Hypothetical_protein_conserved

Quick info Annotations Localization Abundance Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WYZ3_LEIDO

TriTrypDb:

LdBPK_250600.1 , LdCL_250011100 , LDHU3_25.0710

Length:

Annotations

Annotations by Jardim et al.

Uncharacterized Protein, Uncharacterized

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 8
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Abundance

Amastigote (protein)


Source	Evidence on protein	Close homologs
Pescher et al. (upgregulation)	no	yes: 0

Promastigote and amastigote


Source	Evidence on protein	Close homologs
Lahav et al. - mRNA - Protein

Expansion

Sequence features

A0A3S7WYZ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WYZ3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
DOC_AGCK_PIF_1	18	23	PF00069	0.474
DOC_USP7_UBL2_3	9	13	PF12436	0.488
DOC_USP7_UBL2_3	92	96	PF12436	0.496
LIG_14-3-3_CanoR_1	19	24	PF00244	0.488
LIG_BIR_II_1	1	5	PF00653	0.648
LIG_LIR_Gen_1	22	31	PF02991	0.455
LIG_LIR_LC3C_4	22	26	PF02991	0.417
LIG_LIR_Nem_3	22	26	PF02991	0.450
LIG_LIR_Nem_3	89	94	PF02991	0.536
LIG_Pex14_2	31	35	PF04695	0.462
LIG_PTB_Apo_2	17	24	PF02174	0.348
LIG_PTB_Phospho_1	17	23	PF10480	0.348
LIG_SH2_STAT5	23	26	PF00017	0.344
MOD_CK1_1	2	8	PF00069	0.653
MOD_GlcNHglycan	5	8	PF01048	0.500
MOD_N-GLC_1	19	24	PF02516	0.488
MOD_NEK2_1	1	6	PF00069	0.645
MOD_NEK2_1	75	80	PF00069	0.579
MOD_Plk_1	19	25	PF00069	0.484
MOD_Plk_1	75	81	PF00069	0.584
TRG_ENDOCYTIC_2	23	26	PF00928	0.484
TRG_ENDOCYTIC_2	91	94	PF00928	0.501

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL82	Leptomonas seymouri	79%	100%
A0A0S4ITT9	Bodo saltans	38%	97%
A0A422NXB3	Trypanosoma rangeli	49%	79%
A4HEF9	Leishmania braziliensis	81%	100%
A4I1A0	Leishmania infantum	100%	100%
D0A5J1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	93%
E9AXD6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
V5BNA9	Trypanosoma cruzi	54%	100%