Structure-specific endonuclease subunit SLX1 homolog

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

GIY-YIG catalytic domain containing protein, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WZ95_LEIDO

TriTrypDb:

LdBPK_251370.1 , LdCL_250019300 , LDHU3_25.1710

Length:

705

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	7
GO:0033557	Slx1-Slx4 complex	3	7
GO:0140513	nuclear protein-containing complex	2	7

Expansion

Sequence features

A0A3S7WZ95

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WZ95

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006259	DNA metabolic process	4	7
GO:0006281	DNA repair	5	7
GO:0006310	DNA recombination	5	7
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0006950	response to stress	2	7
GO:0006974	DNA damage response	4	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0033554	cellular response to stress	3	7
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0043170	macromolecule metabolic process	3	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0044260	obsolete cellular macromolecule metabolic process	3	7
GO:0046483	heterocycle metabolic process	3	7
GO:0050896	response to stimulus	1	7
GO:0051716	cellular response to stimulus	2	7
GO:0071704	organic substance metabolic process	2	7
GO:0090304	nucleic acid metabolic process	4	7
GO:1901360	organic cyclic compound metabolic process	3	7
GO:0000724	double-strand break repair via homologous recombination	7	1
GO:0000725	recombinational repair	6	1
GO:0006302	double-strand break repair	6	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004518	nuclease activity	4	7
GO:0004519	endonuclease activity	5	7
GO:0004520	DNA endonuclease activity	5	7
GO:0004536	DNA nuclease activity	4	7
GO:0016787	hydrolase activity	2	7
GO:0016788	hydrolase activity, acting on ester bonds	3	7
GO:0016888	endodeoxyribonuclease activity, producing 5'-phosphomonoesters	6	7
GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	7
GO:0017108	5'-flap endonuclease activity	7	7
GO:0048256	flap endonuclease activity	6	7
GO:0140097	catalytic activity, acting on DNA	3	7
GO:0140640	catalytic activity, acting on a nucleic acid	2	7
GO:0005488	binding	1	2
GO:0008821	crossover junction DNA endonuclease activity	7	1
GO:0016889	DNA endonuclease activity, producing 3'-phosphomonoesters	6	1
GO:0016894	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters	6	1
GO:0043167	ion binding	2	2
GO:0043169	cation binding	3	2
GO:0046872	metal ion binding	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	193	197	PF00656	0.619
CLV_NRD_NRD_1	144	146	PF00675	0.543
CLV_NRD_NRD_1	302	304	PF00675	0.720
CLV_NRD_NRD_1	32	34	PF00675	0.346
CLV_NRD_NRD_1	46	48	PF00675	0.346
CLV_NRD_NRD_1	50	52	PF00675	0.346
CLV_NRD_NRD_1	513	515	PF00675	0.600
CLV_NRD_NRD_1	547	549	PF00675	0.571
CLV_NRD_NRD_1	554	556	PF00675	0.521
CLV_NRD_NRD_1	618	620	PF00675	0.768
CLV_NRD_NRD_1	97	99	PF00675	0.480
CLV_PCSK_KEX2_1	143	145	PF00082	0.545
CLV_PCSK_KEX2_1	302	304	PF00082	0.720
CLV_PCSK_KEX2_1	32	34	PF00082	0.346
CLV_PCSK_KEX2_1	46	48	PF00082	0.346
CLV_PCSK_KEX2_1	50	52	PF00082	0.346
CLV_PCSK_KEX2_1	513	515	PF00082	0.600
CLV_PCSK_KEX2_1	541	543	PF00082	0.514
CLV_PCSK_KEX2_1	547	549	PF00082	0.538
CLV_PCSK_KEX2_1	554	556	PF00082	0.511
CLV_PCSK_KEX2_1	573	575	PF00082	0.606
CLV_PCSK_KEX2_1	618	620	PF00082	0.772
CLV_PCSK_KEX2_1	97	99	PF00082	0.480
CLV_PCSK_PC1ET2_1	541	543	PF00082	0.558
CLV_PCSK_PC1ET2_1	573	575	PF00082	0.637
CLV_PCSK_PC7_1	46	52	PF00082	0.346
CLV_PCSK_SKI1_1	145	149	PF00082	0.546
CLV_PCSK_SKI1_1	229	233	PF00082	0.535
CLV_PCSK_SKI1_1	241	245	PF00082	0.630
CLV_PCSK_SKI1_1	537	541	PF00082	0.510
CLV_PCSK_SKI1_1	68	72	PF00082	0.346
DEG_APCC_DBOX_1	469	477	PF00400	0.452
DEG_Nend_UBRbox_2	1	3	PF02207	0.567
DEG_SPOP_SBC_1	401	405	PF00917	0.590
DOC_CKS1_1	180	185	PF01111	0.672
DOC_CKS1_1	215	220	PF01111	0.655
DOC_CYCLIN_yCln2_LP_2	212	215	PF00134	0.525
DOC_MAPK_DCC_7	241	250	PF00069	0.599
DOC_MAPK_gen_1	537	545	PF00069	0.554
DOC_MAPK_gen_1	85	92	PF00069	0.565
DOC_MAPK_MEF2A_6	241	250	PF00069	0.599
DOC_PP2B_LxvP_1	212	215	PF13499	0.525
DOC_PP2B_LxvP_1	243	246	PF13499	0.639
DOC_PP4_FxxP_1	360	363	PF00568	0.803
DOC_USP7_MATH_1	187	191	PF00917	0.693
DOC_USP7_MATH_1	268	272	PF00917	0.681
DOC_USP7_MATH_1	293	297	PF00917	0.787
DOC_USP7_MATH_1	347	351	PF00917	0.712
DOC_USP7_MATH_1	356	360	PF00917	0.669
DOC_USP7_MATH_1	366	370	PF00917	0.606
DOC_USP7_MATH_1	385	389	PF00917	0.508
DOC_USP7_MATH_1	401	405	PF00917	0.570
DOC_USP7_MATH_1	459	463	PF00917	0.491
DOC_USP7_MATH_1	622	626	PF00917	0.739
DOC_USP7_MATH_1	640	644	PF00917	0.571
DOC_USP7_MATH_1	645	649	PF00917	0.794
DOC_USP7_MATH_1	656	660	PF00917	0.617
DOC_USP7_MATH_1	684	688	PF00917	0.723
DOC_USP7_MATH_1	80	84	PF00917	0.546
DOC_USP7_UBL2_3	537	541	PF12436	0.543
DOC_WW_Pin1_4	155	160	PF00397	0.795
DOC_WW_Pin1_4	179	184	PF00397	0.684
DOC_WW_Pin1_4	214	219	PF00397	0.648
DOC_WW_Pin1_4	312	317	PF00397	0.744
DOC_WW_Pin1_4	323	328	PF00397	0.710
DOC_WW_Pin1_4	343	348	PF00397	0.654
DOC_WW_Pin1_4	359	364	PF00397	0.786
DOC_WW_Pin1_4	367	372	PF00397	0.709
DOC_WW_Pin1_4	402	407	PF00397	0.716
DOC_WW_Pin1_4	494	499	PF00397	0.782
DOC_WW_Pin1_4	507	512	PF00397	0.655
DOC_WW_Pin1_4	623	628	PF00397	0.755
DOC_WW_Pin1_4	643	648	PF00397	0.454
DOC_WW_Pin1_4	652	657	PF00397	0.814
DOC_WW_Pin1_4	658	663	PF00397	0.771
LIG_14-3-3_CanoR_1	111	115	PF00244	0.578
LIG_14-3-3_CanoR_1	155	159	PF00244	0.642
LIG_14-3-3_CanoR_1	169	174	PF00244	0.744
LIG_14-3-3_CanoR_1	320	329	PF00244	0.788
LIG_14-3-3_CanoR_1	358	363	PF00244	0.713
LIG_14-3-3_CanoR_1	367	371	PF00244	0.731
LIG_14-3-3_CanoR_1	372	377	PF00244	0.741
LIG_14-3-3_CanoR_1	46	54	PF00244	0.514
LIG_14-3-3_CanoR_1	470	480	PF00244	0.434
LIG_14-3-3_CanoR_1	574	580	PF00244	0.547
LIG_14-3-3_CanoR_1	608	613	PF00244	0.694
LIG_14-3-3_CanoR_1	623	627	PF00244	0.716
LIG_Actin_WH2_2	115	133	PF00022	0.274
LIG_BRCT_BRCA1_1	218	222	PF00533	0.522
LIG_Clathr_ClatBox_1	221	225	PF01394	0.525
LIG_deltaCOP1_diTrp_1	286	292	PF00928	0.783
LIG_deltaCOP1_diTrp_1	74	77	PF00928	0.546
LIG_FHA_1	103	109	PF00498	0.392
LIG_FHA_1	119	125	PF00498	0.277
LIG_FHA_1	180	186	PF00498	0.721
LIG_FHA_1	215	221	PF00498	0.587
LIG_FHA_1	448	454	PF00498	0.381
LIG_FHA_1	609	615	PF00498	0.664
LIG_FHA_2	10	16	PF00498	0.546
LIG_LIR_Apic_2	359	363	PF02991	0.794
LIG_LIR_Apic_2	699	705	PF02991	0.685
LIG_LIR_Apic_2	74	80	PF02991	0.546
LIG_LIR_Gen_1	113	122	PF02991	0.573
LIG_LIR_Gen_1	2	11	PF02991	0.411
LIG_LIR_Nem_3	113	118	PF02991	0.591
LIG_LIR_Nem_3	2	8	PF02991	0.480
LIG_LIR_Nem_3	21	26	PF02991	0.383
LIG_LIR_Nem_3	301	307	PF02991	0.632
LIG_LIR_Nem_3	422	426	PF02991	0.558
LIG_LYPXL_SIV_4	100	108	PF13949	0.536
LIG_MYND_1	214	218	PF01753	0.559
LIG_Pex14_2	73	77	PF04695	0.546
LIG_RPA_C_Fungi	543	555	PF08784	0.688
LIG_SH2_CRK	380	384	PF00017	0.520
LIG_SH2_NCK_1	101	105	PF00017	0.533
LIG_SH2_NCK_1	482	486	PF00017	0.578
LIG_SH2_SRC	482	485	PF00017	0.489
LIG_SH2_STAP1	274	278	PF00017	0.605
LIG_SH2_STAT5	23	26	PF00017	0.411
LIG_SH2_STAT5	236	239	PF00017	0.524
LIG_SH2_STAT5	307	310	PF00017	0.772
LIG_SH2_STAT5	380	383	PF00017	0.518
LIG_SH2_STAT5	460	463	PF00017	0.496
LIG_SH2_STAT5	9	12	PF00017	0.411
LIG_SH3_1	303	309	PF00018	0.712
LIG_SH3_1	514	520	PF00018	0.537
LIG_SH3_2	414	419	PF14604	0.605
LIG_SH3_2	508	513	PF14604	0.749
LIG_SH3_3	177	183	PF00018	0.685
LIG_SH3_3	212	218	PF00018	0.531
LIG_SH3_3	303	309	PF00018	0.799
LIG_SH3_3	360	366	PF00018	0.802
LIG_SH3_3	388	394	PF00018	0.681
LIG_SH3_3	411	417	PF00018	0.745
LIG_SH3_3	449	455	PF00018	0.494
LIG_SH3_3	502	508	PF00018	0.759
LIG_SH3_3	514	520	PF00018	0.420
LIG_SH3_3	621	627	PF00018	0.690
LIG_SH3_CIN85_PxpxPR_1	410	415	PF14604	0.734
LIG_SUMO_SIM_anti_2	275	280	PF11976	0.602
LIG_SUMO_SIM_par_1	690	696	PF11976	0.767
LIG_WRC_WIRS_1	357	362	PF05994	0.732
LIG_WRC_WIRS_1	635	640	PF05994	0.718
LIG_WW_1	377	380	PF00397	0.509
LIG_WW_2	183	186	PF00397	0.698
LIG_WW_3	364	368	PF00397	0.718
MOD_CDC14_SPxK_1	317	320	PF00782	0.758
MOD_CDC14_SPxK_1	510	513	PF00782	0.738
MOD_CDK_SPK_2	155	160	PF00069	0.795
MOD_CDK_SPK_2	367	372	PF00069	0.733
MOD_CDK_SPxK_1	314	320	PF00069	0.755
MOD_CDK_SPxK_1	507	513	PF00069	0.752
MOD_CDK_SPxxK_3	507	514	PF00069	0.711
MOD_CDK_SPxxK_3	658	665	PF00069	0.735
MOD_CK1_1	167	173	PF00069	0.825
MOD_CK1_1	262	268	PF00069	0.757
MOD_CK1_1	277	283	PF00069	0.655
MOD_CK1_1	288	294	PF00069	0.717
MOD_CK1_1	310	316	PF00069	0.743
MOD_CK1_1	346	352	PF00069	0.752
MOD_CK1_1	359	365	PF00069	0.608
MOD_CK1_1	370	376	PF00069	0.698
MOD_CK1_1	447	453	PF00069	0.375
MOD_CK1_1	625	631	PF00069	0.735
MOD_CK1_1	643	649	PF00069	0.571
MOD_CK1_1	661	667	PF00069	0.569
MOD_CK1_1	687	693	PF00069	0.674
MOD_CK2_1	187	193	PF00069	0.801
MOD_CK2_1	293	299	PF00069	0.807
MOD_DYRK1A_RPxSP_1	155	159	PF00069	0.694
MOD_DYRK1A_RPxSP_1	367	371	PF00069	0.672
MOD_DYRK1A_RPxSP_1	623	627	PF00069	0.811
MOD_GlcNHglycan	126	129	PF01048	0.501
MOD_GlcNHglycan	264	267	PF01048	0.796
MOD_GlcNHglycan	372	375	PF01048	0.702
MOD_GlcNHglycan	385	388	PF01048	0.675
MOD_GlcNHglycan	576	579	PF01048	0.530
MOD_GlcNHglycan	61	64	PF01048	0.411
MOD_GlcNHglycan	658	661	PF01048	0.727
MOD_GlcNHglycan	82	85	PF01048	0.607
MOD_GSK3_1	160	167	PF00069	0.794
MOD_GSK3_1	203	210	PF00069	0.749
MOD_GSK3_1	264	271	PF00069	0.712
MOD_GSK3_1	308	315	PF00069	0.730
MOD_GSK3_1	343	350	PF00069	0.654
MOD_GSK3_1	366	373	PF00069	0.733
MOD_GSK3_1	396	403	PF00069	0.613
MOD_GSK3_1	487	494	PF00069	0.635
MOD_GSK3_1	569	576	PF00069	0.680
MOD_GSK3_1	603	610	PF00069	0.772
MOD_GSK3_1	643	650	PF00069	0.710
MOD_GSK3_1	652	659	PF00069	0.664
MOD_GSK3_1	667	674	PF00069	0.815
MOD_LATS_1	571	577	PF00433	0.490
MOD_N-GLC_1	288	293	PF02516	0.675
MOD_N-GLC_1	383	388	PF02516	0.772
MOD_NEK2_1	118	123	PF00069	0.447
MOD_NEK2_1	154	159	PF00069	0.581
MOD_NEK2_1	203	208	PF00069	0.763
