Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WZ94_LEIDO

TriTrypDb:

LdBPK_251900.1 , LdCL_250024700 , LDHU3_25.2350

Length:

724

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	1
GO:0005930	axoneme	2	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A0A3S7WZ94

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WZ94

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	294	298	PF00656	0.705
CLV_C14_Caspase3-7	398	402	PF00656	0.635
CLV_C14_Caspase3-7	499	503	PF00656	0.663
CLV_C14_Caspase3-7	553	557	PF00656	0.653
CLV_NRD_NRD_1	112	114	PF00675	0.414
CLV_NRD_NRD_1	115	117	PF00675	0.393
CLV_NRD_NRD_1	123	125	PF00675	0.439
CLV_NRD_NRD_1	130	132	PF00675	0.389
CLV_NRD_NRD_1	135	137	PF00675	0.363
CLV_NRD_NRD_1	145	147	PF00675	0.412
CLV_NRD_NRD_1	170	172	PF00675	0.639
CLV_NRD_NRD_1	179	181	PF00675	0.639
CLV_NRD_NRD_1	254	256	PF00675	0.679
CLV_NRD_NRD_1	618	620	PF00675	0.722
CLV_NRD_NRD_1	638	640	PF00675	0.767
CLV_NRD_NRD_1	648	650	PF00675	0.754
CLV_NRD_NRD_1	98	100	PF00675	0.514
CLV_PCSK_FUR_1	113	117	PF00082	0.550
CLV_PCSK_FUR_1	252	256	PF00082	0.586
CLV_PCSK_KEX2_1	111	113	PF00082	0.544
CLV_PCSK_KEX2_1	115	117	PF00082	0.516
CLV_PCSK_KEX2_1	129	131	PF00082	0.393
CLV_PCSK_KEX2_1	135	137	PF00082	0.363
CLV_PCSK_KEX2_1	170	172	PF00082	0.624
CLV_PCSK_KEX2_1	254	256	PF00082	0.679
CLV_PCSK_KEX2_1	647	649	PF00082	0.821
CLV_PCSK_PC1ET2_1	647	649	PF00082	0.693
CLV_PCSK_PC7_1	107	113	PF00082	0.532
CLV_PCSK_PC7_1	131	137	PF00082	0.543
CLV_PCSK_SKI1_1	100	104	PF00082	0.507
CLV_PCSK_SKI1_1	130	134	PF00082	0.554
DEG_SCF_FBW7_2	688	693	PF00400	0.583
DEG_SPOP_SBC_1	229	233	PF00917	0.706
DEG_SPOP_SBC_1	314	318	PF00917	0.636
DEG_SPOP_SBC_1	652	656	PF00917	0.647
DOC_CDC14_PxL_1	61	69	PF14671	0.736
DOC_MAPK_MEF2A_6	3	10	PF00069	0.588
DOC_PP2B_PxIxI_1	5	11	PF00149	0.592
DOC_USP7_MATH_1	196	200	PF00917	0.786
DOC_USP7_MATH_1	235	239	PF00917	0.671
DOC_USP7_MATH_1	314	318	PF00917	0.648
DOC_USP7_MATH_1	381	385	PF00917	0.661
DOC_USP7_MATH_1	554	558	PF00917	0.658
DOC_USP7_MATH_1	615	619	PF00917	0.664
DOC_USP7_MATH_1	652	656	PF00917	0.649
DOC_USP7_MATH_1	657	661	PF00917	0.651
DOC_USP7_MATH_1	671	675	PF00917	0.682
DOC_USP7_MATH_1	683	687	PF00917	0.644
DOC_WW_Pin1_4	370	375	PF00397	0.646
DOC_WW_Pin1_4	46	51	PF00397	0.674
DOC_WW_Pin1_4	483	488	PF00397	0.694
DOC_WW_Pin1_4	610	615	PF00397	0.633
DOC_WW_Pin1_4	634	639	PF00397	0.704
DOC_WW_Pin1_4	686	691	PF00397	0.594
LIG_14-3-3_CanoR_1	12	17	PF00244	0.664
LIG_14-3-3_CanoR_1	158	162	PF00244	0.503
LIG_14-3-3_CanoR_1	239	248	PF00244	0.589
LIG_14-3-3_CanoR_1	37	45	PF00244	0.684
LIG_APCC_ABBA_1	82	87	PF00400	0.581
LIG_BIR_II_1	1	5	PF00653	0.656
LIG_BIR_III_2	534	538	PF00653	0.645
LIG_BIR_III_4	442	446	PF00653	0.683
LIG_FHA_1	172	178	PF00498	0.543
LIG_FHA_2	279	285	PF00498	0.686
