Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WZ87_LEIDO

TriTrypDb:

LdBPK_251880.1 , LdCL_250024500 , LDHU3_25.2320

Length:

1032

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WZ87

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WZ87

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	30	34	PF00656	0.678
CLV_C14_Caspase3-7	586	590	PF00656	0.694
CLV_NRD_NRD_1	328	330	PF00675	0.470
CLV_NRD_NRD_1	547	549	PF00675	0.457
CLV_NRD_NRD_1	573	575	PF00675	0.542
CLV_NRD_NRD_1	601	603	PF00675	0.501
CLV_NRD_NRD_1	697	699	PF00675	0.354
CLV_NRD_NRD_1	731	733	PF00675	0.592
CLV_NRD_NRD_1	796	798	PF00675	0.438
CLV_NRD_NRD_1	897	899	PF00675	0.416
CLV_NRD_NRD_1	957	959	PF00675	0.592
CLV_PCSK_FUR_1	729	733	PF00082	0.588
CLV_PCSK_KEX2_1	328	330	PF00082	0.470
CLV_PCSK_KEX2_1	546	548	PF00082	0.461
CLV_PCSK_KEX2_1	573	575	PF00082	0.542
CLV_PCSK_KEX2_1	601	603	PF00082	0.501
CLV_PCSK_KEX2_1	697	699	PF00082	0.354
CLV_PCSK_KEX2_1	731	733	PF00082	0.592
CLV_PCSK_KEX2_1	795	797	PF00082	0.444
CLV_PCSK_KEX2_1	897	899	PF00082	0.416
CLV_PCSK_KEX2_1	957	959	PF00082	0.566
CLV_PCSK_PC7_1	597	603	PF00082	0.510
CLV_PCSK_SKI1_1	328	332	PF00082	0.445
CLV_PCSK_SKI1_1	548	552	PF00082	0.472
CLV_PCSK_SKI1_1	679	683	PF00082	0.448
CLV_PCSK_SKI1_1	698	702	PF00082	0.364
CLV_PCSK_SKI1_1	856	860	PF00082	0.469
DEG_APCC_DBOX_1	327	335	PF00400	0.674
DEG_APCC_DBOX_1	795	803	PF00400	0.659
DEG_APCC_DBOX_1	828	836	PF00400	0.632
DEG_Nend_Nbox_1	1	3	PF02207	0.636
DEG_SPOP_SBC_1	118	122	PF00917	0.733
DEG_SPOP_SBC_1	486	490	PF00917	0.649
DEG_SPOP_SBC_1	504	508	PF00917	0.621
DEG_SPOP_SBC_1	579	583	PF00917	0.736
DOC_ANK_TNKS_1	100	107	PF00023	0.666
DOC_CDC14_PxL_1	44	52	PF14671	0.694
DOC_CKS1_1	566	571	PF01111	0.713
DOC_CKS1_1	703	708	PF01111	0.640
DOC_CYCLIN_RxL_1	679	690	PF00134	0.545
DOC_CYCLIN_yCln2_LP_2	566	572	PF00134	0.698
DOC_MAPK_gen_1	546	558	PF00069	0.664
DOC_MAPK_gen_1	601	607	PF00069	0.661
DOC_MAPK_gen_1	726	735	PF00069	0.376
DOC_MAPK_gen_1	766	776	PF00069	0.640
DOC_MAPK_gen_1	897	905	PF00069	0.581
DOC_MAPK_gen_1	986	996	PF00069	0.658
DOC_MAPK_MEF2A_6	391	400	PF00069	0.611
DOC_MAPK_MEF2A_6	551	558	PF00069	0.660
DOC_MAPK_MEF2A_6	769	776	PF00069	0.639
DOC_PP1_RVXF_1	327	334	PF00149	0.626
DOC_PP1_RVXF_1	824	831	PF00149	0.665
DOC_PP1_RVXF_1	89	96	PF00149	0.654
DOC_PP2B_LxvP_1	403	406	PF13499	0.645
DOC_PP2B_LxvP_1	596	599	PF13499	0.636
DOC_PP2B_LxvP_1	684	687	PF13499	0.555
DOC_PP2B_LxvP_1	744	747	PF13499	0.304
DOC_PP4_FxxP_1	40	43	PF00568	0.713
DOC_USP7_MATH_1	119	123	PF00917	0.729
DOC_USP7_MATH_1	151	155	PF00917	0.751
DOC_USP7_MATH_1	174	178	PF00917	0.703
DOC_USP7_MATH_1	184	188	PF00917	0.675
DOC_USP7_MATH_1	291	295	PF00917	0.668
DOC_USP7_MATH_1	452	456	PF00917	0.673
DOC_USP7_MATH_1	464	468	PF00917	0.709
DOC_USP7_MATH_1	487	491	PF00917	0.713
DOC_USP7_MATH_1	504	508	PF00917	0.775
DOC_USP7_MATH_1	537	541	PF00917	0.676
DOC_USP7_MATH_1	549	553	PF00917	0.697
DOC_USP7_MATH_1	640	644	PF00917	0.616
DOC_USP7_MATH_1	687	691	PF00917	0.517
DOC_USP7_MATH_1	740	744	PF00917	0.304
DOC_USP7_MATH_1	778	782	PF00917	0.676
DOC_USP7_MATH_1	921	925	PF00917	0.722
DOC_USP7_MATH_1	945	949	PF00917	0.677
DOC_USP7_MATH_2	92	98	PF00917	0.687
DOC_WW_Pin1_4	182	187	PF00397	0.821
DOC_WW_Pin1_4	268	273	PF00397	0.824
DOC_WW_Pin1_4	312	317	PF00397	0.688
DOC_WW_Pin1_4	346	351	PF00397	0.676
DOC_WW_Pin1_4	476	481	PF00397	0.664
DOC_WW_Pin1_4	565	570	PF00397	0.754
DOC_WW_Pin1_4	702	707	PF00397	0.642
DOC_WW_Pin1_4	981	986	PF00397	0.686
LIG_14-3-3_CanoR_1	266	272	PF00244	0.680
LIG_14-3-3_CanoR_1	391	400	PF00244	0.725
LIG_14-3-3_CanoR_1	548	554	PF00244	0.686
LIG_14-3-3_CanoR_1	55	61	PF00244	0.685
LIG_14-3-3_CanoR_1	829	833	PF00244	0.632
LIG_14-3-3_CanoR_1	849	857	PF00244	0.580
LIG_14-3-3_CanoR_1	915	923	PF00244	0.639
LIG_14-3-3_CanoR_1	940	949	PF00244	0.706
LIG_Actin_WH2_2	319	334	PF00022	0.682
LIG_Actin_WH2_2	901	917	PF00022	0.549
LIG_BIR_III_4	616	620	PF00653	0.681
LIG_BRCT_BRCA1_1	293	297	PF00533	0.681
LIG_BRCT_BRCA1_1	36	40	PF00533	0.650
LIG_FHA_1	196	202	PF00498	0.636
LIG_FHA_1	313	319	PF00498	0.677
LIG_FHA_1	359	365	PF00498	0.703
LIG_FHA_1	506	512	PF00498	0.686
LIG_FHA_1	60	66	PF00498	0.687
LIG_FHA_1	706	712	PF00498	0.296
LIG_FHA_1	80	86	PF00498	0.607
LIG_FHA_1	807	813	PF00498	0.687
LIG_FHA_1	861	867	PF00498	0.618
LIG_FHA_2	917	923	PF00498	0.670
LIG_FHA_2	985	991	PF00498	0.671
LIG_HCF-1_HBM_1	369	372	PF13415	0.700
LIG_LIR_Apic_2	1011	1017	PF02991	0.562
LIG_LIR_Apic_2	37	43	PF02991	0.685
LIG_LIR_Apic_2	643	647	PF02991	0.586
LIG_LIR_Gen_1	385	392	PF02991	0.600
LIG_LIR_Gen_1	552	559	PF02991	0.674
LIG_LIR_LC3C_4	991	996	PF02991	0.559
LIG_LIR_Nem_3	221	227	PF02991	0.663
