Hypothetical_protein_conserved

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WZB6_LEIDO

TriTrypDb:

LdBPK_252170.1 , LdCL_250027500 , LDHU3_25.2640

Length:

156

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

A0A3S7WZB6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WZB6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	139	143	PF00656	0.516
CLV_C14_Caspase3-7	26	30	PF00656	0.770
CLV_NRD_NRD_1	108	110	PF00675	0.439
CLV_NRD_NRD_1	14	16	PF00675	0.483
CLV_NRD_NRD_1	2	4	PF00675	0.471
CLV_PCSK_KEX2_1	14	16	PF00082	0.517
CLV_PCSK_SKI1_1	14	18	PF00082	0.488
DOC_PP4_FxxP_1	127	130	PF00568	0.551
DOC_PP4_FxxP_1	53	56	PF00568	0.671
DOC_WW_Pin1_4	48	53	PF00397	0.677
LIG_14-3-3_CanoR_1	3	10	PF00244	0.694
LIG_14-3-3_CanoR_1	45	54	PF00244	0.679
LIG_BRCT_BRCA1_1	140	144	PF00533	0.545
LIG_BRCT_BRCA1_1	49	53	PF00533	0.674
LIG_FHA_1	98	104	PF00498	0.670
LIG_FHA_2	137	143	PF00498	0.542
LIG_FHA_2	24	30	PF00498	0.711
LIG_LIR_Apic_2	50	56	PF02991	0.670
LIG_LIR_Apic_2	68	72	PF02991	0.629
LIG_LIR_Gen_1	142	153	PF02991	0.455
LIG_LIR_Nem_3	142	148	PF02991	0.497
LIG_LIR_Nem_3	58	64	PF02991	0.653
LIG_LIR_Nem_3	68	73	PF02991	0.639
LIG_PDZ_Class_3	151	156	PF00595	0.440
LIG_SH2_SRC	88	91	PF00017	0.726
LIG_SH2_STAP1	61	65	PF00017	0.643
LIG_SH2_STAT5	112	115	PF00017	0.348
LIG_SH2_STAT5	118	121	PF00017	0.338
LIG_SH2_STAT5	124	127	PF00017	0.316
LIG_SH2_STAT5	69	72	PF00017	0.631
LIG_SH3_3	143	149	PF00018	0.516
LIG_SUMO_SIM_par_1	99	108	PF11976	0.680
LIG_TRFH_1	126	130	PF08558	0.355
LIG_UBA3_1	103	111	PF00899	0.671
MOD_CK1_1	136	142	PF00069	0.513
MOD_DYRK1A_RPxSP_1	48	52	PF00069	0.674
MOD_GlcNHglycan	135	138	PF01048	0.659
MOD_GlcNHglycan	5	8	PF01048	0.389
MOD_N-GLC_1	31	36	PF02516	0.508
MOD_NEK2_1	2	7	PF00069	0.665
MOD_PKA_1	3	9	PF00069	0.722
MOD_PKA_2	2	8	PF00069	0.698
MOD_PKA_2	47	53	PF00069	0.679
MOD_Plk_1	131	137	PF00069	0.450
MOD_Plk_4	60	66	PF00069	0.664
MOD_ProDKin_1	48	54	PF00069	0.676
TRG_ENDOCYTIC_2	118	121	PF00928	0.349
TRG_ENDOCYTIC_2	124	127	PF00928	0.347
TRG_NLS_Bipartite_1	93	113	PF00514	0.644

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8V9	Leptomonas seymouri	87%	100%
A0A0S4JP84	Bodo saltans	63%	100%
A0A1X0NYC2	Trypanosomatidae	76%	100%
A0A3R7P4M5	Trypanosoma rangeli	75%	100%
A4HEB1	Leishmania braziliensis	91%	100%
A4I1Q7	Leishmania infantum	100%	100%
C9ZKB2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	72%	100%
E9AXU1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4Q9N0	Leishmania major	99%	100%