LIG_FHA_2	415	421	PF00498	0.714
LIG_FHA_2	456	462	PF00498	0.658
LIG_FHA_2	529	535	PF00498	0.645
LIG_HCF-1_HBM_1	225	228	PF13415	0.707
LIG_KLC1_Yacidic_2	279	284	PF13176	0.658
LIG_LIR_Gen_1	19	30	PF02991	0.554
LIG_LIR_Nem_3	19	25	PF02991	0.596
LIG_LIR_Nem_3	55	61	PF02991	0.625
LIG_MYND_1	91	95	PF01753	0.532
LIG_REV1ctd_RIR_1	547	555	PF16727	0.622
LIG_SH2_STAP1	39	43	PF00017	0.687
LIG_SH2_STAP1	716	720	PF00017	0.648
LIG_SH2_STAT5	228	231	PF00017	0.706
LIG_SH2_STAT5	282	285	PF00017	0.664
LIG_SH2_STAT5	392	395	PF00017	0.688
LIG_SH2_STAT5	457	460	PF00017	0.726
LIG_SH3_1	170	176	PF00018	0.672
LIG_SH3_3	170	176	PF00018	0.672
LIG_SH3_3	267	273	PF00018	0.709
LIG_SH3_3	444	450	PF00018	0.790
LIG_SH3_3	608	614	PF00018	0.593
LIG_SH3_3	62	68	PF00018	0.621
LIG_SH3_3	656	662	PF00018	0.722
LIG_SH3_3	665	671	PF00018	0.643
LIG_SH3_3	7	13	PF00018	0.600
LIG_SH3_3	78	84	PF00018	0.479
LIG_TRAF2_1	276	279	PF00917	0.699
LIG_TRAF2_1	406	409	PF00917	0.691
LIG_TRAF2_1	413	416	PF00917	0.628
LIG_TRAF2_1	417	420	PF00917	0.634
LIG_TRAF2_1	458	461	PF00917	0.681
LIG_TRAF2_1	479	482	PF00917	0.722
LIG_TRAF2_1	76	79	PF00917	0.603
LIG_TRFH_1	72	76	PF08558	0.598
MOD_CDC14_SPxK_1	373	376	PF00782	0.643
MOD_CDC14_SPxK_1	637	640	PF00782	0.713
MOD_CDK_SPK_2	634	639	PF00069	0.664
MOD_CDK_SPxK_1	370	376	PF00069	0.646
MOD_CDK_SPxK_1	634	640	PF00069	0.707
MOD_CK1_1	166	172	PF00069	0.642
MOD_CK1_1	23	29	PF00069	0.691
MOD_CK1_1	231	237	PF00069	0.815
MOD_CK1_1	238	244	PF00069	0.611
MOD_CK1_1	306	312	PF00069	0.704
MOD_CK1_1	313	319	PF00069	0.638
MOD_CK1_1	359	365	PF00069	0.668
MOD_CK1_1	384	390	PF00069	0.647
MOD_CK1_1	433	439	PF00069	0.713
MOD_CK1_1	485	491	PF00069	0.734
MOD_CK1_1	56	62	PF00069	0.608
MOD_CK1_1	601	607	PF00069	0.707
MOD_CK1_1	618	624	PF00069	0.678
MOD_CK1_1	651	657	PF00069	0.688
MOD_CK1_1	666	672	PF00069	0.549
MOD_CK1_1	673	679	PF00069	0.647
MOD_CK1_1	686	692	PF00069	0.534
MOD_CK2_1	414	420	PF00069	0.659
MOD_CK2_1	423	429	PF00069	0.611
MOD_CK2_1	455	461	PF00069	0.670
MOD_CK2_1	673	679	PF00069	0.701
MOD_DYRK1A_RPxSP_1	46	50	PF00069	0.674
MOD_GlcNHglycan	181	184	PF01048	0.774
MOD_GlcNHglycan	233	236	PF01048	0.750
MOD_GlcNHglycan	25	28	PF01048	0.696
MOD_GlcNHglycan	312	315	PF01048	0.635
MOD_GlcNHglycan	379	382	PF01048	0.742
MOD_GlcNHglycan	387	390	PF01048	0.699
MOD_GlcNHglycan	41	44	PF01048	0.567
MOD_GlcNHglycan	433	436	PF01048	0.696
MOD_GlcNHglycan	46	49	PF01048	0.684
MOD_GlcNHglycan	552	555	PF01048	0.780
MOD_GlcNHglycan	556	559	PF01048	0.773
MOD_GlcNHglycan	608	611	PF01048	0.699
MOD_GlcNHglycan	650	653	PF01048	0.745
MOD_GlcNHglycan	655	658	PF01048	0.686
MOD_GlcNHglycan	665	668	PF01048	0.622
MOD_GlcNHglycan	685	688	PF01048	0.584
MOD_GlcNHglycan	698	701	PF01048	0.583
MOD_GlcNHglycan	709	712	PF01048	0.573
MOD_GSK3_1	12	19	PF00069	0.667
