Diacylglycerol acyltransferase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

diacylglycerol acyltransferase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WZ82_LEIDO

TriTrypDb:

LdBPK_251690.1 , LdCL_250022600 , LDHU3_25.2130

Length:

611

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8
GO:0005737	cytoplasm	2	1
GO:0005789	endoplasmic reticulum membrane	4	3
GO:0031090	organelle membrane	3	3
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

A0A3S7WZ82

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WZ82

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	1
GO:0006638	neutral lipid metabolic process	4	1
GO:0006639	acylglycerol metabolic process	5	1
GO:0006641	triglyceride metabolic process	6	1
GO:0006643	membrane lipid metabolic process	4	1
GO:0008152	metabolic process	1	1
GO:0008610	lipid biosynthetic process	4	1
GO:0009058	biosynthetic process	2	1
GO:0009987	cellular process	1	1
GO:0019432	triglyceride biosynthetic process	6	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0045017	glycerolipid biosynthetic process	4	1
GO:0046460	neutral lipid biosynthetic process	4	1
GO:0046463	acylglycerol biosynthetic process	5	1
GO:0046467	membrane lipid biosynthetic process	4	1
GO:0046486	glycerolipid metabolic process	4	1
GO:0071704	organic substance metabolic process	2	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0004144	diacylglycerol O-acyltransferase activity	7	5
GO:0008374	O-acyltransferase activity	5	9
GO:0016411	acylglycerol O-acyltransferase activity	6	5
GO:0016740	transferase activity	2	9
GO:0016746	acyltransferase activity	3	9
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	402	406	PF00656	0.509
CLV_NRD_NRD_1	152	154	PF00675	0.318
CLV_NRD_NRD_1	289	291	PF00675	0.316
CLV_NRD_NRD_1	373	375	PF00675	0.323
CLV_NRD_NRD_1	446	448	PF00675	0.260
CLV_NRD_NRD_1	482	484	PF00675	0.255
CLV_NRD_NRD_1	54	56	PF00675	0.485
CLV_NRD_NRD_1	554	556	PF00675	0.479
CLV_NRD_NRD_1	589	591	PF00675	0.509
CLV_PCSK_KEX2_1	152	154	PF00082	0.367
CLV_PCSK_KEX2_1	240	242	PF00082	0.485
CLV_PCSK_KEX2_1	289	291	PF00082	0.316
CLV_PCSK_KEX2_1	372	374	PF00082	0.321
CLV_PCSK_KEX2_1	482	484	PF00082	0.264
CLV_PCSK_KEX2_1	54	56	PF00082	0.482
CLV_PCSK_KEX2_1	554	556	PF00082	0.479
CLV_PCSK_PC1ET2_1	240	242	PF00082	0.507
CLV_PCSK_PC1ET2_1	482	484	PF00082	0.293
CLV_PCSK_PC7_1	369	375	PF00082	0.213
CLV_PCSK_SKI1_1	152	156	PF00082	0.378
CLV_PCSK_SKI1_1	488	492	PF00082	0.254
CLV_PCSK_SKI1_1	541	545	PF00082	0.360
DEG_APCC_DBOX_1	152	160	PF00400	0.589
DEG_Nend_UBRbox_2	1	3	PF02207	0.767
DEG_SPOP_SBC_1	265	269	PF00917	0.622
DOC_CKS1_1	190	195	PF01111	0.725
DOC_CKS1_1	214	219	PF01111	0.654
DOC_CKS1_1	283	288	PF01111	0.634
DOC_CYCLIN_yClb5_NLxxxL_5	421	428	PF00134	0.474
DOC_MAPK_gen_1	289	296	PF00069	0.550
DOC_MAPK_gen_1	472	481	PF00069	0.471
DOC_MAPK_gen_1	482	491	PF00069	0.441
DOC_MAPK_gen_1	554	561	PF00069	0.279
DOC_MAPK_HePTP_8	479	491	PF00069	0.521
DOC_MAPK_MEF2A_6	289	298	PF00069	0.501
DOC_MAPK_MEF2A_6	408	417	PF00069	0.493
DOC_MAPK_MEF2A_6	421	428	PF00069	0.467
DOC_MAPK_MEF2A_6	482	491	PF00069	0.456
DOC_MAPK_MEF2A_6	554	561	PF00069	0.254
DOC_PP2B_LxvP_1	182	185	PF13499	0.680
DOC_PP2B_LxvP_1	365	368	PF13499	0.454
DOC_PP2B_LxvP_1	424	427	PF13499	0.521
DOC_PP2B_LxvP_1	565	568	PF13499	0.321
DOC_PP4_FxxP_1	335	338	PF00568	0.385
DOC_PP4_FxxP_1	533	536	PF00568	0.291
DOC_USP7_MATH_1	171	175	PF00917	0.694
DOC_USP7_MATH_1	207	211	PF00917	0.724
DOC_USP7_MATH_1	30	34	PF00917	0.720
DOC_USP7_MATH_1	441	445	PF00917	0.479
DOC_USP7_MATH_1	454	458	PF00917	0.449
DOC_USP7_MATH_1	465	469	PF00917	0.436
DOC_USP7_UBL2_3	484	488	PF12436	0.521
DOC_WW_Pin1_4	189	194	PF00397	0.762
DOC_WW_Pin1_4	19	24	PF00397	0.766
DOC_WW_Pin1_4	213	218	PF00397	0.657
DOC_WW_Pin1_4	241	246	PF00397	0.647
DOC_WW_Pin1_4	25	30	PF00397	0.779
DOC_WW_Pin1_4	282	287	PF00397	0.635
DOC_WW_Pin1_4	492	497	PF00397	0.479
LIG_14-3-3_CanoR_1	141	151	PF00244	0.612
LIG_14-3-3_CanoR_1	289	295	PF00244	0.523
LIG_14-3-3_CanoR_1	319	323	PF00244	0.321
LIG_14-3-3_CanoR_1	447	451	PF00244	0.479
LIG_14-3-3_CanoR_1	54	58	PF00244	0.664
LIG_ActinCP_TwfCPI_2	335	344	PF01115	0.385
LIG_BRCT_BRCA1_1	266	270	PF00533	0.655
LIG_BRCT_BRCA1_1	65	69	PF00533	0.670
LIG_DLG_GKlike_1	290	298	PF00625	0.521
LIG_eIF4E_1	360	366	PF01652	0.454
LIG_FHA_1	310	316	PF00498	0.401
LIG_FHA_1	412	418	PF00498	0.491
LIG_FHA_1	493	499	PF00498	0.479
LIG_FHA_1	60	66	PF00498	0.743
LIG_FHA_2	39	45	PF00498	0.659
LIG_FHA_2	572	578	PF00498	0.254
LIG_Integrin_isoDGR_2	92	94	PF01839	0.462
LIG_LIR_Apic_2	210	214	PF02991	0.702
LIG_LIR_Apic_2	318	323	PF02991	0.310
LIG_LIR_Apic_2	334	338	PF02991	0.241
LIG_LIR_Gen_1	297	307	PF02991	0.297
LIG_LIR_Gen_1	321	332	PF02991	0.363
LIG_LIR_Gen_1	66	76	PF02991	0.759
LIG_LIR_LC3C_4	457	462	PF02991	0.479
LIG_LIR_Nem_3	278	282	PF02991	0.592
LIG_LIR_Nem_3	297	302	PF02991	0.451
LIG_LIR_Nem_3	359	363	PF02991	0.455
LIG_LIR_Nem_3	378	384	PF02991	0.521
LIG_LIR_Nem_3	392	396	PF02991	0.479
LIG_LIR_Nem_3	516	522	PF02991	0.481
LIG_LIR_Nem_3	66	72	PF02991	0.740
LIG_Pex14_1	331	335	PF04695	0.385
LIG_Pex14_1	581	585	PF04695	0.254
LIG_Pex14_2	348	352	PF04695	0.532
LIG_PTB_Apo_2	542	549	PF02174	0.385
LIG_PTB_Phospho_1	542	548	PF10480	0.385
LIG_SH2_CRK	320	324	PF00017	0.377
LIG_SH2_CRK	548	552	PF00017	0.321
LIG_SH2_NCK_1	320	324	PF00017	0.319
LIG_SH2_NCK_1	509	513	PF00017	0.505
LIG_SH2_PTP2	425	428	PF00017	0.509
LIG_SH2_STAT5	142	145	PF00017	0.604
LIG_SH2_STAT5	260	263	PF00017	0.562
LIG_SH2_STAT5	320	323	PF00017	0.363
LIG_SH2_STAT5	328	331	PF00017	0.263
LIG_SH2_STAT5	357	360	PF00017	0.472
LIG_SH2_STAT5	381	384	PF00017	0.454
LIG_SH2_STAT5	425	428	PF00017	0.521
LIG_SH2_STAT5	522	525	PF00017	0.511
LIG_SH2_STAT5	530	533	PF00017	0.283
LIG_SH2_STAT5	585	588	PF00017	0.254
LIG_SH3_3	15	21	PF00018	0.732
LIG_SH3_3	182	188	PF00018	0.751
LIG_SH3_3	211	217	PF00018	0.700
LIG_SH3_3	335	341	PF00018	0.291
LIG_SH3_3	381	387	PF00018	0.592
LIG_SH3_3	493	499	PF00018	0.479
LIG_SH3_3	558	564	PF00018	0.262
LIG_SH3_3	565	571	PF00018	0.245
LIG_SH3_3	99	105	PF00018	0.664
LIG_SUMO_SIM_anti_2	312	318	PF11976	0.300
LIG_SUMO_SIM_anti_2	457	462	PF11976	0.456
LIG_SUMO_SIM_par_1	293	300	PF11976	0.330
LIG_SUMO_SIM_par_1	312	318	PF11976	0.172
LIG_SUMO_SIM_par_1	557	563	PF11976	0.279
LIG_TRAF2_1	115	118	PF00917	0.602
LIG_TRAF2_1	490	493	PF00917	0.454
LIG_TRFH_1	548	552	PF08558	0.305
LIG_TYR_ITIM	520	525	PF00017	0.414
LIG_UBA3_1	523	528	PF00899	0.514
LIG_WRC_WIRS_1	298	303	PF05994	0.398
LIG_WRC_WIRS_1	332	337	PF05994	0.367
LIG_WRC_WIRS_1	390	395	PF05994	0.479
LIG_WW_3	22	26	PF00397	0.671
MOD_CDK_SPK_2	241	246	PF00069	0.647
MOD_CDK_SPxK_1	189	195	PF00069	0.723
MOD_CDK_SPxK_1	19	25	PF00069	0.714
MOD_CDK_SPxxK_3	282	289	PF00069	0.624
MOD_CK1_1	176	182	PF00069	0.699
MOD_CK1_1	234	240	PF00069	0.704
MOD_CK1_1	266	272	PF00069	0.739
MOD_CK1_1	278	284	PF00069	0.530
MOD_CK1_1	297	303	PF00069	0.479
MOD_CK1_1	318	324	PF00069	0.308
MOD_CK1_1	63	69	PF00069	0.685
MOD_CK1_1	77	83	PF00069	0.683
MOD_CK2_1	112	118	PF00069	0.632
MOD_CK2_1	507	513	PF00069	0.497
MOD_Cter_Amidation	238	241	PF01082	0.497
MOD_Cter_Amidation	52	55	PF01082	0.388
MOD_DYRK1A_RPxSP_1	19	23	PF00069	0.760
MOD_GlcNHglycan	173	176	PF01048	0.451
