Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WZ41_LEIDO

TriTrypDb:

LdBPK_251300.1 , LdCL_250018600 , LDHU3_25.1630

Length:

509

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WZ41

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WZ41

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	336	340	PF00656	0.550
CLV_NRD_NRD_1	134	136	PF00675	0.715
CLV_NRD_NRD_1	183	185	PF00675	0.723
CLV_NRD_NRD_1	194	196	PF00675	0.547
CLV_NRD_NRD_1	252	254	PF00675	0.538
CLV_NRD_NRD_1	387	389	PF00675	0.456
CLV_NRD_NRD_1	62	64	PF00675	0.512
CLV_NRD_NRD_1	99	101	PF00675	0.543
CLV_PCSK_KEX2_1	134	136	PF00082	0.715
CLV_PCSK_KEX2_1	183	185	PF00082	0.638
CLV_PCSK_KEX2_1	194	196	PF00082	0.563
CLV_PCSK_KEX2_1	252	254	PF00082	0.539
CLV_PCSK_KEX2_1	307	309	PF00082	0.589
CLV_PCSK_KEX2_1	386	388	PF00082	0.458
CLV_PCSK_KEX2_1	62	64	PF00082	0.512
CLV_PCSK_KEX2_1	99	101	PF00082	0.543
CLV_PCSK_PC1ET2_1	307	309	PF00082	0.589
CLV_PCSK_PC7_1	383	389	PF00082	0.544
CLV_PCSK_SKI1_1	237	241	PF00082	0.403
CLV_PCSK_SKI1_1	308	312	PF00082	0.582
CLV_PCSK_SKI1_1	80	84	PF00082	0.481
DEG_Nend_Nbox_1	1	3	PF02207	0.493
DEG_SCF_FBW7_1	277	283	PF00400	0.678
DEG_SCF_FBW7_1	407	413	PF00400	0.608
DEG_SCF_FBW7_1	441	447	PF00400	0.559
DEG_SPOP_SBC_1	480	484	PF00917	0.791
DOC_ANK_TNKS_1	123	130	PF00023	0.619
DOC_CKS1_1	277	282	PF01111	0.676
DOC_CKS1_1	407	412	PF01111	0.603
DOC_CKS1_1	416	421	PF01111	0.499
DOC_CKS1_1	441	446	PF01111	0.657
DOC_MAPK_gen_1	383	392	PF00069	0.529
DOC_PP2B_LxvP_1	125	128	PF13499	0.612
DOC_USP7_MATH_1	15	19	PF00917	0.526
DOC_USP7_MATH_1	172	176	PF00917	0.581
DOC_USP7_MATH_1	261	265	PF00917	0.617
DOC_USP7_MATH_1	272	276	PF00917	0.620
DOC_USP7_MATH_1	278	282	PF00917	0.519
DOC_USP7_MATH_1	323	327	PF00917	0.572
DOC_USP7_MATH_1	410	414	PF00917	0.676
DOC_USP7_MATH_1	449	453	PF00917	0.685
DOC_USP7_MATH_1	480	484	PF00917	0.701
DOC_USP7_MATH_1	91	95	PF00917	0.386
DOC_WW_Pin1_4	114	119	PF00397	0.692
DOC_WW_Pin1_4	128	133	PF00397	0.707
DOC_WW_Pin1_4	168	173	PF00397	0.614
DOC_WW_Pin1_4	176	181	PF00397	0.604
DOC_WW_Pin1_4	199	204	PF00397	0.682
DOC_WW_Pin1_4	214	219	PF00397	0.644
DOC_WW_Pin1_4	220	225	PF00397	0.644
DOC_WW_Pin1_4	267	272	PF00397	0.780
DOC_WW_Pin1_4	276	281	PF00397	0.654
DOC_WW_Pin1_4	406	411	PF00397	0.629
DOC_WW_Pin1_4	415	420	PF00397	0.536
DOC_WW_Pin1_4	440	445	PF00397	0.648
DOC_WW_Pin1_4	87	92	PF00397	0.470
LIG_14-3-3_CanoR_1	134	138	PF00244	0.708
LIG_14-3-3_CanoR_1	173	177	PF00244	0.603
LIG_14-3-3_CanoR_1	183	189	PF00244	0.706
LIG_14-3-3_CanoR_1	212	218	PF00244	0.825
LIG_14-3-3_CanoR_1	226	235	PF00244	0.328
LIG_14-3-3_CanoR_1	241	247	PF00244	0.345
LIG_14-3-3_CanoR_1	289	299	PF00244	0.777
LIG_14-3-3_CanoR_1	308	317	PF00244	0.392
LIG_14-3-3_CanoR_1	412	416	PF00244	0.523
LIG_BRCT_BRCA1_1	19	23	PF00533	0.527
