Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WZ17_LEIDO

TriTrypDb:

LdBPK_250610.1 , LdCL_250011300 , LDHU3_25.0730

Length:

415

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WZ17

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WZ17

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	341	345	PF00656	0.648
CLV_C14_Caspase3-7	401	405	PF00656	0.608
CLV_NRD_NRD_1	107	109	PF00675	0.393
CLV_NRD_NRD_1	320	322	PF00675	0.672
CLV_NRD_NRD_1	332	334	PF00675	0.654
CLV_NRD_NRD_1	4	6	PF00675	0.526
CLV_NRD_NRD_1	43	45	PF00675	0.455
CLV_PCSK_FUR_1	105	109	PF00082	0.559
CLV_PCSK_KEX2_1	105	107	PF00082	0.490
CLV_PCSK_KEX2_1	320	322	PF00082	0.627
CLV_PCSK_KEX2_1	332	334	PF00082	0.648
CLV_PCSK_KEX2_1	4	6	PF00082	0.675
CLV_PCSK_KEX2_1	43	45	PF00082	0.455
CLV_PCSK_PC1ET2_1	320	322	PF00082	0.624
CLV_PCSK_SKI1_1	115	119	PF00082	0.447
CLV_PCSK_SKI1_1	5	9	PF00082	0.569
DEG_APCC_DBOX_1	191	199	PF00400	0.483
DEG_APCC_DBOX_1	4	12	PF00400	0.488
DEG_SPOP_SBC_1	170	174	PF00917	0.504
DEG_SPOP_SBC_1	57	61	PF00917	0.433
DEG_SPOP_SBC_1	95	99	PF00917	0.509
DOC_ANK_TNKS_1	107	114	PF00023	0.517
DOC_CKS1_1	124	129	PF01111	0.349
DOC_PP1_RVXF_1	113	119	PF00149	0.311
DOC_PP2B_LxvP_1	179	182	PF13499	0.507
DOC_PP4_FxxP_1	70	73	PF00568	0.596
DOC_USP7_MATH_1	182	186	PF00917	0.531
DOC_USP7_MATH_1	270	274	PF00917	0.577
DOC_USP7_MATH_1	299	303	PF00917	0.705
DOC_USP7_MATH_1	53	57	PF00917	0.497
DOC_USP7_MATH_1	81	85	PF00917	0.704
DOC_USP7_MATH_1	95	99	PF00917	0.476
DOC_WW_Pin1_4	123	128	PF00397	0.328
DOC_WW_Pin1_4	156	161	PF00397	0.348
DOC_WW_Pin1_4	291	296	PF00397	0.615
DOC_WW_Pin1_4	91	96	PF00397	0.680
LIG_14-3-3_CanoR_1	271	276	PF00244	0.420
LIG_14-3-3_CanoR_1	4	11	PF00244	0.488
LIG_Actin_WH2_2	20	35	PF00022	0.355
LIG_BIR_III_2	344	348	PF00653	0.515
LIG_BRCT_BRCA1_1	172	176	PF00533	0.437
LIG_BRCT_BRCA1_1	195	199	PF00533	0.515
LIG_FHA_1	162	168	PF00498	0.529
LIG_FHA_1	176	182	PF00498	0.402
LIG_FHA_1	249	255	PF00498	0.373
LIG_FHA_1	26	32	PF00498	0.480
LIG_FHA_1	291	297	PF00498	0.650
LIG_FHA_1	368	374	PF00498	0.640
LIG_FHA_1	75	81	PF00498	0.751
LIG_FHA_1	99	105	PF00498	0.754
LIG_FHA_2	124	130	PF00498	0.350
LIG_FHA_2	213	219	PF00498	0.447
LIG_FHA_2	58	64	PF00498	0.641
LIG_FHA_2	7	13	PF00498	0.458
LIG_GBD_Chelix_1	145	153	PF00786	0.487
LIG_LIR_Apic_2	394	398	PF02991	0.649
LIG_LIR_Apic_2	67	73	PF02991	0.599
LIG_LIR_Gen_1	128	137	PF02991	0.413
LIG_LIR_Gen_1	173	184	PF02991	0.517
LIG_LIR_Gen_1	251	258	PF02991	0.371
LIG_LIR_Gen_1	370	379	PF02991	0.576
LIG_LIR_Gen_1	38	47	PF02991	0.495
LIG_LIR_LC3C_4	221	225	PF02991	0.339
LIG_LIR_Nem_3	128	133	PF02991	0.309
LIG_LIR_Nem_3	173	179	PF02991	0.484
LIG_LIR_Nem_3	251	256	PF02991	0.472
LIG_LIR_Nem_3	370	374	PF02991	0.513
LIG_LIR_Nem_3	38	42	PF02991	0.490
LIG_MYND_1	286	290	PF01753	0.545
LIG_MYND_1	386	390	PF01753	0.662
LIG_Pex14_2	367	371	PF04695	0.544
