LeishMANIAdb
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Hypothetical_protein_conserved

Quick info Annotations Function or PPIs Localization Phosphorylation Abundance Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Hypothetical_protein_conserved
Gene product:
hypothetical protein, conserved
Species:
Leishmania donovani
UniProt:
A0A3S7WZ21_LEIDO
TriTrypDb:
LdBPK_251120.1 , LdCL_250016600 , LDHU3_25.1440
Length:
448

Annotations

Annotations by Jardim et al.

Nucleic acid binding, Uncharacterized

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Phosphorylation

Amastigote: 70
Promastigote: 220, 222, 226, 302

Abundance

Amastigote (protein)
Source Evidence on protein Close homologs
Pescher et al. (upgregulation) no yes: 0
Promastigote and amastigote
Source Evidence on protein Close homologs
Lahav et al.
- mRNA
- Protein

Expansion

Sequence features

A0A3S7WZ21
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WZ21

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 11
GO:0003723 RNA binding 4 11
GO:0005488 binding 1 11
GO:0097159 organic cyclic compound binding 2 11
GO:1901363 heterocyclic compound binding 2 11

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 155 157 PF00675 0.345
CLV_NRD_NRD_1 294 296 PF00675 0.570
CLV_NRD_NRD_1 300 302 PF00675 0.609
CLV_NRD_NRD_1 446 448 PF00675 0.575
CLV_PCSK_FUR_1 153 157 PF00082 0.475
CLV_PCSK_KEX2_1 155 157 PF00082 0.404
CLV_PCSK_KEX2_1 294 296 PF00082 0.570
CLV_PCSK_KEX2_1 300 302 PF00082 0.609
CLV_PCSK_KEX2_1 446 448 PF00082 0.575
CLV_PCSK_SKI1_1 201 205 PF00082 0.498
CLV_PCSK_SKI1_1 238 242 PF00082 0.634
CLV_PCSK_SKI1_1 49 53 PF00082 0.368
CLV_PCSK_SKI1_1 81 85 PF00082 0.550
DEG_APCC_DBOX_1 226 234 PF00400 0.485
DOC_CYCLIN_yCln2_LP_2 88 94 PF00134 0.410
DOC_MAPK_gen_1 153 161 PF00069 0.338
DOC_MAPK_gen_1 6 15 PF00069 0.459
DOC_MAPK_MEF2A_6 153 161 PF00069 0.405
DOC_PP2B_LxvP_1 88 91 PF13499 0.399
DOC_USP7_MATH_1 179 183 PF00917 0.592
DOC_USP7_MATH_1 368 372 PF00917 0.652
DOC_USP7_MATH_1 431 435 PF00917 0.566
DOC_USP7_MATH_1 74 78 PF00917 0.571
DOC_USP7_UBL2_3 45 49 PF12436 0.539
DOC_USP7_UBL2_3 7 11 PF12436 0.550
DOC_WW_Pin1_4 246 251 PF00397 0.551
DOC_WW_Pin1_4 258 263 PF00397 0.489
DOC_WW_Pin1_4 304 309 PF00397 0.584
DOC_WW_Pin1_4 351 356 PF00397 0.673
DOC_WW_Pin1_4 373 378 PF00397 0.561
LIG_14-3-3_CanoR_1 100 109 PF00244 0.358
LIG_14-3-3_CanoR_1 300 308 PF00244 0.613
LIG_14-3-3_CanoR_1 406 410 PF00244 0.546
LIG_14-3-3_CanoR_1 9 14 PF00244 0.529
LIG_14-3-3_CterR_2 446 448 PF00244 0.575
LIG_BRCT_BRCA1_1 128 132 PF00533 0.315
LIG_deltaCOP1_diTrp_1 29 35 PF00928 0.594
LIG_EH_1 319 323 PF12763 0.594
LIG_FHA_1 10 16 PF00498 0.465
LIG_FHA_1 117 123 PF00498 0.339
LIG_FHA_1 140 146 PF00498 0.445
LIG_FHA_1 71 77 PF00498 0.615
LIG_FHA_2 101 107 PF00498 0.234
LIG_FHA_2 352 358 PF00498 0.623
LIG_FHA_2 82 88 PF00498 0.529
LIG_Integrin_isoDGR_2 380 382 PF01839 0.678
LIG_LIR_Gen_1 105 116 PF02991 0.481
LIG_LIR_Gen_1 129 140 PF02991 0.294
LIG_LIR_Gen_1 56 65 PF02991 0.528
LIG_LIR_Nem_3 105 111 PF02991 0.478
LIG_LIR_Nem_3 129 135 PF02991 0.281
LIG_LIR_Nem_3 439 445 PF02991 0.546
LIG_MYND_1 311 315 PF01753 0.552
LIG_PCNA_yPIPBox_3 164 178 PF02747 0.504
LIG_Pex14_2 108 112 PF04695 0.272
