TAP42-like family, putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TAP42-like family, putative

Species:

Leishmania donovani

UniProt:

A0A3S7WZ42_LEIDO

TriTrypDb:

LdBPK_251410.1 , LdCL_250019700 , LDHU3_25.1750

Length:

473

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

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Expansion

Sequence features

A0A3S7WZ42

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WZ42

Function

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Biological processes
Term	Name	Level	Count
GO:0009966	regulation of signal transduction	4	10
GO:0010646	regulation of cell communication	4	10
GO:0019220	regulation of phosphate metabolic process	6	1
GO:0019222	regulation of metabolic process	3	1
GO:0023051	regulation of signaling	3	10
GO:0031323	regulation of cellular metabolic process	4	1
GO:0035303	regulation of dephosphorylation	7	1
GO:0048583	regulation of response to stimulus	3	10
GO:0050789	regulation of biological process	2	10
GO:0050794	regulation of cellular process	3	10

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Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0019899	enzyme binding	3	1
GO:0019902	phosphatase binding	4	1
GO:0019903	protein phosphatase binding	5	1
GO:0051721	protein phosphatase 2A binding	6	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	138	142	PF00656	0.586
CLV_C14_Caspase3-7	314	318	PF00656	0.502
CLV_NRD_NRD_1	244	246	PF00675	0.330
CLV_NRD_NRD_1	320	322	PF00675	0.320
CLV_PCSK_FUR_1	240	244	PF00082	0.302
CLV_PCSK_KEX2_1	100	102	PF00082	0.357
CLV_PCSK_KEX2_1	242	244	PF00082	0.293
CLV_PCSK_KEX2_1	320	322	PF00082	0.312
CLV_PCSK_PC1ET2_1	100	102	PF00082	0.327
CLV_PCSK_PC1ET2_1	242	244	PF00082	0.293

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCB4	Leptomonas seymouri	71%	100%
A0A0S4JC44	Bodo saltans	37%	100%
A0A1X0NM51	Trypanosomatidae	46%	100%
A4HE53	Leishmania braziliensis	84%	100%
A4I1I1	Leishmania infantum	100%	100%
C9ZJY7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9AXL6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4Q9V6	Leishmania major	94%	100%

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