LIG_BRCT_BRCA1_1	5	9	PF00533	0.536
LIG_CaM_IQ_9	375	390	PF13499	0.552
LIG_FHA_1	312	318	PF00498	0.454
LIG_FHA_1	68	74	PF00498	0.510
LIG_FHA_2	109	115	PF00498	0.589
LIG_FHA_2	292	298	PF00498	0.610
LIG_FHA_2	372	378	PF00498	0.581
LIG_FHA_2	416	422	PF00498	0.606
LIG_FHA_2	485	491	PF00498	0.704
LIG_FHA_2	494	500	PF00498	0.700
LIG_Integrin_RGD_1	37	39	PF01839	0.607
LIG_LIR_Apic_2	68	74	PF02991	0.448
LIG_LIR_Gen_1	153	162	PF02991	0.496
LIG_LIR_Gen_1	296	306	PF02991	0.597
LIG_LIR_Gen_1	498	508	PF02991	0.582
LIG_LIR_Gen_1	6	16	PF02991	0.581
LIG_LIR_Nem_3	153	157	PF02991	0.513
LIG_LIR_Nem_3	20	26	PF02991	0.552
LIG_LIR_Nem_3	232	238	PF02991	0.357
LIG_LIR_Nem_3	296	302	PF02991	0.613
LIG_LIR_Nem_3	6	12	PF02991	0.496
LIG_Pex14_2	12	16	PF04695	0.521
LIG_Pex14_2	235	239	PF04695	0.312
LIG_PTAP_UEV_1	273	278	PF05743	0.612
LIG_REV1ctd_RIR_1	232	241	PF16727	0.360
LIG_SH2_CRK	162	166	PF00017	0.416
LIG_SH2_CRK	71	75	PF00017	0.481
LIG_SH2_SRC	26	29	PF00017	0.504
LIG_SH2_STAT5	238	241	PF00017	0.343
LIG_SH2_STAT5	26	29	PF00017	0.566
LIG_SH2_STAT5	71	74	PF00017	0.402
LIG_SH3_1	71	77	PF00018	0.448
LIG_SH3_3	134	140	PF00018	0.710
LIG_SH3_3	212	218	PF00018	0.626
LIG_SH3_3	268	274	PF00018	0.675
LIG_SH3_3	413	419	PF00018	0.813
LIG_SH3_3	438	444	PF00018	0.729
LIG_SH3_3	459	465	PF00018	0.685
LIG_SH3_3	71	77	PF00018	0.484
LIG_TRAF2_1	143	146	PF00917	0.503
LIG_TRAF2_1	374	377	PF00917	0.416
LIG_TRAF2_1	495	498	PF00917	0.542
LIG_TYR_ITIM	152	157	PF00017	0.475
MOD_CDK_SPK_2	168	173	PF00069	0.535
MOD_CDK_SPxK_1	118	124	PF00069	0.757
MOD_CDK_SPxK_1	128	134	PF00069	0.642
MOD_CDK_SPxK_1	220	226	PF00069	0.713
MOD_CDK_SPxK_1	406	412	PF00069	0.562
MOD_CDK_SPxxK_3	128	135	PF00069	0.820
MOD_CDK_SPxxK_3	176	183	PF00069	0.660
MOD_CDK_SPxxK_3	415	422	PF00069	0.641
MOD_CK1_1	171	177	PF00069	0.526
MOD_CK1_1	213	219	PF00069	0.734
MOD_CK1_1	220	226	PF00069	0.594
MOD_CK1_1	262	268	PF00069	0.695
MOD_CK1_1	270	276	PF00069	0.721
MOD_CK1_1	290	296	PF00069	0.497
MOD_CK1_1	3	9	PF00069	0.545
MOD_CK1_1	326	332	PF00069	0.607
MOD_CK1_1	333	339	PF00069	0.635
MOD_CK1_1	453	459	PF00069	0.640
MOD_CK1_1	478	484	PF00069	0.791
MOD_CK1_1	493	499	PF00069	0.486
MOD_CK1_1	90	96	PF00069	0.409
MOD_CK2_1	108	114	PF00069	0.692
MOD_CK2_1	227	233	PF00069	0.628
MOD_CK2_1	290	296	PF00069	0.597
MOD_CK2_1	371	377	PF00069	0.441
MOD_CK2_1	391	397	PF00069	0.393
MOD_CK2_1	415	421	PF00069	0.606
MOD_CK2_1	503	509	PF00069	0.614
MOD_GlcNHglycan	176	179	PF01048	0.758
MOD_GlcNHglycan	219	222	PF01048	0.770
MOD_GlcNHglycan	261	264	PF01048	0.603
MOD_GlcNHglycan	265	268	PF01048	0.580
MOD_GlcNHglycan	274	277	PF01048	0.553
MOD_GlcNHglycan	335	338	PF01048	0.590
MOD_GlcNHglycan	393	396	PF01048	0.621
MOD_GlcNHglycan	413	416	PF01048	0.748
MOD_GlcNHglycan	452	455	PF01048	0.666
MOD_GlcNHglycan	458	461	PF01048	0.613
MOD_GlcNHglycan	487	490	PF01048	0.723
MOD_GlcNHglycan	492	495	PF01048	0.657
MOD_GlcNHglycan	93	96	PF01048	0.387
MOD_GSK3_1	106	113	PF00069	0.721
MOD_GSK3_1	114	121	PF00069	0.792
MOD_GSK3_1	168	175	PF00069	0.599
MOD_GSK3_1	206	213	PF00069	0.674
MOD_GSK3_1	216	223	PF00069	0.777
MOD_GSK3_1	259	266	PF00069	0.660
MOD_GSK3_1	272	279	PF00069	0.579
MOD_GSK3_1	287	294	PF00069	0.742
MOD_GSK3_1	3	10	PF00069	0.583
MOD_GSK3_1	326	333	PF00069	0.589
MOD_GSK3_1	406	413	PF00069	0.662
MOD_GSK3_1	440	447	PF00069	0.768
MOD_GSK3_1	449	456	PF00069	0.601
MOD_GSK3_1	475	482	PF00069	0.713
MOD_GSK3_1	493	500	PF00069	0.593
MOD_GSK3_1	87	94	PF00069	0.396
MOD_NEK2_1	144	149	PF00069	0.378
MOD_NEK2_1	240	245	PF00069	0.382
MOD_NEK2_1	371	376	PF00069	0.481
MOD_PIKK_1	210	216	PF00454	0.810
MOD_PIKK_1	240	246	PF00454	0.444
MOD_PIKK_1	247	253	PF00454	0.497
MOD_PIKK_1	3	9	PF00454	0.580
MOD_PK_1	17	23	PF00069	0.380
MOD_PKA_2	133	139	PF00069	0.702
MOD_PKA_2	172	178	PF00069	0.624
MOD_PKA_2	227	233	PF00069	0.440
MOD_PKA_2	240	246	PF00069	0.334
MOD_PKA_2	290	296	PF00069	0.731
MOD_PKA_2	333	339	PF00069	0.591
MOD_PKA_2	411	417	PF00069	0.522
MOD_PKA_2	434	440	PF00069	0.642
MOD_PKB_1	289	297	PF00069	0.626
MOD_Plk_1	210	216	PF00069	0.559
MOD_Plk_1	371	377	PF00069	0.417
MOD_Plk_1	423	429	PF00069	0.667
MOD_Plk_1	497	503	PF00069	0.623
MOD_Plk_1	67	73	PF00069	0.564
MOD_Plk_2-3	344	350	PF00069	0.619
MOD_Plk_4	161	167	PF00069	0.492
MOD_Plk_4	323	329	PF00069	0.532
MOD_Plk_4	497	503	PF00069	0.643
MOD_ProDKin_1	114	120	PF00069	0.692
MOD_ProDKin_1	128	134	PF00069	0.709
MOD_ProDKin_1	168	174	PF00069	0.619
MOD_ProDKin_1	176	182	PF00069	0.601
MOD_ProDKin_1	199	205	PF00069	0.679
MOD_ProDKin_1	214	220	PF00069	0.644
MOD_ProDKin_1	267	273	PF00069	0.781
MOD_ProDKin_1	276	282	PF00069	0.659
MOD_ProDKin_1	406	412	PF00069	0.635
MOD_ProDKin_1	415	421	PF00069	0.537
MOD_ProDKin_1	440	446	PF00069	0.647
MOD_ProDKin_1	87	93	PF00069	0.462
MOD_SUMO_for_1	16	19	PF00179	0.529
MOD_SUMO_rev_2	348	358	PF00179	0.695
TRG_AP2beta_CARGO_1	236	246	PF09066	0.330
TRG_DiLeu_BaEn_2	18	24	PF01217	0.527
TRG_DiLeu_BaLyEn_6	147	152	PF01217	0.397
TRG_ENDOCYTIC_2	154	157	PF00928	0.493
TRG_ENDOCYTIC_2	162	165	PF00928	0.376
TRG_ER_diArg_1	148	151	PF00400	0.376
TRG_ER_diArg_1	183	185	PF00400	0.646
TRG_ER_diArg_1	226	229	PF00400	0.517
TRG_ER_diArg_1	386	388	PF00400	0.498
TRG_ER_diArg_1	61	63	PF00400	0.512
TRG_ER_diArg_1	98	100	PF00400	0.483
TRG_Pf-PMV_PEXEL_1	62	66	PF00026	0.509

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC05	Leptomonas seymouri	46%	94%
A0A1X0NLY0	Trypanosomatidae	27%	100%
A0A3R7NU60	Trypanosoma rangeli	28%	100%
A4HE69	Leishmania braziliensis	68%	98%
A4I1H1	Leishmania infantum	99%	100%
E9AXK5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4Q9W6	Leishmania major	92%	100%