LIG_Pex14_2 92 96 PF04695 0.372
LIG_SH2_PTP2 158 161 PF00017 0.352
LIG_SH2_STAP1 57 61 PF00017 0.469
LIG_SH2_STAT5 158 161 PF00017 0.352
LIG_SH2_STAT5 22 25 PF00017 0.463
LIG_SH3_1 427 433 PF00018 0.589
LIG_SH3_3 210 216 PF00018 0.598
LIG_SH3_3 274 280 PF00018 0.586
LIG_SH3_3 302 308 PF00018 0.607
LIG_SH3_3 309 315 PF00018 0.531
LIG_SH3_3 427 433 PF00018 0.611
LIG_SUMO_SIM_par_1 141 146 PF11976 0.379
LIG_TRAF2_1 103 106 PF00917 0.384
MOD_CK1_1 182 188 PF00069 0.549
MOD_CK1_1 217 223 PF00069 0.668
MOD_CK1_1 249 255 PF00069 0.563
MOD_CK1_1 261 267 PF00069 0.521
MOD_CK1_1 288 294 PF00069 0.723
MOD_CK1_1 323 329 PF00069 0.551
MOD_CK1_1 344 350 PF00069 0.619
MOD_CK1_1 375 381 PF00069 0.558
MOD_CK1_1 70 76 PF00069 0.527
MOD_CK2_1 100 106 PF00069 0.369
MOD_CK2_1 351 357 PF00069 0.696
MOD_Cter_Amidation 153 156 PF01082 0.375
MOD_GlcNHglycan 136 139 PF01048 0.388
MOD_GlcNHglycan 184 187 PF01048 0.564
MOD_GlcNHglycan 242 245 PF01048 0.679
MOD_GlcNHglycan 302 305 PF01048 0.727
MOD_GlcNHglycan 322 325 PF01048 0.398
MOD_GlcNHglycan 341 346 PF01048 0.455
MOD_GlcNHglycan 370 373 PF01048 0.682
MOD_GlcNHglycan 412 416 PF01048 0.560
MOD_GlcNHglycan 419 423 PF01048 0.683
MOD_GlcNHglycan 426 430 PF01048 0.600
MOD_GlcNHglycan 433 436 PF01048 0.496
MOD_GSK3_1 139 146 PF00069 0.410
MOD_GSK3_1 219 226 PF00069 0.541
MOD_GSK3_1 300 307 PF00069 0.625
MOD_GSK3_1 349 356 PF00069 0.634
MOD_GSK3_1 368 375 PF00069 0.607
MOD_GSK3_1 400 407 PF00069 0.503
MOD_GSK3_1 70 77 PF00069 0.511
MOD_LATS_1 298 304 PF00433 0.486
MOD_N-GLC_1 100 105 PF02516 0.364
MOD_N-GLC_1 61 66 PF02516 0.598
MOD_NEK2_1 147 152 PF00069 0.343
MOD_NEK2_1 240 245 PF00069 0.625
MOD_NEK2_1 299 304 PF00069 0.750
MOD_PIKK_1 160 166 PF00454 0.497
MOD_PKA_1 300 306 PF00069 0.680
MOD_PKA_2 172 178 PF00069 0.567
MOD_PKA_2 182 188 PF00069 0.616
MOD_PKA_2 299 305 PF00069 0.652
MOD_PKA_2 405 411 PF00069 0.550
MOD_Plk_1 147 153 PF00069 0.349
MOD_Plk_1 288 294 PF00069 0.559
MOD_Plk_1 341 347 PF00069 0.589
MOD_Plk_1 404 410 PF00069 0.539
MOD_Plk_1 55 61 PF00069 0.523
MOD_Plk_2-3 357 363 PF00069 0.574
MOD_Plk_4 107 113 PF00069 0.492
MOD_ProDKin_1 246 252 PF00069 0.550
MOD_ProDKin_1 258 264 PF00069 0.490
MOD_ProDKin_1 304 310 PF00069 0.583
MOD_ProDKin_1 351 357 PF00069 0.675
MOD_ProDKin_1 373 379 PF00069 0.560
MOD_SUMO_for_1 338 341 PF00179 0.603
MOD_SUMO_rev_2 351 360 PF00179 0.614
TRG_DiLeu_BaLyEn_6 118 123 PF01217 0.338
TRG_DiLeu_BaLyEn_6 166 171 PF01217 0.516
TRG_ENDOCYTIC_2 158 161 PF00928 0.352
TRG_ENDOCYTIC_2 57 60 PF00928 0.523
TRG_ER_diArg_1 153 156 PF00400 0.489
TRG_ER_diArg_1 299 301 PF00400 0.617
TRG_ER_diArg_1 445 447 PF00400 0.517
TRG_NLS_MonoExtN_4 4 10 PF00514 0.478
TRG_Pf-PMV_PEXEL_1 121 125 PF00026 0.343

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P3F7 Leptomonas seymouri 65% 100%
A0A0S4IKR5 Bodo saltans 37% 100%
A0A1X0NLV4 Trypanosomatidae 45% 100%
A4HE44 Leishmania braziliensis 84% 98%
A4I1F0 Leishmania infantum 100% 100%
C9ZJX0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 48% 100%
E9AXI7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 98%
Q4Q9Y5 Leishmania major 95% 100%
V5BKV0 Trypanosoma cruzi 50% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS