Protein kinase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WZA6_LEIDO

TriTrypDb:

LdBPK_252070.1 , LdCL_250026500 , LDHU3_25.2540

Length:

576

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WZA6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WZA6

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	10
GO:0006793	phosphorus metabolic process	3	10
GO:0006796	phosphate-containing compound metabolic process	4	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0009987	cellular process	1	10
GO:0016310	phosphorylation	5	10
GO:0019538	protein metabolic process	3	10
GO:0036211	protein modification process	4	10
GO:0043170	macromolecule metabolic process	3	10
GO:0043412	macromolecule modification	4	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0071704	organic substance metabolic process	2	10
GO:1901564	organonitrogen compound metabolic process	3	10

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	10
GO:0003824	catalytic activity	1	10
GO:0004672	protein kinase activity	3	10
GO:0005488	binding	1	10
GO:0005524	ATP binding	5	10
GO:0016301	kinase activity	4	10
GO:0016740	transferase activity	2	10
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	10
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	10
GO:0017076	purine nucleotide binding	4	10
GO:0030554	adenyl nucleotide binding	5	10
GO:0032553	ribonucleotide binding	3	10
GO:0032555	purine ribonucleotide binding	4	10
GO:0032559	adenyl ribonucleotide binding	5	10
GO:0035639	purine ribonucleoside triphosphate binding	4	10
GO:0036094	small molecule binding	2	10
GO:0043167	ion binding	2	10
GO:0043168	anion binding	3	10
GO:0097159	organic cyclic compound binding	2	10
GO:0097367	carbohydrate derivative binding	2	10
GO:0140096	catalytic activity, acting on a protein	2	10
GO:1901265	nucleoside phosphate binding	3	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	256	260	PF00656	0.645
CLV_C14_Caspase3-7	386	390	PF00656	0.564
CLV_NRD_NRD_1	380	382	PF00675	0.713
CLV_NRD_NRD_1	398	400	PF00675	0.770
CLV_NRD_NRD_1	480	482	PF00675	0.795
CLV_NRD_NRD_1	503	505	PF00675	0.650
CLV_NRD_NRD_1	76	78	PF00675	0.321
CLV_NRD_NRD_1	8	10	PF00675	0.314
CLV_PCSK_KEX2_1	398	400	PF00082	0.734
CLV_PCSK_KEX2_1	405	407	PF00082	0.639
CLV_PCSK_KEX2_1	480	482	PF00082	0.795
CLV_PCSK_KEX2_1	503	505	PF00082	0.650
CLV_PCSK_KEX2_1	76	78	PF00082	0.321
CLV_PCSK_PC1ET2_1	405	407	PF00082	0.565
CLV_PCSK_SKI1_1	114	118	PF00082	0.337
CLV_PCSK_SKI1_1	132	136	PF00082	0.321
CLV_PCSK_SKI1_1	399	403	PF00082	0.772
CLV_PCSK_SKI1_1	430	434	PF00082	0.730
DEG_APCC_DBOX_1	113	121	PF00400	0.345
DEG_Nend_UBRbox_2	1	3	PF02207	0.445
DOC_ANK_TNKS_1	75	82	PF00023	0.462
DOC_CDC14_PxL_1	433	441	PF14671	0.721
DOC_CKS1_1	140	145	PF01111	0.462
DOC_CKS1_1	200	205	PF01111	0.321
DOC_MAPK_gen_1	132	141	PF00069	0.321
DOC_MAPK_gen_1	405	414	PF00069	0.565
DOC_MAPK_gen_1	76	84	PF00069	0.321
DOC_MAPK_MEF2A_6	76	84	PF00069	0.314
DOC_USP7_MATH_1	258	262	PF00917	0.734
DOC_USP7_MATH_1	276	280	PF00917	0.365
DOC_USP7_MATH_1	456	460	PF00917	0.590
DOC_USP7_MATH_1	482	486	PF00917	0.750