LIG_LIR_Nem_3	379	383	PF02991	0.628
LIG_LIR_Nem_3	385	389	PF02991	0.575
LIG_LIR_Nem_3	552	556	PF02991	0.677
LIG_LYPXL_yS_3	380	383	PF13949	0.649
LIG_LYPXL_yS_3	47	50	PF13949	0.698
LIG_Pex14_2	382	386	PF04695	0.593
LIG_Pex14_2	40	44	PF04695	0.673
LIG_SH2_CRK	611	615	PF00017	0.619
LIG_SH2_CRK	68	72	PF00017	0.690
LIG_SH2_PTP2	644	647	PF00017	0.621
LIG_SH2_PTP2	712	715	PF00017	0.325
LIG_SH2_STAT5	275	278	PF00017	0.629
LIG_SH2_STAT5	644	647	PF00017	0.712
LIG_SH2_STAT5	712	715	PF00017	0.304
LIG_SH3_3	200	206	PF00018	0.704
LIG_SH3_3	207	213	PF00018	0.654
LIG_SH3_3	444	450	PF00018	0.726
LIG_SH3_3	508	514	PF00018	0.683
LIG_SH3_3	538	544	PF00018	0.701
LIG_SH3_3	553	559	PF00018	0.627
LIG_SH3_3	700	706	PF00018	0.660
LIG_SH3_3	713	719	PF00018	0.313
LIG_SH3_3	72	78	PF00018	0.685
LIG_SH3_3	881	887	PF00018	0.664
LIG_SH3_3	896	902	PF00018	0.568
LIG_SUMO_SIM_anti_2	562	568	PF11976	0.678
LIG_SUMO_SIM_anti_2	801	807	PF11976	0.588
LIG_SUMO_SIM_par_1	192	198	PF11976	0.659
LIG_SUMO_SIM_par_1	801	807	PF11976	0.588
LIG_TYR_ITIM	710	715	PF00017	0.325
LIG_UBA3_1	692	701	PF00899	0.540
LIG_WRC_WIRS_1	805	810	PF05994	0.629
MOD_CDK_SPK_2	981	986	PF00069	0.686
MOD_CK1_1	122	128	PF00069	0.736
MOD_CK1_1	172	178	PF00069	0.709
MOD_CK1_1	187	193	PF00069	0.641
MOD_CK1_1	231	237	PF00069	0.685
MOD_CK1_1	252	258	PF00069	0.754
MOD_CK1_1	267	273	PF00069	0.614
MOD_CK1_1	34	40	PF00069	0.663
MOD_CK1_1	348	354	PF00069	0.679
MOD_CK1_1	358	364	PF00069	0.731
MOD_CK1_1	478	484	PF00069	0.673
MOD_CK1_1	507	513	PF00069	0.821
MOD_CK1_1	57	63	PF00069	0.737
MOD_CK1_1	580	586	PF00069	0.757
MOD_CK1_1	591	597	PF00069	0.663
MOD_CK1_1	630	636	PF00069	0.761
MOD_CK1_1	666	672	PF00069	0.610
MOD_CK1_1	868	874	PF00069	0.694
MOD_CK1_1	973	979	PF00069	0.693
MOD_CK2_1	391	397	PF00069	0.589
MOD_CK2_1	630	636	PF00069	0.696
MOD_CK2_1	804	810	PF00069	0.586
MOD_CK2_1	888	894	PF00069	0.673
MOD_CK2_1	973	979	PF00069	0.714
MOD_CK2_1	984	990	PF00069	0.624
MOD_Cter_Amidation	326	329	PF01082	0.468
MOD_GlcNHglycan	122	125	PF01048	0.610
MOD_GlcNHglycan	132	135	PF01048	0.469
MOD_GlcNHglycan	159	162	PF01048	0.501
MOD_GlcNHglycan	165	168	PF01048	0.483
MOD_GlcNHglycan	186	189	PF01048	0.502
MOD_GlcNHglycan	251	254	PF01048	0.526
MOD_GlcNHglycan	277	280	PF01048	0.485
MOD_GlcNHglycan	35	39	PF01048	0.454
MOD_GlcNHglycan	373	376	PF01048	0.493
