Cytochrome c oxidase assembly protein, putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cytochrome c oxidase assembly protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WZA4_LEIDO

TriTrypDb:

LdBPK_251890.1 , LdCL_250024600 , LDHU3_25.2330

Length:

282

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WZA4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WZA4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	240	242	PF00675	0.428
CLV_NRD_NRD_1	245	247	PF00675	0.429
CLV_NRD_NRD_1	26	28	PF00675	0.493
CLV_PCSK_KEX2_1	185	187	PF00082	0.448
CLV_PCSK_KEX2_1	240	242	PF00082	0.474
CLV_PCSK_KEX2_1	26	28	PF00082	0.495
CLV_PCSK_PC1ET2_1	185	187	PF00082	0.437
CLV_PCSK_SKI1_1	185	189	PF00082	0.441
CLV_PCSK_SKI1_1	192	196	PF00082	0.417
CLV_PCSK_SKI1_1	264	268	PF00082	0.492
CLV_PCSK_SKI1_1	72	76	PF00082	0.376
DEG_Nend_UBRbox_1	1	4	PF02207	0.690
DOC_CYCLIN_RxL_1	22	36	PF00134	0.443
DOC_MAPK_gen_1	24	32	PF00069	0.463
DOC_MAPK_RevD_3	226	241	PF00069	0.561
DOC_PP4_FxxP_1	166	169	PF00568	0.368
DOC_PP4_FxxP_1	248	251	PF00568	0.445
DOC_PP4_FxxP_1	9	12	PF00568	0.679
DOC_USP7_MATH_1	275	279	PF00917	0.529
DOC_USP7_MATH_1	76	80	PF00917	0.382
DOC_USP7_UBL2_3	188	192	PF12436	0.480
DOC_USP7_UBL2_3	221	225	PF12436	0.426
DOC_USP7_UBL2_3	24	28	PF12436	0.510
DOC_WW_Pin1_4	124	129	PF00397	0.509
LIG_14-3-3_CanoR_1	235	240	PF00244	0.533
LIG_14-3-3_CanoR_1	262	267	PF00244	0.563
LIG_BRCT_BRCA1_1	277	281	PF00533	0.525
LIG_deltaCOP1_diTrp_1	259	267	PF00928	0.483
LIG_EH1_1	37	45	PF00400	0.469
LIG_EVH1_2	168	172	PF00568	0.408
LIG_FHA_1	125	131	PF00498	0.482
LIG_FHA_1	142	148	PF00498	0.308
LIG_FHA_1	69	75	PF00498	0.454
LIG_FHA_1	91	97	PF00498	0.587
LIG_FHA_2	76	82	PF00498	0.479
LIG_LIR_Apic_2	163	169	PF02991	0.375
LIG_LIR_Apic_2	6	12	PF02991	0.630
LIG_LIR_Gen_1	113	124	PF02991	0.347
LIG_LIR_Gen_1	174	184	PF02991	0.465
LIG_LIR_Nem_3	113	119	PF02991	0.334
LIG_LIR_Nem_3	174	180	PF02991	0.406
LIG_LIR_Nem_3	242	248	PF02991	0.502
LIG_PCNA_PIPBox_1	227	236	PF02747	0.434
LIG_PCNA_yPIPBox_3	221	234	PF02747	0.411
LIG_PDZ_Class_3	277	282	PF00595	0.502
LIG_Pex14_2	244	248	PF04695	0.476
LIG_SH2_NCK_1	177	181	PF00017	0.522
LIG_SH2_STAT3	233	236	PF00017	0.441
LIG_SH2_STAT3	273	276	PF00017	0.622
LIG_SH2_STAT5	203	206	PF00017	0.431
LIG_SH2_STAT5	223	226	PF00017	0.461
LIG_SH2_STAT5	89	92	PF00017	0.379
LIG_SH3_3	145	151	PF00018	0.390
LIG_SH3_3	269	275	PF00018	0.631
LIG_SUMO_SIM_anti_2	93	100	PF11976	0.336
LIG_SUMO_SIM_par_1	210	217	PF11976	0.378
LIG_TRAF2_1	179	182	PF00917	0.283
LIG_TRAF2_1	79	82	PF00917	0.382
MOD_CDK_SPxxK_3	124	131	PF00069	0.522
MOD_CK2_1	75	81	PF00069	0.396
MOD_GlcNHglycan	13	16	PF01048	0.605
MOD_GlcNHglycan	156	159	PF01048	0.369
MOD_GlcNHglycan	204	207	PF01048	0.370
MOD_GlcNHglycan	3	6	PF01048	0.753
MOD_GlcNHglycan	46	49	PF01048	0.554
MOD_GSK3_1	235	242	PF00069	0.467
MOD_GSK3_1	49	56	PF00069	0.567
MOD_N-GLC_1	104	109	PF02516	0.403
MOD_N-GLC_2	104	106	PF02516	0.455
MOD_NEK2_1	202	207	PF00069	0.412
MOD_NEK2_1	239	244	PF00069	0.556
MOD_NEK2_1	44	49	PF00069	0.550
MOD_PK_1	262	268	PF00069	0.530
MOD_PKA_2	1	7	PF00069	0.657
MOD_PKA_2	239	245	PF00069	0.467
MOD_Plk_4	39	45	PF00069	0.483
MOD_ProDKin_1	124	130	PF00069	0.501
MOD_SUMO_for_1	187	190	PF00179	0.470
MOD_SUMO_rev_2	163	169	PF00179	0.357
MOD_SUMO_rev_2	181	187	PF00179	0.535
TRG_DiLeu_BaEn_4	182	188	PF01217	0.284
TRG_ENDOCYTIC_2	177	180	PF00928	0.434
TRG_ENDOCYTIC_2	245	248	PF00928	0.540
TRG_ER_diArg_1	239	241	PF00400	0.437
TRG_ER_diArg_1	261	264	PF00400	0.600
TRG_NLS_MonoExtC_3	184	190	PF00514	0.463

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8J2	Leptomonas seymouri	81%	100%
A0A0S4ITS5	Bodo saltans	60%	100%
A0A1X0NY80	Trypanosomatidae	70%	100%
A4HEI9	Leishmania braziliensis	88%	100%
A4I1M9	Leishmania infantum	99%	100%
C9ZK74	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	68%	99%
E9AXR3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4Q9Q8	Leishmania major	96%	100%
V5BHW7	Trypanosoma cruzi	68%	100%