Tetratricopeptide_repeat/TPR_repeat_putative/Pfam:PF13181/Pfam:PF07719/Pfam:PF13414/Pfam:PF00515

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TPR repeat, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WZC1_LEIDO

TriTrypDb:

LdBPK_252190.1 , LdCL_250027700 , LDHU3_25.2660

Length:

334

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 2
Pissara et al.	no	yes: 8

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 4

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 4

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WZC1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WZC1

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	17
GO:0009987	cellular process	1	17

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	9
GO:0005488	binding	1	19
GO:0005515	protein binding	2	17
GO:0008270	zinc ion binding	6	9
GO:0030544	Hsp70 protein binding	4	17
GO:0031072	heat shock protein binding	3	17
GO:0043167	ion binding	2	9
GO:0043169	cation binding	3	9
GO:0046872	metal ion binding	4	9
GO:0046914	transition metal ion binding	5	9
GO:0051879	Hsp90 protein binding	4	17
GO:0097159	organic cyclic compound binding	2	9
GO:1901363	heterocyclic compound binding	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	102	106	PF00656	0.324
CLV_C14_Caspase3-7	110	114	PF00656	0.286
CLV_C14_Caspase3-7	132	136	PF00656	0.429
CLV_C14_Caspase3-7	30	34	PF00656	0.579
CLV_NRD_NRD_1	263	265	PF00675	0.505
CLV_NRD_NRD_1	327	329	PF00675	0.548
CLV_PCSK_FUR_1	327	331	PF00082	0.565
CLV_PCSK_KEX2_1	327	329	PF00082	0.551
CLV_PCSK_KEX2_1	8	10	PF00082	0.563
CLV_PCSK_KEX2_1	89	91	PF00082	0.533
CLV_PCSK_PC1ET2_1	329	331	PF00082	0.555
CLV_PCSK_PC1ET2_1	8	10	PF00082	0.472
CLV_PCSK_PC1ET2_1	89	91	PF00082	0.494
CLV_PCSK_SKI1_1	238	242	PF00082	0.416
DOC_CYCLIN_RxL_1	160	172	PF00134	0.519
DOC_MAPK_gen_1	62	70	PF00069	0.320
DOC_USP7_MATH_1	106	110	PF00917	0.548
DOC_USP7_MATH_1	260	264	PF00917	0.576
DOC_USP7_MATH_1	290	294	PF00917	0.596
DOC_USP7_MATH_1	302	306	PF00917	0.579
DOC_USP7_UBL2_3	223	227	PF12436	0.426
DOC_USP7_UBL2_3	241	245	PF12436	0.438
LIG_14-3-3_CanoR_1	90	98	PF00244	0.391
LIG_Actin_WH2_2	212	229	PF00022	0.409
LIG_BIR_II_1	1	5	PF00653	0.430
LIG_FHA_1	151	157	PF00498	0.574
LIG_FHA_1	235	241	PF00498	0.407
LIG_FHA_1	273	279	PF00498	0.589
LIG_FHA_1	280	286	PF00498	0.499
LIG_FHA_1	34	40	PF00498	0.529
LIG_FHA_2	108	114	PF00498	0.370
LIG_FHA_2	172	178	PF00498	0.556
LIG_FHA_2	264	270	PF00498	0.524
LIG_LIR_Gen_1	231	240	PF02991	0.360
LIG_LIR_Gen_1	24	32	PF02991	0.505
LIG_LIR_Gen_1	308	315	PF02991	0.575
LIG_LIR_Gen_1	48	59	PF02991	0.438
LIG_LIR_Nem_3	231	236	PF02991	0.360
LIG_LIR_Nem_3	24	29	PF02991	0.477
LIG_LIR_Nem_3	308	312	PF02991	0.535
LIG_LIR_Nem_3	48	54	PF02991	0.427
LIG_LIR_Nem_3	95	100	PF02991	0.462
LIG_RPA_C_Fungi	180	192	PF08784	0.363
LIG_RPA_C_Fungi	259	271	PF08784	0.602
LIG_SH2_CRK	233	237	PF00017	0.360
LIG_SH2_CRK	51	55	PF00017	0.320
LIG_SH2_NCK_1	26	30	PF00017	0.420
LIG_SH2_NCK_1	91	95	PF00017	0.406
LIG_SH2_NCK_1	98	102	PF00017	0.395
LIG_SH2_SRC	111	114	PF00017	0.359
LIG_SH2_SRC	155	158	PF00017	0.390
