Complex_1_protein_(LYR_family)_putative/Pfam:PF05 347

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WYZ6_LEIDO

TriTrypDb:

LdBPK_251020.1 , LdCL_250015500 , LDHU3_25.1300

Length:

162

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0005929	cilium	4	1
GO:0020023	kinetoplast	2	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A0A3S7WYZ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WYZ6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	121	123	PF00675	0.465
CLV_NRD_NRD_1	159	161	PF00675	0.491
CLV_PCSK_KEX2_1	121	123	PF00082	0.488
CLV_PCSK_PC1ET2_1	121	123	PF00082	0.503
DEG_APCC_DBOX_1	129	137	PF00400	0.481
DEG_Nend_Nbox_1	1	3	PF02207	0.625
DOC_MAPK_gen_1	48	58	PF00069	0.266
DOC_MAPK_MEF2A_6	51	58	PF00069	0.266
DOC_MAPK_MEF2A_6	93	102	PF00069	0.266
DOC_MAPK_NFAT4_5	51	59	PF00069	0.266
DOC_PP2B_LxvP_1	21	24	PF13499	0.516
DOC_PP2B_LxvP_1	59	62	PF13499	0.300
DOC_SPAK_OSR1_1	77	81	PF12202	0.266
DOC_USP7_MATH_1	101	105	PF00917	0.300
DOC_USP7_UBL2_3	143	147	PF12436	0.631
LIG_14-3-3_CanoR_1	3	7	PF00244	0.588
LIG_14-3-3_CanoR_1	45	51	PF00244	0.439
LIG_CaM_IQ_9	99	115	PF13499	0.281
LIG_FHA_1	154	160	PF00498	0.607
LIG_LIR_Gen_1	76	86	PF02991	0.266
LIG_LIR_Nem_3	152	157	PF02991	0.468
LIG_LIR_Nem_3	76	81	PF02991	0.266
LIG_SH2_GRB2like	153	156	PF00017	0.447
LIG_SH2_STAT5	157	160	PF00017	0.522
LIG_SH3_3	35	41	PF00018	0.440
LIG_SH3_3	55	61	PF00018	0.266
LIG_SH3_CIN85_PxpxPR_1	125	130	PF14604	0.496
MOD_GlcNHglycan	4	7	PF01048	0.550
MOD_GlcNHglycan	62	65	PF01048	0.300
MOD_GSK3_1	101	108	PF00069	0.266
MOD_GSK3_1	7	14	PF00069	0.585
MOD_NEK2_1	1	6	PF00069	0.579
MOD_NEK2_1	11	16	PF00069	0.622
MOD_PKA_2	2	8	PF00069	0.561
MOD_Plk_1	105	111	PF00069	0.266
MOD_Plk_4	11	17	PF00069	0.597
MOD_Plk_4	153	159	PF00069	0.454
TRG_ENDOCYTIC_2	146	149	PF00928	0.492
TRG_NLS_MonoExtC_3	120	125	PF00514	0.476
TRG_Pf-PMV_PEXEL_1	113	118	PF00026	0.416

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILI5	Leptomonas seymouri	85%	100%
A0A0S4JY75	Bodo saltans	74%	100%
A0A1X0NLU6	Trypanosomatidae	85%	96%
A0A3R7MRN4	Trypanosoma rangeli	81%	100%
A4HE34	Leishmania braziliensis	91%	100%
A4I1E0	Leishmania infantum	100%	100%
C9ZJV6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	77%	100%
E9AXH7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
Q4Q9Z5	Leishmania major	97%	100%
V5AWD4	Trypanosoma cruzi	80%	100%