LeishMANIAdb
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PHB domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
PHB domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3S7WZB8_LEIDO
TriTrypDb:
LdBPK_252120.1 , LdCL_250027000 , LDHU3_25.2590
Length:
383

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0016020 membrane 2 10
GO:0110165 cellular anatomical entity 1 10

Expansion

Sequence features

A0A3S7WZB8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WZB8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 264 268 PF00656 0.636
CLV_C14_Caspase3-7 97 101 PF00656 0.706
CLV_NRD_NRD_1 162 164 PF00675 0.451
CLV_NRD_NRD_1 234 236 PF00675 0.369
CLV_NRD_NRD_1 318 320 PF00675 0.561
CLV_PCSK_KEX2_1 134 136 PF00082 0.474
CLV_PCSK_KEX2_1 161 163 PF00082 0.422
CLV_PCSK_KEX2_1 168 170 PF00082 0.488
CLV_PCSK_KEX2_1 234 236 PF00082 0.369
CLV_PCSK_PC1ET2_1 134 136 PF00082 0.474
CLV_PCSK_PC1ET2_1 161 163 PF00082 0.420
CLV_PCSK_PC1ET2_1 168 170 PF00082 0.490
CLV_PCSK_SKI1_1 234 238 PF00082 0.430
DEG_APCC_DBOX_1 356 364 PF00400 0.628
DEG_Nend_UBRbox_3 1 3 PF02207 0.464
DOC_CYCLIN_RxL_1 231 238 PF00134 0.577
DOC_MAPK_gen_1 239 249 PF00069 0.596
DOC_MAPK_gen_1 55 64 PF00069 0.667
DOC_PP1_RVXF_1 219 226 PF00149 0.628
DOC_PP1_RVXF_1 343 349 PF00149 0.579
DOC_PP4_FxxP_1 237 240 PF00568 0.558
DOC_PP4_FxxP_1 53 56 PF00568 0.653
DOC_USP7_MATH_1 178 182 PF00917 0.682
DOC_USP7_MATH_1 243 247 PF00917 0.636
DOC_USP7_MATH_1 60 64 PF00917 0.589
DOC_WW_Pin1_4 62 67 PF00397 0.579
DOC_WW_Pin1_4 76 81 PF00397 0.592
LIG_14-3-3_CanoR_1 155 161 PF00244 0.535
LIG_14-3-3_CanoR_1 242 248 PF00244 0.594
LIG_14-3-3_CanoR_1 345 349 PF00244 0.582
LIG_Actin_WH2_2 329 347 PF00022 0.533
LIG_BIR_III_4 274 278 PF00653 0.633
LIG_BRCT_BRCA1_1 9 13 PF00533 0.466
LIG_Clathr_ClatBox_1 145 149 PF01394 0.581
LIG_Clathr_ClatBox_1 222 226 PF01394 0.624
LIG_FHA_1 128 134 PF00498 0.593
LIG_FHA_1 196 202 PF00498 0.575
LIG_FHA_1 335 341 PF00498 0.570
LIG_FHA_2 262 268 PF00498 0.602
LIG_FHA_2 311 317 PF00498 0.814
LIG_FHA_2 354 360 PF00498 0.628
LIG_FXI_DFP_1 222 226 PF00024 0.405
LIG_HP1_1 39 43 PF01393 0.475
LIG_LIR_Gen_1 147 154 PF02991 0.577
LIG_LIR_Gen_1 212 222 PF02991 0.569
LIG_LIR_Gen_1 224 233 PF02991 0.545
LIG_LIR_Gen_1 341 351 PF02991 0.601
LIG_LIR_Gen_1 69 78 PF02991 0.604
LIG_LIR_Nem_3 118 123 PF02991 0.588
LIG_LIR_Nem_3 147 151 PF02991 0.556
LIG_LIR_Nem_3 212 217 PF02991 0.564
LIG_LIR_Nem_3 224 228 PF02991 0.492
LIG_LIR_Nem_3 291 296 PF02991 0.665
LIG_LIR_Nem_3 341 346 PF02991 0.549
LIG_LIR_Nem_3 347 351 PF02991 0.569
LIG_LIR_Nem_3 69 73 PF02991 0.593
LIG_PCNA_PIPBox_1 42 51 PF02747 0.475
LIG_Pex14_2 195 199 PF04695 0.600
LIG_Pex14_2 228 232 PF04695 0.510
LIG_SH2_CRK 293 297 PF00017 0.672
LIG_SH2_NCK_1 297 301 PF00017 0.667
LIG_SH2_PTP2 219 222 PF00017 0.605
LIG_SH2_SRC 297 300 PF00017 0.660
LIG_SH2_STAP1 197 201 PF00017 0.628
LIG_SH2_STAP1 358 362 PF00017 0.544
