Hypothetical_protein_conserved

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania donovani

UniProt:

A0A3S7WYV4_LEIDO

TriTrypDb:

LdBPK_250470.1 , LdCL_250009800 , LDHU3_25.0540

Length:

133

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A0A3S7WYV4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A0A3S7WYV4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	6	8	PF00675	0.441
CLV_PCSK_KEX2_1	109	111	PF00082	0.640
CLV_PCSK_KEX2_1	6	8	PF00082	0.441
CLV_PCSK_KEX2_1	70	72	PF00082	0.413
CLV_PCSK_PC1ET2_1	109	111	PF00082	0.616
CLV_PCSK_PC1ET2_1	6	8	PF00082	0.441
CLV_PCSK_PC1ET2_1	70	72	PF00082	0.413
CLV_PCSK_SKI1_1	79	83	PF00082	0.318
DEG_APCC_DBOX_1	78	86	PF00400	0.540
DOC_CKS1_1	30	35	PF01111	0.645
DOC_MAPK_gen_1	6	14	PF00069	0.641
DOC_MAPK_HePTP_8	4	16	PF00069	0.640
DOC_MAPK_MEF2A_6	7	16	PF00069	0.641
DOC_MAPK_MEF2A_6	79	87	PF00069	0.327
DOC_WW_Pin1_4	17	22	PF00397	0.710
DOC_WW_Pin1_4	25	30	PF00397	0.676
DOC_WW_Pin1_4	53	58	PF00397	0.678
LIG_APCC_ABBA_1	22	27	PF00400	0.674
LIG_eIF4E_1	80	86	PF01652	0.286
LIG_FHA_1	86	92	PF00498	0.403
LIG_FHA_2	26	32	PF00498	0.689
LIG_FHA_2	37	43	PF00498	0.661
LIG_FHA_2	99	105	PF00498	0.401
LIG_LIR_Gen_1	78	87	PF02991	0.479
LIG_NRBOX	86	92	PF00104	0.468
LIG_PDZ_Class_3	128	133	PF00595	0.452
LIG_SH2_CRK	72	76	PF00017	0.585
LIG_SH2_STAT5	80	83	PF00017	0.318
LIG_SH3_3	114	120	PF00018	0.420
LIG_SH3_3	27	33	PF00018	0.795
LIG_SH3_3	51	57	PF00018	0.675
LIG_SUMO_SIM_par_1	82	88	PF11976	0.336
LIG_TRAF2_1	38	41	PF00917	0.645
MOD_CK1_1	52	58	PF00069	0.731
MOD_CK2_1	29	35	PF00069	0.786
MOD_CK2_1	36	42	PF00069	0.686
MOD_CK2_1	44	50	PF00069	0.611
MOD_CK2_1	98	104	PF00069	0.406
MOD_DYRK1A_RPxSP_1	53	57	PF00069	0.678
MOD_GSK3_1	118	125	PF00069	0.512
MOD_GSK3_1	25	32	PF00069	0.648
MOD_GSK3_1	49	56	PF00069	0.671
MOD_NEK2_1	49	54	PF00069	0.711
MOD_NEK2_1	85	90	PF00069	0.345
MOD_NEK2_1	92	97	PF00069	0.376
MOD_PK_1	8	14	PF00069	0.663
MOD_PKA_2	52	58	PF00069	0.731
MOD_Plk_1	8	14	PF00069	0.624
MOD_Plk_2-3	100	106	PF00069	0.402
MOD_Plk_4	85	91	PF00069	0.361
MOD_ProDKin_1	17	23	PF00069	0.712
MOD_ProDKin_1	25	31	PF00069	0.678
MOD_ProDKin_1	53	59	PF00069	0.680
MOD_SUMO_rev_2	104	111	PF00179	0.408
MOD_SUMO_rev_2	95	103	PF00179	0.556
TRG_DiLeu_BaEn_1	78	83	PF01217	0.540
TRG_ENDOCYTIC_2	72	75	PF00928	0.586
TRG_ENDOCYTIC_2	80	83	PF00928	0.333

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0C5	Leptomonas seymouri	50%	100%
A4HDY8	Leishmania braziliensis	70%	100%
A4I189	Leishmania infantum	100%	100%
E9AXC3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QA49	Leishmania major	88%	100%