PH domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WYY8_LEIDO

TriTrypDb:

LdBPK_250870.1 , LdCL_250014000 , LDHU3_25.1100

Length:

378

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WYY8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WYY8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	123	125	PF00675	0.532
CLV_NRD_NRD_1	178	180	PF00675	0.613
CLV_NRD_NRD_1	210	212	PF00675	0.612
CLV_NRD_NRD_1	222	224	PF00675	0.588
CLV_NRD_NRD_1	258	260	PF00675	0.568
CLV_NRD_NRD_1	339	341	PF00675	0.616
CLV_NRD_NRD_1	359	361	PF00675	0.713
CLV_NRD_NRD_1	9	11	PF00675	0.514
CLV_PCSK_KEX2_1	125	127	PF00082	0.483
CLV_PCSK_KEX2_1	178	180	PF00082	0.613
CLV_PCSK_KEX2_1	183	185	PF00082	0.604
CLV_PCSK_KEX2_1	210	212	PF00082	0.571
CLV_PCSK_KEX2_1	221	223	PF00082	0.562
CLV_PCSK_KEX2_1	339	341	PF00082	0.616
CLV_PCSK_KEX2_1	52	54	PF00082	0.597
CLV_PCSK_KEX2_1	8	10	PF00082	0.533
CLV_PCSK_PC1ET2_1	125	127	PF00082	0.485
CLV_PCSK_PC1ET2_1	183	185	PF00082	0.573
CLV_PCSK_PC1ET2_1	52	54	PF00082	0.697
CLV_PCSK_PC7_1	179	185	PF00082	0.619
CLV_PCSK_SKI1_1	10	14	PF00082	0.540
CLV_PCSK_SKI1_1	102	106	PF00082	0.580
CLV_PCSK_SKI1_1	126	130	PF00082	0.511
CLV_PCSK_SKI1_1	178	182	PF00082	0.624
CLV_PCSK_SKI1_1	222	226	PF00082	0.618
DEG_Nend_Nbox_1	1	3	PF02207	0.677
DOC_CYCLIN_RxL_1	123	134	PF00134	0.511
DOC_CYCLIN_RxL_1	206	218	PF00134	0.623
DOC_MAPK_gen_1	124	131	PF00069	0.478
DOC_MAPK_gen_1	339	347	PF00069	0.655
DOC_MAPK_gen_1	51	59	PF00069	0.490
DOC_USP7_MATH_1	243	247	PF00917	0.593
DOC_USP7_MATH_1	296	300	PF00917	0.729
DOC_USP7_MATH_1	303	307	PF00917	0.755
DOC_USP7_MATH_1	372	376	PF00917	0.588
DOC_USP7_MATH_1	77	81	PF00917	0.639
DOC_USP7_UBL2_3	249	253	PF12436	0.543
DOC_USP7_UBL2_3	357	361	PF12436	0.721
DOC_WW_Pin1_4	132	137	PF00397	0.565
DOC_WW_Pin1_4	267	272	PF00397	0.726
LIG_14-3-3_CanoR_1	132	136	PF00244	0.471
LIG_14-3-3_CanoR_1	178	187	PF00244	0.664
LIG_14-3-3_CanoR_1	222	232	PF00244	0.554
LIG_14-3-3_CanoR_1	259	269	PF00244	0.627
LIG_14-3-3_CanoR_1	339	347	PF00244	0.768
LIG_BRCT_BRCA1_1	262	266	PF00533	0.551
LIG_BRCT_BRCA1_1	337	341	PF00533	0.697
LIG_FHA_1	141	147	PF00498	0.453
LIG_FHA_1	191	197	PF00498	0.554
LIG_FHA_1	224	230	PF00498	0.686
LIG_FHA_1	295	301	PF00498	0.639
LIG_FHA_1	86	92	PF00498	0.603
LIG_FHA_1	96	102	PF00498	0.700
LIG_FHA_2	200	206	PF00498	0.505
LIG_FHA_2	313	319	PF00498	0.647
LIG_GBD_Chelix_1	261	269	PF00786	0.561
LIG_LIR_Apic_2	193	198	PF02991	0.540
LIG_LIR_Gen_1	263	274	PF02991	0.655
LIG_LIR_Nem_3	112	118	PF02991	0.470
LIG_LIR_Nem_3	143	148	PF02991	0.557
LIG_LIR_Nem_3	174	180	PF02991	0.646
LIG_LIR_Nem_3	255	261	PF02991	0.543
LIG_LIR_Nem_3	263	269	PF02991	0.602
LIG_LIR_Nem_3	45	49	PF02991	0.541
LIG_PDZ_Class_2	373	378	PF00595	0.506
LIG_Pex14_1	7	11	PF04695	0.628
LIG_Pex14_2	116	120	PF04695	0.407
LIG_SH2_CRK	177	181	PF00017	0.615
LIG_SH2_CRK	258	262	PF00017	0.535
LIG_SH2_CRK	373	377	PF00017	0.505
LIG_SH2_PTP2	195	198	PF00017	0.453
LIG_SH2_SRC	195	198	PF00017	0.586
LIG_SH2_STAT5	115	118	PF00017	0.432
LIG_SH2_STAT5	127	130	PF00017	0.534
LIG_SH2_STAT5	139	142	PF00017	0.442
LIG_SH2_STAT5	145	148	PF00017	0.360
LIG_SH2_STAT5	149	152	PF00017	0.454
LIG_SH2_STAT5	195	198	PF00017	0.589