MOD_GlcNHglycan	393	396	PF01048	0.360
MOD_GlcNHglycan	416	419	PF01048	0.512
MOD_GlcNHglycan	429	432	PF01048	0.438
MOD_GlcNHglycan	447	450	PF01048	0.366
MOD_GlcNHglycan	458	461	PF01048	0.506
MOD_GlcNHglycan	480	483	PF01048	0.461
MOD_GlcNHglycan	489	492	PF01048	0.443
MOD_GlcNHglycan	527	530	PF01048	0.487
MOD_GlcNHglycan	589	593	PF01048	0.611
MOD_GlcNHglycan	665	668	PF01048	0.421
MOD_GlcNHglycan	754	757	PF01048	0.466
MOD_GlcNHglycan	762	765	PF01048	0.470
MOD_GlcNHglycan	766	769	PF01048	0.442
MOD_GlcNHglycan	850	853	PF01048	0.484
MOD_GlcNHglycan	891	894	PF01048	0.462
MOD_GlcNHglycan	922	926	PF01048	0.525
MOD_GlcNHglycan	927	930	PF01048	0.502
MOD_GlcNHglycan	932	935	PF01048	0.532
MOD_GlcNHglycan	975	978	PF01048	0.504
MOD_GSK3_1	114	121	PF00069	0.727
MOD_GSK3_1	147	154	PF00069	0.784
MOD_GSK3_1	231	238	PF00069	0.736
MOD_GSK3_1	243	250	PF00069	0.705
MOD_GSK3_1	260	267	PF00069	0.770
MOD_GSK3_1	27	34	PF00069	0.676
MOD_GSK3_1	291	298	PF00069	0.662
MOD_GSK3_1	310	317	PF00069	0.726
MOD_GSK3_1	341	348	PF00069	0.740
MOD_GSK3_1	351	358	PF00069	0.674
MOD_GSK3_1	423	430	PF00069	0.711
MOD_GSK3_1	452	459	PF00069	0.654
MOD_GSK3_1	471	478	PF00069	0.664
MOD_GSK3_1	481	488	PF00069	0.664
MOD_GSK3_1	49	56	PF00069	0.684
MOD_GSK3_1	503	510	PF00069	0.754
MOD_GSK3_1	579	586	PF00069	0.701
MOD_GSK3_1	666	673	PF00069	0.611
MOD_GSK3_1	760	767	PF00069	0.648
MOD_GSK3_1	856	863	PF00069	0.701
MOD_GSK3_1	921	928	PF00069	0.708
MOD_GSK3_1	930	937	PF00069	0.676
MOD_LATS_1	241	247	PF00433	0.740
MOD_N-GLC_1	151	156	PF02516	0.526
MOD_N-GLC_1	358	363	PF02516	0.495
MOD_N-GLC_1	376	381	PF02516	0.399
MOD_N-GLC_1	670	675	PF02516	0.403
MOD_NEK2_1	195	200	PF00069	0.642
MOD_NEK2_1	260	265	PF00069	0.751
MOD_NEK2_1	345	350	PF00069	0.691
MOD_NEK2_1	355	360	PF00069	0.693
MOD_NEK2_1	427	432	PF00069	0.678
MOD_NEK2_1	470	475	PF00069	0.684
MOD_NEK2_1	54	59	PF00069	0.704
MOD_NEK2_1	721	726	PF00069	0.379
MOD_NEK2_1	87	92	PF00069	0.686
MOD_NEK2_1	888	893	PF00069	0.651
MOD_NEK2_1	914	919	PF00069	0.629
MOD_NEK2_2	658	663	PF00069	0.570
MOD_NEK2_2	670	675	PF00069	0.520
MOD_PIKK_1	252	258	PF00454	0.685
MOD_PIKK_1	54	60	PF00454	0.702
MOD_PIKK_1	630	636	PF00454	0.645
MOD_PIKK_1	789	795	PF00454	0.670
MOD_PIKK_1	94	100	PF00454	0.730
MOD_PKA_2	242	248	PF00069	0.675
MOD_PKA_2	267	273	PF00069	0.656