LIG_SH2_STAP1	139	143	PF00017	0.561
LIG_SH2_STAT5	111	114	PF00017	0.460
LIG_SH2_STAT5	155	158	PF00017	0.445
LIG_SH2_STAT5	189	192	PF00017	0.552
LIG_SH2_STAT5	309	312	PF00017	0.439
LIG_TRAF2_1	266	269	PF00917	0.531
LIG_TRAF2_1	83	86	PF00917	0.493
MOD_CK1_1	171	177	PF00069	0.512
MOD_CK1_1	183	189	PF00069	0.395
MOD_CK1_1	24	30	PF00069	0.461
MOD_CK1_1	263	269	PF00069	0.598
MOD_CK1_1	305	311	PF00069	0.647
MOD_CK1_1	92	98	PF00069	0.367
MOD_CK1_1	99	105	PF00069	0.345
MOD_CK2_1	151	157	PF00069	0.527
MOD_CK2_1	171	177	PF00069	0.455
MOD_CK2_1	24	30	PF00069	0.440
MOD_CK2_1	263	269	PF00069	0.519
MOD_CK2_1	316	322	PF00069	0.456
MOD_GlcNHglycan	129	132	PF01048	0.540
MOD_GlcNHglycan	14	17	PF01048	0.481
MOD_GlcNHglycan	185	188	PF01048	0.364
MOD_GlcNHglycan	196	200	PF01048	0.392
MOD_GlcNHglycan	304	307	PF01048	0.645
MOD_GlcNHglycan	47	50	PF01048	0.330
MOD_GSK3_1	168	175	PF00069	0.531
MOD_GSK3_1	279	286	PF00069	0.579
MOD_GSK3_1	298	305	PF00069	0.735
MOD_GSK3_1	92	99	PF00069	0.471
MOD_N-GLC_1	106	111	PF02516	0.329
MOD_N-GLC_1	183	188	PF02516	0.359
MOD_N-GLC_1	313	318	PF02516	0.562
MOD_N-GLC_1	45	50	PF02516	0.300
MOD_N-GLC_2	311	313	PF02516	0.567
MOD_NEK2_1	150	155	PF00069	0.494
MOD_NEK2_1	96	101	PF00069	0.532
MOD_PKA_1	328	334	PF00069	0.592
MOD_PKA_1	89	95	PF00069	0.497
MOD_PKA_2	263	269	PF00069	0.573
MOD_PKA_2	283	289	PF00069	0.319
MOD_PKA_2	89	95	PF00069	0.486
MOD_PKB_1	270	278	PF00069	0.505
MOD_Plk_1	106	112	PF00069	0.298
MOD_Plk_1	139	145	PF00069	0.503
MOD_Plk_1	208	214	PF00069	0.415
MOD_Plk_1	92	98	PF00069	0.342
MOD_Plk_4	107	113	PF00069	0.364
MOD_Plk_4	151	157	PF00069	0.537
MOD_Plk_4	177	183	PF00069	0.493
MOD_Plk_4	24	30	PF00069	0.404
MOD_Plk_4	92	98	PF00069	0.516
MOD_SUMO_rev_2	130	136	PF00179	0.515
MOD_SUMO_rev_2	2	10	PF00179	0.558
TRG_DiLeu_BaEn_1	177	182	PF01217	0.519
TRG_DiLeu_BaLyEn_6	248	253	PF01217	0.373
TRG_DiLeu_BaLyEn_6	321	326	PF01217	0.468
TRG_ENDOCYTIC_2	233	236	PF00928	0.360
TRG_ENDOCYTIC_2	26	29	PF00928	0.373
TRG_ENDOCYTIC_2	309	312	PF00928	0.568
TRG_ENDOCYTIC_2	51	54	PF00928	0.382
TRG_ENDOCYTIC_2	97	100	PF00928	0.406
TRG_ER_diArg_1	326	328	PF00400	0.542
TRG_ER_diArg_1	330	333	PF00400	0.567
TRG_ER_diArg_1	39	42	PF00400	0.387
TRG_NLS_MonoExtC_3	327	332	PF00514	0.552
TRG_NLS_MonoExtN_4	327	333	PF00514	0.550
TRG_Pf-PMV_PEXEL_1	251	255	PF00026	0.469

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTR8	Leptomonas seymouri	26%	100%
A0A0N1IBD2	Leptomonas seymouri	63%	100%
A0A0S4JRK3	Bodo saltans	35%	95%
A0A1X0NZH9	Trypanosomatidae	38%	91%
A0A3Q8IJP8	Leishmania donovani	24%	100%
A0A3R7LE97	Trypanosoma rangeli	41%	94%
A4HEB3	Leishmania braziliensis	84%	100%
A4HNL2	Leishmania braziliensis	24%	100%
A4I1Q9	Leishmania infantum	99%	100%
A4ICY0	Leishmania infantum	24%	100%
C9ZKB4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	96%
E9ASC5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9AXU3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4Q271	Leishmania major	25%	100%
Q4Q9M8	Leishmania major	95%	100%
V5BA34	Trypanosoma cruzi	25%	100%
V5BCJ3	Trypanosoma cruzi	41%	94%