PHB domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WZB8_LEIDO

TriTrypDb:

LdBPK_252120.1 , LdCL_250027000 , LDHU3_25.2590

Length:

383

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

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Expansion

Sequence features

A0A3S7WZB8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WZB8

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	264	268	PF00656	0.636
CLV_C14_Caspase3-7	97	101	PF00656	0.706
CLV_NRD_NRD_1	162	164	PF00675	0.451
CLV_NRD_NRD_1	234	236	PF00675	0.369
CLV_NRD_NRD_1	318	320	PF00675	0.561
CLV_PCSK_KEX2_1	134	136	PF00082	0.474
CLV_PCSK_KEX2_1	161	163	PF00082	0.422
CLV_PCSK_KEX2_1	168	170	PF00082	0.488
CLV_PCSK_KEX2_1	234	236	PF00082	0.369
CLV_PCSK_PC1ET2_1	134	136	PF00082	0.474

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I861	Leptomonas seymouri	63%	99%
A0A0S4JNZ4	Bodo saltans	30%	100%
A0A1X0NY60	Trypanosomatidae	38%	100%
A0A3R7MC60	Trypanosoma rangeli	37%	100%
A4HEA6	Leishmania braziliensis	88%	100%
A4I1Q2	Leishmania infantum	100%	100%
C9ZKA4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9AXT6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q9N5	Leishmania major	96%	100%
V5BHZ5	Trypanosoma cruzi	36%	100%

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