Mitochondrial RNA binding complex 1 subunit, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WZ80_LEIDO

TriTrypDb:

LdBPK_251820.1 , LdCL_250023900 , LDHU3_25.2260

Length:

307

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WZ80

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WZ80

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009451	RNA modification	5	1
GO:0009892	negative regulation of metabolic process	4	1
GO:0009893	positive regulation of metabolic process	4	1
GO:0009894	regulation of catabolic process	4	1
GO:0009895	negative regulation of catabolic process	5	1
GO:0009987	cellular process	1	1
GO:0010468	regulation of gene expression	5	1
GO:0010604	positive regulation of macromolecule metabolic process	5	1
GO:0010605	negative regulation of macromolecule metabolic process	5	1
GO:0010608	post-transcriptional regulation of gene expression	6	1
GO:0010628	positive regulation of gene expression	6	1
GO:0016070	RNA metabolic process	5	1
GO:0016553	base conversion or substitution editing	6	1
GO:0016554	cytidine to uridine editing	7	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031324	negative regulation of cellular metabolic process	5	1
GO:0031329	regulation of cellular catabolic process	5	1
GO:0031330	negative regulation of cellular catabolic process	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043487	regulation of RNA stability	3	1
GO:0043488	regulation of mRNA stability	4	1
GO:0043489	RNA stabilization	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0045934	negative regulation of nucleobase-containing compound metabolic process	6	1
GO:0046483	heterocycle metabolic process	3	1
GO:0048255	mRNA stabilization	5	1
GO:0048518	positive regulation of biological process	3	1
GO:0048519	negative regulation of biological process	3	1
GO:0048523	negative regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051172	negative regulation of nitrogen compound metabolic process	5	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0051253	negative regulation of RNA metabolic process	6	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0061013	regulation of mRNA catabolic process	6	1
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1
GO:0071704	organic substance metabolic process	2	1
GO:0080090	regulation of primary metabolic process	4	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1902369	negative regulation of RNA catabolic process	7	1
GO:1902373	negative regulation of mRNA catabolic process	7	1
GO:1903311	regulation of mRNA metabolic process	6	1
GO:1903312	negative regulation of mRNA metabolic process	7	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	92	96	PF00656	0.616
CLV_NRD_NRD_1	156	158	PF00675	0.447
CLV_NRD_NRD_1	190	192	PF00675	0.662
CLV_NRD_NRD_1	195	197	PF00675	0.621
CLV_NRD_NRD_1	210	212	PF00675	0.542
CLV_NRD_NRD_1	230	232	PF00675	0.641
CLV_NRD_NRD_1	264	266	PF00675	0.679
CLV_NRD_NRD_1	274	276	PF00675	0.675
CLV_NRD_NRD_1	292	294	PF00675	0.644
CLV_PCSK_KEX2_1	195	197	PF00082	0.671
CLV_PCSK_KEX2_1	210	212	PF00082	0.549
CLV_PCSK_KEX2_1	230	232	PF00082	0.641
CLV_PCSK_KEX2_1	264	266	PF00082	0.676
