Putative_intraflagellar_transport_protein_A1/Gene DB:LmjF.25.1430

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Putative intraflagellar transport protein A1

Species:

Leishmania donovani

UniProt:

A0A3S7WZA7_LEIDO

TriTrypDb:

LdBPK_251470.1 , LdCL_250020300 , LDHU3_25.1810

Length:

487

Annotations

Annotations by Jardim et al.

Flagella, intraflagellar transport A1 (PIFTA1) Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	9
GO:0031514	motile cilium	5	2
GO:0042995	cell projection	2	9
GO:0043226	organelle	2	9
GO:0043227	membrane-bounded organelle	3	9
GO:0110165	cellular anatomical entity	1	9
GO:0120025	plasma membrane bounded cell projection	3	9
GO:0005813	centrosome	3	1
GO:0005815	microtubule organizing center	2	1
GO:0030990	intraciliary transport particle	2	1
GO:0030992	intraciliary transport particle B	2	1
GO:0032991	protein-containing complex	1	1

Expansion

Sequence features

A0A3S7WZA7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WZA7

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	9
GO:0016043	cellular component organization	3	9
GO:0030030	cell projection organization	4	9
GO:0071840	cellular component organization or biogenesis	2	9
GO:0006810	transport	3	1
GO:0006996	organelle organization	4	1
GO:0007017	microtubule-based process	2	1
GO:0007018	microtubule-based movement	3	1
GO:0010970	transport along microtubule	4	1
GO:0022607	cellular component assembly	4	1
GO:0030031	cell projection assembly	5	1
GO:0030705	cytoskeleton-dependent intracellular transport	4	1
GO:0031503	protein-containing complex localization	2	1
GO:0035720	intraciliary anterograde transport	4	1
GO:0035735	intraciliary transport involved in cilium assembly	4	1
GO:0042073	intraciliary transport	3	1
GO:0044782	cilium organization	5	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0060271	cilium assembly	6	1
GO:0070925	organelle assembly	5	1
GO:0099111	microtubule-based transport	4	1
GO:0120031	plasma membrane bounded cell projection assembly	6	1
GO:0120036	plasma membrane bounded cell projection organization	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	455	459	PF00656	0.766
CLV_NRD_NRD_1	179	181	PF00675	0.325
CLV_NRD_NRD_1	294	296	PF00675	0.479
CLV_NRD_NRD_1	309	311	PF00675	0.649
CLV_NRD_NRD_1	314	316	PF00675	0.813
CLV_NRD_NRD_1	385	387	PF00675	0.790
CLV_NRD_NRD_1	423	425	PF00675	0.717
CLV_PCSK_KEX2_1	179	181	PF00082	0.325
CLV_PCSK_KEX2_1	309	311	PF00082	0.766
CLV_PCSK_KEX2_1	314	316	PF00082	0.768
CLV_PCSK_KEX2_1	384	386	PF00082	0.724
CLV_PCSK_KEX2_1	423	425	PF00082	0.717
CLV_PCSK_PC7_1	310	316	PF00082	0.683
CLV_PCSK_SKI1_1	106	110	PF00082	0.405
CLV_PCSK_SKI1_1	182	186	PF00082	0.291
CLV_PCSK_SKI1_1	426	430	PF00082	0.704
DEG_APCC_DBOX_1	181	189	PF00400	0.291
DEG_Kelch_Keap1_1	465	470	PF01344	0.688
DEG_SCF_FBW7_1	322	327	PF00400	0.689
DOC_CDC14_PxL_1	15	23	PF14671	0.291
DOC_CYCLIN_RxL_1	179	189	PF00134	0.332
DOC_CYCLIN_RxL_1	257	266	PF00134	0.385
DOC_MAPK_gen_1	76	83	PF00069	0.291
DOC_MAPK_MEF2A_6	76	83	PF00069	0.291
DOC_MAPK_NFAT4_5	76	84	PF00069	0.325
DOC_PP1_RVXF_1	258	265	PF00149	0.385
DOC_PP1_RVXF_1	60	66	PF00149	0.291
DOC_PP4_FxxP_1	27	30	PF00568	0.291
DOC_USP7_MATH_1	145	149	PF00917	0.319
DOC_USP7_MATH_1	204	208	PF00917	0.387
DOC_USP7_MATH_1	324	328	PF00917	0.624
DOC_USP7_MATH_1	403	407	PF00917	0.734
DOC_USP7_MATH_1	448	452	PF00917	0.708
DOC_USP7_MATH_1	457	461	PF00917	0.717
DOC_USP7_MATH_2	448	454	PF00917	0.641
DOC_USP7_UBL2_3	105	109	PF12436	0.325
DOC_USP7_UBL2_3	212	216	PF12436	0.331
DOC_USP7_UBL2_3	271	275	PF12436	0.367
DOC_USP7_UBL2_3	296	300	PF12436	0.528
DOC_USP7_UBL2_3	76	80	PF12436	0.291
DOC_WW_Pin1_4	320	325	PF00397	0.691
LIG_14-3-3_CanoR_1	170	177	PF00244	0.291
LIG_14-3-3_CanoR_1	62	66	PF00244	0.325
LIG_14-3-3_CanoR_1	7	16	PF00244	0.446
LIG_Actin_WH2_2	287	302	PF00022	0.603
LIG_Actin_WH2_2	90	107	PF00022	0.291
LIG_BIR_II_1	1	5	PF00653	0.419
LIG_BRCT_BRCA1_1	147	151	PF00533	0.291
LIG_BRCT_BRCA1_1	467	471	PF00533	0.711
LIG_Clathr_ClatBox_1	21	25	PF01394	0.291
LIG_EH1_1	91	99	PF00400	0.385
LIG_FHA_1	10	16	PF00498	0.351
LIG_FHA_1	187	193	PF00498	0.303
LIG_FHA_1	51	57	PF00498	0.385
LIG_FHA_2	109	115	PF00498	0.325
LIG_FHA_2	358	364	PF00498	0.779
LIG_FHA_2	42	48	PF00498	0.319
LIG_GBD_Chelix_1	100	108	PF00786	0.291
LIG_Integrin_RGD_1	161	163	PF01839	0.367
LIG_LIR_Apic_2	25	30	PF02991	0.291
LIG_LIR_Gen_1	115	126	PF02991	0.325
LIG_LIR_Nem_3	115	121	PF02991	0.325
LIG_LIR_Nem_3	148	154	PF02991	0.291
LIG_LIR_Nem_3	2	6	PF02991	0.399
LIG_LIR_Nem_3	257	262	PF02991	0.306
LIG_LIR_Nem_3	64	69	PF02991	0.385
LIG_LYPXL_yS_3	18	21	PF13949	0.291
LIG_MLH1_MIPbox_1	148	152	PF16413	0.325
LIG_NRBOX	180	186	PF00104	0.325
LIG_PDZ_Class_1	482	487	PF00595	0.623
LIG_PTB_Apo_2	231	238	PF02174	0.385
LIG_PTB_Apo_2	258	265	PF02174	0.291
LIG_REV1ctd_RIR_1	63	71	PF16727	0.293
LIG_SH2_GRB2like	241	244	PF00017	0.385
LIG_SH2_GRB2like	334	337	PF00017	0.607
LIG_SH2_NCK_1	334	338	PF00017	0.604
LIG_SH2_SRC	241	244	PF00017	0.385
LIG_SH2_SRC	334	337	PF00017	0.607
LIG_SH2_SRC	46	49	PF00017	0.291
LIG_SH2_STAT3	255	258	PF00017	0.291
LIG_SH2_STAT5	255	258	PF00017	0.291
LIG_TRAF2_1	349	352	PF00917	0.687
LIG_TRAF2_1	93	96	PF00917	0.291
LIG_TYR_ITIM	16	21	PF00017	0.291
LIG_UBA3_1	97	105	PF00899	0.291
LIG_WRC_WIRS_1	24	29	PF05994	0.291
LIG_WRC_WIRS_1	6	11	PF05994	0.352
MOD_CK1_1	141	147	PF00069	0.300
MOD_CK1_1	169	175	PF00069	0.297
MOD_CK1_1	23	29	PF00069	0.294
MOD_CK1_1	451	457	PF00069	0.691
MOD_CK1_1	460	466	PF00069	0.618
MOD_CK1_1	473	479	PF00069	0.594
MOD_CK2_1	108	114	PF00069	0.325
MOD_CK2_1	200	206	PF00069	0.332
MOD_CK2_1	23	29	PF00069	0.385
MOD_CK2_1	324	330	PF00069	0.731
MOD_CK2_1	352	358	PF00069	0.736
MOD_CK2_1	41	47	PF00069	0.319
MOD_CK2_1	450	456	PF00069	0.803
MOD_CK2_1	464	470	PF00069	0.643
MOD_CK2_1	5	11	PF00069	0.355
MOD_Cter_Amidation	312	315	PF01082	0.805
MOD_GlcNHglycan	202	205	PF01048	0.392
MOD_GlcNHglycan	228	231	PF01048	0.418
MOD_GlcNHglycan	311	314	PF01048	0.775
MOD_GlcNHglycan	351	357	PF01048	0.683
MOD_GlcNHglycan	360	363	PF01048	0.634
MOD_GlcNHglycan	467	470	PF01048	0.638
MOD_GlcNHglycan	47	51	PF01048	0.342
MOD_GlcNHglycan	478	482	PF01048	0.623
MOD_GSK3_1	141	148	PF00069	0.313
MOD_GSK3_1	200	207	PF00069	0.352
MOD_GSK3_1	226	233	PF00069	0.402
MOD_GSK3_1	320	327	PF00069	0.715
MOD_GSK3_1	352	359	PF00069	0.666
MOD_GSK3_1	448	455	PF00069	0.709
MOD_GSK3_1	456	463	PF00069	0.691
MOD_GSK3_1	46	53	PF00069	0.385
MOD_GSK3_1	465	472	PF00069	0.635
MOD_GSK3_1	473	480	PF00069	0.678
MOD_GSK3_1	5	12	PF00069	0.350
MOD_N-GLC_1	128	133	PF02516	0.385
MOD_N-GLC_1	186	191	PF02516	0.359
MOD_N-GLC_1	200	205	PF02516	0.289
MOD_NEK2_1	462	467	PF00069	0.689
MOD_NEK2_1	9	14	PF00069	0.343
MOD_PIKK_1	186	192	PF00454	0.305
MOD_PKA_1	309	315	PF00069	0.686
MOD_PKA_2	169	175	PF00069	0.291
MOD_PKA_2	309	315	PF00069	0.714
MOD_PKA_2	61	67	PF00069	0.325
MOD_PKB_1	164	172	PF00069	0.291
MOD_PKB_1	424	432	PF00069	0.702
MOD_Plk_1	116	122	PF00069	0.325
MOD_Plk_1	414	420	PF00069	0.711
MOD_Plk_1	438	444	PF00069	0.660
MOD_Plk_1	50	56	PF00069	0.385
MOD_Plk_2-3	363	369	PF00069	0.820
MOD_Plk_2-3	452	458	PF00069	0.595
MOD_Plk_2-3	470	476	PF00069	0.644
MOD_Plk_2-3	5	11	PF00069	0.355
MOD_Plk_4	146	152	PF00069	0.325
MOD_Plk_4	195	201	PF00069	0.399
MOD_Plk_4	414	420	PF00069	0.701
MOD_Plk_4	61	67	PF00069	0.325
MOD_ProDKin_1	320	326	PF00069	0.691
MOD_SUMO_rev_2	131	136	PF00179	0.385
MOD_SUMO_rev_2	205	213	PF00179	0.291
MOD_SUMO_rev_2	240	248	PF00179	0.375
MOD_SUMO_rev_2	281	287	PF00179	0.433
MOD_SUMO_rev_2	292	302	PF00179	0.483
TRG_DiLeu_BaEn_1	11	16	PF01217	0.354
TRG_DiLeu_BaEn_1	414	419	PF01217	0.710
TRG_DiLeu_BaEn_1	439	444	PF01217	0.661
TRG_DiLeu_LyEn_5	11	16	PF01217	0.354
TRG_DiLeu_LyEn_5	439	444	PF01217	0.661
TRG_ENDOCYTIC_2	18	21	PF00928	0.296
TRG_ENDOCYTIC_2	259	262	PF00928	0.296
TRG_ER_diArg_1	164	167	PF00400	0.291
TRG_ER_diArg_1	179	182	PF00400	0.325
TRG_ER_diArg_1	309	311	PF00400	0.781
TRG_ER_diArg_1	344	347	PF00400	0.702
TRG_ER_diArg_1	384	386	PF00400	0.738
TRG_ER_diArg_1	422	424	PF00400	0.725
TRG_ER_diArg_1	440	443	PF00400	0.707
TRG_Pf-PMV_PEXEL_1	179	183	PF00026	0.325

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKV6	Leptomonas seymouri	76%	100%
A0A0S4IPW0	Bodo saltans	53%	100%
A4HEE7	Leishmania braziliensis	88%	100%
A4I1I7	Leishmania infantum	100%	100%
C9ZJX9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	100%
E9AXM2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4Q9V0	Leishmania major	97%	100%