LeishMANIAdb
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Peptidase C51 domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Peptidase C51 domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3S7WZA9_LEIDO
TriTrypDb:
LdBPK_251870.1 , LdCL_250024400 , LDHU3_25.2310
Length:
300

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. yes yes: 18
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 1, no: 31
NetGPI no yes: 0, no: 32
Cellular components
Term Name Level Count
GO:0016020 membrane 2 23
GO:0110165 cellular anatomical entity 1 25
GO:0005737 cytoplasm 2 3

Expansion

Sequence features

A0A3S7WZA9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WZA9

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 3
GO:0016874 ligase activity 2 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 166 168 PF00675 0.551
CLV_NRD_NRD_1 173 175 PF00675 0.525
CLV_NRD_NRD_1 222 224 PF00675 0.566
CLV_NRD_NRD_1 37 39 PF00675 0.655
CLV_NRD_NRD_1 91 93 PF00675 0.658
CLV_PCSK_KEX2_1 173 175 PF00082 0.556
CLV_PCSK_KEX2_1 222 224 PF00082 0.584
CLV_PCSK_KEX2_1 91 93 PF00082 0.642
CLV_PCSK_PC7_1 218 224 PF00082 0.594
CLV_PCSK_SKI1_1 212 216 PF00082 0.583
CLV_PCSK_SKI1_1 5 9 PF00082 0.346
DEG_Nend_UBRbox_3 1 3 PF02207 0.504
DOC_MAPK_gen_1 210 219 PF00069 0.384
DOC_PP1_RVXF_1 113 120 PF00149 0.346
DOC_PP1_RVXF_1 241 248 PF00149 0.296
DOC_PP4_FxxP_1 169 172 PF00568 0.375
DOC_USP7_UBL2_3 212 216 PF12436 0.276
DOC_WW_Pin1_4 48 53 PF00397 0.321
LIG_14-3-3_CanoR_1 99 107 PF00244 0.408
LIG_Actin_WH2_2 266 284 PF00022 0.419
LIG_deltaCOP1_diTrp_1 228 236 PF00928 0.333
LIG_eIF4E_1 112 118 PF01652 0.312
LIG_FHA_1 11 17 PF00498 0.348
LIG_FHA_1 129 135 PF00498 0.387
LIG_FHA_1 96 102 PF00498 0.405
LIG_FHA_2 106 112 PF00498 0.302
LIG_FHA_2 154 160 PF00498 0.276
LIG_Integrin_isoDGR_2 89 91 PF01839 0.511
LIG_Integrin_RGD_1 92 94 PF01839 0.694
LIG_LIR_Apic_2 137 143 PF02991 0.421
LIG_LIR_Apic_2 166 172 PF02991 0.388
LIG_LIR_Apic_2 258 264 PF02991 0.247
LIG_LIR_Gen_1 156 164 PF02991 0.399
LIG_LIR_Nem_3 156 161 PF02991 0.378
LIG_LIR_Nem_3 41 46 PF02991 0.387
LIG_LIR_Nem_3 51 56 PF02991 0.326
LIG_LIR_Nem_3 74 80 PF02991 0.338
LIG_Pex14_1 150 154 PF04695 0.413
LIG_SH2_CRK 241 245 PF00017 0.284
LIG_SH2_CRK 43 47 PF00017 0.430
LIG_SH2_GRB2like 140 143 PF00017 0.286
LIG_SH2_GRB2like 66 69 PF00017 0.306
LIG_SH2_GRB2like 77 80 PF00017 0.325
LIG_SH2_NCK_1 158 162 PF00017 0.386
LIG_SH2_PTP2 261 264 PF00017 0.252
LIG_SH2_PTP2 80 83 PF00017 0.398
LIG_SH2_SRC 158 161 PF00017 0.382
LIG_SH2_SRC 261 264 PF00017 0.257
LIG_SH2_SRC 288 291 PF00017 0.351
LIG_SH2_STAP1 241 245 PF00017 0.303
LIG_SH2_STAP1 29 33 PF00017 0.332
LIG_SH2_STAT5 107 110 PF00017 0.283
LIG_SH2_STAT5 112 115 PF00017 0.239
LIG_SH2_STAT5 140 143 PF00017 0.390
LIG_SH2_STAT5 154 157 PF00017 0.408
LIG_SH2_STAT5 225 228 PF00017 0.332
LIG_SH2_STAT5 261 264 PF00017 0.376
LIG_SH2_STAT5 77 80 PF00017 0.356
LIG_SH3_1 140 146 PF00018 0.283
LIG_SH3_3 140 146 PF00018 0.422
LIG_TRAF2_1 287 290 PF00917 0.506
LIG_TYR_ITIM 21 26 PF00017 0.414
LIG_TYR_ITIM 78 83 PF00017 0.493
LIG_TYR_ITSM 154 161 PF00017 0.322
MOD_CK2_1 153 159 PF00069 0.325
MOD_CMANNOS 116 119 PF00535 0.462
MOD_Cter_Amidation 89 92 PF01082 0.586
MOD_GlcNHglycan 150 153 PF01048 0.423
MOD_GlcNHglycan 40 43 PF01048 0.507
MOD_GSK3_1 44 51 PF00069 0.401
MOD_GSK3_1 64 71 PF00069 0.405
MOD_N-GLC_1 239 244 PF02516 0.381
MOD_NEK2_1 73 78 PF00069 0.401
MOD_NEK2_2 22 27 PF00069 0.563
MOD_PKA_1 38 44 PF00069 0.402
MOD_PKA_2 105 111 PF00069 0.471
MOD_Plk_1 239 245 PF00069 0.323
MOD_Plk_4 11 17 PF00069 0.308
MOD_Plk_4 22 28 PF00069 0.485
MOD_Plk_4 31 37 PF00069 0.565
MOD_Plk_4 73 79 PF00069 0.501
MOD_ProDKin_1 48 54 PF00069 0.390
MOD_SUMO_for_1 144 147 PF00179 0.589
MOD_SUMO_for_1 196 199 PF00179 0.441
MOD_SUMO_rev_2 160 169 PF00179 0.504
MOD_SUMO_rev_2 209 217 PF00179 0.547
TRG_ENDOCYTIC_2 107 110 PF00928 0.352
TRG_ENDOCYTIC_2 158 161 PF00928 0.521
TRG_ENDOCYTIC_2 23 26 PF00928 0.470
TRG_ENDOCYTIC_2 241 244 PF00928 0.350
TRG_ENDOCYTIC_2 43 46 PF00928 0.493
TRG_ENDOCYTIC_2 80 83 PF00928 0.407
TRG_ER_diArg_1 172 174 PF00400 0.416
TRG_ER_diArg_1 221 223 PF00400 0.530
TRG_NLS_MonoExtN_4 212 219 PF00514 0.467

