Putative zinc finger protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

predicted zinc finger protein

Species:

Leishmania donovani

UniProt:

A0A3S7WYX9_LEIDO

TriTrypDb:

LdBPK_250660.1 , LdCL_250011800 , LDHU3_25.0780

Length:

665

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A0A3S7WYX9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WYX9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0008270	zinc ion binding	6	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1
GO:0046914	transition metal ion binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	292	296	PF00656	0.581
CLV_C14_Caspase3-7	334	338	PF00656	0.440
CLV_NRD_NRD_1	145	147	PF00675	0.537
CLV_NRD_NRD_1	191	193	PF00675	0.492
CLV_NRD_NRD_1	305	307	PF00675	0.622
CLV_NRD_NRD_1	321	323	PF00675	0.532
CLV_NRD_NRD_1	407	409	PF00675	0.649
CLV_PCSK_FUR_1	189	193	PF00082	0.511
CLV_PCSK_KEX2_1	145	147	PF00082	0.535
CLV_PCSK_KEX2_1	191	193	PF00082	0.492
CLV_PCSK_KEX2_1	305	307	PF00082	0.640
CLV_PCSK_KEX2_1	407	409	PF00082	0.713
CLV_PCSK_SKI1_1	349	353	PF00082	0.551
CLV_PCSK_SKI1_1	511	515	PF00082	0.507
CLV_PCSK_SKI1_1	569	573	PF00082	0.540
CLV_PCSK_SKI1_1	619	623	PF00082	0.409
CLV_PCSK_SKI1_1	644	648	PF00082	0.507
CLV_PCSK_SKI1_1	651	655	PF00082	0.478
DEG_APCC_DBOX_1	348	356	PF00400	0.477
DEG_SCF_FBW7_2	73	80	PF00400	0.586
DEG_SIAH_1	478	486	PF03145	0.556
DEG_SPOP_SBC_1	369	373	PF00917	0.612
DEG_SPOP_SBC_1	376	380	PF00917	0.438
DEG_SPOP_SBC_1	608	612	PF00917	0.524
DEG_SPOP_SBC_1	67	71	PF00917	0.552
DOC_CDC14_PxL_1	304	312	PF14671	0.500
DOC_CDC14_PxL_1	486	494	PF14671	0.565
DOC_CKS1_1	174	179	PF01111	0.452
DOC_CKS1_1	74	79	PF01111	0.587
DOC_CYCLIN_yCln2_LP_2	171	177	PF00134	0.384
DOC_CYCLIN_yCln2_LP_2	623	629	PF00134	0.461
DOC_MAPK_gen_1	189	198	PF00069	0.489
DOC_MAPK_gen_1	305	312	PF00069	0.609
DOC_MAPK_MEF2A_6	191	200	PF00069	0.470
DOC_MAPK_MEF2A_6	305	312	PF00069	0.552
DOC_MAPK_MEF2A_6	511	520	PF00069	0.518
DOC_PP1_RVXF_1	148	155	PF00149	0.602
DOC_PP1_RVXF_1	242	249	PF00149	0.496
DOC_PP2B_LxvP_1	171	174	PF13499	0.493
DOC_PP2B_LxvP_1	367	370	PF13499	0.499
DOC_USP7_MATH_1	293	297	PF00917	0.626
DOC_USP7_MATH_1	370	374	PF00917	0.613
DOC_USP7_MATH_1	381	385	PF00917	0.561
DOC_USP7_MATH_1	440	444	PF00917	0.729
DOC_USP7_MATH_1	479	483	PF00917	0.678
DOC_USP7_MATH_1	491	495	PF00917	0.458
DOC_USP7_MATH_1	608	612	PF00917	0.556
DOC_USP7_MATH_1	66	70	PF00917	0.630
DOC_WW_Pin1_4	173	178	PF00397	0.452
DOC_WW_Pin1_4	473	478	PF00397	0.569
DOC_WW_Pin1_4	500	505	PF00397	0.534
DOC_WW_Pin1_4	604	609	PF00397	0.528
