Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WZ73_LEIDO

TriTrypDb:

LdBPK_251590.1 , LdCL_250021600 , LDHU3_25.1970

Length:

596

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WZ73

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WZ73

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	171	175	PF00656	0.567
CLV_C14_Caspase3-7	386	390	PF00656	0.788
CLV_NRD_NRD_1	310	312	PF00675	0.728
CLV_NRD_NRD_1	314	316	PF00675	0.690
CLV_PCSK_FUR_1	308	312	PF00082	0.707
CLV_PCSK_KEX2_1	304	306	PF00082	0.581
CLV_PCSK_KEX2_1	310	312	PF00082	0.713
CLV_PCSK_KEX2_1	314	316	PF00082	0.747
CLV_PCSK_PC1ET2_1	304	306	PF00082	0.533
CLV_PCSK_PC7_1	310	316	PF00082	0.631
CLV_PCSK_SKI1_1	188	192	PF00082	0.582
CLV_PCSK_SKI1_1	290	294	PF00082	0.428
CLV_PCSK_SKI1_1	336	340	PF00082	0.612
DOC_ANK_TNKS_1	155	162	PF00023	0.551
DOC_CYCLIN_RxL_1	287	294	PF00134	0.426
DOC_CYCLIN_RxL_1	330	344	PF00134	0.657
DOC_MAPK_gen_1	186	195	PF00069	0.476
DOC_MAPK_gen_1	416	422	PF00069	0.713
DOC_MAPK_MEF2A_6	396	404	PF00069	0.641
DOC_PP1_RVXF_1	225	232	PF00149	0.445
DOC_PP1_RVXF_1	334	341	PF00149	0.648
DOC_PP1_RVXF_1	560	567	PF00149	0.570
DOC_PP4_FxxP_1	135	138	PF00568	0.698
DOC_USP7_MATH_1	23	27	PF00917	0.753
DOC_USP7_MATH_1	265	269	PF00917	0.556
DOC_USP7_MATH_1	324	328	PF00917	0.744
DOC_USP7_MATH_1	366	370	PF00917	0.756
DOC_USP7_MATH_1	430	434	PF00917	0.672
DOC_USP7_MATH_1	514	518	PF00917	0.726
DOC_USP7_MATH_1	526	530	PF00917	0.794
DOC_WW_Pin1_4	162	167	PF00397	0.638
DOC_WW_Pin1_4	19	24	PF00397	0.632
DOC_WW_Pin1_4	395	400	PF00397	0.688
DOC_WW_Pin1_4	445	450	PF00397	0.763
LIG_14-3-3_CanoR_1	188	196	PF00244	0.588
LIG_14-3-3_CanoR_1	290	300	PF00244	0.512
LIG_14-3-3_CanoR_1	308	316	PF00244	0.625
LIG_14-3-3_CanoR_1	326	334	PF00244	0.696
LIG_14-3-3_CanoR_1	455	463	PF00244	0.600
LIG_14-3-3_CanoR_1	569	573	PF00244	0.650
LIG_BIR_II_1	1	5	PF00653	0.704
LIG_BIR_III_2	389	393	PF00653	0.637
LIG_Clathr_ClatBox_1	339	343	PF01394	0.607
LIG_eIF4E_1	333	339	PF01652	0.652
LIG_FHA_1	326	332	PF00498	0.611
LIG_FHA_1	408	414	PF00498	0.645
LIG_FHA_1	46	52	PF00498	0.531
LIG_FHA_1	545	551	PF00498	0.714
LIG_FHA_1	580	586	PF00498	0.688
LIG_FHA_2	115	121	PF00498	0.652
LIG_FHA_2	381	387	PF00498	0.777
LIG_FHA_2	584	590	PF00498	0.699
LIG_GBD_Chelix_1	471	479	PF00786	0.709