MOD_PKA_2	54	60	PF00069	0.687
MOD_PKA_2	828	834	PF00069	0.662
MOD_PKA_2	848	854	PF00069	0.583
MOD_PKA_2	914	920	PF00069	0.621
MOD_PKA_2	950	956	PF00069	0.687
MOD_PKB_1	77	85	PF00069	0.667
MOD_Plk_1	220	226	PF00069	0.658
MOD_Plk_1	291	297	PF00069	0.637
MOD_Plk_1	376	382	PF00069	0.646
MOD_Plk_1	670	676	PF00069	0.675
MOD_Plk_1	817	823	PF00069	0.611
MOD_Plk_2-3	31	37	PF00069	0.680
MOD_Plk_2-3	804	810	PF00069	0.586
MOD_Plk_4	1009	1015	PF00069	0.553
MOD_Plk_4	341	347	PF00069	0.677
MOD_Plk_4	348	354	PF00069	0.609
MOD_Plk_4	537	543	PF00069	0.694
MOD_Plk_4	549	555	PF00069	0.693
MOD_Plk_4	624	630	PF00069	0.779
MOD_Plk_4	640	646	PF00069	0.588
MOD_Plk_4	650	656	PF00069	0.628
MOD_Plk_4	740	746	PF00069	0.304
MOD_Plk_4	772	778	PF00069	0.686
MOD_Plk_4	817	823	PF00069	0.616
MOD_Plk_4	909	915	PF00069	0.565
MOD_ProDKin_1	182	188	PF00069	0.819
MOD_ProDKin_1	268	274	PF00069	0.824
MOD_ProDKin_1	312	318	PF00069	0.687
MOD_ProDKin_1	346	352	PF00069	0.676
MOD_ProDKin_1	476	482	PF00069	0.663
MOD_ProDKin_1	565	571	PF00069	0.755
MOD_ProDKin_1	702	708	PF00069	0.639
MOD_ProDKin_1	981	987	PF00069	0.683
TRG_DiLeu_BaEn_1	990	995	PF01217	0.608
TRG_DiLeu_BaEn_2	35	41	PF01217	0.689
TRG_DiLeu_BaLyEn_6	190	195	PF01217	0.669
TRG_DiLeu_BaLyEn_6	326	331	PF01217	0.611
TRG_DiLeu_BaLyEn_6	831	836	PF01217	0.632
TRG_ENDOCYTIC_2	380	383	PF00928	0.649
TRG_ENDOCYTIC_2	47	50	PF00928	0.698
TRG_ENDOCYTIC_2	68	71	PF00928	0.689
TRG_ENDOCYTIC_2	712	715	PF00928	0.325
TRG_ER_diArg_1	328	330	PF00400	0.674
TRG_ER_diArg_1	546	548	PF00400	0.677
TRG_ER_diArg_1	573	576	PF00400	0.712
TRG_ER_diArg_1	600	602	PF00400	0.707
TRG_ER_diArg_1	696	698	PF00400	0.544
TRG_ER_diArg_1	731	733	PF00400	0.390
TRG_ER_diArg_1	769	772	PF00400	0.660
TRG_ER_diArg_1	794	797	PF00400	0.627
TRG_ER_diArg_1	897	899	PF00400	0.616
TRG_ER_diArg_1	939	942	PF00400	0.690
TRG_ER_diArg_1	956	958	PF00400	0.692
TRG_Pf-PMV_PEXEL_1	332	336	PF00026	0.433
TRG_Pf-PMV_PEXEL_1	726	730	PF00026	0.531
TRG_Pf-PMV_PEXEL_1	797	801	PF00026	0.460
TRG_Pf-PMV_PEXEL_1	986	990	PF00026	0.473
TRG_PTS2	1	20	PF00400	0.638

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8W8	Leptomonas seymouri	42%	100%
A4HEJ0	Leishmania braziliensis	66%	97%
A4I1M8	Leishmania infantum	99%	100%
E9AXR2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	98%
Q4Q9Q9	Leishmania major	91%	100%