RUN domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WYX6_LEIDO

TriTrypDb:

LdBPK_250220.1 , LdCL_250007300 , LDHU3_25.0280

Length:

713

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WYX6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WYX6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	287	291	PF00656	0.524
CLV_C14_Caspase3-7	38	42	PF00656	0.519
CLV_C14_Caspase3-7	507	511	PF00656	0.421
CLV_NRD_NRD_1	142	144	PF00675	0.580
CLV_NRD_NRD_1	237	239	PF00675	0.509
CLV_NRD_NRD_1	253	255	PF00675	0.523
CLV_NRD_NRD_1	475	477	PF00675	0.403
CLV_PCSK_FUR_1	237	241	PF00082	0.513
CLV_PCSK_KEX2_1	237	239	PF00082	0.509
CLV_PCSK_KEX2_1	262	264	PF00082	0.558
CLV_PCSK_KEX2_1	313	315	PF00082	0.536
CLV_PCSK_KEX2_1	447	449	PF00082	0.494
CLV_PCSK_KEX2_1	475	477	PF00082	0.414
CLV_PCSK_KEX2_1	629	631	PF00082	0.556
CLV_PCSK_PC1ET2_1	239	241	PF00082	0.517
CLV_PCSK_PC1ET2_1	262	264	PF00082	0.597
CLV_PCSK_PC1ET2_1	313	315	PF00082	0.536
CLV_PCSK_PC1ET2_1	447	449	PF00082	0.494
CLV_PCSK_PC1ET2_1	629	631	PF00082	0.556
CLV_PCSK_SKI1_1	360	364	PF00082	0.425
CLV_PCSK_SKI1_1	447	451	PF00082	0.502
CLV_PCSK_SKI1_1	55	59	PF00082	0.347
CLV_PCSK_SKI1_1	64	68	PF00082	0.358
CLV_PCSK_SKI1_1	77	81	PF00082	0.369
DEG_APCC_DBOX_1	237	245	PF00400	0.520
DEG_APCC_DBOX_1	54	62	PF00400	0.469
DEG_APCC_DBOX_1	76	84	PF00400	0.358
DEG_SPOP_SBC_1	277	281	PF00917	0.660
DOC_CYCLIN_RxL_1	444	454	PF00134	0.441
DOC_MAPK_gen_1	143	153	PF00069	0.633
DOC_MAPK_gen_1	313	321	PF00069	0.482
DOC_MAPK_gen_1	634	643	PF00069	0.594
DOC_MAPK_MEF2A_6	104	111	PF00069	0.390
DOC_MAPK_MEF2A_6	314	323	PF00069	0.501
DOC_MAPK_MEF2A_6	564	572	PF00069	0.536
DOC_PP4_FxxP_1	559	562	PF00568	0.500
DOC_PP4_FxxP_1	609	612	PF00568	0.549
DOC_PP4_FxxP_1	707	710	PF00568	0.598
DOC_USP7_MATH_1	127	131	PF00917	0.651
DOC_USP7_MATH_1	133	137	PF00917	0.791
DOC_USP7_MATH_1	277	281	PF00917	0.669
DOC_USP7_MATH_1	289	293	PF00917	0.672
DOC_USP7_MATH_1	400	404	PF00917	0.386
DOC_USP7_UBL2_3	134	138	PF12436	0.619
DOC_WW_Pin1_4	364	369	PF00397	0.521
LIG_14-3-3_CanoR_1	146	153	PF00244	0.664
LIG_14-3-3_CanoR_1	343	348	PF00244	0.440
LIG_14-3-3_CanoR_1	418	427	PF00244	0.360
LIG_14-3-3_CanoR_1	448	453	PF00244	0.461
LIG_14-3-3_CanoR_1	550	558	PF00244	0.467
LIG_14-3-3_CanoR_1	569	573	PF00244	0.553
LIG_14-3-3_CanoR_1	634	639	PF00244	0.595
LIG_14-3-3_CanoR_1	91	99	PF00244	0.533
LIG_Actin_RPEL_3	526	545	PF02755	0.467
