Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WZ43_LEIDO

TriTrypDb:

LdBPK_251070.1 , LdCL_250016100 , LDHU3_25.1380

Length:

770

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WZ43

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WZ43

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016740	transferase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	372	376	PF00656	0.664
CLV_C14_Caspase3-7	723	727	PF00656	0.664
CLV_NRD_NRD_1	117	119	PF00675	0.495
CLV_NRD_NRD_1	188	190	PF00675	0.577
CLV_NRD_NRD_1	29	31	PF00675	0.443
CLV_NRD_NRD_1	38	40	PF00675	0.506
CLV_NRD_NRD_1	565	567	PF00675	0.795
CLV_NRD_NRD_1	696	698	PF00675	0.590
CLV_PCSK_KEX2_1	117	119	PF00082	0.495
CLV_PCSK_KEX2_1	188	190	PF00082	0.582
CLV_PCSK_KEX2_1	29	31	PF00082	0.443
CLV_PCSK_KEX2_1	696	698	PF00082	0.590
CLV_PCSK_SKI1_1	696	700	PF00082	0.549
DEG_APCC_DBOX_1	29	37	PF00400	0.482
DEG_APCC_DBOX_1	713	721	PF00400	0.574
DEG_SCF_FBW7_2	504	509	PF00400	0.721
DEG_SIAH_1	667	675	PF03145	0.604
DEG_SPOP_SBC_1	674	678	PF00917	0.521
DOC_CYCLIN_RxL_1	26	37	PF00134	0.550
DOC_CYCLIN_RxL_1	694	704	PF00134	0.545
DOC_CYCLIN_yCln2_LP_2	153	159	PF00134	0.635
DOC_MAPK_gen_1	18	28	PF00069	0.494
DOC_MAPK_gen_1	29	38	PF00069	0.495
DOC_MAPK_gen_1	553	562	PF00069	0.543
DOC_MAPK_HePTP_8	26	38	PF00069	0.472
DOC_MAPK_MEF2A_6	249	257	PF00069	0.654
DOC_MAPK_MEF2A_6	29	38	PF00069	0.567
DOC_MAPK_RevD_3	26	40	PF00069	0.492
DOC_PP1_RVXF_1	235	242	PF00149	0.555
DOC_PP2B_LxvP_1	153	156	PF13499	0.475
DOC_PP2B_LxvP_1	388	391	PF13499	0.391
DOC_PP4_FxxP_1	389	392	PF00568	0.504
DOC_SPAK_OSR1_1	240	244	PF12202	0.683
DOC_USP7_MATH_1	164	168	PF00917	0.706
DOC_USP7_MATH_1	217	221	PF00917	0.739
DOC_USP7_MATH_1	264	268	PF00917	0.534
DOC_USP7_MATH_1	312	316	PF00917	0.671
DOC_USP7_MATH_1	337	341	PF00917	0.665
DOC_USP7_MATH_1	373	377	PF00917	0.687
DOC_USP7_MATH_1	396	400	PF00917	0.633
DOC_USP7_MATH_1	44	48	PF00917	0.563
DOC_USP7_MATH_1	517	521	PF00917	0.597
DOC_USP7_MATH_1	53	57	PF00917	0.390
DOC_USP7_MATH_1	674	678	PF00917	0.623
DOC_WW_Pin1_4	189	194	PF00397	0.625
DOC_WW_Pin1_4	486	491	PF00397	0.809
DOC_WW_Pin1_4	502	507	PF00397	0.597
DOC_WW_Pin1_4	586	591	PF00397	0.526
DOC_WW_Pin1_4	592	597	PF00397	0.635
LIG_14-3-3_CanoR_1	213	222	PF00244	0.745
LIG_14-3-3_CanoR_1	289	293	PF00244	0.485
LIG_14-3-3_CanoR_1	332	341	PF00244	0.735
LIG_14-3-3_CanoR_1	407	413	PF00244	0.455
LIG_14-3-3_CanoR_1	609	613	PF00244	0.586
LIG_14-3-3_CanoR_1	696	702	PF00244	0.555
LIG_14-3-3_CanoR_1	714	724	PF00244	0.596
LIG_APCC_ABBA_1	504	509	PF00400	0.721
LIG_BRCT_BRCA1_1	107	111	PF00533	0.356
LIG_BRCT_BRCA1_1	393	397	PF00533	0.522
LIG_BRCT_BRCA1_1	580	584	PF00533	0.675
LIG_DLG_GKlike_1	697	705	PF00625	0.544
LIG_eIF4E_1	616	622	PF01652	0.422
LIG_FHA_1	105	111	PF00498	0.490
LIG_FHA_1	202	208	PF00498	0.641
LIG_FHA_1	224	230	PF00498	0.803
LIG_FHA_1	269	275	PF00498	0.592
LIG_FHA_1	278	284	PF00498	0.418
LIG_FHA_1	440	446	PF00498	0.540
LIG_FHA_1	625	631	PF00498	0.506
LIG_FHA_1	648	654	PF00498	0.667
LIG_FHA_2	370	376	PF00498	0.730
LIG_FHA_2	381	387	PF00498	0.477
LIG_FHA_2	409	415	PF00498	0.495
LIG_FHA_2	550	556	PF00498	0.599
LIG_FHA_2	635	641	PF00498	0.574
LIG_GBD_Chelix_1	422	430	PF00786	0.411
LIG_GBD_Chelix_1	617	625	PF00786	0.440
LIG_LIR_Apic_2	290	295	PF02991	0.508
LIG_LIR_Apic_2	340	346	PF02991	0.492
LIG_LIR_Apic_2	386	392	PF02991	0.478
LIG_LIR_Apic_2	678	684	PF02991	0.564
LIG_LIR_Gen_1	124	131	PF02991	0.602
LIG_LIR_Gen_1	167	175	PF02991	0.763
LIG_LIR_Gen_1	380	389	PF02991	0.594
LIG_LIR_Gen_1	442	452	PF02991	0.434
LIG_LIR_Gen_1	615	624	PF02991	0.430
LIG_LIR_Nem_3	124	129	PF02991	0.583
LIG_LIR_Nem_3	167	172	PF02991	0.776
LIG_LIR_Nem_3	192	197	PF02991	0.583
LIG_LIR_Nem_3	238	244	PF02991	0.654
LIG_LIR_Nem_3	380	384	PF02991	0.603
LIG_LIR_Nem_3	442	447	PF02991	0.465
LIG_LIR_Nem_3	615	619	PF02991	0.421
LIG_MAD2	195	203	PF02301	0.683
LIG_MYND_1	685	689	PF01753	0.631
LIG_NRBOX	383	389	PF00104	0.582
LIG_NRBOX	56	62	PF00104	0.537
LIG_PDZ_Class_2	765	770	PF00595	0.658
LIG_Pex14_1	194	198	PF04695	0.553
LIG_Rb_LxCxE_1	139	158	PF01857	0.552
LIG_SH2_CRK	250	254	PF00017	0.612
LIG_SH2_CRK	588	592	PF00017	0.452
LIG_SH2_CRK	632	636	PF00017	0.454
LIG_SH2_CRK	681	685	PF00017	0.590
LIG_SH2_NCK_1	126	130	PF00017	0.665
LIG_SH2_PTP2	381	384	PF00017	0.591
LIG_SH2_PTP2	616	619	PF00017	0.350
LIG_SH2_SRC	632	635	PF00017	0.517
LIG_SH2_STAP1	304	308	PF00017	0.617
LIG_SH2_STAT5	304	307	PF00017	0.568
LIG_SH2_STAT5	360	363	PF00017	0.563
LIG_SH2_STAT5	381	384	PF00017	0.532
LIG_SH2_STAT5	428	431	PF00017	0.475
LIG_SH2_STAT5	561	564	PF00017	0.786
LIG_SH2_STAT5	616	619	PF00017	0.360
LIG_SH2_STAT5	634	637	PF00017	0.412
LIG_SH3_1	43	49	PF00018	0.426
LIG_SH3_1	682	688	PF00018	0.632
LIG_SH3_2	668	673	PF14604	0.569
LIG_SH3_3	43	49	PF00018	0.545
LIG_SH3_3	665	671	PF00018	0.650
LIG_SH3_3	682	688	PF00018	0.562
LIG_SH3_3	88	94	PF00018	0.656
LIG_SH3_4	202	209	PF00018	0.502
LIG_SUMO_SIM_par_1	32	37	PF11976	0.490
LIG_SUMO_SIM_par_1	360	366	PF11976	0.643
LIG_SUMO_SIM_par_1	486	497	PF11976	0.687
LIG_TRAF2_1	168	171	PF00917	0.708
LIG_TRAF2_1	328	331	PF00917	0.659
LIG_TRAF2_1	512	515	PF00917	0.747
LIG_TRAF2_1	755	758	PF00917	0.826
LIG_TYR_ITIM	196	201	PF00017	0.679
LIG_TYR_ITIM	630	635	PF00017	0.505
MOD_CDC14_SPxK_1	192	195	PF00782	0.631
MOD_CDK_SPxK_1	189	195	PF00069	0.641
MOD_CDK_SPxxK_3	586	593	PF00069	0.518
MOD_CK1_1	124	130	PF00069	0.572
MOD_CK1_1	315	321	PF00069	0.696
MOD_CK1_1	348	354	PF00069	0.696
MOD_CK1_1	380	386	PF00069	0.545
MOD_CK1_1	398	404	PF00069	0.540
MOD_CK1_1	489	495	PF00069	0.804
MOD_CK1_1	661	667	PF00069	0.765
MOD_CK1_1	675	681	PF00069	0.597
MOD_CK1_1	761	767	PF00069	0.704
MOD_CK2_1	157	163	PF00069	0.740
MOD_CK2_1	164	170	PF00069	0.719
MOD_CK2_1	264	270	PF00069	0.533
MOD_CK2_1	408	414	PF00069	0.464
MOD_CK2_1	509	515	PF00069	0.795
MOD_CK2_1	549	555	PF00069	0.695
MOD_CK2_1	634	640	PF00069	0.583
MOD_CK2_1	661	667	PF00069	0.676
MOD_CK2_1	70	76	PF00069	0.645
MOD_CMANNOS	120	123	PF00535	0.515
MOD_Cter_Amidation	564	567	PF01082	0.720
MOD_GlcNHglycan	159	162	PF01048	0.730
MOD_GlcNHglycan	165	169	PF01048	0.712
MOD_GlcNHglycan	215	218	PF01048	0.732
MOD_GlcNHglycan	219	222	PF01048	0.719
MOD_GlcNHglycan	250	253	PF01048	0.647
MOD_GlcNHglycan	317	320	PF01048	0.598
MOD_GlcNHglycan	334	337	PF01048	0.715
MOD_GlcNHglycan	347	350	PF01048	0.503
MOD_GlcNHglycan	365	368	PF01048	0.596
MOD_GlcNHglycan	375	378	PF01048	0.608
MOD_GlcNHglycan	393	396	PF01048	0.732
MOD_GlcNHglycan	398	401	PF01048	0.641
MOD_GlcNHglycan	478	481	PF01048	0.834
MOD_GlcNHglycan	496	499	PF01048	0.675
MOD_GlcNHglycan	656	659	PF01048	0.744
MOD_GlcNHglycan	663	666	PF01048	0.723
MOD_GlcNHglycan	76	79	PF01048	0.654
MOD_GlcNHglycan	763	766	PF01048	0.773
MOD_GSK3_1	209	216	PF00069	0.727
MOD_GSK3_1	264	271	PF00069	0.631
MOD_GSK3_1	311	318	PF00069	0.689
MOD_GSK3_1	369	376	PF00069	0.640
MOD_GSK3_1	391	398	PF00069	0.740
MOD_GSK3_1	430	437	PF00069	0.579
MOD_GSK3_1	439	446	PF00069	0.491
MOD_GSK3_1	485	492	PF00069	0.825
MOD_GSK3_1	49	56	PF00069	0.419
MOD_GSK3_1	525	532	PF00069	0.600
MOD_GSK3_1	551	558	PF00069	0.730