CLV_PCSK_KEX2_1	274	276	PF00082	0.686
CLV_PCSK_KEX2_1	292	294	PF00082	0.644
CLV_PCSK_PC7_1	191	197	PF00082	0.576
CLV_PCSK_SKI1_1	103	107	PF00082	0.563
CLV_PCSK_SKI1_1	129	133	PF00082	0.436
CLV_PCSK_SKI1_1	151	155	PF00082	0.458
CLV_PCSK_SKI1_1	158	162	PF00082	0.410
DEG_Nend_UBRbox_1	1	4	PF02207	0.531
DOC_MAPK_gen_1	191	200	PF00069	0.516
DOC_PP4_FxxP_1	75	78	PF00568	0.606
DOC_USP7_MATH_1	236	240	PF00917	0.783
DOC_USP7_MATH_1	296	300	PF00917	0.666
DOC_WW_Pin1_4	232	237	PF00397	0.749
DOC_WW_Pin1_4	241	246	PF00397	0.737
DOC_WW_Pin1_4	74	79	PF00397	0.640
LIG_14-3-3_CanoR_1	191	195	PF00244	0.564
LIG_14-3-3_CanoR_1	230	236	PF00244	0.587
LIG_14-3-3_CanoR_1	300	305	PF00244	0.625
LIG_14-3-3_CanoR_1	42	49	PF00244	0.640
LIG_14-3-3_CanoR_1	9	17	PF00244	0.683
LIG_FHA_1	112	118	PF00498	0.485
LIG_FHA_2	163	169	PF00498	0.471
LIG_FHA_2	59	65	PF00498	0.567
LIG_LIR_Apic_2	72	78	PF02991	0.610
LIG_LIR_Gen_1	130	139	PF02991	0.429
LIG_LIR_Nem_3	130	135	PF02991	0.403
LIG_SH2_SRC	173	176	PF00017	0.485
LIG_SH2_STAP1	36	40	PF00017	0.590
LIG_SH2_STAT5	173	176	PF00017	0.450
LIG_SH3_2	238	243	PF14604	0.653
LIG_SH3_3	235	241	PF00018	0.699
LIG_TRAF2_2	268	273	PF00917	0.627
LIG_WRC_WIRS_1	150	155	PF05994	0.430
MOD_CDK_SPK_2	74	79	PF00069	0.577
MOD_CK1_1	127	133	PF00069	0.424
MOD_CK1_1	234	240	PF00069	0.797
MOD_CK1_1	5	11	PF00069	0.628
MOD_CK1_1	50	56	PF00069	0.674
MOD_CK1_1	59	65	PF00069	0.614
MOD_CK1_1	69	75	PF00069	0.511
MOD_CK1_1	99	105	PF00069	0.522
MOD_CK2_1	149	155	PF00069	0.432
MOD_CK2_1	162	168	PF00069	0.374
MOD_CK2_1	58	64	PF00069	0.572
MOD_Cter_Amidation	262	265	PF01082	0.713
MOD_GlcNHglycan	13	16	PF01048	0.738
MOD_GlcNHglycan	132	135	PF01048	0.459
MOD_GlcNHglycan	238	241	PF01048	0.818
MOD_GlcNHglycan	30	33	PF01048	0.562
MOD_GlcNHglycan	36	39	PF01048	0.535
MOD_GlcNHglycan	52	55	PF01048	0.752
MOD_GlcNHglycan	58	61	PF01048	0.819
MOD_GlcNHglycan	97	101	PF01048	0.567
MOD_GSK3_1	107	114	PF00069	0.440
MOD_GSK3_1	232	239	PF00069	0.643
MOD_GSK3_1	276	283	PF00069	0.666
MOD_GSK3_1	296	303	PF00069	0.657
MOD_GSK3_1	30	37	PF00069	0.551
MOD_GSK3_1	43	50	PF00069	0.602
MOD_GSK3_1	56	63	PF00069	0.567
MOD_GSK3_1	74	81	PF00069	0.499
MOD_N-GLC_1	280	285	PF02516	0.730
MOD_N-GLC_1	300	305	PF02516	0.762
MOD_N-GLC_1	90	95	PF02516	0.545
MOD_NEK2_1	66	71	PF00069	0.568
MOD_NEK2_2	124	129	PF00069	0.420
MOD_PK_1	107	113	PF00069	0.442
MOD_PK_1	2	8	PF00069	0.704
MOD_PKA_2	190	196	PF00069	0.570
MOD_PKA_2	50	56	PF00069	0.689
MOD_PKA_2	69	75	PF00069	0.500
MOD_Plk_1	107	113	PF00069	0.501
MOD_Plk_1	300	306	PF00069	0.668
MOD_Plk_4	107	113	PF00069	0.442
MOD_Plk_4	127	133	PF00069	0.424
MOD_ProDKin_1	232	238	PF00069	0.746
MOD_ProDKin_1	241	247	PF00069	0.738
MOD_ProDKin_1	74	80	PF00069	0.640
TRG_ER_diArg_1	194	196	PF00400	0.652
TRG_ER_diArg_1	210	212	PF00400	0.640
TRG_ER_diArg_1	229	231	PF00400	0.609
TRG_ER_diArg_1	291	293	PF00400	0.706

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1H0	Leptomonas seymouri	44%	96%
A4HEG8	Leishmania braziliensis	70%	99%
A4I1M2	Leishmania infantum	99%	100%
E9AXQ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4Q9R5	Leishmania major	91%	100%