DOC_WW_Pin1_4	73	78	PF00397	0.598
LIG_14-3-3_CanoR_1	150	155	PF00244	0.614
LIG_14-3-3_CanoR_1	159	168	PF00244	0.643
LIG_14-3-3_CanoR_1	189	199	PF00244	0.570
LIG_14-3-3_CanoR_1	354	360	PF00244	0.541
LIG_14-3-3_CanoR_1	431	435	PF00244	0.619
LIG_14-3-3_CanoR_1	439	445	PF00244	0.634
LIG_14-3-3_CanoR_1	511	516	PF00244	0.571
LIG_14-3-3_CanoR_1	606	616	PF00244	0.559
LIG_Actin_WH2_2	234	252	PF00022	0.507
LIG_Actin_WH2_2	308	324	PF00022	0.575
LIG_Actin_WH2_2	391	409	PF00022	0.520
LIG_BIR_II_1	1	5	PF00653	0.529
LIG_BIR_III_4	456	460	PF00653	0.634
LIG_BRCT_BRCA1_1	493	497	PF00533	0.523
LIG_FHA_1	191	197	PF00498	0.442
LIG_FHA_1	202	208	PF00498	0.454
LIG_FHA_1	220	226	PF00498	0.566
LIG_FHA_1	328	334	PF00498	0.550
LIG_FHA_1	445	451	PF00498	0.693
LIG_FHA_1	54	60	PF00498	0.787
LIG_FHA_1	572	578	PF00498	0.522
LIG_FHA_1	658	664	PF00498	0.549
LIG_FHA_2	161	167	PF00498	0.581
LIG_FHA_2	290	296	PF00498	0.576
LIG_FHA_2	342	348	PF00498	0.590
LIG_FHA_2	421	427	PF00498	0.560
LIG_FHA_2	465	471	PF00498	0.578
LIG_FHA_2	82	88	PF00498	0.633
LIG_LIR_Gen_1	17	26	PF02991	0.547
LIG_LIR_Gen_1	494	502	PF02991	0.517
LIG_LIR_Nem_3	17	23	PF02991	0.490
LIG_LIR_Nem_3	494	498	PF02991	0.475
LIG_LIR_Nem_3	574	578	PF02991	0.480
LIG_PCNA_yPIPBox_3	349	360	PF02747	0.463
LIG_PTAP_UEV_1	47	52	PF05743	0.584
LIG_REV1ctd_RIR_1	495	503	PF16727	0.544
LIG_SH2_STAT5	125	128	PF00017	0.492
LIG_SH2_STAT5	223	226	PF00017	0.461
LIG_SH2_STAT5	399	402	PF00017	0.560
LIG_SH3_3	171	177	PF00018	0.512
LIG_SH3_3	179	185	PF00018	0.438
LIG_SH3_3	310	316	PF00018	0.553
LIG_SH3_3	415	421	PF00018	0.545
LIG_SH3_3	45	51	PF00018	0.616
LIG_SUMO_SIM_anti_2	193	200	PF11976	0.368
LIG_SUMO_SIM_anti_2	620	625	PF11976	0.469
LIG_SUMO_SIM_par_1	329	334	PF11976	0.565
LIG_SUMO_SIM_par_1	80	87	PF11976	0.588
LIG_TRAF2_1	345	348	PF00917	0.532
LIG_TRAF2_1	77	80	PF00917	0.585
LIG_WRC_WIRS_1	492	497	PF05994	0.522
LIG_WRC_WIRS_1	572	577	PF05994	0.481
MOD_CAAXbox	662	665	PF01239	0.529
MOD_CK1_1	190	196	PF00069	0.640
MOD_CK1_1	271	277	PF00069	0.681
MOD_CK1_1	368	374	PF00069	0.695
MOD_CK1_1	380	386	PF00069	0.516
MOD_CK1_1	433	439	PF00069	0.611
MOD_CK1_1	464	470	PF00069	0.625
MOD_CK1_1	95	101	PF00069	0.553
MOD_CK2_1	341	347	PF00069	0.608
MOD_CK2_1	81	87	PF00069	0.631
MOD_CMANNOS	273	276	PF00535	0.608
MOD_DYRK1A_RPxSP_1	604	608	PF00069	0.495
MOD_GlcNHglycan	212	215	PF01048	0.612
MOD_GlcNHglycan	251	255	PF01048	0.444
MOD_GlcNHglycan	278	281	PF01048	0.570
MOD_GlcNHglycan	295	298	PF01048	0.727
MOD_GlcNHglycan	339	342	PF01048	0.550
MOD_GlcNHglycan	367	370	PF01048	0.578
MOD_GlcNHglycan	372	375	PF01048	0.564
MOD_GlcNHglycan	379	382	PF01048	0.588
MOD_GlcNHglycan	383	386	PF01048	0.496
MOD_GlcNHglycan	442	445	PF01048	0.635
MOD_GlcNHglycan	464	467	PF01048	0.515
MOD_GlcNHglycan	507	510	PF01048	0.592
MOD_GlcNHglycan	581	584	PF01048	0.557
MOD_GlcNHglycan	587	590	PF01048	0.572
MOD_GlcNHglycan	601	604	PF01048	0.346
MOD_GlcNHglycan	70	73	PF01048	0.593
MOD_GlcNHglycan	94	97	PF01048	0.749
MOD_GSK3_1	201	208	PF00069	0.490
MOD_GSK3_1	215	222	PF00069	0.650
MOD_GSK3_1	271	278	PF00069	0.675
MOD_GSK3_1	289	296	PF00069	0.611
MOD_GSK3_1	327	334	PF00069	0.556
MOD_GSK3_1	337	344	PF00069	0.557
MOD_GSK3_1	365	372	PF00069	0.688
MOD_GSK3_1	376	383	PF00069	0.546
MOD_GSK3_1	440	447	PF00069	0.621
MOD_GSK3_1	581	588	PF00069	0.540
MOD_GSK3_1	604	611	PF00069	0.588
MOD_GSK3_1	83	90	PF00069	0.685
MOD_GSK3_1	91	98	PF00069	0.678
MOD_N-GLC_1	327	332	PF02516	0.504
MOD_N-GLC_1	473	478	PF02516	0.563
MOD_NEK2_1	210	215	PF00069	0.557
MOD_NEK2_1	355	360	PF00069	0.592
MOD_NEK2_1	377	382	PF00069	0.491
MOD_NEK2_1	406	411	PF00069	0.565
MOD_NEK2_1	497	502	PF00069	0.491
MOD_NEK2_1	68	73	PF00069	0.583
MOD_NEK2_1	92	97	PF00069	0.653
MOD_NEK2_2	280	285	PF00069	0.573
MOD_NEK2_2	35	40	PF00069	0.524
MOD_OFUCOSY	33	39	PF10250	0.509
MOD_PIKK_1	430	436	PF00454	0.672
MOD_PKA_2	190	196	PF00069	0.553
MOD_PKA_2	381	387	PF00069	0.515
MOD_PKA_2	406	412	PF00069	0.612
MOD_PKA_2	430	436	PF00069	0.613
MOD_PKB_1	604	612	PF00069	0.502
MOD_PKB_1	642	650	PF00069	0.539
MOD_Plk_1	234	240	PF00069	0.439
MOD_Plk_1	327	333	PF00069	0.496
MOD_Plk_1	414	420	PF00069	0.564
MOD_Plk_1	459	465	PF00069	0.521
MOD_Plk_4	107	113	PF00069	0.583
MOD_Plk_4	226	232	PF00069	0.433
MOD_Plk_4	268	274	PF00069	0.697
MOD_Plk_4	280	286	PF00069	0.637
MOD_Plk_4	308	314	PF00069	0.553
MOD_Plk_4	327	333	PF00069	0.544
MOD_Plk_4	355	361	PF00069	0.433
MOD_Plk_4	464	470	PF00069	0.541
MOD_Plk_4	479	485	PF00069	0.493
MOD_ProDKin_1	173	179	PF00069	0.455
MOD_ProDKin_1	473	479	PF00069	0.570
MOD_ProDKin_1	500	506	PF00069	0.534
MOD_ProDKin_1	604	610	PF00069	0.529
MOD_ProDKin_1	73	79	PF00069	0.597
MOD_SUMO_for_1	636	639	PF00179	0.489
TRG_DiLeu_BaEn_4	347	353	PF01217	0.521
TRG_ER_diArg_1	188	191	PF00400	0.520
TRG_ER_diArg_1	304	306	PF00400	0.711
TRG_ER_diArg_1	406	408	PF00400	0.556

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDP2	Leptomonas seymouri	45%	100%
A4HEF3	Leishmania braziliensis	68%	99%
A4I1A6	Leishmania infantum	100%	100%
D0A5J8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9AXE2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	99%
Q4QA30	Leishmania major	86%	100%