LIG_LIR_Apic_2	133	138	PF02991	0.615
LIG_LIR_Gen_1	13	23	PF02991	0.595
LIG_LIR_Gen_1	357	368	PF02991	0.718
LIG_LIR_Gen_1	44	55	PF02991	0.587
LIG_LIR_Gen_1	565	574	PF02991	0.634
LIG_LIR_Nem_3	13	18	PF02991	0.521
LIG_LIR_Nem_3	251	256	PF02991	0.486
LIG_LIR_Nem_3	357	363	PF02991	0.706
LIG_LIR_Nem_3	44	50	PF02991	0.540
LIG_LIR_Nem_3	66	72	PF02991	0.469
LIG_NRBOX	287	293	PF00104	0.460
LIG_PDZ_Class_1	591	596	PF00595	0.623
LIG_Pex14_2	404	408	PF04695	0.550
LIG_Rb_pABgroove_1	12	20	PF01858	0.646
LIG_Rb_pABgroove_1	295	303	PF01858	0.502
LIG_REV1ctd_RIR_1	564	573	PF16727	0.634
LIG_SH2_CRK	47	51	PF00017	0.471
LIG_SH2_CRK	476	480	PF00017	0.734
LIG_SH2_PTP2	360	363	PF00017	0.486
LIG_SH2_STAP1	189	193	PF00017	0.558
LIG_SH2_STAP1	47	51	PF00017	0.499
LIG_SH2_STAT5	246	249	PF00017	0.356
LIG_SH2_STAT5	360	363	PF00017	0.486
LIG_SH2_STAT5	462	465	PF00017	0.552
LIG_SH2_STAT5	47	50	PF00017	0.471
LIG_SH2_STAT5	490	493	PF00017	0.685
LIG_SH3_1	156	162	PF00018	0.596
LIG_SH3_3	156	162	PF00018	0.647
LIG_SH3_3	235	241	PF00018	0.595
LIG_SH3_3	360	366	PF00018	0.566
LIG_SH3_3	389	395	PF00018	0.651
LIG_SH3_3	443	449	PF00018	0.779
LIG_SH3_3	503	509	PF00018	0.703
LIG_SUMO_SIM_anti_2	359	365	PF11976	0.713
LIG_SUMO_SIM_par_1	165	171	PF11976	0.584
LIG_TRAF2_1	221	224	PF00917	0.499
LIG_TYR_ITIM	45	50	PF00017	0.582
LIG_TYR_ITIM	474	479	PF00017	0.722
LIG_UBA3_1	331	336	PF00899	0.698
MOD_CK1_1	199	205	PF00069	0.670
MOD_CK1_1	234	240	PF00069	0.508
MOD_CK1_1	341	347	PF00069	0.700
MOD_CK1_1	426	432	PF00069	0.697
MOD_CK1_1	440	446	PF00069	0.626
MOD_CK1_1	447	453	PF00069	0.668
MOD_CK1_1	521	527	PF00069	0.769
MOD_CK1_1	558	564	PF00069	0.595
MOD_CK1_1	82	88	PF00069	0.684
MOD_CK2_1	351	357	PF00069	0.732
MOD_CK2_1	380	386	PF00069	0.776
MOD_CK2_1	514	520	PF00069	0.716
MOD_CK2_1	526	532	PF00069	0.750
MOD_CK2_1	58	64	PF00069	0.561
MOD_CK2_1	583	589	PF00069	0.655
MOD_GlcNHglycan	24	28	PF01048	0.711
MOD_GlcNHglycan	267	270	PF01048	0.644
MOD_GlcNHglycan	311	314	PF01048	0.659
MOD_GlcNHglycan	353	356	PF01048	0.647
MOD_GlcNHglycan	428	431	PF01048	0.767
MOD_GlcNHglycan	522	526	PF01048	0.747
MOD_GlcNHglycan	528	532	PF01048	0.788
MOD_GlcNHglycan	81	84	PF01048	0.625
MOD_GSK3_1	184	191	PF00069	0.582
MOD_GSK3_1	19	26	PF00069	0.721
MOD_GSK3_1	422	429	PF00069	0.723
MOD_GSK3_1	437	444	PF00069	0.557
MOD_GSK3_1	514	521	PF00069	0.703
MOD_GSK3_1	579	586	PF00069	0.650
MOD_GSK3_1	75	82	PF00069	0.637
MOD_N-GLC_1	322	327	PF02516	0.724
MOD_N-GLC_1	366	371	PF02516	0.714
MOD_N-GLC_1	591	596	PF02516	0.673
MOD_NEK2_1	196	201	PF00069	0.622
MOD_NEK2_1	231	236	PF00069	0.473
MOD_NEK2_1	286	291	PF00069	0.506
MOD_NEK2_1	422	427	PF00069	0.717
MOD_NEK2_1	454	459	PF00069	0.711
MOD_NEK2_1	58	63	PF00069	0.554
MOD_PIKK_1	325	331	PF00454	0.686
MOD_PIKK_1	430	436	PF00454	0.736
MOD_PIKK_1	88	94	PF00454	0.635
MOD_PKA_1	304	310	PF00069	0.452
MOD_PKA_2	304	310	PF00069	0.631
MOD_PKA_2	325	331	PF00069	0.715
MOD_PKA_2	426	432	PF00069	0.738
MOD_PKA_2	454	460	PF00069	0.626
MOD_PKA_2	568	574	PF00069	0.642
MOD_PKA_2	583	589	PF00069	0.595
MOD_PKB_1	186	194	PF00069	0.585
MOD_Plk_1	356	362	PF00069	0.693
MOD_Plk_1	366	372	PF00069	0.669
MOD_Plk_2-3	114	120	PF00069	0.659
MOD_Plk_2-3	209	215	PF00069	0.588
MOD_Plk_2-3	538	544	PF00069	0.737
MOD_Plk_2-3	560	566	PF00069	0.683
MOD_Plk_4	356	362	PF00069	0.513
MOD_Plk_4	486	492	PF00069	0.670
MOD_Plk_4	568	574	PF00069	0.564
MOD_ProDKin_1	162	168	PF00069	0.631
MOD_ProDKin_1	19	25	PF00069	0.635
MOD_ProDKin_1	395	401	PF00069	0.687
MOD_ProDKin_1	445	451	PF00069	0.760
MOD_SUMO_rev_2	412	419	PF00179	0.648
MOD_SUMO_rev_2	588	593	PF00179	0.720
MOD_SUMO_rev_2	82	91	PF00179	0.643
TRG_DiLeu_BaLyEn_6	287	292	PF01217	0.462
TRG_DiLeu_BaLyEn_6	334	339	PF01217	0.642
TRG_DiLeu_BaLyEn_6	344	349	PF01217	0.641
TRG_DiLeu_BaLyEn_6	475	480	PF01217	0.687
TRG_ENDOCYTIC_2	360	363	PF00928	0.700
TRG_ENDOCYTIC_2	47	50	PF00928	0.438
TRG_ENDOCYTIC_2	476	479	PF00928	0.735
TRG_ENDOCYTIC_2	72	75	PF00928	0.530
TRG_ER_diArg_1	186	189	PF00400	0.586
TRG_ER_diArg_1	308	311	PF00400	0.709
TRG_ER_diArg_1	314	316	PF00400	0.661
TRG_Pf-PMV_PEXEL_1	194	198	PF00026	0.562
TRG_Pf-PMV_PEXEL_1	347	351	PF00026	0.593

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZM0	Leptomonas seymouri	46%	100%
A0A1X0NY83	Trypanosomatidae	27%	100%
A0A422NL47	Trypanosoma rangeli	29%	100%
A4HEJ9	Leishmania braziliensis	77%	100%
A4I1J9	Leishmania infantum	100%	100%
C9ZK33	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9AXN3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q9T8	Leishmania major	91%	99%