MOD_GSK3_1	608	615	PF00069	0.454
MOD_GSK3_1	654	661	PF00069	0.733
MOD_GSK3_1	697	704	PF00069	0.568
MOD_GSK3_1	70	77	PF00069	0.664
MOD_GSK3_1	716	723	PF00069	0.559
MOD_LATS_1	483	489	PF00433	0.738
MOD_N-GLC_1	315	320	PF02516	0.556
MOD_N-GLC_1	654	659	PF02516	0.710
MOD_N-GLC_2	693	695	PF02516	0.583
MOD_NEK2_1	157	162	PF00069	0.730
MOD_NEK2_1	209	214	PF00069	0.593
MOD_NEK2_1	369	374	PF00069	0.681
MOD_NEK2_1	653	658	PF00069	0.736
MOD_NEK2_1	701	706	PF00069	0.593
MOD_NEK2_1	713	718	PF00069	0.355
MOD_NEK2_2	121	126	PF00069	0.612
MOD_OFUCOSY	293	300	PF10250	0.517
MOD_PIKK_1	105	111	PF00454	0.401
MOD_PIKK_1	268	274	PF00454	0.651
MOD_PIKK_1	417	423	PF00454	0.329
MOD_PIKK_1	44	50	PF00454	0.622
MOD_PIKK_1	517	523	PF00454	0.595
MOD_PIKK_1	675	681	PF00454	0.626
MOD_PIKK_1	701	707	PF00454	0.598
MOD_PKA_2	248	254	PF00069	0.652
MOD_PKA_2	288	294	PF00069	0.482
MOD_PKA_2	484	490	PF00069	0.809
MOD_PKA_2	555	561	PF00069	0.714
MOD_PKA_2	608	614	PF00069	0.549
MOD_PKA_2	713	719	PF00069	0.545
MOD_PKB_1	213	221	PF00069	0.573
MOD_Plk_1	164	170	PF00069	0.778
MOD_Plk_1	315	321	PF00069	0.560
MOD_Plk_1	539	545	PF00069	0.767
MOD_Plk_4	377	383	PF00069	0.552
MOD_Plk_4	612	618	PF00069	0.479
MOD_ProDKin_1	189	195	PF00069	0.622
MOD_ProDKin_1	486	492	PF00069	0.809
MOD_ProDKin_1	502	508	PF00069	0.598
MOD_ProDKin_1	586	592	PF00069	0.531
MOD_SUMO_rev_2	323	328	PF00179	0.575
TRG_DiLeu_BaLyEn_6	29	34	PF01217	0.561
TRG_DiLeu_BaLyEn_6	365	370	PF01217	0.601
TRG_DiLeu_BaLyEn_6	46	51	PF01217	0.394
TRG_ENDOCYTIC_2	103	106	PF00928	0.571
TRG_ENDOCYTIC_2	116	119	PF00928	0.382
TRG_ENDOCYTIC_2	126	129	PF00928	0.567
TRG_ENDOCYTIC_2	198	201	PF00928	0.626
TRG_ENDOCYTIC_2	250	253	PF00928	0.610
TRG_ENDOCYTIC_2	381	384	PF00928	0.589
TRG_ENDOCYTIC_2	616	619	PF00928	0.450
TRG_ENDOCYTIC_2	632	635	PF00928	0.353
TRG_ER_diArg_1	116	118	PF00400	0.496
TRG_ER_diArg_1	28	30	PF00400	0.446
TRG_ER_diArg_1	577	580	PF00400	0.685
TRG_Pf-PMV_PEXEL_1	195	199	PF00026	0.687
TRG_Pf-PMV_PEXEL_1	697	702	PF00026	0.545

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUQ4	Leptomonas seymouri	41%	90%
A0A3R7LA44	Trypanosoma rangeli	25%	100%
A4HE39	Leishmania braziliensis	66%	100%
A4I1E5	Leishmania infantum	100%	100%
C9ZJW3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	100%
E9AXI2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q9Z0	Leishmania major	87%	98%