LIG_SH2_CRK	130	134	PF00017	0.317
LIG_SH2_SRC	239	242	PF00017	0.547
LIG_SH2_SRC	363	366	PF00017	0.587
LIG_SH2_STAP1	130	134	PF00017	0.476
LIG_SH2_STAT5	39	42	PF00017	0.385
LIG_SH3_3	279	285	PF00018	0.620
LIG_SH3_3	381	387	PF00018	0.651
LIG_SH3_3	69	75	PF00018	0.607
LIG_SUMO_SIM_anti_2	9	15	PF11976	0.402
LIG_TRAF2_1	204	207	PF00917	0.457
LIG_WRC_WIRS_1	250	255	PF05994	0.375
MOD_CK1_1	25	31	PF00069	0.327
MOD_CK1_1	302	308	PF00069	0.726
MOD_CK1_1	56	62	PF00069	0.501
MOD_CK1_1	6	12	PF00069	0.380
MOD_CK1_1	84	90	PF00069	0.706
MOD_CK1_1	94	100	PF00069	0.703
MOD_CK2_1	163	169	PF00069	0.507
MOD_CK2_1	201	207	PF00069	0.455
MOD_CK2_1	57	63	PF00069	0.450
MOD_CK2_1	6	12	PF00069	0.489
MOD_GlcNHglycan	120	123	PF01048	0.393
MOD_GlcNHglycan	189	192	PF01048	0.539
MOD_GlcNHglycan	195	198	PF01048	0.443
MOD_GlcNHglycan	206	211	PF01048	0.453
MOD_GlcNHglycan	220	223	PF01048	0.371
MOD_GlcNHglycan	301	304	PF01048	0.728
MOD_GlcNHglycan	5	8	PF01048	0.514
MOD_GlcNHglycan	55	58	PF01048	0.514
MOD_GlcNHglycan	81	84	PF01048	0.712
MOD_GSK3_1	161	168	PF00069	0.524
MOD_GSK3_1	170	177	PF00069	0.410
MOD_GSK3_1	187	194	PF00069	0.522
MOD_GSK3_1	230	237	PF00069	0.528
MOD_GSK3_1	271	278	PF00069	0.453
MOD_GSK3_1	297	304	PF00069	0.682
MOD_GSK3_1	308	315	PF00069	0.544
MOD_GSK3_1	53	60	PF00069	0.581
MOD_GSK3_1	91	98	PF00069	0.715
MOD_N-GLC_1	25	30	PF02516	0.305
MOD_NEK2_1	118	123	PF00069	0.399
MOD_NEK2_1	163	168	PF00069	0.539
MOD_NEK2_1	175	180	PF00069	0.500
MOD_NEK2_1	230	235	PF00069	0.378
MOD_NEK2_1	367	372	PF00069	0.539
MOD_NEK2_1	402	407	PF00069	0.551
MOD_NEK2_2	171	176	PF00069	0.483
MOD_NEK2_2	308	313	PF00069	0.680
MOD_PIKK_1	161	167	PF00454	0.531
MOD_PIKK_1	98	104	PF00454	0.781
MOD_PK_1	271	277	PF00069	0.427
MOD_PKA_2	191	197	PF00069	0.406
MOD_PKA_2	270	276	PF00069	0.453
MOD_PKA_2	3	9	PF00069	0.407
MOD_PKA_2	312	318	PF00069	0.602
MOD_Plk_1	206	212	PF00069	0.422
MOD_Plk_1	248	254	PF00069	0.499
MOD_Plk_4	171	177	PF00069	0.539
MOD_Plk_4	234	240	PF00069	0.469
MOD_Plk_4	249	255	PF00069	0.473
MOD_ProDKin_1	123	129	PF00069	0.325
MOD_ProDKin_1	156	162	PF00069	0.352
MOD_ProDKin_1	291	297	PF00069	0.616
MOD_ProDKin_1	91	97	PF00069	0.679
TRG_DiLeu_BaLyEn_6	27	32	PF01217	0.448
TRG_ENDOCYTIC_2	130	133	PF00928	0.320
TRG_ENDOCYTIC_2	39	42	PF00928	0.408
TRG_ER_diArg_1	104	107	PF00400	0.523
TRG_ER_diArg_1	3	5	PF00400	0.539
TRG_ER_diArg_1	337	340	PF00400	0.557
TRG_ER_diArg_1	42	44	PF00400	0.353

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5X9	Leptomonas seymouri	53%	98%
A0A0S4IKU6	Bodo saltans	25%	100%
A0A1X0P4Q1	Trypanosomatidae	30%	100%
A0A3S5IS63	Trypanosoma rangeli	31%	100%
A4HEF8	Leishmania braziliensis	75%	100%
A4I1A1	Leishmania infantum	100%	100%
D0A5J3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9AXD7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QA35	Leishmania major	89%	100%
V5B7R1	Trypanosoma cruzi	29%	100%