MOD_GSK3_1	171	178	PF00069	0.772
MOD_GSK3_1	227	234	PF00069	0.842
MOD_GSK3_1	235	242	PF00069	0.716
MOD_GSK3_1	246	253	PF00069	0.632
MOD_GSK3_1	305	312	PF00069	0.778
MOD_GSK3_1	313	320	PF00069	0.654
MOD_GSK3_1	372	379	PF00069	0.711
MOD_GSK3_1	381	388	PF00069	0.611
MOD_GSK3_1	430	437	PF00069	0.758
MOD_GSK3_1	46	53	PF00069	0.719
MOD_GSK3_1	481	488	PF00069	0.756
MOD_GSK3_1	490	497	PF00069	0.781
MOD_GSK3_1	550	557	PF00069	0.591
MOD_GSK3_1	56	63	PF00069	0.575
MOD_GSK3_1	598	605	PF00069	0.695
MOD_GSK3_1	606	613	PF00069	0.679
MOD_GSK3_1	648	655	PF00069	0.692
MOD_GSK3_1	666	673	PF00069	0.601
MOD_LATS_1	646	652	PF00433	0.653
MOD_N-GLC_1	163	168	PF02516	0.557
MOD_N-GLC_1	488	493	PF02516	0.603
MOD_NEK2_1	1	6	PF00069	0.609
MOD_NEK2_1	38	43	PF00069	0.593
MOD_NEK2_1	430	435	PF00069	0.823
MOD_NEK2_1	490	495	PF00069	0.653
MOD_NEK2_1	550	555	PF00069	0.585
MOD_NEK2_1	653	658	PF00069	0.721
MOD_NEK2_1	663	668	PF00069	0.720
MOD_NEK2_2	691	696	PF00069	0.565
MOD_PIKK_1	53	59	PF00454	0.633
MOD_PK_1	12	18	PF00069	0.667
MOD_PK_1	602	608	PF00069	0.573
MOD_PKA_1	602	608	PF00069	0.668
MOD_PKA_1	648	654	PF00069	0.572
MOD_PKA_2	157	163	PF00069	0.539
MOD_PKA_2	179	185	PF00069	0.702
MOD_PKA_2	23	29	PF00069	0.691
MOD_PKA_2	238	244	PF00069	0.626
MOD_PKA_2	309	315	PF00069	0.672
MOD_PKA_2	618	624	PF00069	0.661
MOD_PKA_2	648	654	PF00069	0.577
MOD_PKA_2	696	702	PF00069	0.638
MOD_Plk_1	278	284	PF00069	0.721
MOD_Plk_1	359	365	PF00069	0.789
MOD_Plk_1	70	76	PF00069	0.598
MOD_Plk_2-3	278	284	PF00069	0.697
MOD_Plk_2-3	423	429	PF00069	0.667
MOD_Plk_2-3	542	548	PF00069	0.653
MOD_Plk_4	157	163	PF00069	0.499
MOD_ProDKin_1	370	376	PF00069	0.646
MOD_ProDKin_1	46	52	PF00069	0.674
MOD_ProDKin_1	483	489	PF00069	0.694
MOD_ProDKin_1	610	616	PF00069	0.636
MOD_ProDKin_1	634	640	PF00069	0.707
MOD_ProDKin_1	686	692	PF00069	0.594
MOD_SUMO_for_1	339	342	PF00179	0.610
MOD_SUMO_rev_2	178	182	PF00179	0.650
MOD_SUMO_rev_2	415	424	PF00179	0.677
MOD_SUMO_rev_2	533	538	PF00179	0.714
MOD_SUMO_rev_2	539	545	PF00179	0.639
TRG_DiLeu_BaEn_1	89	94	PF01217	0.535
TRG_DiLeu_BaEn_3	156	162	PF01217	0.495
TRG_DiLeu_BaEn_4	278	284	PF01217	0.657
TRG_DiLeu_BaEn_4	409	415	PF01217	0.654
TRG_ENDOCYTIC_2	22	25	PF00928	0.563
TRG_ENDOCYTIC_2	566	569	PF00928	0.634
TRG_ENDOCYTIC_2	85	88	PF00928	0.708
TRG_ER_diArg_1	111	113	PF00400	0.544
TRG_ER_diArg_1	114	116	PF00400	0.523
TRG_ER_diArg_1	129	131	PF00400	0.393
TRG_ER_diArg_1	170	172	PF00400	0.604
TRG_ER_diArg_1	252	255	PF00400	0.633
TRG_Pf-PMV_PEXEL_1	112	117	PF00026	0.549
TRG_Pf-PMV_PEXEL_1	175	179	PF00026	0.551

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HE84	Leishmania braziliensis	66%	86%
A4I1N0	Leishmania infantum	99%	100%
E9AXR4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4Q9Q7	Leishmania major	86%	100%