Protein kinase domain family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

casein kinase I, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WZA2_LEIDO

TriTrypDb:

LdBPK_251640.1 , LdCL_250022100 , LDHU3_25.2080

Length:

518

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 2
Pissara et al.	yes	yes: 18

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 4

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

A0A3S7WZA2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WZA2

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	15
GO:0006793	phosphorus metabolic process	3	15
GO:0006796	phosphate-containing compound metabolic process	4	15
GO:0006807	nitrogen compound metabolic process	2	15
GO:0008152	metabolic process	1	15
GO:0009987	cellular process	1	15
GO:0016310	phosphorylation	5	15
GO:0019538	protein metabolic process	3	15
GO:0036211	protein modification process	4	15
GO:0043170	macromolecule metabolic process	3	15
GO:0043412	macromolecule modification	4	15
GO:0044237	cellular metabolic process	2	15
GO:0044238	primary metabolic process	2	15
GO:0071704	organic substance metabolic process	2	15
GO:1901564	organonitrogen compound metabolic process	3	15
GO:0006810	transport	3	2
GO:0006897	endocytosis	5	2
GO:0007165	signal transduction	2	2
GO:0016192	vesicle-mediated transport	4	2
GO:0018105	peptidyl-serine phosphorylation	6	2
GO:0018193	peptidyl-amino acid modification	5	2
GO:0018209	peptidyl-serine modification	6	2
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0065007	biological regulation	1	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	15
GO:0003824	catalytic activity	1	15
GO:0004672	protein kinase activity	3	15
GO:0005488	binding	1	15
GO:0005524	ATP binding	5	15
GO:0016301	kinase activity	4	15
GO:0016740	transferase activity	2	15
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	15
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	15
GO:0017076	purine nucleotide binding	4	15
GO:0030554	adenyl nucleotide binding	5	15
GO:0032553	ribonucleotide binding	3	15
GO:0032555	purine ribonucleotide binding	4	15
GO:0032559	adenyl ribonucleotide binding	5	15
GO:0035639	purine ribonucleoside triphosphate binding	4	15
GO:0036094	small molecule binding	2	15
GO:0043167	ion binding	2	15
GO:0043168	anion binding	3	15
GO:0097159	organic cyclic compound binding	2	15
GO:0097367	carbohydrate derivative binding	2	15
GO:0140096	catalytic activity, acting on a protein	2	15
GO:1901265	nucleoside phosphate binding	3	15
GO:1901363	heterocyclic compound binding	2	15
GO:0004674	protein serine/threonine kinase activity	4	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	124	126	PF00675	0.575
CLV_NRD_NRD_1	169	171	PF00675	0.391
CLV_NRD_NRD_1	263	265	PF00675	0.405
CLV_NRD_NRD_1	341	343	PF00675	0.564
CLV_NRD_NRD_1	409	411	PF00675	0.649
CLV_NRD_NRD_1	53	55	PF00675	0.484
CLV_PCSK_KEX2_1	169	171	PF00082	0.377
CLV_PCSK_KEX2_1	263	265	PF00082	0.405
CLV_PCSK_KEX2_1	341	343	PF00082	0.525
CLV_PCSK_KEX2_1	349	351	PF00082	0.523
CLV_PCSK_KEX2_1	409	411	PF00082	0.649
CLV_PCSK_KEX2_1	447	449	PF00082	0.534
CLV_PCSK_KEX2_1	453	455	PF00082	0.564
CLV_PCSK_KEX2_1	503	505	PF00082	0.638
CLV_PCSK_PC1ET2_1	349	351	PF00082	0.515
CLV_PCSK_PC1ET2_1	447	449	PF00082	0.534
CLV_PCSK_PC1ET2_1	453	455	PF00082	0.564
CLV_PCSK_PC1ET2_1	503	505	PF00082	0.638
CLV_PCSK_PC7_1	345	351	PF00082	0.454
CLV_PCSK_SKI1_1	174	178	PF00082	0.353
CLV_PCSK_SKI1_1	198	202	PF00082	0.457
CLV_PCSK_SKI1_1	21	25	PF00082	0.413
CLV_PCSK_SKI1_1	242	246	PF00082	0.398
CLV_PCSK_SKI1_1	295	299	PF00082	0.405
CLV_PCSK_SKI1_1	303	307	PF00082	0.376
CLV_PCSK_SKI1_1	317	321	PF00082	0.473
CLV_PCSK_SKI1_1	341	345	PF00082	0.473
CLV_PCSK_SKI1_1	504	508	PF00082	0.607
CLV_PCSK_SKI1_1	85	89	PF00082	0.567
DEG_APCC_DBOX_1	169	177	PF00400	0.377
DEG_APCC_DBOX_1	263	271	PF00400	0.428
DEG_SCF_FBW7_2	304	310	PF00400	0.343
DOC_CKS1_1	304	309	PF01111	0.443
DOC_CKS1_1	414	419	PF01111	0.635
DOC_CYCLIN_RxL_1	324	332	PF00134	0.469
DOC_CYCLIN_RxL_1	345	354	PF00134	0.420
DOC_CYCLIN_yCln2_LP_2	379	385	PF00134	0.632
DOC_MAPK_gen_1	125	132	PF00069	0.514
DOC_MAPK_gen_1	210	218	PF00069	0.379
DOC_MAPK_gen_1	231	238	PF00069	0.348
DOC_MAPK_gen_1	349	355	PF00069	0.497
DOC_MAPK_gen_1	42	52	PF00069	0.457
DOC_MAPK_MEF2A_6	125	134	PF00069	0.480
DOC_MAPK_MEF2A_6	43	52	PF00069	0.452
DOC_PP1_RVXF_1	223	229	PF00149	0.377
DOC_PP1_RVXF_1	325	332	PF00149	0.461
DOC_PP2B_LxvP_1	353	356	PF13499	0.462
DOC_PP2B_LxvP_1	379	382	PF13499	0.600
DOC_PP4_FxxP_1	414	417	PF00568	0.610
DOC_PP4_FxxP_1	507	510	PF00568	0.614
DOC_USP7_MATH_1	2	6	PF00917	0.628
DOC_USP7_MATH_1	373	377	PF00917	0.725
DOC_USP7_MATH_1	392	396	PF00917	0.628
DOC_USP7_MATH_1	471	475	PF00917	0.617
DOC_USP7_MATH_1	499	503	PF00917	0.880
DOC_USP7_MATH_1	89	93	PF00917	0.566
DOC_USP7_UBL2_3	313	317	PF12436	0.614
DOC_USP7_UBL2_3	51	55	PF12436	0.439
DOC_WW_Pin1_4	106	111	PF00397	0.615
DOC_WW_Pin1_4	303	308	PF00397	0.441
DOC_WW_Pin1_4	388	393	PF00397	0.593
DOC_WW_Pin1_4	413	418	PF00397	0.632
DOC_WW_Pin1_4	506	511	PF00397	0.649
LIG_14-3-3_CanoR_1	125	129	PF00244	0.575
LIG_14-3-3_CanoR_1	169	174	PF00244	0.395
LIG_14-3-3_CanoR_1	327	332	PF00244	0.513
LIG_14-3-3_CanoR_1	350	356	PF00244	0.463
LIG_14-3-3_CanoR_1	396	401	PF00244	0.645
LIG_14-3-3_CanoR_1	409	413	PF00244	0.602
LIG_14-3-3_CanoR_1	475	481	PF00244	0.554
LIG_14-3-3_CanoR_1	504	510	PF00244	0.588
LIG_AP2alpha_1	33	37	PF02296	0.462
LIG_APCC_ABBAyCdc20_2	193	199	PF00400	0.377
LIG_BIR_II_1	1	5	PF00653	0.609
LIG_BRCT_BRCA1_1	268	272	PF00533	0.377
LIG_BRCT_BRCA1_1	327	331	PF00533	0.449
LIG_BRCT_BRCA1_1	361	365	PF00533	0.567
LIG_BRCT_BRCA1_1	410	414	PF00533	0.616
LIG_deltaCOP1_diTrp_1	439	445	PF00928	0.516
LIG_FHA_1	294	300	PF00498	0.418
LIG_FHA_2	304	310	PF00498	0.343
LIG_FHA_2	425	431	PF00498	0.665
LIG_FHA_2	490	496	PF00498	0.606
LIG_FHA_2	9	15	PF00498	0.519
LIG_LIR_Apic_2	411	417	PF02991	0.608
LIG_LIR_Gen_1	145	155	PF02991	0.463
LIG_LIR_Gen_1	269	278	PF02991	0.529
LIG_LIR_Gen_1	336	344	PF02991	0.443
LIG_LIR_Gen_1	439	450	PF02991	0.550
LIG_LIR_Nem_3	224	230	PF02991	0.348
LIG_LIR_Nem_3	269	275	PF02991	0.473
LIG_LIR_Nem_3	318	322	PF02991	0.591
LIG_LIR_Nem_3	32	36	PF02991	0.567
LIG_LIR_Nem_3	336	340	PF02991	0.355
LIG_LIR_Nem_3	439	445	PF02991	0.564
LIG_LIR_Nem_3	66	72	PF02991	0.480
LIG_LYPXL_yS_3	59	62	PF13949	0.476
LIG_MYND_3	425	429	PF01753	0.613
LIG_Pex14_2	33	37	PF04695	0.580
LIG_PTB_Apo_2	27	34	PF02174	0.484
LIG_SH2_CRK	337	341	PF00017	0.548
LIG_SH2_CRK	69	73	PF00017	0.474
LIG_SH2_STAP1	438	442	PF00017	0.547
LIG_SH2_STAP1	64	68	PF00017	0.443
LIG_SH2_STAT5	141	144	PF00017	0.424
LIG_SH2_STAT5	166	169	PF00017	0.334
LIG_SH2_STAT5	189	192	PF00017	0.424
LIG_SH2_STAT5	217	220	PF00017	0.466
LIG_SH2_STAT5	250	253	PF00017	0.405
LIG_SH2_STAT5	276	279	PF00017	0.403
LIG_SH2_STAT5	322	325	PF00017	0.459
LIG_SH3_2	510	515	PF14604	0.578
LIG_SH3_3	131	137	PF00018	0.448
LIG_SH3_3	372	378	PF00018	0.611
LIG_SH3_3	507	513	PF00018	0.650
LIG_SUMO_SIM_anti_2	129	134	PF11976	0.440
LIG_SUMO_SIM_par_1	175	181	PF11976	0.440
LIG_SUMO_SIM_par_1	393	405	PF11976	0.774
LIG_TRAF2_1	307	310	PF00917	0.374
LIG_UBA3_1	343	349	PF00899	0.421
MOD_CK1_1	106	112	PF00069	0.606
MOD_CK1_1	172	178	PF00069	0.400
MOD_CK1_1	399	405	PF00069	0.689
MOD_CK1_1	408	414	PF00069	0.629
MOD_CK1_1	474	480	PF00069	0.656
MOD_CK1_1	63	69	PF00069	0.400
MOD_CK1_1	92	98	PF00069	0.591
MOD_CK2_1	303	309	PF00069	0.371
MOD_CK2_1	8	14	PF00069	0.687
MOD_Cter_Amidation	347	350	PF01082	0.400
MOD_GlcNHglycan	361	364	PF01048	0.742
MOD_GlcNHglycan	469	472	PF01048	0.605
MOD_GlcNHglycan	497	500	PF01048	0.729
MOD_GSK3_1	113	120	PF00069	0.615
MOD_GSK3_1	124	131	PF00069	0.544
MOD_GSK3_1	299	306	PF00069	0.348
MOD_GSK3_1	325	332	PF00069	0.419
MOD_GSK3_1	383	390	PF00069	0.714
MOD_GSK3_1	392	399	PF00069	0.803
MOD_GSK3_1	401	408	PF00069	0.758
MOD_GSK3_1	467	474	PF00069	0.590
MOD_GSK3_1	495	502	PF00069	0.748
MOD_N-GLC_1	106	111	PF02516	0.608
MOD_N-GLC_1	117	122	PF02516	0.573
MOD_N-GLC_1	29	34	PF02516	0.486
MOD_N-GLC_1	368	373	PF02516	0.705
MOD_N-GLC_1	488	493	PF02516	0.621
MOD_N-GLC_1	92	97	PF02516	0.609
MOD_N-GLC_2	165	167	PF02516	0.329
MOD_N-GLC_2	321	323	PF02516	0.348
MOD_N-GLC_2	364	366	PF02516	0.586
MOD_NEK2_1	128	133	PF00069	0.499
MOD_NEK2_1	22	27	PF00069	0.464
MOD_NEK2_1	244	249	PF00069	0.446
MOD_NEK2_1	259	264	PF00069	0.343
MOD_NEK2_1	329	334	PF00069	0.473
MOD_NEK2_1	351	356	PF00069	0.594
MOD_NEK2_1	488	493	PF00069	0.795
MOD_PIKK_1	329	335	PF00454	0.408
MOD_PIKK_1	464	470	PF00454	0.554
MOD_PIKK_1	489	495	PF00454	0.616
MOD_PK_1	396	402	PF00069	0.646
MOD_PKA_1	169	175	PF00069	0.392
MOD_PKA_1	231	237	PF00069	0.348
MOD_PKA_2	124	130	PF00069	0.570
MOD_PKA_2	169	175	PF00069	0.382
MOD_PKA_2	408	414	PF00069	0.676
MOD_PKA_2	474	480	PF00069	0.566
MOD_Plk_1	128	134	PF00069	0.498
MOD_Plk_1	402	408	PF00069	0.625
MOD_Plk_1	92	98	PF00069	0.596
MOD_Plk_4	172	178	PF00069	0.435
MOD_Plk_4	396	402	PF00069	0.759
MOD_Plk_4	92	98	PF00069	0.587
MOD_ProDKin_1	106	112	PF00069	0.616
MOD_ProDKin_1	303	309	PF00069	0.441
MOD_ProDKin_1	388	394	PF00069	0.594
MOD_ProDKin_1	413	419	PF00069	0.631
MOD_ProDKin_1	506	512	PF00069	0.648
MOD_SUMO_for_1	200	203	PF00179	0.370
MOD_SUMO_for_1	50	53	PF00179	0.470
MOD_SUMO_rev_2	35	44	PF00179	0.417
MOD_SUMO_rev_2	63	68	PF00179	0.402
TRG_DiLeu_BaEn_2	267	273	PF01217	0.329
TRG_DiLeu_BaLyEn_6	393	398	PF01217	0.638
TRG_ENDOCYTIC_2	148	151	PF00928	0.411
TRG_ENDOCYTIC_2	227	230	PF00928	0.348
TRG_ENDOCYTIC_2	337	340	PF00928	0.443
TRG_ENDOCYTIC_2	59	62	PF00928	0.494
TRG_ENDOCYTIC_2	69	72	PF00928	0.496
TRG_ER_diArg_1	169	171	PF00400	0.377
TRG_ER_diArg_1	340	342	PF00400	0.456
TRG_ER_diArg_1	515	518	PF00400	0.606
TRG_NLS_Bipartite_1	42	59	PF00514	0.434
TRG_NLS_MonoExtN_4	54	59	PF00514	0.482
TRG_Pf-PMV_PEXEL_1	341	346	PF00026	0.476
TRG_Pf-PMV_PEXEL_1	70	74	PF00026	0.471

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3F5	Leptomonas seymouri	40%	100%
A0A0N1I2H3	Leptomonas seymouri	31%	100%
A0A0N1IKB0	Leptomonas seymouri	31%	91%
A0A1X0NZS9	Trypanosomatidae	46%	100%
A0A3Q8IJ66	Leishmania donovani	46%	100%
A0A3Q8ISA0	Leishmania donovani	42%	100%
A0A3R7K1Y6	Trypanosoma rangeli	27%	78%
A0A3S7WNZ6	Leishmania donovani	33%	100%
A0A422NL83	Trypanosoma rangeli	52%	100%
A4H436	Leishmania braziliensis	33%	100%
A4HEI6	Leishmania braziliensis	79%	99%
A4HFV0	Leishmania braziliensis	31%	93%
A4HMD1	Leishmania braziliensis	46%	100%
A4HSC0	Leishmania infantum	33%	100%
A4I1K4	Leishmania infantum	100%	100%
A4I638	Leishmania infantum	42%	100%
A4IAZ8	Leishmania infantum	46%	100%
A7E3X2	Bos taurus	42%	100%
C9ZK43	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
C9ZM31	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	75%
E9AKA2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
E9AXN8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
E9AZ78	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9B1C3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
E9B5Y1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
O96999	Leishmania major	32%	100%
P39962	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	34%	99%
Q4Q6U1	Leishmania major	41%	100%
Q4Q9T3	Leishmania major	93%	97%
Q62761	Rattus norvegicus	41%	100%
Q8BN21	Mus musculus	28%	100%
Q8BTH8	Mus musculus	41%	100%
Q9NHE1	Leishmania major	46%	100%