DOC_USP7_MATH_1	512	516	PF00917	0.723
DOC_USP7_MATH_1	522	526	PF00917	0.592
DOC_USP7_MATH_1	540	544	PF00917	0.501
DOC_USP7_MATH_1	554	558	PF00917	0.687
DOC_USP7_UBL2_3	174	178	PF12436	0.248
DOC_USP7_UBL2_3	278	282	PF12436	0.651
DOC_USP7_UBL2_3	6	10	PF12436	0.345
DOC_WW_Pin1_4	139	144	PF00397	0.401
DOC_WW_Pin1_4	159	164	PF00397	0.132
DOC_WW_Pin1_4	181	186	PF00397	0.445
DOC_WW_Pin1_4	199	204	PF00397	0.237
DOC_WW_Pin1_4	260	265	PF00397	0.717
DOC_WW_Pin1_4	333	338	PF00397	0.339
DOC_WW_Pin1_4	452	457	PF00397	0.659
DOC_WW_Pin1_4	475	480	PF00397	0.708
DOC_WW_Pin1_4	502	507	PF00397	0.723
LIG_14-3-3_CanoR_1	365	372	PF00244	0.397
LIG_14-3-3_CanoR_1	481	487	PF00244	0.737
LIG_Actin_WH2_2	349	367	PF00022	0.377
LIG_BRCT_BRCA1_1	240	244	PF00533	0.675
LIG_FHA_1	111	117	PF00498	0.336
LIG_FHA_1	124	130	PF00498	0.288
LIG_FHA_1	448	454	PF00498	0.688
LIG_FHA_1	65	71	PF00498	0.403
LIG_FHA_2	254	260	PF00498	0.720
LIG_FHA_2	293	299	PF00498	0.304
LIG_FHA_2	303	309	PF00498	0.307
LIG_FHA_2	365	371	PF00498	0.377
LIG_FHA_2	429	435	PF00498	0.744
LIG_FHA_2	563	569	PF00498	0.731
LIG_LIR_Apic_2	202	208	PF02991	0.321
LIG_LIR_Apic_2	270	276	PF02991	0.666
LIG_LIR_Apic_2	35	41	PF02991	0.462
LIG_LIR_Gen_1	305	315	PF02991	0.321
LIG_LIR_Gen_1	352	360	PF02991	0.357
LIG_LIR_Gen_1	525	535	PF02991	0.677
LIG_LIR_Gen_1	568	576	PF02991	0.641
LIG_LIR_Nem_3	271	277	PF02991	0.612
LIG_LIR_Nem_3	305	310	PF02991	0.321
LIG_LIR_Nem_3	352	356	PF02991	0.338
LIG_LIR_Nem_3	431	436	PF02991	0.662
LIG_LIR_Nem_3	525	531	PF02991	0.668
LIG_LIR_Nem_3	568	572	PF02991	0.618
LIG_MYND_1	375	379	PF01753	0.457
LIG_Pex14_2	244	248	PF04695	0.676
LIG_SH2_CRK	274	278	PF00017	0.629
LIG_SH2_CRK	528	532	PF00017	0.664
LIG_SH2_GRB2like	273	276	PF00017	0.648
LIG_SH2_NCK_1	307	311	PF00017	0.393
LIG_SH2_STAP1	112	116	PF00017	0.321
LIG_SH2_STAP1	293	297	PF00017	0.321
LIG_SH2_STAP1	360	364	PF00017	0.420
LIG_SH2_STAT5	112	115	PF00017	0.211
LIG_SH2_STAT5	122	125	PF00017	0.272
LIG_SH2_STAT5	195	198	PF00017	0.420
LIG_SH2_STAT5	293	296	PF00017	0.308
LIG_SH2_STAT5	88	91	PF00017	0.345
LIG_SH2_STAT5	96	99	PF00017	0.337
LIG_SH3_3	160	166	PF00018	0.420
LIG_SH3_3	197	203	PF00018	0.321
LIG_SH3_3	335	341	PF00018	0.322
LIG_SH3_3	442	448	PF00018	0.681
LIG_SH3_3	450	456	PF00018	0.655
LIG_SH3_4	396	403	PF00018	0.665
LIG_TYR_ITSM	303	310	PF00017	0.377
LIG_WRC_WIRS_1	350	355	PF05994	0.406
LIG_WW_1	265	268	PF00397	0.712
MOD_CDC14_SPxK_1	478	481	PF00782	0.711
MOD_CDK_SPK_2	181	186	PF00069	0.365
MOD_CDK_SPK_2	475	480	PF00069	0.572
MOD_CDK_SPxK_1	159	165	PF00069	0.287
MOD_CDK_SPxK_1	475	481	PF00069	0.711
MOD_CDK_SPxxK_3	139	146	PF00069	0.401
MOD_CDK_SPxxK_3	181	188	PF00069	0.365
MOD_CK1_1	269	275	PF00069	0.551
MOD_CK1_1	455	461	PF00069	0.669
MOD_CK1_1	497	503	PF00069	0.757
MOD_CK1_1	505	511	PF00069	0.674
MOD_CK1_1	514	520	PF00069	0.642
MOD_CK1_1	543	549	PF00069	0.685
MOD_CK1_1	561	567	PF00069	0.529
MOD_CK1_1	90	96	PF00069	0.420
MOD_CK2_1	240	246	PF00069	0.720
MOD_CK2_1	302	308	PF00069	0.314
MOD_CK2_1	364	370	PF00069	0.345
MOD_CK2_1	389	395	PF00069	0.771
MOD_CK2_1	514	520	PF00069	0.670
MOD_CK2_1	562	568	PF00069	0.729