LIG_SH2_STAT5	63	66	PF00017	0.545
LIG_SH3_2	74	79	PF14604	0.699
LIG_SH3_3	268	274	PF00018	0.614
LIG_SH3_3	71	77	PF00018	0.605
LIG_SUMO_SIM_par_1	127	135	PF11976	0.559
LIG_SUMO_SIM_par_1	86	93	PF11976	0.531
LIG_SxIP_EBH_1	40	53	PF03271	0.531
LIG_TRAF2_1	119	122	PF00917	0.460
LIG_TRAF2_1	254	257	PF00917	0.551
LIG_TYR_ITIM	175	180	PF00017	0.575
MOD_CK1_1	106	112	PF00069	0.530
MOD_CK1_1	190	196	PF00069	0.648
MOD_CK1_1	239	245	PF00069	0.574
MOD_CK1_1	333	339	PF00069	0.718
MOD_CK1_1	97	103	PF00069	0.641
MOD_CK2_1	116	122	PF00069	0.445
MOD_CK2_1	199	205	PF00069	0.512
MOD_CK2_1	251	257	PF00069	0.627
MOD_CK2_1	261	267	PF00069	0.692
MOD_CK2_1	285	291	PF00069	0.536
MOD_CK2_1	87	93	PF00069	0.636
MOD_GlcNHglycan	152	156	PF01048	0.553
MOD_GlcNHglycan	226	229	PF01048	0.518
MOD_GlcNHglycan	243	246	PF01048	0.635
MOD_GlcNHglycan	30	33	PF01048	0.547
MOD_GlcNHglycan	305	308	PF01048	0.714
MOD_GlcNHglycan	335	338	PF01048	0.639
MOD_GlcNHglycan	353	356	PF01048	0.671
MOD_GlcNHglycan	66	71	PF01048	0.697
MOD_GSK3_1	102	109	PF00069	0.636
MOD_GSK3_1	183	190	PF00069	0.636
MOD_GSK3_1	239	246	PF00069	0.565
MOD_GSK3_1	312	319	PF00069	0.653
MOD_GSK3_1	329	336	PF00069	0.729
MOD_GSK3_1	83	90	PF00069	0.618
MOD_GSK3_1	93	100	PF00069	0.675
MOD_N-GLC_1	106	111	PF02516	0.495
MOD_NEK2_1	130	135	PF00069	0.515
MOD_NEK2_1	141	146	PF00069	0.540
MOD_NEK2_1	224	229	PF00069	0.498
MOD_NEK2_1	329	334	PF00069	0.703
MOD_NEK2_1	341	346	PF00069	0.531
MOD_NEK2_2	372	377	PF00069	0.566
MOD_PK_1	285	291	PF00069	0.686
MOD_PKA_1	178	184	PF00069	0.664
MOD_PKA_1	339	345	PF00069	0.536
MOD_PKA_2	131	137	PF00069	0.567
MOD_PKA_2	178	184	PF00069	0.664
MOD_PKA_2	329	335	PF00069	0.572
MOD_PKA_2	339	345	PF00069	0.536
MOD_PKB_1	221	229	PF00069	0.555
MOD_Plk_1	285	291	PF00069	0.706
MOD_Plk_2-3	199	205	PF00069	0.501
MOD_Plk_2-3	87	93	PF00069	0.578
MOD_Plk_4	109	115	PF00069	0.591
MOD_Plk_4	141	147	PF00069	0.470
MOD_Plk_4	183	189	PF00069	0.597
MOD_Plk_4	190	196	PF00069	0.541
MOD_Plk_4	261	267	PF00069	0.594
MOD_Plk_4	341	347	PF00069	0.598
MOD_Plk_4	42	48	PF00069	0.517
MOD_ProDKin_1	132	138	PF00069	0.564
MOD_ProDKin_1	267	273	PF00069	0.729
MOD_SUMO_for_1	363	366	PF00179	0.592
MOD_SUMO_rev_2	275	281	PF00179	0.575
TRG_ENDOCYTIC_2	113	116	PF00928	0.455
TRG_ENDOCYTIC_2	127	130	PF00928	0.530
TRG_ENDOCYTIC_2	145	148	PF00928	0.403
TRG_ENDOCYTIC_2	177	180	PF00928	0.594
TRG_ENDOCYTIC_2	258	261	PF00928	0.539
TRG_ENDOCYTIC_2	373	376	PF00928	0.508
TRG_ER_diArg_1	124	127	PF00400	0.552
TRG_ER_diArg_1	177	179	PF00400	0.612
TRG_ER_diArg_1	209	211	PF00400	0.614
TRG_ER_diArg_1	221	223	PF00400	0.624
TRG_ER_diArg_1	339	341	PF00400	0.616
TRG_ER_diArg_1	7	10	PF00400	0.577
TRG_NLS_MonoExtC_3	50	56	PF00514	0.594
TRG_NLS_MonoExtN_4	48	55	PF00514	0.569
TRG_Pf-PMV_PEXEL_1	178	182	PF00026	0.623
TRG_Pf-PMV_PEXEL_1	210	215	PF00026	0.653

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILI8	Leptomonas seymouri	51%	92%
A0A1X0P4C2	Trypanosomatidae	31%	100%
A0A422MPP3	Trypanosoma rangeli	34%	100%
A4HE19	Leishmania braziliensis	68%	100%
A4I1C6	Leishmania infantum	99%	100%
E9AXG2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QA10	Leishmania major	84%	100%
V5BXG5	Trypanosoma cruzi	34%	100%