmania infantum 100% 100%
C9ZKA2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 50% 99%
E9AXT4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%
Q4Q9N7 Leishmania major 98% 100%
V5BMH9 Trypanosoma cruzi 57% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS