Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WYX4_LEIDO

TriTrypDb:

LdBPK_250700.1 , LdCL_250012200 , LDHU3_25.0850

Length:

1058

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A0A3S7WYX4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WYX4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1043	1047	PF00656	0.692
CLV_C14_Caspase3-7	259	263	PF00656	0.734
CLV_C14_Caspase3-7	516	520	PF00656	0.731
CLV_C14_Caspase3-7	712	716	PF00656	0.773
CLV_C14_Caspase3-7	749	753	PF00656	0.752
CLV_MEL_PAP_1	224	230	PF00089	0.672
CLV_NRD_NRD_1	199	201	PF00675	0.689
CLV_NRD_NRD_1	25	27	PF00675	0.682
CLV_NRD_NRD_1	290	292	PF00675	0.696
CLV_NRD_NRD_1	489	491	PF00675	0.712
CLV_NRD_NRD_1	676	678	PF00675	0.651
CLV_NRD_NRD_1	690	692	PF00675	0.580
CLV_NRD_NRD_1	71	73	PF00675	0.667
CLV_NRD_NRD_1	920	922	PF00675	0.669
CLV_PCSK_FUR_1	197	201	PF00082	0.678
CLV_PCSK_FUR_1	487	491	PF00082	0.756
CLV_PCSK_KEX2_1	199	201	PF00082	0.689
CLV_PCSK_KEX2_1	290	292	PF00082	0.684
CLV_PCSK_KEX2_1	489	491	PF00082	0.712
CLV_PCSK_KEX2_1	675	677	PF00082	0.627
CLV_PCSK_KEX2_1	690	692	PF00082	0.571
CLV_PCSK_KEX2_1	71	73	PF00082	0.667
CLV_PCSK_PC7_1	195	201	PF00082	0.724
CLV_PCSK_PC7_1	672	678	PF00082	0.551
CLV_PCSK_SKI1_1	26	30	PF00082	0.692
CLV_PCSK_SKI1_1	304	308	PF00082	0.670
CLV_PCSK_SKI1_1	600	604	PF00082	0.645
CLV_PCSK_SKI1_1	637	641	PF00082	0.532
CLV_PCSK_SKI1_1	71	75	PF00082	0.618
CLV_PCSK_SKI1_1	891	895	PF00082	0.519
CLV_PCSK_SKI1_1	913	917	PF00082	0.661
CLV_PCSK_SKI1_1	959	963	PF00082	0.542
DEG_APCC_DBOX_1	890	898	PF00400	0.516
DEG_SCF_TRCP1_1	810	816	PF00400	0.767
DEG_SPOP_SBC_1	469	473	PF00917	0.675
DEG_SPOP_SBC_1	706	710	PF00917	0.806
DOC_MAPK_DCC_7	294	303	PF00069	0.644
DOC_MAPK_DCC_7	436	445	PF00069	0.634
DOC_MAPK_DCC_7	489	499	PF00069	0.633
DOC_MAPK_gen_1	36	45	PF00069	0.545
DOC_MAPK_gen_1	487	494	PF00069	0.740
DOC_MAPK_HePTP_8	433	445	PF00069	0.618
DOC_MAPK_JIP1_4	785	791	PF00069	0.628
DOC_MAPK_MEF2A_6	167	176	PF00069	0.709
DOC_MAPK_MEF2A_6	294	303	PF00069	0.651
DOC_MAPK_MEF2A_6	436	445	PF00069	0.634
DOC_MAPK_MEF2A_6	490	499	PF00069	0.629
DOC_MAPK_MEF2A_6	576	584	PF00069	0.601
DOC_PP1_RVXF_1	1048	1055	PF00149	0.767
DOC_PP2B_LxvP_1	385	388	PF13499	0.661
DOC_PP2B_LxvP_1	798	801	PF13499	0.682
DOC_PP2B_LxvP_1	897	900	PF13499	0.520
DOC_SPAK_OSR1_1	656	660	PF12202	0.589
DOC_USP7_MATH_1	1004	1008	PF00917	0.763
DOC_USP7_MATH_1	1010	1014	PF00917	0.632
DOC_USP7_MATH_1	306	310	PF00917	0.608
DOC_USP7_MATH_1	346	350	PF00917	0.686
DOC_USP7_MATH_1	37	41	PF00917	0.658
DOC_USP7_MATH_1	371	375	PF00917	0.655
DOC_USP7_MATH_1	380	384	PF00917	0.534
DOC_USP7_MATH_1	469	473	PF00917	0.675
DOC_USP7_MATH_1	523	527	PF00917	0.730
DOC_USP7_MATH_1	536	540	PF00917	0.494
DOC_USP7_MATH_1	565	569	PF00917	0.738
DOC_USP7_MATH_1	64	68	PF00917	0.651
DOC_USP7_MATH_1	707	711	PF00917	0.814
DOC_USP7_MATH_1	764	768	PF00917	0.805
DOC_USP7_MATH_1	779	783	PF00917	0.559
DOC_USP7_MATH_1	801	805	PF00917	0.675
DOC_USP7_MATH_1	842	846	PF00917	0.701
DOC_USP7_MATH_1	97	101	PF00917	0.684
DOC_WW_Pin1_4	361	366	PF00397	0.692
DOC_WW_Pin1_4	470	475	PF00397	0.711
DOC_WW_Pin1_4	532	537	PF00397	0.641
DOC_WW_Pin1_4	791	796	PF00397	0.817
DOC_WW_Pin1_4	926	931	PF00397	0.645
DOC_WW_Pin1_4	936	941	PF00397	0.625
DOC_WW_Pin1_4	945	950	PF00397	0.381
DOC_WW_Pin1_4	992	997	PF00397	0.777
LIG_14-3-3_CanoR_1	255	261	PF00244	0.704
LIG_14-3-3_CanoR_1	294	298	PF00244	0.574
LIG_14-3-3_CanoR_1	324	329	PF00244	0.639
LIG_14-3-3_CanoR_1	36	45	PF00244	0.582
LIG_14-3-3_CanoR_1	399	404	PF00244	0.625
LIG_14-3-3_CanoR_1	503	508	PF00244	0.656
LIG_14-3-3_CanoR_1	823	831	PF00244	0.725
LIG_14-3-3_CanoR_1	913	920	PF00244	0.664
LIG_14-3-3_CanoR_1	98	106	PF00244	0.719
LIG_14-3-3_CanoR_1	988	992	PF00244	0.673
LIG_Actin_WH2_2	127	143	PF00022	0.693
LIG_Actin_WH2_2	378	393	PF00022	0.646
LIG_APCC_ABBA_1	583	588	PF00400	0.523
LIG_BIR_II_1	1	5	PF00653	0.592
LIG_BIR_III_2	635	639	PF00653	0.627
LIG_BRCT_BRCA1_1	328	332	PF00533	0.640
LIG_BRCT_BRCA1_1	57	61	PF00533	0.520
LIG_BRCT_BRCA1_1	78	82	PF00533	0.648
LIG_BRCT_BRCA1_1	803	807	PF00533	0.726
LIG_Clathr_ClatBox_1	583	587	PF01394	0.555
LIG_CSL_BTD_1	533	536	PF09270	0.706
LIG_CtBP_PxDLS_1	454	458	PF00389	0.772
LIG_EH1_1	577	585	PF00400	0.586
LIG_eIF4E_1	888	894	PF01652	0.625
LIG_EVH1_2	795	799	PF00568	0.756
LIG_EVH1_2	860	864	PF00568	0.702
LIG_FHA_1	1026	1032	PF00498	0.658
LIG_FHA_1	323	329	PF00498	0.723
LIG_FHA_1	40	46	PF00498	0.603
LIG_FHA_1	749	755	PF00498	0.713
LIG_FHA_1	769	775	PF00498	0.498
LIG_FHA_2	828	834	PF00498	0.795
LIG_FHA_2	907	913	PF00498	0.582
LIG_FHA_2	91	97	PF00498	0.664
LIG_FHA_2	976	982	PF00498	0.709
LIG_LIR_Gen_1	1006	1016	PF02991	0.640
LIG_LIR_Gen_1	247	257	PF02991	0.667
LIG_LIR_Gen_1	609	618	PF02991	0.552
LIG_LIR_Gen_1	741	747	PF02991	0.713
LIG_LIR_Gen_1	964	970	PF02991	0.552