LIG_SH2_STAT3 197 200 PF00017 0.633
LIG_SH2_STAT5 197 200 PF00017 0.576
LIG_SH2_STAT5 219 222 PF00017 0.604
LIG_SH2_STAT5 331 334 PF00017 0.603
LIG_SH2_STAT5 343 346 PF00017 0.543
LIG_SH2_STAT5 49 52 PF00017 0.389
LIG_SH2_STAT5 72 75 PF00017 0.567
LIG_SH3_3 293 299 PF00018 0.679
LIG_SH3_3 305 311 PF00018 0.766
LIG_SH3_3 33 39 PF00018 0.475
LIG_TYR_ITIM 217 222 PF00017 0.621
LIG_TYR_ITSM 289 296 PF00017 0.663
LIG_WRC_WIRS_1 201 206 PF05994 0.593
LIG_WRC_WIRS_1 67 72 PF05994 0.584
LIG_WW_3 239 243 PF00397 0.647
MOD_CK1_1 282 288 PF00069 0.653
MOD_CK2_1 178 184 PF00069 0.697
MOD_CK2_1 248 254 PF00069 0.609
MOD_CK2_1 310 316 PF00069 0.722
MOD_CK2_1 353 359 PF00069 0.606
MOD_CK2_1 90 96 PF00069 0.664
MOD_Cter_Amidation 317 320 PF01082 0.601
MOD_GlcNHglycan 257 260 PF01048 0.478
MOD_GlcNHglycan 348 351 PF01048 0.379
MOD_GSK3_1 178 185 PF00069 0.685
MOD_GSK3_1 195 202 PF00069 0.588
MOD_GSK3_1 261 268 PF00069 0.631
MOD_GSK3_1 278 285 PF00069 0.532
MOD_GSK3_1 62 69 PF00069 0.541
MOD_GSK3_1 7 14 PF00069 0.486
MOD_GSK3_1 72 79 PF00069 0.488
MOD_NEK2_1 199 204 PF00069 0.536
MOD_NEK2_1 248 253 PF00069 0.603
MOD_NEK2_1 265 270 PF00069 0.578
MOD_NEK2_1 279 284 PF00069 0.624
MOD_NEK2_1 344 349 PF00069 0.536
MOD_PKA_2 127 133 PF00069 0.573
MOD_PKA_2 16 22 PF00069 0.424
MOD_PKA_2 344 350 PF00069 0.585
MOD_PKB_1 169 177 PF00069 0.713
MOD_Plk_1 288 294 PF00069 0.616
MOD_Plk_2-3 310 316 PF00069 0.788
MOD_Plk_4 127 133 PF00069 0.588
MOD_Plk_4 16 22 PF00069 0.434
MOD_Plk_4 182 188 PF00069 0.682
MOD_Plk_4 243 249 PF00069 0.592
MOD_Plk_4 376 382 PF00069 0.650
MOD_Plk_4 66 72 PF00069 0.614
MOD_Plk_4 90 96 PF00069 0.609
MOD_ProDKin_1 62 68 PF00069 0.576
MOD_ProDKin_1 76 82 PF00069 0.587
MOD_SUMO_for_1 133 136 PF00179 0.659
TRG_AP2beta_CARGO_1 212 221 PF09066 0.657
TRG_AP2beta_CARGO_1 226 235 PF09066 0.566
TRG_DiLeu_BaEn_2 181 187 PF01217 0.691
TRG_DiLeu_BaEn_4 302 308 PF01217 0.726
TRG_DiLeu_BaLyEn_6 358 363 PF01217 0.620
TRG_DiLeu_BaLyEn_6 63 68 PF01217 0.609
TRG_ENDOCYTIC_2 219 222 PF00928 0.591
TRG_ENDOCYTIC_2 293 296 PF00928 0.653
TRG_ENDOCYTIC_2 297 300 PF00928 0.689
TRG_ENDOCYTIC_2 343 346 PF00928 0.595
TRG_ENDOCYTIC_2 49 52 PF00928 0.364
TRG_ER_diArg_1 162 164 PF00400 0.650
TRG_ER_diArg_1 233 235 PF00400 0.568
TRG_Pf-PMV_PEXEL_1 114 118 PF00026 0.376
TRG_Pf-PMV_PEXEL_1 234 238 PF00026 0.370
TRG_Pf-PMV_PEXEL_1 361 365 PF00026 0.419

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I861 Leptomonas seymouri 63% 99%
A0A0S4JNZ4 Bodo saltans 30% 100%
A0A1X0NY60 Trypanosomatidae 38% 100%
A0A3R7MC60 Trypanosoma rangeli 37% 100%
A4HEA6 Leishmania braziliensis 88% 100%
A4I1Q2 Leishmania infantum 100% 100%
C9ZKA4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 39% 100%
E9AXT6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
Q4Q9N5 Leishmania major 96% 100%
V5BHZ5 Trypanosoma cruzi 36% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS