Non-specific serine/threonine protein kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WZ44_LEIDO

TriTrypDb:

LdBPK_250900.1 , LdCL_250014300 , LDHU3_25.1170

Length:

292

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000408	EKC/KEOPS complex	2	1
GO:0005634	nucleus	5	1
GO:0005654	nucleoplasm	2	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WZ44

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WZ44

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006396	RNA processing	6	12
GO:0006399	tRNA metabolic process	7	12
GO:0006468	protein phosphorylation	5	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008033	tRNA processing	8	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0016310	phosphorylation	5	12
GO:0019538	protein metabolic process	3	12
GO:0034470	ncRNA processing	7	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034660	ncRNA metabolic process	6	12
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:0070525	tRNA threonylcarbamoyladenosine metabolic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0004672	protein kinase activity	3	12
GO:0004674	protein serine/threonine kinase activity	4	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016301	kinase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	12
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140096	catalytic activity, acting on a protein	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12
GO:0106310	protein serine kinase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	197	201	PF00656	0.644
CLV_NRD_NRD_1	285	287	PF00675	0.392
CLV_NRD_NRD_1	68	70	PF00675	0.486
CLV_PCSK_FUR_1	66	70	PF00082	0.410
CLV_PCSK_KEX2_1	287	289	PF00082	0.447
CLV_PCSK_KEX2_1	51	53	PF00082	0.483
CLV_PCSK_KEX2_1	68	70	PF00082	0.365
CLV_PCSK_PC1ET2_1	287	289	PF00082	0.473
CLV_PCSK_PC1ET2_1	51	53	PF00082	0.483
CLV_PCSK_SKI1_1	108	112	PF00082	0.348
CLV_PCSK_SKI1_1	23	27	PF00082	0.368
CLV_PCSK_SKI1_1	48	52	PF00082	0.431
CLV_PCSK_SKI1_1	76	80	PF00082	0.444
CLV_Separin_Fungi	18	24	PF03568	0.369
DEG_SCF_FBW7_1	135	142	PF00400	0.586
DOC_CDC14_PxL_1	38	46	PF14671	0.315
DOC_CKS1_1	136	141	PF01111	0.588
DOC_PP1_RVXF_1	21	27	PF00149	0.369
DOC_USP7_MATH_1	12	16	PF00917	0.513
DOC_USP7_MATH_1	139	143	PF00917	0.600
DOC_USP7_MATH_1	201	205	PF00917	0.671
DOC_USP7_MATH_1	242	246	PF00917	0.302
DOC_USP7_MATH_1	252	256	PF00917	0.309
DOC_WW_Pin1_4	135	140	PF00397	0.699
DOC_WW_Pin1_4	147	152	PF00397	0.401
LIG_14-3-3_CanoR_1	241	250	PF00244	0.305
LIG_14-3-3_CanoR_1	286	291	PF00244	0.513
LIG_BIR_II_1	1	5	PF00653	0.692
LIG_eIF4E_1	92	98	PF01652	0.364
LIG_FHA_1	14	20	PF00498	0.501
LIG_FHA_1	151	157	PF00498	0.433
LIG_FHA_1	203	209	PF00498	0.518
LIG_FHA_1	93	99	PF00498	0.429
LIG_FHA_2	104	110	PF00498	0.352
LIG_FHA_2	209	215	PF00498	0.458
LIG_FHA_2	65	71	PF00498	0.369
LIG_LIR_Apic_2	37	42	PF02991	0.330
LIG_LIR_Gen_1	95	103	PF02991	0.440
LIG_LIR_Nem_3	219	223	PF02991	0.317
LIG_SH2_CRK	39	43	PF00017	0.354
LIG_SH2_GRB2like	92	95	PF00017	0.462
LIG_SH2_STAT3	118	121	PF00017	0.412
LIG_SH2_STAT5	237	240	PF00017	0.296
LIG_SH2_STAT5	249	252	PF00017	0.320
LIG_SH2_STAT5	35	38	PF00017	0.299
LIG_SH2_STAT5	92	95	PF00017	0.476
LIG_SUMO_SIM_anti_2	213	219	PF11976	0.328
LIG_SUMO_SIM_par_1	213	219	PF11976	0.295
LIG_TRAF2_1	228	231	PF00917	0.302
LIG_WRC_WIRS_1	35	40	PF05994	0.266
LIG_WRC_WIRS_1	93	98	PF05994	0.441
MOD_CK1_1	15	21	PF00069	0.538
MOD_CK1_1	150	156	PF00069	0.448
MOD_CK2_1	103	109	PF00069	0.394
MOD_CK2_1	225	231	PF00069	0.342
MOD_CK2_1	54	60	PF00069	0.399
MOD_CK2_1	64	70	PF00069	0.324
MOD_Cter_Amidation	284	287	PF01082	0.401
MOD_GlcNHglycan	128	131	PF01048	0.750
MOD_GlcNHglycan	141	144	PF01048	0.616
MOD_GlcNHglycan	250	253	PF01048	0.397
MOD_GlcNHglycan	263	266	PF01048	0.390
MOD_GSK3_1	120	127	PF00069	0.463
MOD_GSK3_1	135	142	PF00069	0.611
MOD_GSK3_1	152	159	PF00069	0.266
MOD_GSK3_1	221	228	PF00069	0.469
MOD_GSK3_1	248	255	PF00069	0.491
MOD_NEK2_1	1	6	PF00069	0.716
MOD_NEK2_1	156	161	PF00069	0.407
MOD_NEK2_1	177	182	PF00069	0.289
MOD_NEK2_1	202	207	PF00069	0.629
MOD_NEK2_2	34	39	PF00069	0.421
MOD_PIKK_1	61	67	PF00454	0.511
MOD_PKA_1	286	292	PF00069	0.478
MOD_PKB_1	284	292	PF00069	0.451
MOD_PKB_1	52	60	PF00069	0.516
MOD_Plk_4	152	158	PF00069	0.300
MOD_Plk_4	34	40	PF00069	0.385
MOD_Plk_4	92	98	PF00069	0.342
MOD_ProDKin_1	135	141	PF00069	0.696
MOD_ProDKin_1	147	153	PF00069	0.387
TRG_DiLeu_BaEn_1	20	25	PF01217	0.432
TRG_DiLeu_BaLyEn_6	83	88	PF01217	0.453
TRG_DiLeu_LyEn_5	20	25	PF01217	0.380
TRG_ENDOCYTIC_2	35	38	PF00928	0.347
TRG_ER_diArg_1	281	284	PF00400	0.380
TRG_ER_diArg_1	66	69	PF00400	0.463
TRG_NLS_Bipartite_1	269	290	PF00514	0.517
TRG_NLS_MonoExtN_4	284	290	PF00514	0.434
TRG_Pf-PMV_PEXEL_1	23	27	PF00026	0.368
TRG_Pf-PMV_PEXEL_1	86	91	PF00026	0.459

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P733	Leptomonas seymouri	62%	96%
A0A0S4J0K1	Bodo saltans	38%	100%
A0A1X0P554	Trypanosomatidae	46%	100%
A0A3R7L6S7	Trypanosoma rangeli	45%	100%
A1CLD2	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	38%	100%
A4HE22	Leishmania braziliensis	82%	100%
A4I1C8	Leishmania infantum	100%	100%
B7XIB8	Enterocytozoon bieneusi (strain H348)	27%	100%
D0A5M3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9AXG5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
P0CP72	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	34%	100%
P0CP73	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	34%	100%
P53323	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	100%
Q1EBD3	Coccidioides immitis (strain RS)	35%	100%
Q2HGY8	Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)	37%	100%
Q2U3T8	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	35%	100%
Q4HYC1	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	32%	100%
Q4QA07	Leishmania major	96%	100%
Q4WYU4	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	36%	100%
Q54W07	Dictyostelium discoideum	35%	100%
Q5AGC7	Candida albicans (strain SC5314 / ATCC MYA-2876)	29%	99%
Q5BAB7	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	37%	100%
Q6BHA8	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	30%	100%
Q6C2A3	Yarrowia lipolytica (strain CLIB 122 / E 150)	35%	100%
Q6CXB9	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	28%	100%
Q6FTW0	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	29%	100%
Q74Z75	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	32%	100%
Q96S44	Homo sapiens	37%	100%
Q99PW4	Mus musculus	36%	100%
Q9P7N1	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	33%	100%
Q9UYB9	Pyrococcus abyssi (strain GE5 / Orsay)	30%	100%
V5BXG1	Trypanosoma cruzi	46%	100%