MOD_Cter_Amidation	403	406	PF01082	0.564
MOD_GlcNHglycan	240	243	PF01048	0.692
MOD_GlcNHglycan	250	253	PF01048	0.726
MOD_GlcNHglycan	259	263	PF01048	0.699
MOD_GlcNHglycan	295	298	PF01048	0.340
MOD_GlcNHglycan	323	326	PF01048	0.376
MOD_GlcNHglycan	346	349	PF01048	0.389
MOD_GlcNHglycan	385	388	PF01048	0.710
MOD_GlcNHglycan	391	394	PF01048	0.672
MOD_GlcNHglycan	409	412	PF01048	0.701
MOD_GlcNHglycan	458	461	PF01048	0.748
MOD_GlcNHglycan	466	469	PF01048	0.734
MOD_GlcNHglycan	491	494	PF01048	0.644
MOD_GlcNHglycan	496	499	PF01048	0.567
MOD_GlcNHglycan	542	545	PF01048	0.653
MOD_GlcNHglycan	548	551	PF01048	0.676
MOD_GlcNHglycan	89	92	PF01048	0.411
MOD_GSK3_1	195	202	PF00069	0.377
MOD_GSK3_1	238	245	PF00069	0.763
MOD_GSK3_1	287	294	PF00069	0.367
MOD_GSK3_1	298	305	PF00069	0.264
MOD_GSK3_1	447	454	PF00069	0.675
MOD_GSK3_1	487	494	PF00069	0.722
MOD_GSK3_1	507	514	PF00069	0.714
MOD_GSK3_1	554	561	PF00069	0.705
MOD_N-GLC_1	389	394	PF02516	0.699
MOD_N-GLC_2	229	231	PF02516	0.542
MOD_NEK2_1	123	128	PF00069	0.415
MOD_NEK2_1	253	258	PF00069	0.763
MOD_NEK2_1	267	272	PF00069	0.602
MOD_NEK2_1	364	369	PF00069	0.383
MOD_NEK2_1	489	494	PF00069	0.744
MOD_NEK2_1	562	567	PF00069	0.721
MOD_NEK2_2	428	433	PF00069	0.620
MOD_NEK2_2	482	487	PF00069	0.644
MOD_PKA_1	405	411	PF00069	0.785
MOD_PKA_2	364	370	PF00069	0.333
MOD_PKA_2	405	411	PF00069	0.657
MOD_PKA_2	482	488	PF00069	0.734
MOD_PKA_2	538	544	PF00069	0.678
MOD_Plk_2-3	349	355	PF00069	0.384
MOD_Plk_4	269	275	PF00069	0.648
MOD_Plk_4	276	282	PF00069	0.625
MOD_Plk_4	302	308	PF00069	0.321
MOD_Plk_4	349	355	PF00069	0.406
MOD_Plk_4	558	564	PF00069	0.669
MOD_ProDKin_1	139	145	PF00069	0.401
MOD_ProDKin_1	159	165	PF00069	0.132
MOD_ProDKin_1	181	187	PF00069	0.445
MOD_ProDKin_1	199	205	PF00069	0.237
MOD_ProDKin_1	260	266	PF00069	0.716
MOD_ProDKin_1	333	339	PF00069	0.339
MOD_ProDKin_1	452	458	PF00069	0.660
MOD_ProDKin_1	475	481	PF00069	0.711
MOD_ProDKin_1	502	508	PF00069	0.723
MOD_SUMO_rev_2	389	397	PF00179	0.661
TRG_DiLeu_BaEn_2	348	354	PF01217	0.462
TRG_DiLeu_BaEn_2	567	573	PF01217	0.673
TRG_DiLeu_BaLyEn_6	434	439	PF01217	0.718
TRG_ENDOCYTIC_2	20	23	PF00928	0.420
TRG_ENDOCYTIC_2	274	277	PF00928	0.579
TRG_ENDOCYTIC_2	307	310	PF00928	0.377
TRG_ENDOCYTIC_2	528	531	PF00928	0.655
TRG_ER_diArg_1	185	188	PF00400	0.423
TRG_ER_diArg_1	397	399	PF00400	0.797
TRG_ER_diArg_1	479	481	PF00400	0.788
TRG_ER_diArg_1	531	534	PF00400	0.648
TRG_NES_CRM1_1	118	133	PF08389	0.420

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8W2	Leptomonas seymouri	54%	96%
A0A0S4JI27	Bodo saltans	24%	80%
A0A1X0NYS1	Trypanosomatidae	41%	100%
A0A422P4L8	Trypanosoma rangeli	46%	100%
A4HEA1	Leishmania braziliensis	78%	98%
A4I1P7	Leishmania infantum	99%	100%
A4K2S1	Lemur catta	27%	100%
C9ZK98	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9AXT1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
P22216	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	70%
Q4Q9P0	Leishmania major	93%	100%
Q5ZJK4	Gallus gallus	26%	100%
Q99078	Ustilago maydis (strain 521 / FGSC 9021)	23%	100%
Q9JI11	Mus musculus	27%	100%