MOD_GlcNHglycan	179	182	PF01048	0.475
MOD_GlcNHglycan	217	220	PF01048	0.482
MOD_GlcNHglycan	222	225	PF01048	0.444
MOD_GlcNHglycan	440	444	PF01048	0.254
MOD_GlcNHglycan	451	454	PF01048	0.254
MOD_GlcNHglycan	75	79	PF01048	0.512
MOD_GSK3_1	173	180	PF00069	0.668
MOD_GSK3_1	203	210	PF00069	0.747
MOD_GSK3_1	25	32	PF00069	0.673
MOD_GSK3_1	278	285	PF00069	0.612
MOD_GSK3_1	290	297	PF00069	0.419
MOD_GSK3_1	38	45	PF00069	0.598
MOD_GSK3_1	59	66	PF00069	0.692
MOD_GSK3_1	83	90	PF00069	0.764
MOD_NEK2_1	194	199	PF00069	0.636
MOD_NEK2_1	294	299	PF00069	0.291
MOD_NEK2_1	309	314	PF00069	0.291
MOD_NEK2_1	315	320	PF00069	0.441
MOD_NEK2_1	602	607	PF00069	0.321
MOD_NEK2_1	61	66	PF00069	0.593
MOD_NEK2_2	406	411	PF00069	0.449
MOD_OFUCOSY	438	445	PF10250	0.321
MOD_PIKK_1	13	19	PF00454	0.719
MOD_PIKK_1	80	86	PF00454	0.814
MOD_PKA_2	234	240	PF00069	0.677
MOD_PKA_2	318	324	PF00069	0.321
MOD_PKA_2	446	452	PF00069	0.454
MOD_PKA_2	53	59	PF00069	0.682
MOD_Plk_1	465	471	PF00069	0.521
MOD_Plk_2-3	38	44	PF00069	0.615
MOD_Plk_4	290	296	PF00069	0.437
MOD_Plk_4	454	460	PF00069	0.466
MOD_Plk_4	465	471	PF00069	0.436
MOD_ProDKin_1	189	195	PF00069	0.763
MOD_ProDKin_1	19	25	PF00069	0.767
MOD_ProDKin_1	213	219	PF00069	0.654
MOD_ProDKin_1	241	247	PF00069	0.636
MOD_ProDKin_1	282	288	PF00069	0.632
MOD_ProDKin_1	492	498	PF00069	0.479
MOD_SUMO_rev_2	145	151	PF00179	0.611
MOD_SUMO_rev_2	44	50	PF00179	0.600
TRG_DiLeu_BaLyEn_6	249	254	PF01217	0.575
TRG_ENDOCYTIC_2	360	363	PF00928	0.440
TRG_ENDOCYTIC_2	381	384	PF00928	0.454
TRG_ENDOCYTIC_2	425	428	PF00928	0.521
TRG_ENDOCYTIC_2	522	525	PF00928	0.494
TRG_ENDOCYTIC_2	530	533	PF00928	0.266
TRG_ENDOCYTIC_2	548	551	PF00928	0.345
TRG_ER_diArg_1	139	142	PF00400	0.630
TRG_ER_diArg_1	151	153	PF00400	0.550
TRG_ER_diArg_1	289	291	PF00400	0.517
TRG_ER_diArg_1	371	374	PF00400	0.521
TRG_ER_diArg_1	538	541	PF00400	0.435
TRG_ER_diArg_1	554	556	PF00400	0.225
TRG_Pf-PMV_PEXEL_1	55	60	PF00026	0.461
TRG_Pf-PMV_PEXEL_1	590	595	PF00026	0.509
TRG_Pf-PMV_PEXEL_1	597	601	PF00026	0.457

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE36	Leptomonas seymouri	56%	94%
A0A3R7NQK7	Trypanosoma rangeli	45%	100%
A4HEI1	Leishmania braziliensis	78%	99%
A4I1K9	Leishmania infantum	100%	100%
C9ZK51	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9AXP3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4Q9S8	Leishmania major	90%	100%