Protein kinase, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WZ58_LEIDO

TriTrypDb:

LdBPK_251620.1 , LdCL_250021900 , LDHU3_25.2060

Length:

863

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WZ58

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WZ58

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	8
GO:0006793	phosphorus metabolic process	3	8
GO:0006796	phosphate-containing compound metabolic process	4	8
GO:0006807	nitrogen compound metabolic process	2	8
GO:0008152	metabolic process	1	8
GO:0009987	cellular process	1	8
GO:0016310	phosphorylation	5	8
GO:0019538	protein metabolic process	3	8
GO:0036211	protein modification process	4	8
GO:0043170	macromolecule metabolic process	3	8
GO:0043412	macromolecule modification	4	8
GO:0044237	cellular metabolic process	2	8
GO:0044238	primary metabolic process	2	8
GO:0071704	organic substance metabolic process	2	8
GO:1901564	organonitrogen compound metabolic process	3	8

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	8
GO:0003824	catalytic activity	1	8
GO:0004672	protein kinase activity	3	8
GO:0005488	binding	1	8
GO:0005524	ATP binding	5	8
GO:0016301	kinase activity	4	8
GO:0016740	transferase activity	2	8
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	8
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	8
GO:0017076	purine nucleotide binding	4	8
GO:0030554	adenyl nucleotide binding	5	8
GO:0032553	ribonucleotide binding	3	8
GO:0032555	purine ribonucleotide binding	4	8
GO:0032559	adenyl ribonucleotide binding	5	8
GO:0035639	purine ribonucleoside triphosphate binding	4	8
GO:0036094	small molecule binding	2	8
GO:0043167	ion binding	2	8
GO:0043168	anion binding	3	8
GO:0097159	organic cyclic compound binding	2	8
GO:0097367	carbohydrate derivative binding	2	8
GO:0140096	catalytic activity, acting on a protein	2	8
GO:1901265	nucleoside phosphate binding	3	8
GO:1901363	heterocyclic compound binding	2	8
GO:0004674	protein serine/threonine kinase activity	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	408	412	PF00656	0.705
CLV_NRD_NRD_1	189	191	PF00675	0.600
CLV_NRD_NRD_1	456	458	PF00675	0.551
CLV_NRD_NRD_1	518	520	PF00675	0.684
CLV_NRD_NRD_1	838	840	PF00675	0.376
CLV_PCSK_FUR_1	394	398	PF00082	0.650
CLV_PCSK_FUR_1	454	458	PF00082	0.451
CLV_PCSK_KEX2_1	11	13	PF00082	0.745
CLV_PCSK_KEX2_1	189	191	PF00082	0.603
CLV_PCSK_KEX2_1	396	398	PF00082	0.651
CLV_PCSK_KEX2_1	454	456	PF00082	0.631
CLV_PCSK_KEX2_1	518	520	PF00082	0.634
CLV_PCSK_KEX2_1	526	528	PF00082	0.545
CLV_PCSK_KEX2_1	536	538	PF00082	0.710
CLV_PCSK_KEX2_1	838	840	PF00082	0.341
CLV_PCSK_KEX2_1	847	849	PF00082	0.341
CLV_PCSK_PC1ET2_1	11	13	PF00082	0.745
CLV_PCSK_PC1ET2_1	396	398	PF00082	0.653
CLV_PCSK_PC1ET2_1	526	528	PF00082	0.759
CLV_PCSK_PC1ET2_1	536	538	PF00082	0.710
CLV_PCSK_PC1ET2_1	847	849	PF00082	0.430
CLV_PCSK_SKI1_1	190	194	PF00082	0.614
CLV_PCSK_SKI1_1	244	248	PF00082	0.442
CLV_PCSK_SKI1_1	268	272	PF00082	0.492
CLV_PCSK_SKI1_1	387	391	PF00082	0.558
CLV_PCSK_SKI1_1	469	473	PF00082	0.347
CLV_PCSK_SKI1_1	747	751	PF00082	0.430
CLV_PCSK_SKI1_1	838	842	PF00082	0.364
CLV_PCSK_SKI1_1	847	851	PF00082	0.355
DEG_Nend_Nbox_1	1	3	PF02207	0.725
DEG_SPOP_SBC_1	141	145	PF00917	0.746
DOC_ANK_TNKS_1	595	602	PF00023	0.735
DOC_CDC14_PxL_1	827	835	PF14671	0.430
DOC_CKS1_1	130	135	PF01111	0.707
DOC_CKS1_1	75	80	PF01111	0.756
DOC_MAPK_gen_1	552	561	PF00069	0.794
DOC_MAPK_MEF2A_6	503	511	PF00069	0.488
DOC_MAPK_MEF2A_6	680	688	PF00069	0.376
DOC_PP2B_LxvP_1	463	466	PF13499	0.443
DOC_PP2B_LxvP_1	712	715	PF13499	0.430
DOC_PP2B_PxIxI_1	322	328	PF00149	0.742
DOC_PP4_FxxP_1	351	354	PF00568	0.433
DOC_SPAK_OSR1_1	350	354	PF12202	0.436
DOC_USP7_MATH_1	140	144	PF00917	0.760
DOC_USP7_MATH_1	211	215	PF00917	0.723
DOC_USP7_MATH_1	594	598	PF00917	0.663
DOC_USP7_MATH_1	603	607	PF00917	0.713
DOC_USP7_MATH_1	67	71	PF00917	0.718
DOC_WW_Pin1_4	129	134	PF00397	0.700
DOC_WW_Pin1_4	190	195	PF00397	0.525
DOC_WW_Pin1_4	207	212	PF00397	0.569
DOC_WW_Pin1_4	251	256	PF00397	0.674
DOC_WW_Pin1_4	319	324	PF00397	0.764
DOC_WW_Pin1_4	32	37	PF00397	0.738
DOC_WW_Pin1_4	5	10	PF00397	0.662
DOC_WW_Pin1_4	562	567	PF00397	0.740
DOC_WW_Pin1_4	615	620	PF00397	0.760
DOC_WW_Pin1_4	678	683	PF00397	0.417
DOC_WW_Pin1_4	74	79	PF00397	0.700
LIG_14-3-3_CanoR_1	121	131	PF00244	0.753
LIG_14-3-3_CanoR_1	207	211	PF00244	0.716
LIG_14-3-3_CanoR_1	315	325	PF00244	0.677
LIG_14-3-3_CanoR_1	419	428	PF00244	0.660
LIG_14-3-3_CanoR_1	758	764	PF00244	0.501
LIG_14-3-3_CanoR_1	848	855	PF00244	0.378
LIG_APCC_ABBA_1	271	276	PF00400	0.487
LIG_APCC_ABBAyCdc20_2	176	182	PF00400	0.575
LIG_APCC_ABBAyCdc20_2	485	491	PF00400	0.376
LIG_BIR_III_2	191	195	PF00653	0.586
LIG_deltaCOP1_diTrp_1	282	288	PF00928	0.505
LIG_EVH1_1	130	134	PF00568	0.707
LIG_FHA_1	210	216	PF00498	0.814
LIG_FHA_1	335	341	PF00498	0.606
LIG_FHA_1	47	53	PF00498	0.772
LIG_FHA_1	5	11	PF00498	0.645
LIG_FHA_1	512	518	PF00498	0.517
LIG_FHA_1	54	60	PF00498	0.735
LIG_FHA_2	16	22	PF00498	0.660
LIG_FHA_2	406	412	PF00498	0.788
LIG_FHA_2	652	658	PF00498	0.430
LIG_FHA_2	690	696	PF00498	0.397
LIG_FHA_2	729	735	PF00498	0.385
LIG_FHA_2	796	802	PF00498	0.473
LIG_FHA_2	820	826	PF00498	0.408
LIG_FHA_2	848	854	PF00498	0.376
LIG_LIR_Apic_2	128	133	PF02991	0.705
LIG_LIR_Apic_2	56	61	PF02991	0.734
LIG_LIR_Apic_2	676	682	PF02991	0.376
LIG_LIR_Apic_2	72	78	PF02991	0.747
LIG_LIR_Gen_1	193	202	PF02991	0.568
LIG_LIR_Gen_1	241	250	PF02991	0.494
LIG_LIR_Gen_1	282	291	PF02991	0.495
LIG_LIR_Gen_1	321	332	PF02991	0.666
LIG_LIR_Gen_1	411	421	PF02991	0.700
LIG_LIR_Gen_1	477	482	PF02991	0.376
LIG_LIR_Nem_3	174	180	PF02991	0.699
LIG_LIR_Nem_3	193	198	PF02991	0.323
LIG_LIR_Nem_3	222	228	PF02991	0.508
LIG_LIR_Nem_3	241	245	PF02991	0.510
LIG_LIR_Nem_3	282	288	PF02991	0.505
LIG_LIR_Nem_3	321	327	PF02991	0.651
LIG_LIR_Nem_3	477	481	PF02991	0.376
LIG_LIR_Nem_3	670	674	PF02991	0.364
LIG_LIR_Nem_3	756	760	PF02991	0.430
LIG_MAD2	244	252	PF02301	0.589
LIG_Pex14_2	651	655	PF04695	0.430
LIG_Pex14_2	757	761	PF04695	0.376
LIG_Pex14_2	770	774	PF04695	0.376
LIG_REV1ctd_RIR_1	857	863	PF16727	0.430
LIG_SH2_CRK	460	464	PF00017	0.432
LIG_SH2_CRK	473	477	PF00017	0.376
LIG_SH2_CRK	671	675	PF00017	0.376
LIG_SH2_CRK	75	79	PF00017	0.736
LIG_SH2_NCK_1	664	668	PF00017	0.451
LIG_SH2_NCK_1	671	675	PF00017	0.407
LIG_SH2_PTP2	324	327	PF00017	0.732
LIG_SH2_PTP2	58	61	PF00017	0.690
LIG_SH2_PTP2	630	633	PF00017	0.512
LIG_SH2_SRC	280	283	PF00017	0.510
LIG_SH2_SRC	58	61	PF00017	0.807
LIG_SH2_SRC	664	667	PF00017	0.472
LIG_SH2_STAP1	169	173	PF00017	0.754
LIG_SH2_STAP1	184	188	PF00017	0.411
LIG_SH2_STAP1	228	232	PF00017	0.517
LIG_SH2_STAP1	233	237	PF00017	0.459
LIG_SH2_STAP1	513	517	PF00017	0.590
LIG_SH2_STAT5	231	234	PF00017	0.436
LIG_SH2_STAT5	280	283	PF00017	0.457
LIG_SH2_STAT5	324	327	PF00017	0.732
LIG_SH2_STAT5	344	347	PF00017	0.509
LIG_SH2_STAT5	357	360	PF00017	0.519
LIG_SH2_STAT5	513	516	PF00017	0.455
LIG_SH2_STAT5	58	61	PF00017	0.807
LIG_SH2_STAT5	630	633	PF00017	0.512
LIG_SH2_STAT5	760	763	PF00017	0.366
LIG_SH2_STAT5	816	819	PF00017	0.376
LIG_SH3_3	128	134	PF00018	0.748
LIG_SH3_3	212	218	PF00018	0.719
LIG_SH3_3	249	255	PF00018	0.646
LIG_SH3_3	293	299	PF00018	0.559
LIG_SH3_3	355	361	PF00018	0.458
LIG_SH3_3	367	373	PF00018	0.371
LIG_SH3_3	436	442	PF00018	0.757
LIG_SH3_3	628	634	PF00018	0.527
LIG_SUMO_SIM_anti_2	606	614	PF11976	0.542
LIG_SUMO_SIM_par_1	48	56	PF11976	0.627
LIG_SUMO_SIM_par_1	500	508	PF11976	0.430
LIG_SUMO_SIM_par_1	613	618	PF11976	0.662
LIG_SUMO_SIM_par_1	832	837	PF11976	0.392
LIG_TRAF2_1	219	222	PF00917	0.583
LIG_TRAF2_1	302	305	PF00917	0.669
LIG_TRAF2_1	805	808	PF00917	0.370
LIG_TRAF2_1	850	853	PF00917	0.410
LIG_TRAF2_2	619	624	PF00917	0.732
LIG_TRFH_1	761	765	PF08558	0.501
LIG_TYR_ITIM	458	463	PF00017	0.446
LIG_TYR_ITIM	471	476	PF00017	0.376
LIG_TYR_ITIM	669	674	PF00017	0.376
LIG_WRC_WIRS_1	475	480	PF05994	0.430
LIG_WRC_WIRS_1	652	657	PF05994	0.430
LIG_WRC_WIRS_1	729	734	PF05994	0.421
LIG_WRC_WIRS_1	754	759	PF05994	0.430
LIG_WW_2	135	138	PF00397	0.709
MOD_CDC14_SPxK_1	8	11	PF00782	0.720
MOD_CDK_SPxK_1	5	11	PF00069	0.723
MOD_CDK_SPxxK_3	190	197	PF00069	0.567
MOD_CDK_SPxxK_3	5	12	PF00069	0.726
MOD_CDK_SPxxK_3	615	622	PF00069	0.761
MOD_CK1_1	106	112	PF00069	0.713
MOD_CK1_1	116	122	PF00069	0.639
MOD_CK1_1	125	131	PF00069	0.525
MOD_CK1_1	143	149	PF00069	0.494
MOD_CK1_1	150	156	PF00069	0.671
MOD_CK1_1	17	23	PF00069	0.718
MOD_CK1_1	203	209	PF00069	0.700
MOD_CK1_1	326	332	PF00069	0.620
MOD_CK1_1	404	410	PF00069	0.763
MOD_CK1_1	570	576	PF00069	0.695
MOD_CK1_1	604	610	PF00069	0.781
MOD_CK1_1	70	76	PF00069	0.677
MOD_CK1_1	792	798	PF00069	0.397
MOD_CK2_1	15	21	PF00069	0.783
MOD_CK2_1	39	45	PF00069	0.801
MOD_CK2_1	527	533	PF00069	0.669
MOD_CK2_1	544	550	PF00069	0.716
MOD_CK2_1	594	600	PF00069	0.709
MOD_CK2_1	847	853	PF00069	0.376
MOD_GlcNHglycan	105	108	PF01048	0.687
MOD_GlcNHglycan	202	205	PF01048	0.676
MOD_GlcNHglycan	215	218	PF01048	0.718
MOD_GlcNHglycan	261	264	PF01048	0.616
MOD_GlcNHglycan	403	406	PF01048	0.637
MOD_GlcNHglycan	41	44	PF01048	0.758
MOD_GlcNHglycan	421	424	PF01048	0.590
MOD_GlcNHglycan	432	435	PF01048	0.640
MOD_GlcNHglycan	529	532	PF01048	0.701
MOD_GlcNHglycan	596	599	PF01048	0.690
MOD_GlcNHglycan	64	67	PF01048	0.695
MOD_GlcNHglycan	692	695	PF01048	0.376
MOD_GlcNHglycan	739	742	PF01048	0.424
MOD_GlcNHglycan	791	794	PF01048	0.417
MOD_GSK3_1	106	113	PF00069	0.670
MOD_GSK3_1	119	126	PF00069	0.591
MOD_GSK3_1	13	20	PF00069	0.707
MOD_GSK3_1	140	147	PF00069	0.710
MOD_GSK3_1	203	210	PF00069	0.683
MOD_GSK3_1	286	293	PF00069	0.493
MOD_GSK3_1	315	322	PF00069	0.670
MOD_GSK3_1	383	390	PF00069	0.529
MOD_GSK3_1	397	404	PF00069	0.627
MOD_GSK3_1	499	506	PF00069	0.430
MOD_GSK3_1	527	534	PF00069	0.727
MOD_GSK3_1	562	569	PF00069	0.733
MOD_GSK3_1	601	608	PF00069	0.772
MOD_GSK3_1	62	69	PF00069	0.754
MOD_GSK3_1	674	681	PF00069	0.376
MOD_GSK3_1	70	77	PF00069	0.725
MOD_GSK3_1	737	744	PF00069	0.445
MOD_GSK3_1	815	822	PF00069	0.501
MOD_LATS_1	395	401	PF00433	0.697
MOD_N-GLC_1	46	51	PF02516	0.648
MOD_N-GLC_1	570	575	PF02516	0.767
MOD_N-GLC_1	690	695	PF02516	0.501
MOD_N-GLC_1	715	720	PF02516	0.430
MOD_NEK2_1	112	117	PF00069	0.707
MOD_NEK2_1	205	210	PF00069	0.574
MOD_NEK2_1	227	232	PF00069	0.465
MOD_NEK2_1	333	338	PF00069	0.636
MOD_NEK2_1	421	426	PF00069	0.604
MOD_NEK2_1	498	503	PF00069	0.430
MOD_NEK2_1	53	58	PF00069	0.821
MOD_NEK2_1	544	549	PF00069	0.700
MOD_NEK2_1	559	564	PF00069	0.653
MOD_NEK2_1	605	610	PF00069	0.662
MOD_NEK2_1	651	656	PF00069	0.430
MOD_NEK2_1	806	811	PF00069	0.503
MOD_NEK2_1	834	839	PF00069	0.430
MOD_NEK2_2	323	328	PF00069	0.741
MOD_PIKK_1	110	116	PF00454	0.789
MOD_PIKK_1	123	129	PF00454	0.598
MOD_PIKK_1	256	262	PF00454	0.715
MOD_PIKK_1	441	447	PF00454	0.612
MOD_PIKK_1	617	623	PF00454	0.666
MOD_PIKK_1	77	83	PF00454	0.832
MOD_PK_1	503	509	PF00069	0.496
MOD_PKA_1	518	524	PF00069	0.637
MOD_PKA_1	535	541	PF00069	0.744
MOD_PKA_1	847	853	PF00069	0.376
MOD_PKA_2	122	128	PF00069	0.707
MOD_PKA_2	13	19	PF00069	0.707
MOD_PKA_2	206	212	PF00069	0.800
MOD_PKA_2	390	396	PF00069	0.578
MOD_PKA_2	518	524	PF00069	0.712
MOD_PKA_2	847	853	PF00069	0.376
MOD_PKB_1	12	20	PF00069	0.741
MOD_PKB_1	121	129	PF00069	0.821
MOD_Plk_1	233	239	PF00069	0.521
MOD_Plk_1	286	292	PF00069	0.490
MOD_Plk_1	570	576	PF00069	0.769
MOD_Plk_1	623	629	PF00069	0.561
MOD_Plk_1	656	662	PF00069	0.430
MOD_Plk_1	715	721	PF00069	0.430
MOD_Plk_1	806	812	PF00069	0.408
MOD_Plk_4	227	233	PF00069	0.491
MOD_Plk_4	371	377	PF00069	0.437
MOD_Plk_4	474	480	PF00069	0.430
MOD_Plk_4	48	54	PF00069	0.757
MOD_Plk_4	608	614	PF00069	0.537
MOD_Plk_4	656	662	PF00069	0.397
MOD_Plk_4	70	76	PF00069	0.735
MOD_Plk_4	776	782	PF00069	0.501
MOD_ProDKin_1	129	135	PF00069	0.700
MOD_ProDKin_1	190	196	PF00069	0.511
MOD_ProDKin_1	207	213	PF00069	0.572
MOD_ProDKin_1	251	257	PF00069	0.671
MOD_ProDKin_1	319	325	PF00069	0.760
MOD_ProDKin_1	32	38	PF00069	0.739
MOD_ProDKin_1	5	11	PF00069	0.664
MOD_ProDKin_1	562	568	PF00069	0.736
MOD_ProDKin_1	615	621	PF00069	0.761
MOD_ProDKin_1	678	684	PF00069	0.417
MOD_ProDKin_1	74	80	PF00069	0.701
MOD_SUMO_for_1	492	495	PF00179	0.376
MOD_SUMO_rev_2	538	544	PF00179	0.778
MOD_SUMO_rev_2	769	775	PF00179	0.444
TRG_DiLeu_BaLyEn_6	463	468	PF01217	0.482
TRG_ENDOCYTIC_2	177	180	PF00928	0.508
TRG_ENDOCYTIC_2	324	327	PF00928	0.732
TRG_ENDOCYTIC_2	460	463	PF00928	0.432
TRG_ENDOCYTIC_2	473	476	PF00928	0.364
TRG_ENDOCYTIC_2	630	633	PF00928	0.512
TRG_ENDOCYTIC_2	664	667	PF00928	0.380
TRG_ENDOCYTIC_2	671	674	PF00928	0.328
TRG_ENDOCYTIC_2	760	763	PF00928	0.360
TRG_ENDOCYTIC_2	843	846	PF00928	0.366
TRG_ER_diArg_1	188	190	PF00400	0.537
TRG_ER_diArg_1	454	457	PF00400	0.594
TRG_ER_diArg_1	517	519	PF00400	0.669
TRG_ER_diArg_1	838	840	PF00400	0.342
TRG_NES_CRM1_1	753	764	PF08389	0.501
TRG_NLS_Bipartite_1	518	539	PF00514	0.679
TRG_NLS_MonoExtC_3	395	401	PF00514	0.648
TRG_NLS_MonoExtC_3	534	540	PF00514	0.717
TRG_NLS_MonoExtN_4	394	400	PF00514	0.652
TRG_NLS_MonoExtN_4	9	15	PF00514	0.703

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMK2	Leptomonas seymouri	62%	99%
A0A422NL22	Trypanosoma rangeli	33%	100%
A4HEJ6	Leishmania braziliensis	82%	99%
A4I1K2	Leishmania infantum	100%	100%
E9AXN6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4Q9T5	Leishmania major	95%	100%