LIG_AP_GAE_1	596	602	PF02883	0.577
LIG_APCC_ABBA_1	524	529	PF00400	0.464
LIG_BIR_II_1	1	5	PF00653	0.424
LIG_BIR_III_4	432	436	PF00653	0.545
LIG_BRCT_BRCA1_1	107	111	PF00533	0.523
LIG_BRCT_BRCA1_1	366	370	PF00533	0.513
LIG_deltaCOP1_diTrp_1	94	99	PF00928	0.399
LIG_FHA_1	164	170	PF00498	0.580
LIG_FHA_1	367	373	PF00498	0.392
LIG_FHA_1	420	426	PF00498	0.358
LIG_FHA_1	550	556	PF00498	0.495
LIG_FHA_1	626	632	PF00498	0.533
LIG_FHA_2	652	658	PF00498	0.548
LIG_FHA_2	90	96	PF00498	0.528
LIG_LIR_Apic_2	608	612	PF02991	0.574
LIG_LIR_Gen_1	295	303	PF02991	0.532
LIG_LIR_Gen_1	361	370	PF02991	0.380
LIG_LIR_Gen_1	656	666	PF02991	0.678
LIG_LIR_Gen_1	93	103	PF02991	0.388
LIG_LIR_Nem_3	290	296	PF02991	0.569
LIG_LIR_Nem_3	355	359	PF02991	0.434
LIG_LIR_Nem_3	361	365	PF02991	0.382
LIG_LIR_Nem_3	367	373	PF02991	0.405
LIG_LIR_Nem_3	391	397	PF02991	0.470
LIG_LIR_Nem_3	482	488	PF02991	0.427
LIG_LIR_Nem_3	575	579	PF02991	0.459
LIG_LIR_Nem_3	656	662	PF02991	0.645
LIG_LIR_Nem_3	93	99	PF02991	0.397
LIG_Pex14_2	620	624	PF04695	0.561
LIG_SH2_SRC	198	201	PF00017	0.518
LIG_SH2_SRC	233	236	PF00017	0.617
LIG_SH3_3	197	203	PF00018	0.527
LIG_SH3_3	552	558	PF00018	0.448
LIG_SH3_3	559	565	PF00018	0.506
LIG_SUMO_SIM_anti_2	114	120	PF11976	0.393
LIG_SUMO_SIM_anti_2	336	342	PF11976	0.414
LIG_SUMO_SIM_par_1	448	454	PF11976	0.452
LIG_SUMO_SIM_par_1	611	618	PF11976	0.536
LIG_TRAF2_1	248	251	PF00917	0.558
LIG_UBA3_1	119	128	PF00899	0.541
LIG_WW_3	561	565	PF00397	0.511
MOD_CDK_SPxxK_3	364	371	PF00069	0.454
MOD_CK1_1	105	111	PF00069	0.526
MOD_CK1_1	14	20	PF00069	0.612
MOD_CK1_1	193	199	PF00069	0.708
MOD_CK1_1	270	276	PF00069	0.720
MOD_CK1_1	342	348	PF00069	0.540
MOD_CK1_1	618	624	PF00069	0.673
MOD_CK2_1	245	251	PF00069	0.661
MOD_CK2_1	281	287	PF00069	0.787
MOD_CK2_1	448	454	PF00069	0.452
MOD_CK2_1	590	596	PF00069	0.559
MOD_CK2_1	597	603	PF00069	0.581
MOD_CK2_1	651	657	PF00069	0.569
MOD_CK2_1	89	95	PF00069	0.549
MOD_GlcNHglycan	129	132	PF01048	0.726
MOD_GlcNHglycan	172	176	PF01048	0.590
MOD_GlcNHglycan	269	272	PF01048	0.742
MOD_GlcNHglycan	284	287	PF01048	0.719
MOD_GlcNHglycan	3	6	PF01048	0.505
MOD_GlcNHglycan	49	52	PF01048	0.570
MOD_GlcNHglycan	669	672	PF01048	0.698
MOD_GSK3_1	107	114	PF00069	0.479
MOD_GSK3_1	11	18	PF00069	0.520
MOD_GSK3_1	145	152	PF00069	0.650
MOD_GSK3_1	190	197	PF00069	0.613
MOD_GSK3_1	272	279	PF00069	0.755