LIG_LIR_Gen_1	980	989	PF02991	0.593
LIG_LIR_Nem_3	1006	1011	PF02991	0.655
LIG_LIR_Nem_3	1013	1018	PF02991	0.626
LIG_LIR_Nem_3	104	109	PF02991	0.592
LIG_LIR_Nem_3	183	188	PF02991	0.592
LIG_LIR_Nem_3	247	253	PF02991	0.630
LIG_LIR_Nem_3	266	272	PF02991	0.627
LIG_LIR_Nem_3	741	746	PF02991	0.714
LIG_LIR_Nem_3	964	968	PF02991	0.555
LIG_LIR_Nem_3	980	986	PF02991	0.591
LIG_LYPXL_SIV_4	1014	1022	PF13949	0.654
LIG_MYND_1	388	392	PF01753	0.646
LIG_MYND_1	796	800	PF01753	0.751
LIG_NRBOX	8	14	PF00104	0.577
LIG_NRBOX	922	928	PF00104	0.603
LIG_Pex14_2	275	279	PF04695	0.590
LIG_Pex14_2	57	61	PF04695	0.582
LIG_Rb_LxCxE_1	335	356	PF01857	0.645
LIG_SH2_CRK	185	189	PF00017	0.599
LIG_SH2_GRB2like	173	176	PF00017	0.678
LIG_SH2_NCK_1	989	993	PF00017	0.718
LIG_SH2_SRC	627	630	PF00017	0.486
LIG_SH2_SRC	705	708	PF00017	0.797
LIG_SH2_SRC	884	887	PF00017	0.643
LIG_SH2_STAP1	726	730	PF00017	0.791
LIG_SH2_STAT5	1015	1018	PF00017	0.616
LIG_SH2_STAT5	1053	1056	PF00017	0.759
LIG_SH2_STAT5	109	112	PF00017	0.612
LIG_SH2_STAT5	16	19	PF00017	0.638
LIG_SH2_STAT5	173	176	PF00017	0.678
LIG_SH2_STAT5	217	220	PF00017	0.629
LIG_SH2_STAT5	277	280	PF00017	0.699
LIG_SH2_STAT5	627	630	PF00017	0.486
LIG_SH2_STAT5	743	746	PF00017	0.646
LIG_SH2_STAT5	947	950	PF00017	0.695
LIG_SH2_STAT5	989	992	PF00017	0.706
LIG_SH3_1	854	860	PF00018	0.643
LIG_SH3_3	124	130	PF00018	0.669
LIG_SH3_3	438	444	PF00018	0.598
LIG_SH3_3	489	495	PF00018	0.637
LIG_SH3_3	522	528	PF00018	0.718
LIG_SH3_3	530	536	PF00018	0.583
LIG_SH3_3	790	796	PF00018	0.619
LIG_SH3_3	854	860	PF00018	0.615
LIG_SH3_3	86	92	PF00018	0.724
LIG_SUMO_SIM_anti_2	335	341	PF11976	0.529
LIG_SUMO_SIM_anti_2	581	588	PF11976	0.565
LIG_SUMO_SIM_par_1	39	46	PF11976	0.633
LIG_SUMO_SIM_par_1	452	459	PF11976	0.770
LIG_SUMO_SIM_par_1	581	588	PF11976	0.565
LIG_SUMO_SIM_par_1	637	643	PF11976	0.536
LIG_TYR_ITIM	963	968	PF00017	0.590
LIG_WRC_WIRS_1	103	108	PF05994	0.671
LIG_WRC_WIRS_1	400	405	PF05994	0.539
MOD_CK1_1	1044	1050	PF00069	0.722
MOD_CK1_1	327	333	PF00069	0.650
MOD_CK1_1	361	367	PF00069	0.712
MOD_CK1_1	39	45	PF00069	0.635
MOD_CK1_1	402	408	PF00069	0.615
MOD_CK1_1	456	462	PF00069	0.767
MOD_CK1_1	470	476	PF00069	0.550
MOD_CK1_1	67	73	PF00069	0.630
MOD_CK1_1	709	715	PF00069	0.830
MOD_CK1_1	767	773	PF00069	0.793
MOD_CK1_1	794	800	PF00069	0.719
MOD_CK1_1	811	817	PF00069	0.801
MOD_CK1_1	824	830	PF00069	0.548
MOD_CK1_1	832	838	PF00069	0.630
