Vacuolar_protein_sorting_55_putative/Pfam:PF04133

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Vacuolar protein sorting 55, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WZC0_LEIDO

TriTrypDb:

LdBPK_251960.1 , LdCL_250025400 , LDHU3_25.2430

Length:

139

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0005768	endosome	7	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097708	intracellular vesicle	5	1

Expansion

Sequence features

A0A3S7WZC0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WZC0

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0007034	vacuolar transport	4	1
GO:0009987	cellular process	1	1
GO:0016192	vesicle-mediated transport	4	1
GO:0016197	endosomal transport	4	1
GO:0032509	endosome transport via multivesicular body sorting pathway	5	1
GO:0032511	late endosome to vacuole transport via multivesicular body sorting pathway	6	1
GO:0045324	late endosome to vacuole transport	5	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0071985	multivesicular body sorting pathway	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	123	127	PF00656	0.498
CLV_C14_Caspase3-7	132	136	PF00656	0.363
CLV_NRD_NRD_1	28	30	PF00675	0.173
CLV_PCSK_KEX2_1	30	32	PF00082	0.259
CLV_PCSK_PC1ET2_1	30	32	PF00082	0.259
DOC_USP7_MATH_1	118	122	PF00917	0.437
DOC_USP7_MATH_1	35	39	PF00917	0.393
LIG_BIR_II_1	1	5	PF00653	0.320
LIG_BRCT_BRCA1_1	57	61	PF00533	0.276
LIG_BRCT_BRCA1_1	9	13	PF00533	0.300
LIG_FHA_1	72	78	PF00498	0.259
LIG_FHA_1	95	101	PF00498	0.436
LIG_FHA_2	121	127	PF00498	0.320
LIG_FXI_DFP_1	61	65	PF00024	0.412
LIG_IRF3_LxIS_1	4	10	PF10401	0.243
LIG_LIR_Gen_1	10	21	PF02991	0.328
LIG_LIR_Gen_1	58	69	PF02991	0.243
LIG_LIR_Gen_1	70	79	PF02991	0.167
LIG_LIR_Nem_3	10	15	PF02991	0.328
LIG_LIR_Nem_3	58	64	PF02991	0.216
LIG_LIR_Nem_3	70	75	PF02991	0.198
LIG_MLH1_MIPbox_1	9	13	PF16413	0.268
LIG_PCNA_PIPBox_1	6	15	PF02747	0.277
LIG_PCNA_yPIPBox_3	5	13	PF02747	0.228
LIG_PDZ_Class_2	134	139	PF00595	0.412
LIG_SH2_STAT5	42	45	PF00017	0.400
LIG_SUMO_SIM_par_1	81	86	PF11976	0.329
MOD_GlcNHglycan	1	4	PF01048	0.562
MOD_GlcNHglycan	110	113	PF01048	0.393
MOD_GlcNHglycan	85	88	PF01048	0.311
MOD_GlcNHglycan	9	12	PF01048	0.364
MOD_NEK2_1	105	110	PF00069	0.219
MOD_NEK2_1	23	28	PF00069	0.257
MOD_NEK2_1	7	12	PF00069	0.364
MOD_NEK2_1	83	88	PF00069	0.355
MOD_NEK2_1	94	99	PF00069	0.267
MOD_Plk_4	23	29	PF00069	0.293
MOD_Plk_4	95	101	PF00069	0.428
TRG_ER_diArg_1	28	31	PF00400	0.373

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDL8	Leptomonas seymouri	66%	100%
A0A0S4JPU8	Bodo saltans	37%	100%
A0A1X0NY46	Trypanosomatidae	41%	100%
A0A3R7KZE9	Trypanosoma rangeli	40%	100%
A4HE90	Leishmania braziliensis	81%	100%
A4I1N6	Leishmania infantum	100%	100%
B9TRX0	Sus scrofa	30%	100%
C9ZK85	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	89%
E9AXS0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
O15243	Homo sapiens	30%	100%
O89013	Mus musculus	33%	100%
O95214	Homo sapiens	30%	100%
P47111	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	99%
Q32PD8	Bos taurus	30%	100%
Q3SYT0	Bos taurus	31%	100%
Q4Q9Q1	Leishmania major	95%	100%
Q54VP1	Dictyostelium discoideum	35%	100%
Q561T9	Danio rerio	31%	100%
Q5RDE9	Pongo abelii	30%	100%
Q6PDU4	Rattus norvegicus	31%	100%
Q9CQ74	Mus musculus	31%	100%
Q9JLS8	Rattus norvegicus	31%	100%
Q9UUH1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	100%