MOD_NEK2_1	264	269	PF00069	0.748
MOD_NEK2_2	102	107	PF00069	0.528
MOD_NEK2_2	465	470	PF00069	0.519
MOD_NEK2_2	603	608	PF00069	0.600
MOD_PIKK_1	160	166	PF00454	0.805
MOD_PIKK_1	277	283	PF00454	0.529
MOD_PIKK_1	499	505	PF00454	0.702
MOD_PIKK_1	515	521	PF00454	0.536
MOD_PKA_1	46	52	PF00069	0.367
MOD_PKA_1	573	579	PF00069	0.718
MOD_PKA_2	110	116	PF00069	0.576
MOD_PKA_2	154	160	PF00069	0.629
MOD_PKA_2	168	174	PF00069	0.665
MOD_PKA_2	366	372	PF00069	0.725
MOD_PKA_2	45	51	PF00069	0.411
MOD_PKA_2	573	579	PF00069	0.718
MOD_PKA_2	607	613	PF00069	0.819
MOD_PKA_2	622	628	PF00069	0.640
MOD_PKB_1	51	59	PF00069	0.411
MOD_PKB_1	581	589	PF00069	0.640
MOD_Plk_1	118	124	PF00069	0.434
MOD_Plk_1	274	280	PF00069	0.657
MOD_Plk_1	288	294	PF00069	0.698
MOD_Plk_1	687	693	PF00069	0.728
MOD_Plk_4	110	116	PF00069	0.576
MOD_Plk_4	216	222	PF00069	0.549
MOD_Plk_4	274	280	PF00069	0.603
MOD_Plk_4	531	537	PF00069	0.529
MOD_Plk_4	687	693	PF00069	0.742
MOD_ProDKin_1	155	161	PF00069	0.798
MOD_ProDKin_1	179	185	PF00069	0.684
MOD_ProDKin_1	214	220	PF00069	0.653
MOD_ProDKin_1	312	318	PF00069	0.744
MOD_ProDKin_1	323	329	PF00069	0.711
MOD_ProDKin_1	343	349	PF00069	0.653
MOD_ProDKin_1	359	365	PF00069	0.783
MOD_ProDKin_1	367	373	PF00069	0.707
MOD_ProDKin_1	402	408	PF00069	0.713
MOD_ProDKin_1	494	500	PF00069	0.784
MOD_ProDKin_1	507	513	PF00069	0.654
MOD_ProDKin_1	623	629	PF00069	0.753
MOD_ProDKin_1	643	649	PF00069	0.458
MOD_ProDKin_1	652	658	PF00069	0.814
MOD_SUMO_for_1	71	74	PF00179	0.411
TRG_DiLeu_BaEn_1	699	704	PF01217	0.623
TRG_DiLeu_BaEn_4	434	440	PF01217	0.633
TRG_DiLeu_BaEn_4	699	705	PF01217	0.648
TRG_DiLeu_BaLyEn_6	511	516	PF01217	0.602
TRG_ENDOCYTIC_2	380	383	PF00928	0.518
TRG_ENDOCYTIC_2	423	426	PF00928	0.593
TRG_ER_diArg_1	143	145	PF00400	0.520
TRG_ER_diArg_1	302	304	PF00400	0.720
TRG_ER_diArg_1	31	33	PF00400	0.411
TRG_ER_diArg_1	50	53	PF00400	0.411
TRG_ER_diArg_1	512	514	PF00400	0.627
TRG_ER_diArg_1	547	549	PF00400	0.613
TRG_ER_diArg_1	554	557	PF00400	0.600
TRG_ER_diArg_1	580	583	PF00400	0.681
TRG_ER_diArg_1	585	588	PF00400	0.626
TRG_ER_diArg_1	96	98	PF00400	0.481
TRG_NLS_MonoExtN_4	537	544	PF00514	0.549
TRG_Pf-PMV_PEXEL_1	32	36	PF00026	0.411

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7G5	Leptomonas seymouri	51%	100%
A4I1H7	Leishmania infantum	99%	100%
E9AIR5	Leishmania braziliensis	77%	100%
E9AXL2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q9W0	Leishmania major	90%	100%