MOD_CK2_1	147	153	PF00069	0.741
MOD_CK2_1	157	163	PF00069	0.781
MOD_CK2_1	588	594	PF00069	0.583
MOD_CK2_1	812	818	PF00069	0.734
MOD_CK2_1	90	96	PF00069	0.720
MOD_CK2_1	906	912	PF00069	0.596
MOD_CK2_1	975	981	PF00069	0.719
MOD_CK2_1	992	998	PF00069	0.581
MOD_GlcNHglycan	1012	1015	PF01048	0.620
MOD_GlcNHglycan	1036	1040	PF01048	0.813
MOD_GlcNHglycan	1046	1049	PF01048	0.612
MOD_GlcNHglycan	17	20	PF01048	0.618
MOD_GlcNHglycan	2	5	PF01048	0.608
MOD_GlcNHglycan	206	209	PF01048	0.730
MOD_GlcNHglycan	228	231	PF01048	0.733
MOD_GlcNHglycan	258	261	PF01048	0.650
MOD_GlcNHglycan	33	36	PF01048	0.501
MOD_GlcNHglycan	360	363	PF01048	0.737
MOD_GlcNHglycan	511	514	PF01048	0.700
MOD_GlcNHglycan	524	528	PF01048	0.634
MOD_GlcNHglycan	551	554	PF01048	0.794
MOD_GlcNHglycan	569	572	PF01048	0.507
MOD_GlcNHglycan	642	645	PF01048	0.558
MOD_GlcNHglycan	663	666	PF01048	0.665
MOD_GlcNHglycan	681	684	PF01048	0.539
MOD_GlcNHglycan	711	714	PF01048	0.833
MOD_GlcNHglycan	761	764	PF01048	0.744
MOD_GlcNHglycan	809	813	PF01048	0.766
MOD_GlcNHglycan	826	829	PF01048	0.818
MOD_GlcNHglycan	909	912	PF01048	0.662
MOD_GlcNHglycan	936	939	PF01048	0.712
MOD_GSK3_1	143	150	PF00069	0.749
MOD_GSK3_1	153	160	PF00069	0.810
MOD_GSK3_1	322	329	PF00069	0.654
MOD_GSK3_1	342	349	PF00069	0.524
MOD_GSK3_1	361	368	PF00069	0.468
MOD_GSK3_1	399	406	PF00069	0.515
MOD_GSK3_1	495	502	PF00069	0.619
MOD_GSK3_1	509	516	PF00069	0.679
MOD_GSK3_1	528	535	PF00069	0.691
MOD_GSK3_1	545	552	PF00069	0.615
MOD_GSK3_1	616	623	PF00069	0.656
MOD_GSK3_1	705	712	PF00069	0.735
MOD_GSK3_1	755	762	PF00069	0.759
MOD_GSK3_1	764	771	PF00069	0.741
MOD_GSK3_1	808	815	PF00069	0.764
MOD_GSK3_1	817	824	PF00069	0.694
MOD_GSK3_1	827	834	PF00069	0.685
MOD_GSK3_1	922	929	PF00069	0.671
MOD_GSK3_1	97	104	PF00069	0.679
MOD_GSK3_1	975	982	PF00069	0.711
MOD_GSK3_1	987	994	PF00069	0.521
MOD_LATS_1	722	728	PF00433	0.758
MOD_LATS_1	806	812	PF00433	0.763
MOD_N-GLC_1	143	148	PF02516	0.740
MOD_N-GLC_1	661	666	PF02516	0.653
MOD_N-GLC_1	759	764	PF02516	0.774
MOD_NEK2_1	1025	1030	PF00069	0.647
MOD_NEK2_1	403	408	PF00069	0.460
MOD_NEK2_1	56	61	PF00069	0.639
MOD_NEK2_1	640	645	PF00069	0.547
MOD_NEK2_1	661	666	PF00069	0.446
MOD_NEK2_1	819	824	PF00069	0.647
MOD_NEK2_1	831	836	PF00069	0.619
MOD_NEK2_1	979	984	PF00069	0.636
MOD_NEK2_2	130	135	PF00069	0.678
MOD_NEK2_2	371	376	PF00069	0.632
MOD_NEK2_2	801	806	PF00069	0.693
MOD_PIKK_1	1041	1047	PF00454	0.740
MOD_PIKK_1	408	414	PF00454	0.775
MOD_PIKK_1	545	551	PF00454	0.752
MOD_PIKK_1	76	82	PF00454	0.650
MOD_PIKK_1	779	785	PF00454	0.764
MOD_PKA_2	226	232	PF00069	0.681
MOD_PKA_2	293	299	PF00069	0.622
MOD_PKA_2	37	43	PF00069	0.587
MOD_PKA_2	768	774	PF00069	0.676
MOD_PKA_2	784	790	PF00069	0.762
MOD_PKA_2	90	96	PF00069	0.720
MOD_PKA_2	97	103	PF00069	0.583
MOD_PKA_2	987	993	PF00069	0.681
MOD_PKB_1	324	332	PF00069	0.643
MOD_PKB_1	675	683	PF00069	0.606
MOD_Plk_1	246	252	PF00069	0.686
MOD_Plk_1	353	359	PF00069	0.637
MOD_Plk_1	628	634	PF00069	0.569
MOD_Plk_1	979	985	PF00069	0.700
MOD_Plk_2-3	588	594	PF00069	0.583
MOD_Plk_2-3	975	981	PF00069	0.719
MOD_Plk_4	1004	1010	PF00069	0.660
MOD_Plk_4	102	108	PF00069	0.641
MOD_Plk_4	1025	1031	PF00069	0.753
MOD_Plk_4	335	341	PF00069	0.597
MOD_Plk_4	371	377	PF00069	0.678
MOD_Plk_4	56	62	PF00069	0.630
MOD_Plk_4	794	800	PF00069	0.731
MOD_Plk_4	865	871	PF00069	0.705
MOD_Plk_4	922	928	PF00069	0.665
MOD_ProDKin_1	361	367	PF00069	0.685
MOD_ProDKin_1	470	476	PF00069	0.711
MOD_ProDKin_1	532	538	PF00069	0.641
MOD_ProDKin_1	791	797	PF00069	0.816
MOD_ProDKin_1	926	932	PF00069	0.654
MOD_ProDKin_1	936	942	PF00069	0.626
MOD_ProDKin_1	945	951	PF00069	0.376
MOD_ProDKin_1	992	998	PF00069	0.784
MOD_SUMO_rev_2	20	29	PF00179	0.675
TRG_DiLeu_BaEn_1	183	188	PF01217	0.648
TRG_DiLeu_BaEn_2	740	746	PF01217	0.617
TRG_DiLeu_BaLyEn_6	385	390	PF01217	0.647
TRG_DiLeu_BaLyEn_6	8	13	PF01217	0.604
TRG_DiLeu_BaLyEn_6	888	893	PF01217	0.525
TRG_DiLeu_LyEn_5	183	188	PF01217	0.648
TRG_ENDOCYTIC_2	1015	1018	PF00928	0.616
TRG_ENDOCYTIC_2	173	176	PF00928	0.688
TRG_ENDOCYTIC_2	185	188	PF00928	0.520
TRG_ENDOCYTIC_2	272	275	PF00928	0.611
TRG_ENDOCYTIC_2	277	280	PF00928	0.582
TRG_ENDOCYTIC_2	743	746	PF00928	0.715
TRG_ENDOCYTIC_2	965	968	PF00928	0.551
TRG_ER_diArg_1	290	292	PF00400	0.708
TRG_ER_diArg_1	301	304	PF00400	0.459
TRG_ER_diArg_1	487	490	PF00400	0.658
TRG_ER_diArg_1	674	677	PF00400	0.693
TRG_ER_diArg_1	71	73	PF00400	0.667
TRG_Pf-PMV_PEXEL_1	222	226	PF00026	0.610
TRG_Pf-PMV_PEXEL_1	676	681	PF00026	0.650
TRG_Pf-PMV_PEXEL_1	891	896	PF00026	0.618
TRG_Pf-PMV_PEXEL_1	977	981	PF00026	0.715

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKX0	Leptomonas seymouri	35%	97%
A4HDZ9	Leishmania braziliensis	74%	100%
A4I1B0	Leishmania infantum	100%	100%
E9AXE6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
Q4QA26	Leishmania major	92%	100%