JmjC domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WZ10_LEIDO

TriTrypDb:

LdBPK_251030.1 , LdCL_250015600 , LDHU3_25.1310

Length:

967

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WZ10

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WZ10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	276	280	PF00656	0.571
CLV_C14_Caspase3-7	467	471	PF00656	0.650
CLV_C14_Caspase3-7	765	769	PF00656	0.584
CLV_C14_Caspase3-7	85	89	PF00656	0.646
CLV_NRD_NRD_1	635	637	PF00675	0.851
CLV_NRD_NRD_1	691	693	PF00675	0.727
CLV_NRD_NRD_1	872	874	PF00675	0.533
CLV_NRD_NRD_1	891	893	PF00675	0.642
CLV_NRD_NRD_1	895	897	PF00675	0.602
CLV_PCSK_KEX2_1	635	637	PF00082	0.713
CLV_PCSK_KEX2_1	691	693	PF00082	0.727
CLV_PCSK_KEX2_1	700	702	PF00082	0.750
CLV_PCSK_KEX2_1	884	886	PF00082	0.624
CLV_PCSK_KEX2_1	891	893	PF00082	0.638
CLV_PCSK_KEX2_1	895	897	PF00082	0.556
CLV_PCSK_KEX2_1	937	939	PF00082	0.573
CLV_PCSK_PC1ET2_1	700	702	PF00082	0.620
CLV_PCSK_PC1ET2_1	884	886	PF00082	0.501
CLV_PCSK_PC1ET2_1	937	939	PF00082	0.569
CLV_PCSK_PC7_1	891	897	PF00082	0.454
CLV_PCSK_SKI1_1	784	788	PF00082	0.614
CLV_PCSK_SKI1_1	790	794	PF00082	0.583
CLV_PCSK_SKI1_1	853	857	PF00082	0.457
CLV_PCSK_SKI1_1	949	953	PF00082	0.541
DEG_APCC_DBOX_1	17	25	PF00400	0.577
DEG_Nend_Nbox_1	1	3	PF02207	0.665
DEG_SCF_FBW7_1	804	809	PF00400	0.535
DEG_SPOP_SBC_1	819	823	PF00917	0.557
DEG_SPOP_SBC_1	831	835	PF00917	0.580
DEG_SPOP_SBC_1	867	871	PF00917	0.519
DOC_CKS1_1	286	291	PF01111	0.574
DOC_CKS1_1	477	482	PF01111	0.648
DOC_CKS1_1	791	796	PF01111	0.599
DOC_CKS1_1	95	100	PF01111	0.645
DOC_CYCLIN_yCln2_LP_2	725	728	PF00134	0.577
DOC_PP1_SILK_1	914	919	PF00149	0.465
DOC_PP2B_LxvP_1	725	728	PF13499	0.615
DOC_USP7_MATH_1	117	121	PF00917	0.586
DOC_USP7_MATH_1	128	132	PF00917	0.600
DOC_USP7_MATH_1	145	149	PF00917	0.571
DOC_USP7_MATH_1	185	189	PF00917	0.655
DOC_USP7_MATH_1	230	234	PF00917	0.563
DOC_USP7_MATH_1	250	254	PF00917	0.633
DOC_USP7_MATH_1	289	293	PF00917	0.571
DOC_USP7_MATH_1	308	312	PF00917	0.548
DOC_USP7_MATH_1	319	323	PF00917	0.547
DOC_USP7_MATH_1	336	340	PF00917	0.551
DOC_USP7_MATH_1	376	380	PF00917	0.557
DOC_USP7_MATH_1	421	425	PF00917	0.538
DOC_USP7_MATH_1	441	445	PF00917	0.558
DOC_USP7_MATH_1	46	50	PF00917	0.674
DOC_USP7_MATH_1	480	484	PF00917	0.603
DOC_USP7_MATH_1	499	503	PF00917	0.573
DOC_USP7_MATH_1	510	514	PF00917	0.596
DOC_USP7_MATH_1	527	531	PF00917	0.568
DOC_USP7_MATH_1	567	571	PF00917	0.643
DOC_USP7_MATH_1	612	616	PF00917	0.552
DOC_USP7_MATH_1	634	638	PF00917	0.667
DOC_USP7_MATH_1	657	661	PF00917	0.534
DOC_USP7_MATH_1	806	810	PF00917	0.742
DOC_USP7_MATH_1	814	818	PF00917	0.606
DOC_USP7_MATH_1	820	824	PF00917	0.523
DOC_USP7_MATH_1	831	835	PF00917	0.494
DOC_USP7_MATH_1	912	916	PF00917	0.465
DOC_USP7_MATH_1	957	961	PF00917	0.679
DOC_USP7_MATH_1	98	102	PF00917	0.602
DOC_USP7_UBL2_3	933	937	PF12436	0.540
DOC_WW_Pin1_4	139	144	PF00397	0.589
DOC_WW_Pin1_4	181	186	PF00397	0.647
DOC_WW_Pin1_4	207	212	PF00397	0.662
DOC_WW_Pin1_4	285	290	PF00397	0.571
DOC_WW_Pin1_4	330	335	PF00397	0.559
DOC_WW_Pin1_4	372	377	PF00397	0.546
DOC_WW_Pin1_4	398	403	PF00397	0.559
DOC_WW_Pin1_4	4	9	PF00397	0.629
DOC_WW_Pin1_4	476	481	PF00397	0.647
DOC_WW_Pin1_4	521	526	PF00397	0.594
DOC_WW_Pin1_4	563	568	PF00397	0.638
DOC_WW_Pin1_4	589	594	PF00397	0.649
DOC_WW_Pin1_4	728	733	PF00397	0.698
DOC_WW_Pin1_4	790	795	PF00397	0.601
DOC_WW_Pin1_4	802	807	PF00397	0.540
DOC_WW_Pin1_4	94	99	PF00397	0.644
LIG_14-3-3_CanoR_1	656	664	PF00244	0.593
LIG_14-3-3_CanoR_1	691	699	PF00244	0.624
LIG_14-3-3_CanoR_1	701	707	PF00244	0.559
LIG_Actin_WH2_2	699	716	PF00022	0.609
LIG_BIR_III_2	279	283	PF00653	0.563
LIG_BIR_III_2	470	474	PF00653	0.649
LIG_BIR_III_2	88	92	PF00653	0.644
LIG_FHA_1	155	161	PF00498	0.661
LIG_FHA_1	346	352	PF00498	0.561
LIG_FHA_1	537	543	PF00498	0.849
LIG_FHA_2	240	246	PF00498	0.664
LIG_FHA_2	431	437	PF00498	0.561
LIG_FHA_2	757	763	PF00498	0.624
LIG_FHA_2	791	797	PF00498	0.632
LIG_GBD_Chelix_1	13	21	PF00786	0.580
LIG_LIR_Apic_2	161	165	PF02991	0.599
LIG_LIR_Apic_2	352	356	PF02991	0.543
LIG_LIR_Apic_2	543	547	PF02991	0.600
LIG_LIR_Apic_2	869	875	PF02991	0.589
LIG_LIR_Apic_2	939	944	PF02991	0.511
LIG_LIR_Nem_3	888	893	PF02991	0.510
LIG_LIR_Nem_3	894	900	PF02991	0.428
LIG_LIR_Nem_3	945	951	PF02991	0.493
LIG_PCNA_PIPBox_1	706	715	PF02747	0.559
LIG_SH2_CRK	162	166	PF00017	0.658
LIG_SH2_CRK	353	357	PF00017	0.556
LIG_SH2_CRK	544	548	PF00017	0.655
LIG_SH2_CRK	872	876	PF00017	0.741
LIG_SH2_CRK	897	901	PF00017	0.442
LIG_SH2_NCK_1	162	166	PF00017	0.658
LIG_SH2_NCK_1	353	357	PF00017	0.556
LIG_SH2_NCK_1	544	548	PF00017	0.655
LIG_SH2_STAP1	815	819	PF00017	0.554
LIG_SH2_STAP1	893	897	PF00017	0.474
LIG_SH2_STAT5	739	742	PF00017	0.667
LIG_SH3_1	39	45	PF00018	0.621
LIG_SH3_3	254	260	PF00018	0.673
LIG_SH3_3	39	45	PF00018	0.621
LIG_SH3_3	445	451	PF00018	0.572
LIG_SH3_3	63	69	PF00018	0.621
LIG_SH3_3	788	794	PF00018	0.600
LIG_SH3_4	933	940	PF00018	0.545
LIG_TRAF2_1	260	263	PF00917	0.577
LIG_TRAF2_1	284	287	PF00917	0.555
LIG_TRAF2_1	327	330	PF00917	0.544
LIG_TRAF2_1	451	454	PF00917	0.649
LIG_TRAF2_1	475	478	PF00917	0.588
LIG_TRAF2_1	518	521	PF00917	0.577
LIG_TRAF2_1	69	72	PF00917	0.646
LIG_TRAF2_1	93	96	PF00917	0.589
MOD_CDC14_SPxK_1	210	213	PF00782	0.635
MOD_CDC14_SPxK_1	401	404	PF00782	0.563
MOD_CDC14_SPxK_1	592	595	PF00782	0.621
MOD_CDK_SPK_2	790	795	PF00069	0.601
MOD_CDK_SPxK_1	207	213	PF00069	0.664
MOD_CDK_SPxK_1	398	404	PF00069	0.562
MOD_CDK_SPxK_1	589	595	PF00069	0.651
MOD_CK1_1	181	187	PF00069	0.648
MOD_CK1_1	197	203	PF00069	0.534
MOD_CK1_1	3	9	PF00069	0.633
MOD_CK1_1	372	378	PF00069	0.548
MOD_CK1_1	388	394	PF00069	0.515
MOD_CK1_1	47	53	PF00069	0.676
MOD_CK1_1	563	569	PF00069	0.640
MOD_CK1_1	579	585	PF00069	0.661
MOD_CK1_1	731	737	PF00069	0.558
MOD_CK1_1	745	751	PF00069	0.537
MOD_CK1_1	818	824	PF00069	0.585
MOD_CK1_1	960	966	PF00069	0.607
MOD_CK2_1	145	151	PF00069	0.602
MOD_CK2_1	215	221	PF00069	0.639
MOD_CK2_1	239	245	PF00069	0.661
MOD_CK2_1	324	330	PF00069	0.544
MOD_CK2_1	336	342	PF00069	0.550
MOD_CK2_1	406	412	PF00069	0.561
MOD_CK2_1	430	436	PF00069	0.559
MOD_CK2_1	515	521	PF00069	0.589
MOD_CK2_1	527	533	PF00069	0.589
MOD_CK2_1	597	603	PF00069	0.624
MOD_CK2_1	6	12	PF00069	0.527
MOD_CK2_1	634	640	PF00069	0.591
MOD_CK2_1	702	708	PF00069	0.509
MOD_CK2_1	745	751	PF00069	0.594
MOD_CK2_1	756	762	PF00069	0.613
MOD_CK2_1	790	796	PF00069	0.630
MOD_CK2_1	936	942	PF00069	0.524
MOD_GlcNHglycan	119	122	PF01048	0.688
MOD_GlcNHglycan	129	133	PF01048	0.610
MOD_GlcNHglycan	147	150	PF01048	0.580
MOD_GlcNHglycan	165	168	PF01048	0.601
MOD_GlcNHglycan	180	183	PF01048	0.553
MOD_GlcNHglycan	194	197	PF01048	0.566
MOD_GlcNHglycan	205	208	PF01048	0.584
MOD_GlcNHglycan	228	231	PF01048	0.630
MOD_GlcNHglycan	232	235	PF01048	0.586
MOD_GlcNHglycan	310	313	PF01048	0.585
MOD_GlcNHglycan	320	324	PF01048	0.552
MOD_GlcNHglycan	338	341	PF01048	0.547
MOD_GlcNHglycan	356	359	PF01048	0.524
MOD_GlcNHglycan	371	374	PF01048	0.527
MOD_GlcNHglycan	385	388	PF01048	0.537
MOD_GlcNHglycan	396	399	PF01048	0.541
MOD_GlcNHglycan	419	422	PF01048	0.549
MOD_GlcNHglycan	423	426	PF01048	0.537
MOD_GlcNHglycan	501	504	PF01048	0.690
MOD_GlcNHglycan	511	515	PF01048	0.606
MOD_GlcNHglycan	529	532	PF01048	0.594
MOD_GlcNHglycan	547	550	PF01048	0.792
MOD_GlcNHglycan	562	565	PF01048	0.593
MOD_GlcNHglycan	576	579	PF01048	0.668
MOD_GlcNHglycan	587	590	PF01048	0.576
MOD_GlcNHglycan	610	613	PF01048	0.616
MOD_GlcNHglycan	614	617	PF01048	0.576
MOD_GlcNHglycan	673	676	PF01048	0.628
MOD_GlcNHglycan	685	689	PF01048	0.543
MOD_GlcNHglycan	764	767	PF01048	0.570
MOD_GlcNHglycan	843	846	PF01048	0.536
MOD_GlcNHglycan	875	878	PF01048	0.559
MOD_GlcNHglycan	902	906	PF01048	0.560
MOD_GSK3_1	141	148	PF00069	0.648
MOD_GSK3_1	154	161	PF00069	0.582
MOD_GSK3_1	177	184	PF00069	0.653
MOD_GSK3_1	194	201	PF00069	0.536
MOD_GSK3_1	203	210	PF00069	0.583
MOD_GSK3_1	212	219	PF00069	0.546
MOD_GSK3_1	226	233	PF00069	0.594
MOD_GSK3_1	285	292	PF00069	0.573
MOD_GSK3_1	3	10	PF00069	0.552
MOD_GSK3_1	332	339	PF00069	0.575
MOD_GSK3_1	345	352	PF00069	0.539
MOD_GSK3_1	368	375	PF00069	0.550
MOD_GSK3_1	385	392	PF00069	0.520
MOD_GSK3_1	394	401	PF00069	0.544
MOD_GSK3_1	403	410	PF00069	0.537
MOD_GSK3_1	417	424	PF00069	0.547
MOD_GSK3_1	476	483	PF00069	0.647
MOD_GSK3_1	523	530	PF00069	0.649
MOD_GSK3_1	536	543	PF00069	0.610
MOD_GSK3_1	559	566	PF00069	0.776
MOD_GSK3_1	576	583	PF00069	0.529
MOD_GSK3_1	585	592	PF00069	0.575
MOD_GSK3_1	594	601	PF00069	0.533
MOD_GSK3_1	608	615	PF00069	0.587
MOD_GSK3_1	680	687	PF00069	0.555
MOD_GSK3_1	738	745	PF00069	0.549
MOD_GSK3_1	802	809	PF00069	0.621
MOD_GSK3_1	814	821	PF00069	0.537
MOD_GSK3_1	912	919	PF00069	0.616
MOD_GSK3_1	94	101	PF00069	0.644
MOD_N-GLC_1	192	197	PF02516	0.662
MOD_N-GLC_1	383	388	PF02516	0.561
MOD_N-GLC_1	574	579	PF02516	0.657
MOD_N-GLC_1	717	722	PF02516	0.568
MOD_NEK2_1	107	112	PF00069	0.643
MOD_NEK2_1	178	183	PF00069	0.655
MOD_NEK2_1	194	199	PF00069	0.548
MOD_NEK2_1	298	303	PF00069	0.571
MOD_NEK2_1	369	374	PF00069	0.553
MOD_NEK2_1	385	390	PF00069	0.529
MOD_NEK2_1	489	494	PF00069	0.642
MOD_NEK2_1	560	565	PF00069	0.645
MOD_NEK2_1	576	581	PF00069	0.541
MOD_NEK2_1	673	678	PF00069	0.604
MOD_NEK2_1	742	747	PF00069	0.570
MOD_NEK2_1	773	778	PF00069	0.553
MOD_NEK2_1	832	837	PF00069	0.657
MOD_NEK2_1	840	845	PF00069	0.467
MOD_NEK2_2	185	190	PF00069	0.657
MOD_NEK2_2	376	381	PF00069	0.560
MOD_NEK2_2	567	572	PF00069	0.647
MOD_NEK2_2	738	743	PF00069	0.547
MOD_PIKK_1	115	121	PF00454	0.683
MOD_PIKK_1	134	140	PF00454	0.544
MOD_PIKK_1	194	200	PF00454	0.651
MOD_PIKK_1	306	312	PF00454	0.575
MOD_PIKK_1	325	331	PF00454	0.531
MOD_PIKK_1	385	391	PF00454	0.550
MOD_PIKK_1	497	503	PF00454	0.674
MOD_PIKK_1	516	522	PF00454	0.541
MOD_PIKK_1	576	582	PF00454	0.643
MOD_PIKK_1	657	663	PF00454	0.592
MOD_PIKK_1	731	737	PF00454	0.549
MOD_PKA_1	691	697	PF00069	0.623
MOD_PKA_1	873	879	PF00069	0.489
MOD_PKA_1	891	897	PF00069	0.443
MOD_PKA_2	212	218	PF00069	0.665
MOD_PKA_2	403	409	PF00069	0.564
MOD_PKA_2	594	600	PF00069	0.727
MOD_PKA_2	634	640	PF00069	0.667
MOD_PKA_2	691	697	PF00069	0.623
MOD_PKA_2	891	897	PF00069	0.483
MOD_Plk_1	107	113	PF00069	0.644
MOD_Plk_1	185	191	PF00069	0.661
MOD_Plk_1	298	304	PF00069	0.572
MOD_Plk_1	376	382	PF00069	0.562
MOD_Plk_1	489	495	PF00069	0.643
MOD_Plk_1	567	573	PF00069	0.649
MOD_Plk_1	756	762	PF00069	0.624
MOD_Plk_1	885	891	PF00069	0.622
MOD_Plk_1	901	907	PF00069	0.349
MOD_Plk_2-3	52	58	PF00069	0.585
MOD_Plk_4	738	744	PF00069	0.546
MOD_Plk_4	775	781	PF00069	0.531
MOD_Plk_4	885	891	PF00069	0.654
MOD_Plk_4	912	918	PF00069	0.465
MOD_ProDKin_1	139	145	PF00069	0.589
MOD_ProDKin_1	181	187	PF00069	0.648
MOD_ProDKin_1	207	213	PF00069	0.664
MOD_ProDKin_1	285	291	PF00069	0.573
MOD_ProDKin_1	330	336	PF00069	0.559
MOD_ProDKin_1	372	378	PF00069	0.548
MOD_ProDKin_1	398	404	PF00069	0.562
MOD_ProDKin_1	4	10	PF00069	0.627
MOD_ProDKin_1	476	482	PF00069	0.647
MOD_ProDKin_1	521	527	PF00069	0.593
MOD_ProDKin_1	563	569	PF00069	0.640
MOD_ProDKin_1	589	595	PF00069	0.651
MOD_ProDKin_1	728	734	PF00069	0.694
MOD_ProDKin_1	790	796	PF00069	0.600
MOD_ProDKin_1	802	808	PF00069	0.539
MOD_ProDKin_1	94	100	PF00069	0.645
MOD_SUMO_rev_2	276	282	PF00179	0.567
MOD_SUMO_rev_2	467	473	PF00179	0.650
MOD_SUMO_rev_2	85	91	PF00179	0.644
MOD_SUMO_rev_2	928	935	PF00179	0.538
TRG_DiLeu_BaEn_2	769	775	PF01217	0.566
TRG_ENDOCYTIC_2	739	742	PF00928	0.580
TRG_ENDOCYTIC_2	897	900	PF00928	0.453
TRG_ER_diArg_1	634	636	PF00400	0.714
TRG_ER_diArg_1	691	693	PF00400	0.623
TRG_ER_diArg_1	890	892	PF00400	0.690
TRG_ER_diArg_1	895	897	PF00400	0.586
TRG_Pf-PMV_PEXEL_1	105	109	PF00026	0.642
TRG_Pf-PMV_PEXEL_1	296	300	PF00026	0.576
TRG_Pf-PMV_PEXEL_1	487	491	PF00026	0.646
TRG_Pf-PMV_PEXEL_1	691	695	PF00026	0.621
TRG_Pf-PMV_PEXEL_1	758	762	PF00026	0.656
TRG_Pf-PMV_PEXEL_1	784	788	PF00026	0.614
TRG_Pf-PMV_PEXEL_1	898	902	PF00026	0.446
TRG_Pf-PMV_PEXEL_1	950	954	PF00026	0.505

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4I1E1	Leishmania infantum	98%	100%
E9AXH8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
Q4Q9Z4	Leishmania major	83%	100%