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I309 Leptomonas seymouri 63% 100%
A0A0N1I7J8 Leptomonas seymouri 27% 76%
A0A0N1PB04 Leptomonas seymouri 28% 84%
A0A0S4ITA7 Bodo saltans 24% 97%
A0A1X0NR96 Trypanosomatidae 27% 100%
A0A1X0NR98 Trypanosomatidae 29% 100%
A0A1X0NY88 Trypanosomatidae 39% 100%
A0A1X0NYK9 Trypanosomatidae 37% 100%
A0A3R7KMG1 Trypanosoma rangeli 37% 92%
A0A3R7LYQ4 Trypanosoma rangeli 28% 97%
A0A3S7X769 Leishmania donovani 27% 100%
A0A3S7X774 Leishmania donovani 27% 74%
A4HEJ1 Leishmania braziliensis 84% 100%
A4HLZ4 Leishmania braziliensis 28% 100%
A4HLZ6 Leishmania braziliensis 29% 79%
A4I1M7 Leishmania infantum 100% 100%
A4I9C4 Leishmania infantum 26% 81%
A4I9C6 Leishmania infantum 28% 74%
C9ZJ94 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 28% 100%
C9ZJ95 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 26% 100%
C9ZK72 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 36% 100%
D0A867 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 27% 100%
E9AXR1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%
E9B4C3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 94%
E9B4C6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 78%
Q4Q3Q0 Leishmania major 28% 71%
Q4Q3Q2 Leishmania major 27% 100%
Q4Q9R0 Leishmania major 94% 100%
V5BF57 Trypanosoma cruzi 28% 91%
V5DB66 Trypanosoma cruzi 30% 97%
V5DIU8 Trypanosoma cruzi 38% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS