NPL4_family_putative/Pfam:PF05021

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NPL4 family, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WZ51_LEIDO

TriTrypDb:

LdBPK_251320.1 , LdCL_250018800 , LDHU3_25.1650

Length:

427

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WZ51

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WZ51

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	11
GO:0006511	ubiquitin-dependent protein catabolic process	7	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009056	catabolic process	2	11
GO:0009057	macromolecule catabolic process	4	11
GO:0009987	cellular process	1	11
GO:0019538	protein metabolic process	3	11
GO:0019941	modification-dependent protein catabolic process	6	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043632	modification-dependent macromolecule catabolic process	5	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044248	cellular catabolic process	3	11
GO:0044260	obsolete cellular macromolecule metabolic process	3	11
GO:0044265	obsolete cellular macromolecule catabolic process	4	11
GO:0051603	proteolysis involved in protein catabolic process	5	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11
GO:1901575	organic substance catabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0019899	enzyme binding	3	1
GO:0031625	ubiquitin protein ligase binding	5	1
GO:0032182	ubiquitin-like protein binding	3	1
GO:0043130	ubiquitin binding	4	1
GO:0044389	ubiquitin-like protein ligase binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	2	6	PF00656	0.643
CLV_NRD_NRD_1	16	18	PF00675	0.495
CLV_NRD_NRD_1	171	173	PF00675	0.246
CLV_NRD_NRD_1	30	32	PF00675	0.557
CLV_NRD_NRD_1	368	370	PF00675	0.465
CLV_PCSK_KEX2_1	15	17	PF00082	0.492
CLV_PCSK_KEX2_1	171	173	PF00082	0.265
CLV_PCSK_KEX2_1	22	24	PF00082	0.525
CLV_PCSK_KEX2_1	368	370	PF00082	0.427
CLV_PCSK_PC1ET2_1	22	24	PF00082	0.544
CLV_PCSK_PC1ET2_1	368	370	PF00082	0.427
CLV_PCSK_PC7_1	11	17	PF00082	0.574
CLV_PCSK_SKI1_1	163	167	PF00082	0.349
CLV_PCSK_SKI1_1	192	196	PF00082	0.357
CLV_PCSK_SKI1_1	311	315	PF00082	0.503
CLV_PCSK_SKI1_1	324	328	PF00082	0.299
CLV_PCSK_SKI1_1	341	345	PF00082	0.379
CLV_PCSK_SKI1_1	408	412	PF00082	0.546
DEG_APCC_DBOX_1	90	98	PF00400	0.476
DEG_SPOP_SBC_1	70	74	PF00917	0.594
DOC_MAPK_gen_1	160	170	PF00069	0.532
DOC_MAPK_gen_1	365	374	PF00069	0.469
DOC_MAPK_MEF2A_6	182	191	PF00069	0.486
DOC_MAPK_RevD_3	156	172	PF00069	0.490
DOC_PP1_RVXF_1	82	88	PF00149	0.393
DOC_PP2B_PxIxI_1	247	253	PF00149	0.513
DOC_PP4_FxxP_1	335	338	PF00568	0.407
DOC_PP4_MxPP_1	352	355	PF00568	0.441
DOC_USP7_MATH_1	217	221	PF00917	0.665
DOC_USP7_MATH_1	234	238	PF00917	0.737
DOC_USP7_MATH_1	239	243	PF00917	0.686
DOC_USP7_MATH_1	3	7	PF00917	0.557
DOC_USP7_MATH_1	400	404	PF00917	0.448
DOC_WW_Pin1_4	24	29	PF00397	0.648
DOC_WW_Pin1_4	257	262	PF00397	0.356
DOC_WW_Pin1_4	334	339	PF00397	0.406
LIG_14-3-3_CanoR_1	324	330	PF00244	0.337
LIG_14-3-3_CanoR_1	369	375	PF00244	0.401
LIG_14-3-3_CanoR_1	399	405	PF00244	0.388
LIG_Actin_WH2_2	157	173	PF00022	0.520
LIG_BIR_II_1	1	5	PF00653	0.580
LIG_BRCT_BRCA1_1	370	374	PF00533	0.456
LIG_BRCT_BRCA1_1	48	52	PF00533	0.512
LIG_Clathr_ClatBox_1	94	98	PF01394	0.424
LIG_FHA_1	128	134	PF00498	0.476
LIG_FHA_1	247	253	PF00498	0.607
LIG_FHA_1	25	31	PF00498	0.625
LIG_FHA_1	292	298	PF00498	0.516
LIG_FHA_1	325	331	PF00498	0.360
LIG_FHA_1	65	71	PF00498	0.548
LIG_FHA_1	90	96	PF00498	0.381
LIG_FHA_2	300	306	PF00498	0.560
LIG_FHA_2	317	323	PF00498	0.354
LIG_FHA_2	375	381	PF00498	0.420
LIG_FHA_2	391	397	PF00498	0.368
LIG_LIR_Gen_1	327	335	PF02991	0.357
LIG_LIR_Gen_1	380	388	PF02991	0.310
LIG_LIR_Gen_1	49	60	PF02991	0.497
LIG_LIR_Nem_3	147	153	PF02991	0.473
LIG_LIR_Nem_3	323	329	PF02991	0.350
LIG_LIR_Nem_3	380	384	PF02991	0.308
LIG_LIR_Nem_3	49	55	PF02991	0.468
LIG_MYND_1	244	248	PF01753	0.431
LIG_NRBOX	383	389	PF00104	0.458
LIG_Pex14_1	325	329	PF04695	0.346
LIG_Rb_pABgroove_1	120	128	PF01858	0.549
LIG_SH2_CRK	119	123	PF00017	0.457
LIG_SH2_CRK	417	421	PF00017	0.509
LIG_SH2_NCK_1	126	130	PF00017	0.507
LIG_SH2_PTP2	329	332	PF00017	0.362
LIG_SH2_SRC	126	129	PF00017	0.532
LIG_SH2_STAP1	119	123	PF00017	0.478
LIG_SH2_STAP1	41	45	PF00017	0.537
LIG_SH2_STAT5	148	151	PF00017	0.490
LIG_SH2_STAT5	329	332	PF00017	0.362
LIG_SH2_STAT5	363	366	PF00017	0.426
LIG_SH2_STAT5	386	389	PF00017	0.440
LIG_SH3_3	135	141	PF00018	0.487
LIG_SH3_3	347	353	PF00018	0.497
LIG_SUMO_SIM_par_1	247	253	PF11976	0.586
LIG_TYR_ITSM	325	332	PF00017	0.348
LIG_UBA3_1	51	59	PF00899	0.546
LIG_WRC_WIRS_1	105	110	PF05994	0.349
MOD_CDK_SPxxK_3	24	31	PF00069	0.626
MOD_CDK_SPxxK_3	334	341	PF00069	0.403
MOD_CK1_1	146	152	PF00069	0.560
MOD_CK1_1	220	226	PF00069	0.659
MOD_CK1_1	242	248	PF00069	0.706
MOD_CK1_1	64	70	PF00069	0.496
MOD_CK2_1	273	279	PF00069	0.401
MOD_CK2_1	370	376	PF00069	0.410
MOD_CK2_1	391	397	PF00069	0.467
MOD_GlcNHglycan	1	4	PF01048	0.626
MOD_GlcNHglycan	222	225	PF01048	0.709
MOD_GlcNHglycan	227	230	PF01048	0.651
MOD_GlcNHglycan	236	239	PF01048	0.524
MOD_GlcNHglycan	241	244	PF01048	0.502
MOD_GlcNHglycan	274	278	PF01048	0.485
MOD_GlcNHglycan	41	44	PF01048	0.588
MOD_GlcNHglycan	48	51	PF01048	0.462
MOD_GSK3_1	220	227	PF00069	0.679
MOD_GSK3_1	234	241	PF00069	0.667
MOD_GSK3_1	242	249	PF00069	0.569
MOD_GSK3_1	311	318	PF00069	0.461
MOD_GSK3_1	320	327	PF00069	0.339
MOD_GSK3_1	370	377	PF00069	0.493
MOD_GSK3_1	386	393	PF00069	0.479
MOD_GSK3_1	400	407	PF00069	0.412
MOD_GSK3_1	61	68	PF00069	0.512
MOD_LATS_1	309	315	PF00433	0.522
MOD_N-GLC_1	3	8	PF02516	0.600
MOD_N-GLC_2	44	46	PF02516	0.524
MOD_NEK2_1	272	277	PF00069	0.426
MOD_NEK2_1	345	350	PF00069	0.447
MOD_NEK2_1	374	379	PF00069	0.386
MOD_PIKK_1	386	392	PF00454	0.453
MOD_PIKK_1	71	77	PF00454	0.572
MOD_PIKK_1	89	95	PF00454	0.286
MOD_PKA_1	368	374	PF00069	0.458
MOD_PKA_2	345	351	PF00069	0.412
MOD_PKA_2	368	374	PF00069	0.458
MOD_Plk_1	199	205	PF00069	0.350
MOD_Plk_1	3	9	PF00069	0.501
MOD_Plk_1	80	86	PF00069	0.424
MOD_Plk_4	104	110	PF00069	0.348
MOD_Plk_4	246	252	PF00069	0.648
MOD_Plk_4	325	331	PF00069	0.353
MOD_Plk_4	61	67	PF00069	0.447
MOD_ProDKin_1	24	30	PF00069	0.644
MOD_ProDKin_1	257	263	PF00069	0.354
MOD_ProDKin_1	334	340	PF00069	0.400
MOD_SUMO_for_1	21	24	PF00179	0.487
MOD_SUMO_rev_2	107	116	PF00179	0.452
MOD_SUMO_rev_2	54	60	PF00179	0.451
TRG_ENDOCYTIC_2	119	122	PF00928	0.457
TRG_ENDOCYTIC_2	329	332	PF00928	0.362
TRG_ENDOCYTIC_2	417	420	PF00928	0.410
TRG_ER_diArg_1	15	17	PF00400	0.494
TRG_ER_diArg_1	170	172	PF00400	0.446
TRG_NES_CRM1_1	185	200	PF08389	0.453
TRG_NES_CRM1_1	376	390	PF08389	0.409
TRG_NLS_MonoExtN_4	365	372	PF00514	0.459

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4H2	Leptomonas seymouri	72%	99%
A0A0S4KHU4	Bodo saltans	40%	100%
A0A1X0NM08	Trypanosomatidae	46%	100%
A0A422P221	Trypanosoma rangeli	51%	100%
A4HE71	Leishmania braziliensis	89%	100%
C9ZK00	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	85%
E9AXK7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4Q9W4	Leishmania major	96%	100%
Q54GD3	Dictyostelium discoideum	24%	74%
V5BCY4	Trypanosoma cruzi	50%	100%