MOD_GSK3_1	339	346	PF00069	0.425
MOD_GSK3_1	43	50	PF00069	0.482
MOD_GSK3_1	649	656	PF00069	0.620
MOD_GSK3_1	98	105	PF00069	0.473
MOD_N-GLC_1	681	686	PF02516	0.647
MOD_NEK2_1	1	6	PF00069	0.405
MOD_NEK2_1	102	107	PF00069	0.369
MOD_NEK2_1	111	116	PF00069	0.372
MOD_NEK2_1	145	150	PF00069	0.661
MOD_NEK2_1	190	195	PF00069	0.594
MOD_NEK2_1	43	48	PF00069	0.417
MOD_NEK2_1	479	484	PF00069	0.466
MOD_NEK2_1	662	667	PF00069	0.705
MOD_PIKK_1	185	191	PF00454	0.556
MOD_PIKK_1	649	655	PF00454	0.561
MOD_PIKK_1	665	671	PF00454	0.586
MOD_PKA_2	145	151	PF00069	0.635
MOD_PKA_2	342	348	PF00069	0.413
MOD_PKA_2	381	387	PF00069	0.568
MOD_PKA_2	549	555	PF00069	0.423
MOD_PKA_2	568	574	PF00069	0.548
MOD_PKA_2	625	631	PF00069	0.530
MOD_PKA_2	90	96	PF00069	0.543
MOD_PKB_1	263	271	PF00069	0.678
MOD_PKB_1	476	484	PF00069	0.567
MOD_Plk_1	390	396	PF00069	0.587
MOD_Plk_1	43	49	PF00069	0.525
MOD_Plk_1	516	522	PF00069	0.442
MOD_Plk_2-3	590	596	PF00069	0.565
MOD_Plk_2-3	597	603	PF00069	0.573
MOD_Plk_4	111	117	PF00069	0.377
MOD_Plk_4	615	621	PF00069	0.592
MOD_Plk_4	67	73	PF00069	0.437
MOD_Plk_4	98	104	PF00069	0.451
MOD_ProDKin_1	364	370	PF00069	0.516
MOD_SUMO_rev_2	125	130	PF00179	0.630
MOD_SUMO_rev_2	172	180	PF00179	0.687
MOD_SUMO_rev_2	506	516	PF00179	0.519
MOD_SUMO_rev_2	625	631	PF00179	0.530
TRG_DiLeu_BaEn_1	336	341	PF01217	0.411
TRG_DiLeu_BaEn_2	574	580	PF01217	0.447
TRG_ENDOCYTIC_2	293	296	PF00928	0.592
TRG_ENDOCYTIC_2	576	579	PF00928	0.480
TRG_ENDOCYTIC_2	659	662	PF00928	0.648
TRG_ER_diArg_1	237	240	PF00400	0.512
TRG_ER_diArg_1	406	409	PF00400	0.392
TRG_ER_diArg_1	474	476	PF00400	0.386
TRG_ER_diArg_1	708	711	PF00400	0.736
TRG_NES_CRM1_1	113	126	PF08389	0.594
TRG_NLS_MonoExtC_3	237	242	PF00514	0.516
TRG_NLS_MonoExtC_3	261	267	PF00514	0.603
TRG_NLS_MonoExtN_4	237	242	PF00514	0.517
TRG_Pf-PMV_PEXEL_1	239	243	PF00026	0.518
TRG_Pf-PMV_PEXEL_1	322	326	PF00026	0.399
TRG_Pf-PMV_PEXEL_1	645	650	PF00026	0.590

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I765	Leptomonas seymouri	82%	100%
A0A0S4JHQ3	Bodo saltans	42%	82%
A0A1X0P4I5	Trypanosomatidae	60%	100%
A0A422NF47	Trypanosoma rangeli	60%	100%
A4HDW9	Leishmania braziliensis	88%	100%
A4I164	Leishmania infantum	100%	100%
D0A5F0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
E9AX98	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q4QA74	Leishmania major	95%	100%
V5DPB1	Trypanosoma cruzi	60%	100%