Mitochondrial RNA binding complex 1 subunit, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WZ80_LEIDO

TriTrypDb:

LdBPK_251820.1 , LdCL_250023900 , LDHU3_25.2260

Length:

307

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

A0A3S7WZ80

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WZ80

Function

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Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009451	RNA modification	5	1
GO:0009892	negative regulation of metabolic process	4	1
GO:0009893	positive regulation of metabolic process	4	1
GO:0009894	regulation of catabolic process	4	1
GO:0009895	negative regulation of catabolic process	5	1
GO:0009987	cellular process	1	1

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Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	92	96	PF00656	0.616
CLV_NRD_NRD_1	156	158	PF00675	0.447
CLV_NRD_NRD_1	190	192	PF00675	0.662
CLV_NRD_NRD_1	195	197	PF00675	0.621
CLV_NRD_NRD_1	210	212	PF00675	0.542
CLV_NRD_NRD_1	230	232	PF00675	0.641
CLV_NRD_NRD_1	264	266	PF00675	0.679
CLV_NRD_NRD_1	274	276	PF00675	0.675
CLV_NRD_NRD_1	292	294	PF00675	0.644
CLV_PCSK_KEX2_1	195	197	PF00082	0.671

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1H0	Leptomonas seymouri	44%	96%
A4HEG8	Leishmania braziliensis	70%	99%
A4I1M2	Leishmania infantum	99%	100%
E9AXQ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q9R5	Leishmania major	91%	100%

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